TNMD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TNMD
Entrez Gene ID	64102
Full Name	tenomodulin
Synonyms	BRICD4,CHM1L,TEM
General protein information	Preferred Names tenomodulin Names tenomodulin BRICHOS domain containing 4 chondromodulin-1-like protein chondromodulin-I-like protein chondromodulin-IB hChM1L hTeM myodulin tendin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq22.1
Summary	This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009].
Disorder MIM:	300459

mRNA and Protein(s)

mRNA	Protein	Name
NM_022144.2	NP_071427.2	tenomodulin
NM_022144.3	NP_071427.2	tenomodulin

Pathways from BioSystems

Homologies

Homo sapiens (human)	TNMD	NP_071427.2
Mus musculus (house mouse)	Tnmd	NP_071717.1
Rattus norvegicus (Norway rat)	Tnmd	NP_071626.1
	TNMD	XP_001088648.1
Xenopus tropicalis (tropical clawed frog)	LOC101731375	XP_004919251.1
Bos taurus (cattle)	TNMD	NP_001093418.1
Gallus gallus (chicken)	TNMD	NP_996868.1
Danio rerio (zebrafish)	tnmd	NP_001107885.1
Pan troglodytes (chimpanzee)	TNMD	XP_529070.2
Canis lupus familiaris (dog)	TNMD	XP_538101.1

Gene Ontology
Bibliography

Related articles in PubMed

Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load.
Dex S, Alberton P, Willkomm L, S?llradl T, Bago S, Milz S, Shakibaei M, Ignatius A, Bloch W, Clausen-Schaumann H, Shukunami C, Schieker M, Docheva D
EBioMedicine20240-254(2017 Jun)

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.
Senol-Cosar O, Flach RJ, DiStefano M, Chawla A, Nicoloro S, Straubhaar J, Hardy OT, Noh HL, Kim JK, Wabitsch M, Scherer PE, Czech MP
Nature communications710686(2016 Feb)

Tenomodulin expression in the periodontal ligament enhances cellular adhesion.
Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung UI
PloS one8(4)e60203(2013)

Differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin.
Qi J, Dmochowski JM, Banes AN, Tsuzaki M, Bynum D, Patterson M, Creighton A, Gomez S, Tech K, Cederlund A, Banes AJ
Journal of applied physiology (Bethesda, Md. : 1985)113(6)861-71(2012 Sep)

Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss.
Saiki A, Olsson M, Jern?s M, Gummesson A, McTernan PG, Andersson J, Jacobson P, Sj?holm K, Olsson B, Yamamura S, Walley A, Froguel P, Carlsson B, Sj?str?m L, Svensson PA, Carlsson LM
The Journal of clinical endocrinology and metabolism94(10)3987-94(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TNMD is upregulated in adipose tissue of insulin-resistant versus insulin-sensitive individuals. TNMD expression increases in human preadipocytes during differentiation, whereas silencing TNMD blocks adipogenesis.
Title: Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.

results suggest that Tnmd acts on the maturation or maintenance of the PDL by positively regulating cell adhesion via its BRICHOS domain
Title: Tenomodulin expression in the periodontal ligament enhances cellular adhesion.

Report differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin and suggest possible roles in tenocyte proliferation and tendon injury.
Title: Differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Tenomodulin variants, APOE and Alzheimer's disease in a Finnish case-control cohort.

Human adipose tissue TNMD gene expression is highly affected by obesity, adipose tissue location, and weight loss, indicating that TNMD may play a role in adipose tissue function.
Title: Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss.

The following TNMD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TNMD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17818	NM_022144.3 Latest version!	Homo sapiens tenomodulin (TNMD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu17818	NM_022144.2	Homo sapiens tenomodulin (TNMD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TNMD ( NM_022144.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071427.2 Homo sapiens tenomodulin (TNMD), mRNA.

