PDIA2 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PDIA2
Entrez Gene ID	64714
Full Name	protein disulfide isomerase family A member 2
Synonyms	PDA2,PDI,PDIP,PDIR
General protein information	Preferred Names protein disulfide isomerase family A member 2 Names protein disulfide-isomerase A2 Rho GDP dissociation inhibitor gamma pancreas-specific protein disulfide isomerase pancreatic protein disulfide isomerase protein disulfide isomerase, pancreatic protein disulfide isomerase-associated 2
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels. [provided by RefSeq, Sep 2017].
Disorder MIM:	608012

mRNA and Protein(s)

mRNA	Protein	Name
NM_006849.3	NP_006840.2	protein disulfide-isomerase A2 precursor
NM_006849.4	NP_006840.2	protein disulfide-isomerase A2 precursor
NM_006849.2	NP_006840.2	protein disulfide-isomerase A2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PDIA2	XP_003434921.2
Xenopus tropicalis (tropical clawed frog)	pdia2	NP_001011281.1
Homo sapiens (human)	PDIA2	NP_006840.2
Rattus norvegicus (Norway rat)	Pdia2	NP_001099245.2
Bos taurus (cattle)	PDIA2	NP_001092331.1
Gallus gallus (chicken)	LOC100857897	XP_003642202.2
	PDIA2	XP_001084171.1
Mus musculus (house mouse)	Pdia2	NP_001074539.1

Gene Ontology
Bibliography

Related articles in PubMed

Galectin-9 binds to O-glycans on protein disulfide isomerase.
Schaefer K, Webb NE, Pang M, Hernandez-Davies JE, Lee KP, Gonzalez P, Douglass MV, Lee B, Baum LG
Glycobiology27(9)878-887(2017 Sep)

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.
Vatolin S, Phillips JG, Jha BK, Govindgari S, Hu J, Grabowski D, Parker Y, Lindner DJ, Zhong F, Distelhorst CW, Smith MR, Cotta C, Xu Y, Chilakala S, Kuang RR, Tall S, Reu FJ
Cancer research76(11)3340-50(2016 06)

Protein disulfide isomerase mediates dengue virus entry in association with lipid rafts.
Diwaker D, Mishra KP, Ganju L, Singh SB
Viral immunology28(3)153-60(2015 Apr)

Protein disulphide-isomerase A2 regulated intracellular tissue factor mobilisation in migrating human vascular smooth muscle cells.
Pe?a E, Arderiu G, Badimon L
Thrombosis and haemostasis113(4)891-902(2015 Apr)

Cell surface protein disulfide isomerase regulates natriuretic peptide generation of cyclic guanosine monophosphate.
Pan S, Chen HH, Correia C, Dai H, Witt TA, Kleppe LS, Burnett JC Jr, Simari RD
PloS one9(11)e112986(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PDI overexpression is associated with Multiple Myeloma.
Title: Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.

It was found that PDI interacts with dengue virus nonstructural protein 1 (NS1) intracellularly as well as on the surface in the lipid raft domain.
Title: Protein disulfide isomerase mediates dengue virus entry in association with lipid rafts.

Tissue factor-regulated vascular smooth cell migration and microvessel formation is under the control of the ER-protein PDIA2.
Title: Protein disulphide-isomerase A2 regulated intracellular tissue factor mobilisation in migrating human vascular smooth muscle cells.

These results indicate that BPA, a widely distributed and potentially harmful chemical, inhibits Ero1-PDI-mediated disulfide bond formation.
Title: Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1? (Ero1?) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A.

Data show that cell surface disulfide isomerase (PDI) expression and function regulate the capacity of natriuretic peptides to generate cyclic guanosine monophosphate (cGMP) through interaction with their receptors.
Title: Cell surface protein disulfide isomerase regulates natriuretic peptide generation of cyclic guanosine monophosphate.

The following PDIA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PDIA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17255	NM_006849.4 Latest version!	Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu17255	NM_006849.3	Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu17255	NM_006849.2	Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PDIA2 ( NM_006849.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_006840.2 Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.

