Pdia2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pdia2
Entrez Gene ID	287164
Full Name	protein disulfide isomerase family A, member 2
Synonyms	Pdip
General protein information	Preferred Names protein disulfide isomerase family A, member 2 Names protein disulfide-isomerase A2 protein disulfide isomerase associated 2 protein disulfide isomerase, pancreatic
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q12

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105775.2	NP_001099245.2	protein disulfide-isomerase A2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PDIA2	XP_003434921.2
Xenopus tropicalis (tropical clawed frog)	pdia2	NP_001011281.1
Homo sapiens (human)	PDIA2	NP_006840.2
Rattus norvegicus (Norway rat)	Pdia2	NP_001099245.2
Bos taurus (cattle)	PDIA2	NP_001092331.1
Gallus gallus (chicken)	LOC100857897	XP_003642202.2
	PDIA2	XP_001084171.1
Mus musculus (house mouse)	Pdia2	NP_001074539.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1? (Ero1?) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A.
Okumura M, Kadokura H, Hashimoto S, Yutani K, Kanemura S, Hikima T, Hidaka Y, Ito L, Shiba K, Masui S, Imai D, Imaoka S, Yamaguchi H, Inaba K
The Journal of biological chemistry289(39)27004-18(2014 Sep)

Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells.
Fu XM, Zhu BT
The Journal of steroid biochemistry and molecular biology115(1-2)20-9(2009 May)

GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.
Zhang L, Lai E, Teodoro T, Volchuk A
The Journal of biological chemistry284(8)5289-98(2009 Feb)

pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family.
Alanen HI, Salo KE, Pirneskoski A, Ruddock LW
Antioxidants & redox signaling8(3-4)283-91(2006 Mar-Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that BPA, a widely distributed and potentially harmful chemical, inhibits Ero1-PDI-mediated disulfide bond formation.
Title: Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1? (Ero1?) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A.

PDIp can also serve as an effective modulator of the cellular levels and biological actions of endogenous estrogens in the pancreas where estrogen receptors alpha and beta and PDIp are co-present.
Title: Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells.

a role for both GRP78 and PDI in insulin biosynthesis, although an excess of PDI disrupts normal proinsulin processing.
Title: GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.

The following Pdia2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pdia2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa04293	NM_001105775.2 Latest version!	Rattus norvegicus protein disulfide isomerase family A, member 2 (Pdia2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pdia2 ( NM_001105775.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001099245.2 Rattus norvegicus protein disulfide isomerase family A, member 2 (Pdia2), mRNA.