Price & Availability↑

CloneID	OHu17818
Clone ID Related Accession (Same CDS sequence)	NM_022144.2 , NM_022144.3
Accession Version	NM_022144.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	tenomodulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP319044.1, AF191770.1, AF291656.1 and AB055421.1. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2007 this sequence version replaced NM_022144.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF234259.1, AF191770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2153427 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAAAGA ATCCTCCAGA GAATTGTGAA GACTGTCACA TTCTAAATGC AGAAGCTTTT 
AAATCCAAGA AAATATGTAA ATCACTTAAG ATTTGTGGAC TGGTGTTTGG TATCCTGGCC 
CTAACTCTAA TTGTCCTGTT TTGGGGGAGC AAGCACTTCT GGCCGGAGGT ACCCAAAAAA 
GCCTATGACA TGGAGCACAC TTTCTACAGC AATGGAGAGA AGAAGAAGAT TTACATGGAA 
ATTGATCCTG TGACCAGAAC TGAAATATTC AGAAGCGGAA ATGGCACTGA TGAAACATTG 
GAAGTGCACG ACTTTAAAAA CGGATACACT GGCATCTACT TCGTGGGTCT TCAAAAATGT 
TTTATCAAAA CTCAGATTAA AGTGATTCCT GAATTTTCTG AACCAGAAGA GGAAATAGAT 
GAGAATGAAG AAATTACCAC AACTTTCTTT GAACAGTCAG TGATTTGGGT CCCAGCAGAA 
AAGCCTATTG AAAACCGAGA TTTTCTTAAA AATTCCAAAA TTCTGGAGAT TTGTGATAAC 
GTGACCATGT ATTGGATCAA TCCCACTCTA ATATCAGTTT CTGAGTTACA AGACTTTGAG 
GAGGAGGGAG AAGATCTTCA CTTTCCTGCC AACGAAAAAA AAGGGATTGA ACAAAATGAA 
CAGTGGGTGG TCCCTCAAGT GAAAGTAGAG AAGACCCGTC ACGCCAGACA AGCAAGTGAG 
GAAGAACTTC CAATAAATGA CTATACTGAA AATGGAATAG AATTTGATCC CATGCTGGAT 
GAGAGAGGTT ATTGTTGTAT TTACTGCCGT CGAGGCAACC GCTATTGCCG CCGCGTCTGT 
GAACCTTTAC TAGGCTACTA CCCATATCCA TACTGCTACC AAGGAGGACG AGTCATCTGT 
CGTGTCATCA TGCCTTGTAA CTGGTGGGTG GCCCGCATGC TGGGGAGGGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071427.2
CDS	227..1180
Translation	MAKNPPENCEDCHILNAEAFKSKKICKSLKICGLVFGILALTLIVLFWGSKHFWPEVPKKAYDMEHTFYSNGEKKKIYMEIDPVTRTEIFRSGNGTDETLEVHDFKNGYTGIYFVGLQKCFIKTQIKVIPEFSEPEEEIDENEEITTTFFEQSVIWVPAEKPIENRDFLKNSKILEICDNVTMYWINPTLISVSELQDFEEEGEDLHFPANEKKGIEQNEQWVVPQVKVEKTRHARQASEEELPINDYTENGIEFDPMLDERGYCCIYCRRGNRYCRRVCEPLLGYYPYPYCYQGGRVICRVIMPCNWWVARMLGRV

Target ORF information:

RefSeq Version	NM_022144.2
Organism	Homo sapiens(human)
Definition	Homo sapiens tenomodulin (TNMD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022144.2

ORF Insert Sequence:

ATGGCAAAGA ATCCTCCAGA GAATTGTGAA GACTGTCACA TTCTAAATGC AGAAGCTTTT 
AAATCCAAGA AAATATGTAA ATCACTTAAG ATTTGTGGAC TGGTGTTTGG TATCCTGGCC 
CTAACTCTAA TTGTCCTGTT TTGGGGGAGC AAGCACTTCT GGCCGGAGGT ACCCAAAAAA 
GCCTATGACA TGGAGCACAC TTTCTACAGC AATGGAGAGA AGAAGAAGAT TTACATGGAA 
ATTGATCCTG TGACCAGAAC TGAAATATTC AGAAGCGGAA ATGGCACTGA TGAAACATTG 
GAAGTGCACG ACTTTAAAAA CGGATACACT GGCATCTACT TCGTGGGTCT TCAAAAATGT 
TTTATCAAAA CTCAGATTAA AGTGATTCCT GAATTTTCTG AACCAGAAGA GGAAATAGAT 
GAGAATGAAG AAATTACCAC AACTTTCTTT GAACAGTCAG TGATTTGGGT CCCAGCAGAA 
AAGCCTATTG AAAACCGAGA TTTTCTTAAA AATTCCAAAA TTCTGGAGAT TTGTGATAAC 
GTGACCATGT ATTGGATCAA TCCCACTCTA ATATCAGTTT CTGAGTTACA AGACTTTGAG 
GAGGAGGGAG AAGATCTTCA CTTTCCTGCC AACGAAAAAA AAGGGATTGA ACAAAATGAA 
CAGTGGGTGG TCCCTCAAGT GAAAGTAGAG AAGACCCGTC ACGCCAGACA AGCAAGTGAG 
GAAGAACTTC CAATAAATGA CTATACTGAA AATGGAATAG AATTTGATCC CATGCTGGAT 
GAGAGAGGTT ATTGTTGTAT TTACTGCCGT CGAGGCAACC GCTATTGCCG CCGCGTCTGT 
GAACCTTTAC TAGGCTACTA CCCATATCCA TACTGCTACC AAGGAGGACG AGTCATCTGT 
CGTGTCATCA TGCCTTGTAA CTGGTGGGTG GCCCGCATGC TGGGGAGGGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TNMD ( NM_022144.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_071427.2 Homo sapiens tenomodulin (TNMD), mRNA.