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CloneID	OHu17255
Clone ID Related Accession (Same CDS sequence)	NM_006849.3 , NM_006849.4 , NM_006849.2
Accession Version	NM_006849.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	protein disulfide-isomerase A2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC327068.1, BC000537.2, BX110662.1 and CK906330.1. On Sep 4, 2017 this sequence version replaced NM_006849.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.15802.1, BC000537.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGCCGCC AGCTTCTGCC TGTACTGCTG CTGCTGCTGC TCAGGGCTTC GTGCCCATGG 
GGTCAGGAAC AGGGAGCGAG GAGCCCCTCG GAGGAGCCTC CAGAGGAGGA AATCCCCAAG 
GAGGATGGGA TCTTGGTGCT GAGCCGCCAC ACCCTGGGCC TGGCCCTGCG GGAGCACCCT 
GCCCTGCTGG TGGAATTCTA TGCCCCGTGG TGTGGGCACT GCCAGGCCCT GGCCCCCGAG 
TACAGCAAGG CAGCTGCCGT GCTCGCGGCC GAGTCAATGG TGGTCACGCT GGCCAAGGTG 
GATGGGCCCG CGCAGCGCGA GCTGGCTGAG GAGTTTGGTG TGACGGAGTA CCCTACGCTC 
AAGTTCTTCC GCAATGGGAA CCGCACGCAC CCGGAGGAGT ACACAGGACC ACGGGACGCT 
GAGGGCATTG CCGAGTGGCT GCGACGGCGG GTGGGGCCCA GTGCCATGCG GCTGGAGGAC 
GAGGCGGCCG CCCAGGCGCT GATCGGTGGC CGGGACCTAG TGGTCATTGG CTTCTTCCAG 
GACCTGCAGG ACGAGGACGT GGCCACCTTC TTGGCCTTGG CCCAGGACGC CCTGGACATG 
ACCTTTGGCC TCACAGACCG GCCGCGGCTC TTTCAGCAGT TTGGCCTCAC CAAGGACACT 
GTGGTTCTCT TCAAGAAGTT TGATGAGGGG CGGGCAGACT TCCCCGTGGA CGAGGAGCTT 
GGCCTGGACC TGGGGGATCT GTCGCGCTTC CTGGTCACAC ACAGCATGCG CCTGGTCACG 
GAGTTCAACA GCCAGACGTC TGCCAAGATC TTCGCGGCCA GGATCCTCAA CCACCTGCTG 
CTGTTTGTCA ACCAGACGCT GGCTGCGCAC CGGGAGCTCC TAGCGGGCTT TGGGGAGGCA 
GCTCCCCGCT TCCGGGGGCA GGTGCTGTTC GTGGTGGTGG ACGTGGCGGC CGACAATGAG 
CACGTGCTGC AGTACTTTGG ACTCAAGGCT GAGGCAGCCC CCACTCTGCG CTTGGTCAAC 
CTTGAAACCA CTAAGAAGTA TGCGCCTGTG GATGGGGGCC CTGTCACCGC AGCGTCCATC 
ACTGCTTTCT GCCATGCAGT CCTCAACGGC CAAGTCAAGC CCTATCTCCT GAGCCAGGAG 
ATACCCCCTG ATTGGGATCA GCGGCCAGTT AAGACCCTCG TGGGCAAGAA TTTTGAGCAG 
GTGGCTTTTG ACGAAACCAA GAATGTGTTT GTCAAGTTCT ATGCCCCGTG GTGCACCCAC 
TGCAAGGAGA TGGCCCCTGC CTGGGAGGCA TTGGCTGAGA AGTACCAAGA CCACGAGGAC 
ATCATCATTG CTGAGCTGGA TGCCACGGCC AACGAGCTGG ATGCCTTCGC TGTGCACGGC 
TTCCCTACTC TCAAGTACTT CCCAGCAGGG CCAGGTCGGA AGGTGATTGA ATACAAAAGC 
ACCAGGGACC TGGAGACTTT CTCCAAGTTC CTGGACAACG GGGGCGTGCT GCCCACGGAG 
GAGCCCCCGG AGGAGCCAGC AGCCCCGTTC CCGGAGCCAC CGGCCAACTC CACTATGGGG 
TCCAAGGAGG AACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006840.2
CDS	34..1611
Translation	MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL

Target ORF information:

RefSeq Version	NM_006849.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006849.3

ORF Insert Sequence:

ATGAGCCGCC AGCTTCTGCC TGTACTGCTG CTGCTGCTGC TCAGGGCTTC GTGCCCATGG 
GGTCAGGAAC AGGGAGCGAG GAGCCCCTCG GAGGAGCCTC CAGAGGAGGA AATCCCCAAG 
GAGGATGGGA TCTTGGTGCT GAGCCGCCAC ACCCTGGGCC TGGCCCTGCG GGAGCACCCT 
GCCCTGCTGG TGGAATTCTA TGCCCCGTGG TGTGGGCACT GCCAGGCCCT GGCCCCCGAG 
TACAGCAAGG CAGCTGCCGT GCTCGCGGCC GAGTCAATGG TGGTCACGCT GGCCAAGGTG 
GATGGGCCCG CGCAGCGCGA GCTGGCTGAG GAGTTTGGTG TGACGGAGTA CCCTACGCTC 
AAGTTCTTCC GCAATGGGAA CCGCACGCAC CCGGAGGAGT ACACAGGACC ACGGGACGCT 
GAGGGCATTG CCGAGTGGCT GCGACGGCGG GTGGGGCCCA GTGCCATGCG GCTGGAGGAC 
GAGGCGGCCG CCCAGGCGCT GATCGGTGGC CGGGACCTAG TGGTCATTGG CTTCTTCCAG 
GACCTGCAGG ACGAGGACGT GGCCACCTTC TTGGCCTTGG CCCAGGACGC CCTGGACATG 
ACCTTTGGCC TCACAGACCG GCCGCGGCTC TTTCAGCAGT TTGGCCTCAC CAAGGACACT 
GTGGTTCTCT TCAAGAAGTT TGATGAGGGG CGGGCAGACT TCCCCGTGGA CGAGGAGCTT 
GGCCTGGACC TGGGGGATCT GTCGCGCTTC CTGGTCACAC ACAGCATGCG CCTGGTCACG 
GAGTTCAACA GCCAGACGTC TGCCAAGATC TTCGCGGCCA GGATCCTCAA CCACCTGCTG 
CTGTTTGTCA ACCAGACGCT GGCTGCGCAC CGGGAGCTCC TAGCGGGCTT TGGGGAGGCA 
GCTCCCCGCT TCCGGGGGCA GGTGCTGTTC GTGGTGGTGG ACGTGGCGGC CGACAATGAG 
CACGTGCTGC AGTACTTTGG ACTCAAGGCT GAGGCAGCCC CCACTCTGCG CTTGGTCAAC 
CTTGAAACCA CTAAGAAGTA TGCGCCTGTG GATGGGGGCC CTGTCACCGC AGCGTCCATC 
ACTGCTTTCT GCCATGCAGT CCTCAACGGC CAAGTCAAGC CCTATCTCCT GAGCCAGGAG 
ATACCCCCTG ATTGGGATCA GCGGCCAGTT AAGACCCTCG TGGGCAAGAA TTTTGAGCAG 
GTGGCTTTTG ACGAAACCAA GAATGTGTTT GTCAAGTTCT ATGCCCCGTG GTGCACCCAC 
TGCAAGGAGA TGGCCCCTGC CTGGGAGGCA TTGGCTGAGA AGTACCAAGA CCACGAGGAC 
ATCATCATTG CTGAGCTGGA TGCCACGGCC AACGAGCTGG ATGCCTTCGC TGTGCACGGC 
TTCCCTACTC TCAAGTACTT CCCAGCAGGG CCAGGTCGGA AGGTGATTGA ATACAAAAGC 
ACCAGGGACC TGGAGACTTT CTCCAAGTTC CTGGACAACG GGGGCGTGCT GCCCACGGAG 
GAGCCCCCGG AGGAGCCAGC AGCCCCGTTC CCGGAGCCAC CGGCCAACTC CACTATGGGG 
TCCAAGGAGG AACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDIA2 ( NM_006849.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_006840.2 Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.

Price & Availability↑

CloneID	OHu17255
Clone ID Related Accession (Same CDS sequence)	NM_006849.3 , NM_006849.4 , NM_006849.2
Accession Version	NM_006849.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-27
Organism	Homo sapiens(Human)
Product	protein disulfide-isomerase A2 precursor
Comment	VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA207692.1, BC000537.2 and BC075029.2. On May 9, 2006 this sequence version replaced NM_006849.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U19948.1, SRR1660809.15802.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142586, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END##

