RPLP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RPLP1
Entrez Gene ID	6176
Full Name	ribosomal protein lateral stalk subunit P1
Synonyms	LP1,P1,RPP1
General protein information	Preferred Names ribosomal protein lateral stalk subunit P1 Names 60S acidic ribosomal protein P1 acidic ribosomal phosphoprotein P1 large ribosomal subunit protein P1 ribosomal protein, large, P1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q23
Summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008].
Disorder MIM:	180520

mRNA and Protein(s)

mRNA	Protein	Name
NM_001003.2	NP_000994.1	60S acidic ribosomal protein P1 isoform 1
NM_001003.3	NP_000994.1	60S acidic ribosomal protein P1 isoform 1
NM_213725.1	NP_998890.1	60S acidic ribosomal protein P1 isoform 2
NM_213725.2	NP_998890.1	60S acidic ribosomal protein P1 isoform 2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	RPLP1	XP_003952735.1
Bos taurus (cattle)	RPLP1	NP_001020511.1
Rattus norvegicus (Norway rat)	Rplp1	NP_001007605.1
Gallus gallus (chicken)	RPLP1	NP_990653.1
Xenopus tropicalis (tropical clawed frog)	rplp1	NP_001017204.1
Danio rerio (zebrafish)	rplp1	NP_956323.1
Homo sapiens (human)	RPLP1	NP_000994.1
	RPLP1	XP_001087245.1

Gene Ontology
Bibliography

Related articles in PubMed

Disruption of the ribosomal P complex leads to stress-induced autophagy.
Artero-Castro A, Perez-Alea M, Feliciano A, Leal JA, Genestar M, Castellvi J, Peg V, Ram?n Y Cajal S, Lleonart ME
Autophagy11(9)1499-519(2015)

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
Speedy HE, Di Bernardo MC, Sava GP, Dyer MJ, Holroyd A, Wang Y, Sunter NJ, Mansouri L, Juliusson G, Smedby KE, Roos G, Jayne S, Majid A, Dearden C, Hall AG, Mainou-Fowler T, Jackson GH, Summerfield G, Harris RJ, Pettitt AR, Allsup DJ, Bailey JR, Pratt G, Pepper C, Fegan C, Rosenquist R, Catovsky D, Allan JM, Houlston RS
Nature genetics46(1)56-60(2014 Jan)

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Berndt SI, Skibola CF, Joseph V, Camp NJ, Nieters A, Wang Z, Cozen W, Monnereau A, Wang SS, Kelly RS, Lan Q, Teras LR, Chatterjee N, Chung CC, Yeager M, Brooks-Wilson AR, Hartge P, Purdue MP, Birmann BM, Armstrong BK, Cocco P, Zhang Y, Severi G, Zeleniuch-Jacquotte A, Lawrence C, Burdette L, Yuenger J, Hutchinson A, Jacobs KB, Call TG, Shanafelt TD, Novak AJ, Kay NE, Liebow M, Wang AH, Smedby KE, Adami HO, Melbye M, Glimelius B, Chang ET, Glenn M, Curtin K, Cannon-Albright LA, Jones B, Diver WR, Link BK, Weiner GJ, Conde L, Bracci PM, Riby J, Holly EA, Smith MT, Jackson RD, Tinker LF, Benavente Y, Becker N, Boffetta P, Brennan P, Foretova L, Maynadie M, McKay J, Staines A, Rabe KG, Achenbach SJ, Vachon CM, Goldin LR, Strom SS, Lanasa MC, Spector LG, Leis JF, Cunningham JM, Weinberg JB, Morrison VA, Caporaso NE, Norman AD, Linet MS, De Roos AJ, Morton LM, Severson RK, Riboli E, Vineis P, Kaaks R, Trichopoulos D, Masala G, Weiderpass E, Chirlaque MD, Vermeulen RC, Travis RC, Giles GG, Albanes D, Virtamo J, Weinstein S, Clavel J, Zheng T, Holford TR, Offit K, Zelenetz A, Klein RJ, Spinelli JJ, Bertrand KA, Laden F, Giovannucci E, Kraft P, Kricker A, Turner J, Vajdic CM, Ennas MG, Ferri GM, Miligi L, Liang L, Sampson J, Crouch S, Park JH, North KE, Cox A, Snowden JA, Wright J, Carracedo A, Lopez-Otin C, Bea S, Salaverria I, Martin-Garcia D, Campo E, Fraumeni JF Jr, de Sanjose S, Hjalgrim H, Cerhan JR, Chanock SJ, Rothman N, Slager SL
Nature genetics45(8)868-76(2013 Aug)