Price & Availability↑

CloneID	OHu17818
Clone ID Related Accession (Same CDS sequence)	NM_022144.2 , NM_022144.3
Accession Version	NM_022144.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 954bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	tenomodulin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF191770.1, AF291656.1 and AB055421.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_022144.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF234259.1, AF191770.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151741, SAMEA2153427 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373031.5/ ENSP00000362122.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAAAGA ATCCTCCAGA GAATTGTGAA GACTGTCACA TTCTAAATGC AGAAGCTTTT 
AAATCCAAGA AAATATGTAA ATCACTTAAG ATTTGTGGAC TGGTGTTTGG TATCCTGGCC 
CTAACTCTAA TTGTCCTGTT TTGGGGGAGC AAGCACTTCT GGCCGGAGGT ACCCAAAAAA 
GCCTATGACA TGGAGCACAC TTTCTACAGC AATGGAGAGA AGAAGAAGAT TTACATGGAA 
ATTGATCCTG TGACCAGAAC TGAAATATTC AGAAGCGGAA ATGGCACTGA TGAAACATTG 
GAAGTGCACG ACTTTAAAAA CGGATACACT GGCATCTACT TCGTGGGTCT TCAAAAATGT 
TTTATCAAAA CTCAGATTAA AGTGATTCCT GAATTTTCTG AACCAGAAGA GGAAATAGAT 
GAGAATGAAG AAATTACCAC AACTTTCTTT GAACAGTCAG TGATTTGGGT CCCAGCAGAA 
AAGCCTATTG AAAACCGAGA TTTTCTTAAA AATTCCAAAA TTCTGGAGAT TTGTGATAAC 
GTGACCATGT ATTGGATCAA TCCCACTCTA ATATCAGTTT CTGAGTTACA AGACTTTGAG 
GAGGAGGGAG AAGATCTTCA CTTTCCTGCC AACGAAAAAA AAGGGATTGA ACAAAATGAA 
CAGTGGGTGG TCCCTCAAGT GAAAGTAGAG AAGACCCGTC ACGCCAGACA AGCAAGTGAG 
GAAGAACTTC CAATAAATGA CTATACTGAA AATGGAATAG AATTTGATCC CATGCTGGAT 
GAGAGAGGTT ATTGTTGTAT TTACTGCCGT CGAGGCAACC GCTATTGCCG CCGCGTCTGT 
GAACCTTTAC TAGGCTACTA CCCATATCCA TACTGCTACC AAGGAGGACG AGTCATCTGT 
CGTGTCATCA TGCCTTGTAA CTGGTGGGTG GCCCGCATGC TGGGGAGGGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071427.2
CDS	84..1037
Translation	MAKNPPENCEDCHILNAEAFKSKKICKSLKICGLVFGILALTLIVLFWGSKHFWPEVPKKAYDMEHTFYSNGEKKKIYMEIDPVTRTEIFRSGNGTDETLEVHDFKNGYTGIYFVGLQKCFIKTQIKVIPEFSEPEEEIDENEEITTTFFEQSVIWVPAEKPIENRDFLKNSKILEICDNVTMYWINPTLISVSELQDFEEEGEDLHFPANEKKGIEQNEQWVVPQVKVEKTRHARQASEEELPINDYTENGIEFDPMLDERGYCCIYCRRGNRYCRRVCEPLLGYYPYPYCYQGGRVICRVIMPCNWWVARMLGRV