ATGAGCCGCC AGCTTCTGCC TGTACTGCTG CTGCTGCTGC TCAGGGCTTC GTGCCCATGG 
GGTCAGGAAC AGGGAGCGAG GAGCCCCTCG GAGGAGCCTC CAGAGGAGGA AATCCCCAAG 
GAGGATGGGA TCTTGGTGCT GAGCCGCCAC ACCCTGGGCC TGGCCCTGCG GGAGCACCCT 
GCCCTGCTGG TGGAATTCTA TGCCCCGTGG TGTGGGCACT GCCAGGCCCT GGCCCCCGAG 
TACAGCAAGG CAGCTGCCGT GCTCGCGGCC GAGTCAATGG TGGTCACGCT GGCCAAGGTG 
GATGGGCCCG CGCAGCGCGA GCTGGCTGAG GAGTTTGGTG TGACGGAGTA CCCTACGCTC 
AAGTTCTTCC GCAATGGGAA CCGCACGCAC CCGGAGGAGT ACACAGGACC ACGGGACGCT 
GAGGGCATTG CCGAGTGGCT GCGACGGCGG GTGGGGCCCA GTGCCATGCG GCTGGAGGAC 
GAGGCGGCCG CCCAGGCGCT GATCGGTGGC CGGGACCTAG TGGTCATTGG CTTCTTCCAG 
GACCTGCAGG ACGAGGACGT GGCCACCTTC TTGGCCTTGG CCCAGGACGC CCTGGACATG 
ACCTTTGGCC TCACAGACCG GCCGCGGCTC TTTCAGCAGT TTGGCCTCAC CAAGGACACT 
GTGGTTCTCT TCAAGAAGTT TGATGAGGGG CGGGCAGACT TCCCCGTGGA CGAGGAGCTT 
GGCCTGGACC TGGGGGATCT GTCGCGCTTC CTGGTCACAC ACAGCATGCG CCTGGTCACG 
GAGTTCAACA GCCAGACGTC TGCCAAGATC TTCGCGGCCA GGATCCTCAA CCACCTGCTG 
CTGTTTGTCA ACCAGACGCT GGCTGCGCAC CGGGAGCTCC TAGCGGGCTT TGGGGAGGCA 
GCTCCCCGCT TCCGGGGGCA GGTGCTGTTC GTGGTGGTGG ACGTGGCGGC CGACAATGAG 
CACGTGCTGC AGTACTTTGG ACTCAAGGCT GAGGCAGCCC CCACTCTGCG CTTGGTCAAC 
CTTGAAACCA CTAAGAAGTA TGCGCCTGTG GATGGGGGCC CTGTCACCGC AGCGTCCATC 
ACTGCTTTCT GCCATGCAGT CCTCAACGGC CAAGTCAAGC CCTATCTCCT GAGCCAGGAG 
ATACCCCCTG ATTGGGATCA GCGGCCAGTT AAGACCCTCG TGGGCAAGAA TTTTGAGCAG 
GTGGCTTTTG ACGAAACCAA GAATGTGTTT GTCAAGTTCT ATGCCCCGTG GTGCACCCAC 
TGCAAGGAGA TGGCCCCTGC CTGGGAGGCA TTGGCTGAGA AGTACCAAGA CCACGAGGAC 
ATCATCATTG CTGAGCTGGA TGCCACGGCC AACGAGCTGG ATGCCTTCGC TGTGCACGGC 
TTCCCTACTC TCAAGTACTT CCCAGCAGGG CCAGGTCGGA AGGTGATTGA ATACAAAAGC 
ACCAGGGACC TGGAGACTTT CTCCAAGTTC CTGGACAACG GGGGCGTGCT GCCCACGGAG 
GAGCCCCCGG AGGAGCCAGC AGCCCCGTTC CCGGAGCCAC CGGCCAACTC CACTATGGGG 
TCCAAGGAGG AACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006840.2
CDS	53..1630
Translation	MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL

Target ORF information:

RefSeq Version	NM_006849.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006849.2

ORF Insert Sequence:

ATGAGCCGCC AGCTTCTGCC TGTACTGCTG CTGCTGCTGC TCAGGGCTTC GTGCCCATGG 
GGTCAGGAAC AGGGAGCGAG GAGCCCCTCG GAGGAGCCTC CAGAGGAGGA AATCCCCAAG 
GAGGATGGGA TCTTGGTGCT GAGCCGCCAC ACCCTGGGCC TGGCCCTGCG GGAGCACCCT 
GCCCTGCTGG TGGAATTCTA TGCCCCGTGG TGTGGGCACT GCCAGGCCCT GGCCCCCGAG 
TACAGCAAGG CAGCTGCCGT GCTCGCGGCC GAGTCAATGG TGGTCACGCT GGCCAAGGTG 
GATGGGCCCG CGCAGCGCGA GCTGGCTGAG GAGTTTGGTG TGACGGAGTA CCCTACGCTC 
AAGTTCTTCC GCAATGGGAA CCGCACGCAC CCGGAGGAGT ACACAGGACC ACGGGACGCT 
GAGGGCATTG CCGAGTGGCT GCGACGGCGG GTGGGGCCCA GTGCCATGCG GCTGGAGGAC 
GAGGCGGCCG CCCAGGCGCT GATCGGTGGC CGGGACCTAG TGGTCATTGG CTTCTTCCAG 
GACCTGCAGG ACGAGGACGT GGCCACCTTC TTGGCCTTGG CCCAGGACGC CCTGGACATG 
ACCTTTGGCC TCACAGACCG GCCGCGGCTC TTTCAGCAGT TTGGCCTCAC CAAGGACACT 
GTGGTTCTCT TCAAGAAGTT TGATGAGGGG CGGGCAGACT TCCCCGTGGA CGAGGAGCTT 
GGCCTGGACC TGGGGGATCT GTCGCGCTTC CTGGTCACAC ACAGCATGCG CCTGGTCACG 
GAGTTCAACA GCCAGACGTC TGCCAAGATC TTCGCGGCCA GGATCCTCAA CCACCTGCTG 
CTGTTTGTCA ACCAGACGCT GGCTGCGCAC CGGGAGCTCC TAGCGGGCTT TGGGGAGGCA 
GCTCCCCGCT TCCGGGGGCA GGTGCTGTTC GTGGTGGTGG ACGTGGCGGC CGACAATGAG 
CACGTGCTGC AGTACTTTGG ACTCAAGGCT GAGGCAGCCC CCACTCTGCG CTTGGTCAAC 
CTTGAAACCA CTAAGAAGTA TGCGCCTGTG GATGGGGGCC CTGTCACCGC AGCGTCCATC 
ACTGCTTTCT GCCATGCAGT CCTCAACGGC CAAGTCAAGC CCTATCTCCT GAGCCAGGAG 
ATACCCCCTG ATTGGGATCA GCGGCCAGTT AAGACCCTCG TGGGCAAGAA TTTTGAGCAG 
GTGGCTTTTG ACGAAACCAA GAATGTGTTT GTCAAGTTCT ATGCCCCGTG GTGCACCCAC 
TGCAAGGAGA TGGCCCCTGC CTGGGAGGCA TTGGCTGAGA AGTACCAAGA CCACGAGGAC 
ATCATCATTG CTGAGCTGGA TGCCACGGCC AACGAGCTGG ATGCCTTCGC TGTGCACGGC 
TTCCCTACTC TCAAGTACTT CCCAGCAGGG CCAGGTCGGA AGGTGATTGA ATACAAAAGC 
ACCAGGGACC TGGAGACTTT CTCCAAGTTC CTGGACAACG GGGGCGTGCT GCCCACGGAG 
GAGCCCCCGG AGGAGCCAGC AGCCCCGTTC CCGGAGCCAC CGGCCAACTC CACTATGGGG 
TCCAAGGAGG AACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PDIA2 ( NM_006849.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_006840.2 Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.