Significance of antibodies against the native ribosomal P protein complex and recombinant P0, P1, and P2 proteins in the diagnosis of Chinese patients with systemic lupus erythematosus.
Li J, Shen Y, He J, Jia R, Wang X, Chen X, Wang D, Han L, Zhu L, Chi X, Saschenbrecker S, D?hnrich C, St?cker W, Schlumberger W, Li ZG
Journal of clinical laboratory analysis27(2)87-95(2013 Mar)

The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.
May KL, Li XP, Mart?nez-Azor?n F, Ballesta JP, Grela P, Tch?rzewski M, Tumer NE
The FEBS journal279(20)3925-36(2012 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

absence of RPLP0, RPLP1, or RPLP2 resulted in reactive oxygen species (ROS) accumulation and MAPK1/ERK2 signaling pathway activation.
Title: Disruption of the ribosomal P complex leads to stress-induced autophagy.

Evaluated autoantibodies against native ribosomal P complex and recombinant ribosomal P proteins (anti-Rib-P0, anti-Rib-P1, anti-Rib-P2) for prevalence, diagnostic relevance&clinical associations in a Chinese cohort with systemic lupus erythematosus.
Title: Significance of antibodies against the native ribosomal P protein complex and recombinant P0, P1, and P2 proteins in the diagnosis of Chinese patients with systemic lupus erythematosus.

Data show that ricin A-chain (RTA) interacts directly with recombinant P1-P2 dimer, indicating the importance of P1 and P2 in enabling RTA to bind and depurinate ribosomes.
Title: The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.

P proteins are up-regulated in a considerable number of patients with the most common types of cancer.
Title: Expression of the ribosomal proteins Rplp0, Rplp1, and Rplp2 in gynecologic tumors.

These results support the hypothesis that at least some of the changes in the profile of newly synthesized proteins detected in cells deprived of P1 and P2 proteins might be due to an effect on the efficiency of cap-independent translation.
Title: Internal translation initiation on the foot-and-mouth disease virus IRES is affected by ribosomal stalk conformation.

The following RPLP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RPLP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02153	NM_001003.3 Latest version!	Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03245	NM_213725.2 Latest version!	Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu02153	NM_001003.2	Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu03245	NM_213725.1	Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RPLP1 ( NM_001003.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000994.1 Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02153
Clone ID Related Accession (Same CDS sequence)	NM_001003.2 , NM_001003.3
Accession Version	NM_001003.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	60S acidic ribosomal protein P1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from M17886.1. On or before Mar 28, 2007 this sequence version replaced NM_001080857.1, NM_001003.1. Transcript Variant: This predominant variant (1) is the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AU122921.1, AU123099.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCTCTG TCTCCGAGCT CGCCTGCATC TACTCGGCCC TCATTCTGCA CGACGATGAG 
GTGACAGTCA CGGAGGATAA GATCAATGCC CTCATTAAAG CAGCCGGTGT AAATGTTGAG 
CCTTTTTGGC CTGGCTTGTT TGCAAAGGCC CTGGCCAACG TCAACATTGG GAGCCTCATC 
TGCAATGTAG GGGCCGGTGG ACCTGCTCCA GCAGCTGGTG CTGCACCAGC AGGAGGTCCT 
GCCCCCTCCA CTGCTGCTGC TCCAGCTGAG GAGAAGAAAG TGGAAGCAAA GAAAGAAGAA 
TCCGAGGAGT CTGATGATGA CATGGGCTTT GGTCTTTTTG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000994.1
CDS	130..474
Translation	MASVSELACIYSALILHDDEVTVTEDKINALIKAAGVNVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD

Target ORF information:

RefSeq Version	NM_001003.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003.2

ORF Insert Sequence:

ATGGCCTCTG TCTCCGAGCT CGCCTGCATC TACTCGGCCC TCATTCTGCA CGACGATGAG 
GTGACAGTCA CGGAGGATAA GATCAATGCC CTCATTAAAG CAGCCGGTGT AAATGTTGAG 
CCTTTTTGGC CTGGCTTGTT TGCAAAGGCC CTGGCCAACG TCAACATTGG GAGCCTCATC 
TGCAATGTAG GGGCCGGTGG ACCTGCTCCA GCAGCTGGTG CTGCACCAGC AGGAGGTCCT 
GCCCCCTCCA CTGCTGCTGC TCCAGCTGAG GAGAAGAAAG TGGAAGCAAA GAAAGAAGAA 
TCCGAGGAGT CTGATGATGA CATGGGCTTT GGTCTTTTTG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPLP1 ( NM_001003.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000994.1 Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02153
Clone ID Related Accession (Same CDS sequence)	NM_001003.2 , NM_001003.3
Accession Version	NM_001003.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 345bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	60S acidic ribosomal protein P1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AC027237.8. On Nov 25, 2018 this sequence version replaced NM_001003.2. Transcript Variant: This predominant variant (1) is the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP367167.1, SRR5189652.227177.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000260379.11/ ENSP00000346037.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCCTCTG TCTCCGAGCT CGCCTGCATC TACTCGGCCC TCATTCTGCA CGACGATGAG 
GTGACAGTCA CGGAGGATAA GATCAATGCC CTCATTAAAG CAGCCGGTGT AAATGTTGAG 
CCTTTTTGGC CTGGCTTGTT TGCAAAGGCC CTGGCCAACG TCAACATTGG GAGCCTCATC 
TGCAATGTAG GGGCCGGTGG ACCTGCTCCA GCAGCTGGTG CTGCACCAGC AGGAGGTCCT 
GCCCCCTCCA CTGCTGCTGC TCCAGCTGAG GAGAAGAAAG TGGAAGCAAA GAAAGAAGAA 
TCCGAGGAGT CTGATGATGA CATGGGCTTT GGTCTTTTTG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000994.1
CDS	132..476
Translation	MASVSELACIYSALILHDDEVTVTEDKINALIKAAGVNVEPFWPGLFAKALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD

Target ORF information:

RefSeq Version	NM_001003.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003.3

ORF Insert Sequence:

ATGGCCTCTG TCTCCGAGCT CGCCTGCATC TACTCGGCCC TCATTCTGCA CGACGATGAG 
GTGACAGTCA CGGAGGATAA GATCAATGCC CTCATTAAAG CAGCCGGTGT AAATGTTGAG 
CCTTTTTGGC CTGGCTTGTT TGCAAAGGCC CTGGCCAACG TCAACATTGG GAGCCTCATC 
TGCAATGTAG GGGCCGGTGG ACCTGCTCCA GCAGCTGGTG CTGCACCAGC AGGAGGTCCT 
GCCCCCTCCA CTGCTGCTGC TCCAGCTGAG GAGAAGAAAG TGGAAGCAAA GAAAGAAGAA 
TCCGAGGAGT CTGATGATGA CATGGGCTTT GGTCTTTTTG ACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPLP1 ( NM_213725.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_998890.1 Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03245
Clone ID Related Accession (Same CDS sequence)	NM_213725.1 , NM_213725.2
Accession Version	NM_213725.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	60S acidic ribosomal protein P1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from BM745938.1 and M17886.1. Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) when compared to isoform 1. CCDS Note: This CCDS ID represents a variant of the RPLP1 gene that is based on a splice pattern found in several ESTs, including BM768334.1, BM508180.1, EL948616.1 and AJ713466.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM822274.1, BM768334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCTCTG TCTCCGAGCT CGCCTGCATC TACTCGGCCC TCATTCTGCA CGACGATGAG 
GTGACAGTCA CGGCCCTGGC CAACGTCAAC ATTGGGAGCC TCATCTGCAA TGTAGGGGCC 
GGTGGACCTG CTCCAGCAGC TGGTGCTGCA CCAGCAGGAG GTCCTGCCCC CTCCACTGCT 
GCTGCTCCAG CTGAGGAGAA GAAAGTGGAA GCAAAGAAAG AAGAATCCGA GGAGTCTGAT 
GATGACATGG GCTTTGGTCT TTTTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_998890.1
CDS	130..399
Translation	MASVSELACIYSALILHDDEVTVTALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD

Target ORF information:

RefSeq Version	NM_213725.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_213725.1

ORF Insert Sequence:

ATGGCCTCTG TCTCCGAGCT CGCCTGCATC TACTCGGCCC TCATTCTGCA CGACGATGAG 
GTGACAGTCA CGGCCCTGGC CAACGTCAAC ATTGGGAGCC TCATCTGCAA TGTAGGGGCC 
GGTGGACCTG CTCCAGCAGC TGGTGCTGCA CCAGCAGGAG GTCCTGCCCC CTCCACTGCT 
GCTGCTCCAG CTGAGGAGAA GAAAGTGGAA GCAAAGAAAG AAGAATCCGA GGAGTCTGAT 
GATGACATGG GCTTTGGTCT TTTTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RPLP1 ( NM_213725.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_998890.1 Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu03245
Clone ID Related Accession (Same CDS sequence)	NM_213725.1 , NM_213725.2
Accession Version	NM_213725.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 270bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	60S acidic ribosomal protein P1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AC027237.8, BM745938.1 and M17886.1. On May 31, 2019 this sequence version replaced NM_213725.1. Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) when compared to isoform 1. CCDS Note: This CCDS ID represents a variant of the RPLP1 gene that is based on a splice pattern found in several ESTs, including BM768334.1, BM508180.1, EL948616.1 and AJ713466.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM768334.1, DRR138512.32340.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCCTCTG TCTCCGAGCT CGCCTGCATC TACTCGGCCC TCATTCTGCA CGACGATGAG 
GTGACAGTCA CGGCCCTGGC CAACGTCAAC ATTGGGAGCC TCATCTGCAA TGTAGGGGCC 
GGTGGACCTG CTCCAGCAGC TGGTGCTGCA CCAGCAGGAG GTCCTGCCCC CTCCACTGCT 
GCTGCTCCAG CTGAGGAGAA GAAAGTGGAA GCAAAGAAAG AAGAATCCGA GGAGTCTGAT 
GATGACATGG GCTTTGGTCT TTTTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_998890.1
CDS	132..401
Translation	MASVSELACIYSALILHDDEVTVTALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAKKEESEESDDDMGFGLFD

Target ORF information:

RefSeq Version	NM_213725.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ribosomal protein lateral stalk subunit P1 (RPLP1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_213725.2

ORF Insert Sequence:

ATGGCCTCTG TCTCCGAGCT CGCCTGCATC TACTCGGCCC TCATTCTGCA CGACGATGAG 
GTGACAGTCA CGGCCCTGGC CAACGTCAAC ATTGGGAGCC TCATCTGCAA TGTAGGGGCC 
GGTGGACCTG CTCCAGCAGC TGGTGCTGCA CCAGCAGGAG GTCCTGCCCC CTCCACTGCT 
GCTGCTCCAG CTGAGGAGAA GAAAGTGGAA GCAAAGAAAG AAGAATCCGA GGAGTCTGAT 
GATGACATGG GCTTTGGTCT TTTTGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disruption of the ribosomal P complex leads to stress-induced autophagy.
Autophagy11(9)1499-519(2015)
Artero-Castro A,Perez-Alea M,Feliciano A,Leal JA,Genestar M,Castellvi J,Peg V,Ram?n Y Cajal S,Lleonart ME