Price & Availability↑

CloneID	ORa04293
Clone ID Related Accession (Same CDS sequence)	NM_001105775.2
Accession Version	NM_001105775.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Rattus norvegicus(Norway rat)
Product	protein disulfide-isomerase A2 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AAHX01062955.1. On Jan 12, 2008 this sequence version replaced NM_001105775.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGATGATC GGTTTCTGCC AGTGTTGCTG CTCCTGCTGG GTGTCTCAGG CTCATGGGGA 
CAGGGAGAGG AGCCGGGGGG TCCCCCAGAG GTGCTCTCTG AGGAGTCCAT TGGGGAAGAA 
GTCCCCGAGG AGGATGGAAT CTTGGTTTTG AACAACCAAA CCCTGAGCCT GGCACTGCAG 
GAGCATTCAG CCCTGATGGT GGAGTTTTAT GCCCCATGGT GTGGTCACTG CAAGGCACTA 
GCTCCTGAGT ACAGCAAGGC AGCTGCCCTG CTGGCAGCTG AGTCAGCTGC GGTCACCTTG 
GCCAAGGTGG ATGGGCCTGC GGAACCAGAG CTGACCAAGG AGTTTGGAGT GGTAGGGTAC 
CCTACACTCA AGTTCTTCCA GAATGGAAAC CGCACAAACC CAGAAGAATA CATAGGGCCC 
AAGACAGCTG AGGGCATTGC TGAGTGGCTG AGGCGGCGAG TGGGGCCCAG CGCCACACGT 
CTGGAGGATG AGGAAGGTGT CCAGGCACTG ATGGCCAAAT GGGATATGGT GGTCATTGGC 
TTCTTTCAGG ATCTACAGGA AGAGGATGTG GCAACTTTCC TGGCCTTGGC CAGGGATGCT 
CTGGACATGG CCTTTGGCTT CACTGACCAG CCACAGCTTT TTGAGAAGTT TGGCCTCACC 
AAGGACACTG TGGTCCTTTT CAAGAAGTTT GATGAGGGTC GGGCCGACTT CCCGGTAGAC 
AAGGAGGCTG GCCTGGACCT GGGGGACCTG TCCCGCTTCC TCATCACACA CAGCATGCAC 
CTGGTCACAG AATTCAACAG CCAGACATCA CCTAAGATCT TTGCAGCCAG GATCCTCAAC 
CACCTGCTGC TGTTTGTGAA CCAGACACTA GCTCAGCACA GGGAGCTACT GACAGGCTTC 
AGGGAGGCAG CTCCTCCATT CCGGGGACAG GTGTTGTTTG TGATGGTGGA TGTGGCCGCT 
GACAACAGCC ATGTGCTAAA TTATTTTGGC CTCAAGGCTG AGGAAGCCCC CACCCTGCGT 
CTGATTAATG TTGAGACTAC CAAGAAGTAT GCACCTGCAG GGGTGATACC CATCACTGCA 
GCTTCTGTGG CTGCATTCTG CCAGGCAGTC CTCCATGGGG AAGTCAAGCA CTATCTCCTG 
AGCCAGGAGA TACCCCCCGA CTGGGACCAG CGGCCAGTCA AGACTCTTGT GAGCAAGAAT 
TTTGAGCAGG TTGCCTTTGA TGAAACCAAG AATGTGTTTG TCAAGTTCTA TGCCCCATGG 
TGCAGCCACT GCAAGGAGAT GGCTCCAGCC TGGGAGGCAC TGGCAGAGAA GTACAGGGAT 
CGTGAGGACA TTGTCATTGC TGAGATGGAT GCTACAGCTA ACGAGCTGGA GGCCTTCTCT 
GTGCATGGCT ATCCCACTCT CAAGTTCTTC CCTGCAGGAC CTGACCGAAA GATTATAGAA 
TACAAAAGCA CCAGGGACCT AGAGACATTC TCCAAGTTCC TGGACAGAGG AGGTGACCTG 
CCTGAGGAAG AATCCAAGGA GCCTGCAGTC TCTGCCCCAG AAGCACAACC CAATTCCACC 
TTGGGTCCCA AGGAGGAGCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099245.2
CDS	1..1584
Translation	MDDRFLPVLLLLLGVSGSWGQGEEPGGPPEVLSEESIGEEVPEEDGILVLNNQTLSLALQEHSALMVEFYAPWCGHCKALAPEYSKAAALLAAESAAVTLAKVDGPAEPELTKEFGVVGYPTLKFFQNGNRTNPEEYIGPKTAEGIAEWLRRRVGPSATRLEDEEGVQALMAKWDMVVIGFFQDLQEEDVATFLALARDALDMAFGFTDQPQLFEKFGLTKDTVVLFKKFDEGRADFPVDKEAGLDLGDLSRFLITHSMHLVTEFNSQTSPKIFAARILNHLLLFVNQTLAQHRELLTGFREAAPPFRGQVLFVMVDVAADNSHVLNYFGLKAEEAPTLRLINVETTKKYAPAGVIPITAASVAAFCQAVLHGEVKHYLLSQEIPPDWDQRPVKTLVSKNFEQVAFDETKNVFVKFYAPWCSHCKEMAPAWEALAEKYRDREDIVIAEMDATANELEAFSVHGYPTLKFFPAGPDRKIIEYKSTRDLETFSKFLDRGGDLPEEESKEPAVSAPEAQPNSTLGPKEEL

Target ORF information:

RefSeq Version	NM_001105775.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus protein disulfide isomerase family A, member 2 (Pdia2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105775.2

ORF Insert Sequence:

ATGGATGATC GGTTTCTGCC AGTGTTGCTG CTCCTGCTGG GTGTCTCAGG CTCATGGGGA 
CAGGGAGAGG AGCCGGGGGG TCCCCCAGAG GTGCTCTCTG AGGAGTCCAT TGGGGAAGAA 
GTCCCCGAGG AGGATGGAAT CTTGGTTTTG AACAACCAAA CCCTGAGCCT GGCACTGCAG 
GAGCATTCAG CCCTGATGGT GGAGTTTTAT GCCCCATGGT GTGGTCACTG CAAGGCACTA 
GCTCCTGAGT ACAGCAAGGC AGCTGCCCTG CTGGCAGCTG AGTCAGCTGC GGTCACCTTG 
GCCAAGGTGG ATGGGCCTGC GGAACCAGAG CTGACCAAGG AGTTTGGAGT GGTAGGGTAC 
CCTACACTCA AGTTCTTCCA GAATGGAAAC CGCACAAACC CAGAAGAATA CATAGGGCCC 
AAGACAGCTG AGGGCATTGC TGAGTGGCTG AGGCGGCGAG TGGGGCCCAG CGCCACACGT 
CTGGAGGATG AGGAAGGTGT CCAGGCACTG ATGGCCAAAT GGGATATGGT GGTCATTGGC 
TTCTTTCAGG ATCTACAGGA AGAGGATGTG GCAACTTTCC TGGCCTTGGC CAGGGATGCT 
CTGGACATGG CCTTTGGCTT CACTGACCAG CCACAGCTTT TTGAGAAGTT TGGCCTCACC 
AAGGACACTG TGGTCCTTTT CAAGAAGTTT GATGAGGGTC GGGCCGACTT CCCGGTAGAC 
AAGGAGGCTG GCCTGGACCT GGGGGACCTG TCCCGCTTCC TCATCACACA CAGCATGCAC 
CTGGTCACAG AATTCAACAG CCAGACATCA CCTAAGATCT TTGCAGCCAG GATCCTCAAC 
CACCTGCTGC TGTTTGTGAA CCAGACACTA GCTCAGCACA GGGAGCTACT GACAGGCTTC 
AGGGAGGCAG CTCCTCCATT CCGGGGACAG GTGTTGTTTG TGATGGTGGA TGTGGCCGCT 
GACAACAGCC ATGTGCTAAA TTATTTTGGC CTCAAGGCTG AGGAAGCCCC CACCCTGCGT 
CTGATTAATG TTGAGACTAC CAAGAAGTAT GCACCTGCAG GGGTGATACC CATCACTGCA 
GCTTCTGTGG CTGCATTCTG CCAGGCAGTC CTCCATGGGG AAGTCAAGCA CTATCTCCTG 
AGCCAGGAGA TACCCCCCGA CTGGGACCAG CGGCCAGTCA AGACTCTTGT GAGCAAGAAT 
TTTGAGCAGG TTGCCTTTGA TGAAACCAAG AATGTGTTTG TCAAGTTCTA TGCCCCATGG 
TGCAGCCACT GCAAGGAGAT GGCTCCAGCC TGGGAGGCAC TGGCAGAGAA GTACAGGGAT 
CGTGAGGACA TTGTCATTGC TGAGATGGAT GCTACAGCTA ACGAGCTGGA GGCCTTCTCT 
GTGCATGGCT ATCCCACTCT CAAGTTCTTC CCTGCAGGAC CTGACCGAAA GATTATAGAA 
TACAAAAGCA CCAGGGACCT AGAGACATTC TCCAAGTTCC TGGACAGAGG AGGTGACCTG 
CCTGAGGAAG AATCCAAGGA GCCTGCAGTC TCTGCCCCAG AAGCACAACC CAATTCCACC 
TTGGGTCCCA AGGAGGAGCT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of the functional interplay between endoplasmic reticulum (ER) oxidoreduclin-1? (Ero1?) and protein-disulfide isomerase (PDI) by the endocrine disruptor bisphenol A.
The Journal of biological chemistry289(39)27004-18(2014 Sep)
Okumura M,Kadokura H,Hashimoto S,Yutani K,Kanemura S,Hikima T,Hidaka Y,Ito L,Shiba K,Masui S,Imai D,Imaoka S,Yamaguchi H,Inaba K

Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells.
The Journal of steroid biochemistry and molecular biology115(1-2)20-9(2009 May)
Fu XM,Zhu BT

GRP78, but Not Protein-disulfide Isomerase, Partially Reverses Hyperglycemia-induced Inhibition of Insulin Synthesis and Secretion in Pancreatic {beta}-Cells.
The Journal of biological chemistry284(8)5289-98(2009 Feb)
Zhang L,Lai E,Teodoro T,Volchuk A

pH dependence of the peptide thiol-disulfide oxidase activity of six members of the human protein disulfide isomerase family.
Antioxidants & redox signaling8(3-4)283-91(2006 Mar-Apr)
Alanen HI,Salo KE,Pirneskoski A,Ruddock LW

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Pdia2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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