Price & Availability↑

CloneID	OHu17255
Clone ID Related Accession (Same CDS sequence)	NM_006849.3 , NM_006849.4 , NM_006849.2
Accession Version	NM_006849.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1578bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-29
Organism	Homo sapiens(human)
Product	protein disulfide-isomerase A2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z69667.1. On Aug 16, 2019 this sequence version replaced NM_006849.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.571219.1, SRR7410570.571220.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCCGCC AGCTTCTGCC TGTACTGCTG CTGCTGCTGC TCAGGGCTTC GTGCCCATGG 
GGTCAGGAAC AGGGAGCGAG GAGCCCCTCG GAGGAGCCTC CAGAGGAGGA AATCCCCAAG 
GAGGATGGGA TCTTGGTGCT GAGCCGCCAC ACCCTGGGCC TGGCCCTGCG GGAGCACCCT 
GCCCTGCTGG TGGAATTCTA TGCCCCGTGG TGTGGGCACT GCCAGGCCCT GGCCCCCGAG 
TACAGCAAGG CAGCTGCCGT GCTCGCGGCC GAGTCAATGG TGGTCACGCT GGCCAAGGTG 
GATGGGCCCG CGCAGCGCGA GCTGGCTGAG GAGTTTGGTG TGACGGAGTA CCCTACGCTC 
AAGTTCTTCC GCAATGGGAA CCGCACGCAC CCGGAGGAGT ACACAGGACC ACGGGACGCT 
GAGGGCATTG CCGAGTGGCT GCGACGGCGG GTGGGGCCCA GTGCCATGCG GCTGGAGGAC 
GAGGCGGCCG CCCAGGCGCT GATCGGTGGC CGGGACCTAG TGGTCATTGG CTTCTTCCAG 
GACCTGCAGG ACGAGGACGT GGCCACCTTC TTGGCCTTGG CCCAGGACGC CCTGGACATG 
ACCTTTGGCC TCACAGACCG GCCGCGGCTC TTTCAGCAGT TTGGCCTCAC CAAGGACACT 
GTGGTTCTCT TCAAGAAGTT TGATGAGGGG CGGGCAGACT TCCCCGTGGA CGAGGAGCTT 
GGCCTGGACC TGGGGGATCT GTCGCGCTTC CTGGTCACAC ACAGCATGCG CCTGGTCACG 
GAGTTCAACA GCCAGACGTC TGCCAAGATC TTCGCGGCCA GGATCCTCAA CCACCTGCTG 
CTGTTTGTCA ACCAGACGCT GGCTGCGCAC CGGGAGCTCC TAGCGGGCTT TGGGGAGGCA 
GCTCCCCGCT TCCGGGGGCA GGTGCTGTTC GTGGTGGTGG ACGTGGCGGC CGACAATGAG 
CACGTGCTGC AGTACTTTGG ACTCAAGGCT GAGGCAGCCC CCACTCTGCG CTTGGTCAAC 
CTTGAAACCA CTAAGAAGTA TGCGCCTGTG GATGGGGGCC CTGTCACCGC AGCGTCCATC 
ACTGCTTTCT GCCATGCAGT CCTCAACGGC CAAGTCAAGC CCTATCTCCT GAGCCAGGAG 
ATACCCCCTG ATTGGGATCA GCGGCCAGTT AAGACCCTCG TGGGCAAGAA TTTTGAGCAG 
GTGGCTTTTG ACGAAACCAA GAATGTGTTT GTCAAGTTCT ATGCCCCGTG GTGCACCCAC 
TGCAAGGAGA TGGCCCCTGC CTGGGAGGCA TTGGCTGAGA AGTACCAAGA CCACGAGGAC 
ATCATCATTG CTGAGCTGGA TGCCACGGCC AACGAGCTGG ATGCCTTCGC TGTGCACGGC 
TTCCCTACTC TCAAGTACTT CCCAGCAGGG CCAGGTCGGA AGGTGATTGA ATACAAAAGC 
ACCAGGGACC TGGAGACTTT CTCCAAGTTC CTGGACAACG GGGGCGTGCT GCCCACGGAG 
GAGCCCCCGG AGGAGCCAGC AGCCCCGTTC CCGGAGCCAC CGGCCAACTC CACTATGGGG 
TCCAAGGAGG AACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_006840.2
CDS	7..1584
Translation	MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL

Target ORF information:

RefSeq Version	NM_006849.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein disulfide isomerase family A member 2 (PDIA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_006849.4

ORF Insert Sequence:

ATGAGCCGCC AGCTTCTGCC TGTACTGCTG CTGCTGCTGC TCAGGGCTTC GTGCCCATGG 
GGTCAGGAAC AGGGAGCGAG GAGCCCCTCG GAGGAGCCTC CAGAGGAGGA AATCCCCAAG 
GAGGATGGGA TCTTGGTGCT GAGCCGCCAC ACCCTGGGCC TGGCCCTGCG GGAGCACCCT 
GCCCTGCTGG TGGAATTCTA TGCCCCGTGG TGTGGGCACT GCCAGGCCCT GGCCCCCGAG 
TACAGCAAGG CAGCTGCCGT GCTCGCGGCC GAGTCAATGG TGGTCACGCT GGCCAAGGTG 
GATGGGCCCG CGCAGCGCGA GCTGGCTGAG GAGTTTGGTG TGACGGAGTA CCCTACGCTC 
AAGTTCTTCC GCAATGGGAA CCGCACGCAC CCGGAGGAGT ACACAGGACC ACGGGACGCT 
GAGGGCATTG CCGAGTGGCT GCGACGGCGG GTGGGGCCCA GTGCCATGCG GCTGGAGGAC 
GAGGCGGCCG CCCAGGCGCT GATCGGTGGC CGGGACCTAG TGGTCATTGG CTTCTTCCAG 
GACCTGCAGG ACGAGGACGT GGCCACCTTC TTGGCCTTGG CCCAGGACGC CCTGGACATG 
ACCTTTGGCC TCACAGACCG GCCGCGGCTC TTTCAGCAGT TTGGCCTCAC CAAGGACACT 
GTGGTTCTCT TCAAGAAGTT TGATGAGGGG CGGGCAGACT TCCCCGTGGA CGAGGAGCTT 
GGCCTGGACC TGGGGGATCT GTCGCGCTTC CTGGTCACAC ACAGCATGCG CCTGGTCACG 
GAGTTCAACA GCCAGACGTC TGCCAAGATC TTCGCGGCCA GGATCCTCAA CCACCTGCTG 
CTGTTTGTCA ACCAGACGCT GGCTGCGCAC CGGGAGCTCC TAGCGGGCTT TGGGGAGGCA 
GCTCCCCGCT TCCGGGGGCA GGTGCTGTTC GTGGTGGTGG ACGTGGCGGC CGACAATGAG 
CACGTGCTGC AGTACTTTGG ACTCAAGGCT GAGGCAGCCC CCACTCTGCG CTTGGTCAAC 
CTTGAAACCA CTAAGAAGTA TGCGCCTGTG GATGGGGGCC CTGTCACCGC AGCGTCCATC 
ACTGCTTTCT GCCATGCAGT CCTCAACGGC CAAGTCAAGC CCTATCTCCT GAGCCAGGAG 
ATACCCCCTG ATTGGGATCA GCGGCCAGTT AAGACCCTCG TGGGCAAGAA TTTTGAGCAG 
GTGGCTTTTG ACGAAACCAA GAATGTGTTT GTCAAGTTCT ATGCCCCGTG GTGCACCCAC 
TGCAAGGAGA TGGCCCCTGC CTGGGAGGCA TTGGCTGAGA AGTACCAAGA CCACGAGGAC 
ATCATCATTG CTGAGCTGGA TGCCACGGCC AACGAGCTGG ATGCCTTCGC TGTGCACGGC 
TTCCCTACTC TCAAGTACTT CCCAGCAGGG CCAGGTCGGA AGGTGATTGA ATACAAAAGC 
ACCAGGGACC TGGAGACTTT CTCCAAGTTC CTGGACAACG GGGGCGTGCT GCCCACGGAG 
GAGCCCCCGG AGGAGCCAGC AGCCCCGTTC CCGGAGCCAC CGGCCAACTC CACTATGGGG 
TCCAAGGAGG AACTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Galectin-9 binds to O-glycans on protein disulfide isomerase.
Glycobiology27(9)878-887(2017 Sep)
Schaefer K,Webb NE,Pang M,Hernandez-Davies JE,Lee KP,Gonzalez P,Douglass MV,Lee B,Baum LG

Novel Protein Disulfide Isomerase Inhibitor with Anticancer Activity in Multiple Myeloma.
Cancer research76(11)3340-50(2016 06)
Vatolin S,Phillips JG,Jha BK,Govindgari S,Hu J,Grabowski D,Parker Y,Lindner DJ,Zhong F,Distelhorst CW,Smith MR,Cotta C,Xu Y,Chilakala S,Kuang RR,Tall S,Reu FJ

Protein disulfide isomerase mediates dengue virus entry in association with lipid rafts.
Viral immunology28(3)153-60(2015 Apr)
Diwaker D,Mishra KP,Ganju L,Singh SB

Protein disulphide-isomerase A2 regulated intracellular tissue factor mobilisation in migrating human vascular smooth muscle cells.
Thrombosis and haemostasis113(4)891-902(2015 Apr)
Pe?a E,Arderiu G,Badimon L

Cell surface protein disulfide isomerase regulates natriuretic peptide generation of cyclic guanosine monophosphate.
PloS one9(11)e112986(2014)
Pan S,Chen HH,Correia C,Dai H,Witt TA,Kleppe LS,Burnett JC Jr,Simari RD

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PDIA2 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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