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
Nature genetics46(1)56-60(2014 Jan)
Speedy HE,Di Bernardo MC,Sava GP,Dyer MJ,Holroyd A,Wang Y,Sunter NJ,Mansouri L,Juliusson G,Smedby KE,Roos G,Jayne S,Majid A,Dearden C,Hall AG,Mainou-Fowler T,Jackson GH,Summerfield G,Harris RJ,Pettitt AR,Allsup DJ,Bailey JR,Pratt G,Pepper C,Fegan C,Rosenquist R,Catovsky D,Allan JM,Houlston RS

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
Nature genetics45(8)868-76(2013 Aug)
Berndt SI,Skibola CF,Joseph V,Camp NJ,Nieters A,Wang Z,Cozen W,Monnereau A,Wang SS,Kelly RS,Lan Q,Teras LR,Chatterjee N,Chung CC,Yeager M,Brooks-Wilson AR,Hartge P,Purdue MP,Birmann BM,Armstrong BK,Cocco P,Zhang Y,Severi G,Zeleniuch-Jacquotte A,Lawrence C,Burdette L,Yuenger J,Hutchinson A,Jacobs KB,Call TG,Shanafelt TD,Novak AJ,Kay NE,Liebow M,Wang AH,Smedby KE,Adami HO,Melbye M,Glimelius B,Chang ET,Glenn M,Curtin K,Cannon-Albright LA,Jones B,Diver WR,Link BK,Weiner GJ,Conde L,Bracci PM,Riby J,Holly EA,Smith MT,Jackson RD,Tinker LF,Benavente Y,Becker N,Boffetta P,Brennan P,Foretova L,Maynadie M,McKay J,Staines A,Rabe KG,Achenbach SJ,Vachon CM,Goldin LR,Strom SS,Lanasa MC,Spector LG,Leis JF,Cunningham JM,Weinberg JB,Morrison VA,Caporaso NE,Norman AD,Linet MS,De Roos AJ,Morton LM,Severson RK,Riboli E,Vineis P,Kaaks R,Trichopoulos D,Masala G,Weiderpass E,Chirlaque MD,Vermeulen RC,Travis RC,Giles GG,Albanes D,Virtamo J,Weinstein S,Clavel J,Zheng T,Holford TR,Offit K,Zelenetz A,Klein RJ,Spinelli JJ,Bertrand KA,Laden F,Giovannucci E,Kraft P,Kricker A,Turner J,Vajdic CM,Ennas MG,Ferri GM,Miligi L,Liang L,Sampson J,Crouch S,Park JH,North KE,Cox A,Snowden JA,Wright J,Carracedo A,Lopez-Otin C,Bea S,Salaverria I,Martin-Garcia D,Campo E,Fraumeni JF Jr,de Sanjose S,Hjalgrim H,Cerhan JR,Chanock SJ,Rothman N,Slager SL

Significance of antibodies against the native ribosomal P protein complex and recombinant P0, P1, and P2 proteins in the diagnosis of Chinese patients with systemic lupus erythematosus.
Journal of clinical laboratory analysis27(2)87-95(2013 Mar)
Li J,Shen Y,He J,Jia R,Wang X,Chen X,Wang D,Han L,Zhu L,Chi X,Saschenbrecker S,D?hnrich C,St?cker W,Schlumberger W,Li ZG

The P1/P2 proteins of the human ribosomal stalk are required for ribosome binding and depurination by ricin in human cells.
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RPLP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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