Target ORF information:

RefSeq Version	NM_022144.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tenomodulin (TNMD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022144.3

ORF Insert Sequence:

ATGGCAAAGA ATCCTCCAGA GAATTGTGAA GACTGTCACA TTCTAAATGC AGAAGCTTTT 
AAATCCAAGA AAATATGTAA ATCACTTAAG ATTTGTGGAC TGGTGTTTGG TATCCTGGCC 
CTAACTCTAA TTGTCCTGTT TTGGGGGAGC AAGCACTTCT GGCCGGAGGT ACCCAAAAAA 
GCCTATGACA TGGAGCACAC TTTCTACAGC AATGGAGAGA AGAAGAAGAT TTACATGGAA 
ATTGATCCTG TGACCAGAAC TGAAATATTC AGAAGCGGAA ATGGCACTGA TGAAACATTG 
GAAGTGCACG ACTTTAAAAA CGGATACACT GGCATCTACT TCGTGGGTCT TCAAAAATGT 
TTTATCAAAA CTCAGATTAA AGTGATTCCT GAATTTTCTG AACCAGAAGA GGAAATAGAT 
GAGAATGAAG AAATTACCAC AACTTTCTTT GAACAGTCAG TGATTTGGGT CCCAGCAGAA 
AAGCCTATTG AAAACCGAGA TTTTCTTAAA AATTCCAAAA TTCTGGAGAT TTGTGATAAC 
GTGACCATGT ATTGGATCAA TCCCACTCTA ATATCAGTTT CTGAGTTACA AGACTTTGAG 
GAGGAGGGAG AAGATCTTCA CTTTCCTGCC AACGAAAAAA AAGGGATTGA ACAAAATGAA 
CAGTGGGTGG TCCCTCAAGT GAAAGTAGAG AAGACCCGTC ACGCCAGACA AGCAAGTGAG 
GAAGAACTTC CAATAAATGA CTATACTGAA AATGGAATAG AATTTGATCC CATGCTGGAT 
GAGAGAGGTT ATTGTTGTAT TTACTGCCGT CGAGGCAACC GCTATTGCCG CCGCGTCTGT 
GAACCTTTAC TAGGCTACTA CCCATATCCA TACTGCTACC AAGGAGGACG AGTCATCTGT 
CGTGTCATCA TGCCTTGTAA CTGGTGGGTG GCCCGCATGC TGGGGAGGGT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tenomodulin is Required for Tendon Endurance Running and Collagen I Fibril Adaptation to Mechanical Load.
EBioMedicine20240-254(2017 Jun)
Dex S,Alberton P,Willkomm L,S?llradl T,Bago S,Milz S,Shakibaei M,Ignatius A,Bloch W,Clausen-Schaumann H,Shukunami C,Schieker M,Docheva D

Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion.
Nature communications710686(2016 Feb)
Senol-Cosar O,Flach RJ,DiStefano M,Chawla A,Nicoloro S,Straubhaar J,Hardy OT,Noh HL,Kim JK,Wabitsch M,Scherer PE,Czech MP

Tenomodulin expression in the periodontal ligament enhances cellular adhesion.
PloS one8(4)e60203(2013)
Komiyama Y,Ohba S,Shimohata N,Nakajima K,Hojo H,Yano F,Takato T,Docheva D,Shukunami C,Hiraki Y,Chung UI

Differential expression and cellular localization of novel isoforms of the tendon biomarker tenomodulin.
Journal of applied physiology (Bethesda, Md. : 1985)113(6)861-71(2012 Sep)
Qi J,Dmochowski JM,Banes AN,Tsuzaki M,Bynum D,Patterson M,Creighton A,Gomez S,Tech K,Cederlund A,Banes AJ

Tenomodulin is highly expressed in adipose tissue, increased in obesity, and down-regulated during diet-induced weight loss.
The Journal of clinical endocrinology and metabolism94(10)3987-94(2009 Oct)
Saiki A,Olsson M,Jern?s M,Gummesson A,McTernan PG,Andersson J,Jacobson P,Sj?holm K,Olsson B,Yamamura S,Walley A,Froguel P,Carlsson B,Sj?str?m L,Svensson PA,Carlsson LM

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TNMD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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