RLN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RLN2
Entrez Gene ID	6019
Full Name	relaxin 2
Synonyms	H2,H2-RLX,RLXH2,bA12D24.1.1,bA12D24.1.2
General protein information	Preferred Names relaxin 2 Names prorelaxin H2 H2-preprorelaxin relaxin H2 relaxin, ovarian, of pregnancy
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p24.1
Summary	This gene encodes a member of the relaxin subfamily and insulin superfamily of peptide hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016].
Disorder MIM:	179740

mRNA and Protein(s)

mRNA	Protein	Name
NM_134441.2	NP_604390.1	prorelaxin H2 isoform 1 preproprotein
XM_024447647.1	XP_024303415.1	prorelaxin H2 isoform X1
XM_017015011.1	XP_016870500.1	prorelaxin H2 isoform X1
XM_024447646.1	XP_024303414.1	prorelaxin H2 isoform X1
NM_134441.3	NP_604390.1	prorelaxin H2 isoform 1 preproprotein
NM_005059.3	NP_005050.2	prorelaxin H2 isoform 2 precursor
NM_001329191.1	NP_001316120.1	prorelaxin H2 isoform 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	RLN2	NP_604390.1
	RLN2	NP_001108598.1
Canis lupus familiaris (dog)	RLN1	NP_001003132.1
Pan troglodytes (chimpanzee)	RLN2	NP_001116246.1

Gene Ontology
Bibliography

Related articles in PubMed

Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.
Pintalhao M, Castro-Chaves P, Vasques-Novoa F, Gon?alves F, Mendon?a L, Fontes-Carvalho R, Louren?o P, Almeida P, Leite-Moreira A, Bettencourt P
European journal of heart failure19(2)218-225(2017 Feb)

The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells.
Konopka JA, DeBaun MR, Chang W, Dragoo JL
The American journal of sports medicine44(9)2384-92(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In a population of acute HF patients, admission relaxin serum levels were associated with clinical and echocardiographic markers of pulmonary hypertension, RV dysfunction, and overload, suggesting a role for circulating relaxin as a biomarker in this setting.
Title: Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.

Relaxin-2 significantly upregulated intracellular processes in human female ACL cells, but no effect was observed in male cells. Relaxin increased MMP (MMP1 and MMP3) and decreased alphaSMA and type I and III collagen expression, which may act to alter the structural integrity of the ACL tissue over time.
Title: The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells.

Data suggest that enhanced survival of normal prostate epithelial cells (PNT1A cell line) in presence of either or both angiotensin II (Ang II) and relaxin 2 (RLN2) appears to be associated with increased ratio of BCL2/BAX messenger RNA expression; thus, Ang II and/or RLN2 appear to be involved in regulation of apoptosis in prostate epithelium.
Title: A common effect of angiotensin II and relaxin 2 on the PNT1A normal prostate epithelial cell line.

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1 has been deciphered.
Title: The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1.

Relaxin in the hypothalamic paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway.
Title: Relaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway.

The following RLN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RLN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29068	NM_134441.3 Latest version!	Homo sapiens relaxin 2 (RLN2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu04766	NM_005059.3 Latest version!	Homo sapiens relaxin 2 (RLN2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu101710	NM_001329191.1 Latest version!	Homo sapiens relaxin 2 (RLN2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu60275	XM_024447647.1 Latest version!	Homo sapiens relaxin 2 (RLN2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu60275	XM_017015011.1 Latest version!	Homo sapiens relaxin 2 (RLN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu60275	XM_024447646.1 Latest version!	Homo sapiens relaxin 2 (RLN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu29068	NM_134441.2	Homo sapiens relaxin 2 (RLN2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RLN2 ( NM_134441.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_604390.1 Homo sapiens relaxin 2 (RLN2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29068
Clone ID Related Accession (Same CDS sequence)	NM_134441.2 , NM_134441.3
Accession Version	NM_134441.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	prorelaxin H2 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC126415.1, BX094853.1, BG206251.1 and AI033912.1. On Jan 18, 2013 this sequence version replaced NM_134441.1. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC126419.1, X00948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145313, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCGCC TGTTTTTTTT CCACCTGCTA GGAGTCTGTT TACTACTGAA CCAATTTTCC 
AGAGCAGTCG CGGACTCATG GATGGAGGAA GTTATTAAAT TATGCGGCCG CGAATTAGTT 
CGCGCGCAGA TTGCCATTTG CGGCATGAGC ACCTGGAGCA AAAGGTCTCT GAGCCAGGAA 
GATGCTCCTC AGACACCTAG ACCAGTGGCA GAAATTGTGC CATCCTTCAT CAACAAAGAT 
ACAGAAACCA TAAATATGAT GTCAGAATTT GTTGCTAATT TGCCACAGGA GCTGAAGTTA 
ACCCTGTCTG AGATGCAGCC AGCATTACCA CAGCTACAAC AACATGTACC TGTATTAAAA 
GATTCCAGTC TTCTCTTTGA AGAATTTAAG AAACTTATTC GCAATAGACA AAGTGAAGCC 
GCAGACAGCA GTCCTTCAGA ATTAAAATAC TTAGGCTTGG ATACTCATTC TCGAAAAAAG 
AGACAACTCT ACAGTGCATT GGCTAATAAA TGTTGCCATG TTGGTTGTAC CAAAAGATCT 
CTTGCTAGAT TTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_604390.1
CDS	32..589
Translation	MPRLFFFHLLGVCLLLNQFSRAVADSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC

Target ORF information:

RefSeq Version	NM_134441.2
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 2 (RLN2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134441.2

ORF Insert Sequence:

ATGCCTCGCC TGTTTTTTTT CCACCTGCTA GGAGTCTGTT TACTACTGAA CCAATTTTCC 
AGAGCAGTCG CGGACTCATG GATGGAGGAA GTTATTAAAT TATGCGGCCG CGAATTAGTT 
CGCGCGCAGA TTGCCATTTG CGGCATGAGC ACCTGGAGCA AAAGGTCTCT GAGCCAGGAA 
GATGCTCCTC AGACACCTAG ACCAGTGGCA GAAATTGTGC CATCCTTCAT CAACAAAGAT 
ACAGAAACCA TAAATATGAT GTCAGAATTT GTTGCTAATT TGCCACAGGA GCTGAAGTTA 
ACCCTGTCTG AGATGCAGCC AGCATTACCA CAGCTACAAC AACATGTACC TGTATTAAAA 
GATTCCAGTC TTCTCTTTGA AGAATTTAAG AAACTTATTC GCAATAGACA AAGTGAAGCC 
GCAGACAGCA GTCCTTCAGA ATTAAAATAC TTAGGCTTGG ATACTCATTC TCGAAAAAAG 
AGACAACTCT ACAGTGCATT GGCTAATAAA TGTTGCCATG TTGGTTGTAC CAAAAGATCT 
CTTGCTAGAT TTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RLN2 ( NM_134441.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_604390.1 Homo sapiens relaxin 2 (RLN2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu29068
Clone ID Related Accession (Same CDS sequence)	NM_134441.2 , NM_134441.3
Accession Version	NM_134441.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 558bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	prorelaxin H2 isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL135786.17, BC126415.1, BX094853.1, BG206251.1 and AI033912.1. On Nov 23, 2018 this sequence version replaced NM_134441.2. Transcript Variant: This variant (1) encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC126419.1, X00948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145313, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000381627.4/ ENSP00000371040.3 RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCTCGCC TGTTTTTTTT CCACCTGCTA GGAGTCTGTT TACTACTGAA CCAATTTTCC 
AGAGCAGTCG CGGACTCATG GATGGAGGAA GTTATTAAAT TATGCGGCCG CGAATTAGTT 
CGCGCGCAGA TTGCCATTTG CGGCATGAGC ACCTGGAGCA AAAGGTCTCT GAGCCAGGAA 
GATGCTCCTC AGACACCTAG ACCAGTGGCA GAAATTGTGC CATCCTTCAT CAACAAAGAT 
ACAGAAACCA TAAATATGAT GTCAGAATTT GTTGCTAATT TGCCACAGGA GCTGAAGTTA 
ACCCTGTCTG AGATGCAGCC AGCATTACCA CAGCTACAAC AACATGTACC TGTATTAAAA 
GATTCCAGTC TTCTCTTTGA AGAATTTAAG AAACTTATTC GCAATAGACA AAGTGAAGCC 
GCAGACAGCA GTCCTTCAGA ATTAAAATAC TTAGGCTTGG ATACTCATTC TCGAAAAAAG 
AGACAACTCT ACAGTGCATT GGCTAATAAA TGTTGCCATG TTGGTTGTAC CAAAAGATCT 
CTTGCTAGAT TTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_604390.1
CDS	137..694
Translation	MPRLFFFHLLGVCLLLNQFSRAVADSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC

Target ORF information:

RefSeq Version	NM_134441.3
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 2 (RLN2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_134441.3

ORF Insert Sequence:

ATGCCTCGCC TGTTTTTTTT CCACCTGCTA GGAGTCTGTT TACTACTGAA CCAATTTTCC 
AGAGCAGTCG CGGACTCATG GATGGAGGAA GTTATTAAAT TATGCGGCCG CGAATTAGTT 
CGCGCGCAGA TTGCCATTTG CGGCATGAGC ACCTGGAGCA AAAGGTCTCT GAGCCAGGAA 
GATGCTCCTC AGACACCTAG ACCAGTGGCA GAAATTGTGC CATCCTTCAT CAACAAAGAT 
ACAGAAACCA TAAATATGAT GTCAGAATTT GTTGCTAATT TGCCACAGGA GCTGAAGTTA 
ACCCTGTCTG AGATGCAGCC AGCATTACCA CAGCTACAAC AACATGTACC TGTATTAAAA 
GATTCCAGTC TTCTCTTTGA AGAATTTAAG AAACTTATTC GCAATAGACA AAGTGAAGCC 
GCAGACAGCA GTCCTTCAGA ATTAAAATAC TTAGGCTTGG ATACTCATTC TCGAAAAAAG 
AGACAACTCT ACAGTGCATT GGCTAATAAA TGTTGCCATG TTGGTTGTAC CAAAAGATCT 
CTTGCTAGAT TTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RLN2 ( NM_005059.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005050.2 Homo sapiens relaxin 2 (RLN2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu04766
Clone ID Related Accession (Same CDS sequence)	NM_005059.3
Accession Version	NM_005059.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	prorelaxin H2 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC126415.1, AA935560.1, BX094853.1, BG206251.1 and AI033912.1. On Jan 18, 2013 this sequence version replaced NM_005059.2. Transcript Variant: This variant (2) includes an additional alternate exon, resulting in a frameshift in the central and 3' coding regions, compared to variant 1. The encoded isoform (2) is shorter, has a distinct C-terminus and lacks the relaxin A chain compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AA935560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145313, SAMEA2153427 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCGCC TGTTTTTTTT CCACCTGCTA GGAGTCTGTT TACTACTGAA CCAATTTTCC 
AGAGCAGTCG CGGACTCATG GATGGAGGAA GTTATTAAAT TATGCGGCCG CGAATTAGTT 
CGCGCGCAGA TTGCCATTTG CGGCATGAGC ACCTGGAGCA AAAGGTCTCT GAGCCAGGAA 
GATGCTCCTC AGACACCTAG ACCAGTGGCA GGTGATTTTA TTCAAACAGT CTCACTGGGA 
ATCTCACCGG ACGGAGGGAA AGCACTGAGA ACAGGAAGCT GCTTCACCCG AGAGTTCCTT 
GGTGCCCTTT CCAAATTGTG CCATCCTTCA TCAACAAAGA TACAGAAACC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005050.2
CDS	32..385
Translation	MPRLFFFHLLGVCLLLNQFSRAVADSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAGDFIQTVSLGISPDGGKALRTGSCFTREFLGALSKLCHPSSTKIQKP

Target ORF information:

RefSeq Version	NM_005059.3
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 2 (RLN2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005059.3

ORF Insert Sequence:

ATGCCTCGCC TGTTTTTTTT CCACCTGCTA GGAGTCTGTT TACTACTGAA CCAATTTTCC 
AGAGCAGTCG CGGACTCATG GATGGAGGAA GTTATTAAAT TATGCGGCCG CGAATTAGTT 
CGCGCGCAGA TTGCCATTTG CGGCATGAGC ACCTGGAGCA AAAGGTCTCT GAGCCAGGAA 
GATGCTCCTC AGACACCTAG ACCAGTGGCA GGTGATTTTA TTCAAACAGT CTCACTGGGA 
ATCTCACCGG ACGGAGGGAA AGCACTGAGA ACAGGAAGCT GCTTCACCCG AGAGTTCCTT 
GGTGCCCTTT CCAAATTGTG CCATCCTTCA TCAACAAAGA TACAGAAACC ATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RLN2 ( NM_001329191.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001316120.1 Homo sapiens relaxin 2 (RLN2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu101710
Clone ID Related Accession (Same CDS sequence)	NM_001329191.1
Accession Version	NM_001329191.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	prorelaxin H2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL135786.17 and AI033912.1. Transcript Variant: This variant (3) differs in the 5' UTR and lacks a portion of the 5' coding region compared to variant 1. The encoded isoform (3) has a shorter N-terminus and lacks the predicted signal peptide and the relaxin B chain compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.388196.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGTCAG AATTTGTTGC TAATTTGCCA CAGGAGCTGA AGTTAACCCT GTCTGAGATG 
CAGCCAGCAT TACCACAGCT ACAACAACAT GTACCTGTAT TAAAAGATTC CAGTCTTCTC 
TTTGAAGAAT TTAAGAAACT TATTCGCAAT AGACAAAGTG AAGCCGCAGA CAGCAGTCCT 
TCAGAATTAA AATACTTAGG CTTGGATACT CATTCTCGAA AAAAGAGACA ACTCTACAGT 
GCATTGGCTA ATAAATGTTG CCATGTTGGT TGTACCAAAA GATCTCTTGC TAGATTTTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001316120.1
CDS	77..379
Translation	MMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC

Target ORF information:

RefSeq Version	NM_001329191.1
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 2 (RLN2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001329191.1

ORF Insert Sequence:

ATGATGTCAG AATTTGTTGC TAATTTGCCA CAGGAGCTGA AGTTAACCCT GTCTGAGATG 
CAGCCAGCAT TACCACAGCT ACAACAACAT GTACCTGTAT TAAAAGATTC CAGTCTTCTC 
TTTGAAGAAT TTAAGAAACT TATTCGCAAT AGACAAAGTG AAGCCGCAGA CAGCAGTCCT 
TCAGAATTAA AATACTTAGG CTTGGATACT CATTCTCGAA AAAAGAGACA ACTCTACAGT 
GCATTGGCTA ATAAATGTTG CCATGTTGGT TGTACCAAAA GATCTCTTGC TAGATTTTGC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RLN2 ( XM_024447647.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303415.1 Homo sapiens relaxin 2 (RLN2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu60275
Clone ID Related Accession (Same CDS sequence)	XM_024447647.1 , XM_017015011.1 , XM_024447646.1
Accession Version	XM_024447647.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prorelaxin H2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACACAA GCAAAGCAGT CGCGGACTCA TGGATGGAGG AAGTTATTAA ATTATGCGGC 
CGCGAATTAG TTCGCGCGCA GATTGCCATT TGCGGCATGA GCACCTGGAG CAAAAGGTCT 
CTGAGCCAGG AAGATGCTCC TCAGACACCT AGACCAGTGG CAGAAATTGT GCCATCCTTC 
ATCAACAAAG ATACAGAAAC CATAAATATG ATGTCAGAAT TTGTTGCTAA TTTGCCACAG 
GAGCTGAAGT TAACCCTGTC TGAGATGCAG CCAGCATTAC CACAGCTACA ACAACATGTA 
CCTGTATTAA AAGATTCCAG TCTTCTCTTT GAAGAATTTA AGAAACTTAT TCGCAATAGA 
CAAAGTGAAG CCGCAGACAG CAGTCCTTCA GAATTAAAAT ACTTAGGCTT GGATACTCAT 
TCTCGAAAAA AGAGACAACT CTACAGTGCA TTGGCTAATA AATGTTGCCA TGTTGGTTGT 
ACCAAAAGAT CTCTTGCTAG ATTTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303415.1
CDS	1131..1640
Translation	MNTSKAVADSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC

Target ORF information:

RefSeq Version	XM_024447647.1
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 2 (RLN2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447647.1

ORF Insert Sequence:

ATGAACACAA GCAAAGCAGT CGCGGACTCA TGGATGGAGG AAGTTATTAA ATTATGCGGC 
CGCGAATTAG TTCGCGCGCA GATTGCCATT TGCGGCATGA GCACCTGGAG CAAAAGGTCT 
CTGAGCCAGG AAGATGCTCC TCAGACACCT AGACCAGTGG CAGAAATTGT GCCATCCTTC 
ATCAACAAAG ATACAGAAAC CATAAATATG ATGTCAGAAT TTGTTGCTAA TTTGCCACAG 
GAGCTGAAGT TAACCCTGTC TGAGATGCAG CCAGCATTAC CACAGCTACA ACAACATGTA 
CCTGTATTAA AAGATTCCAG TCTTCTCTTT GAAGAATTTA AGAAACTTAT TCGCAATAGA 
CAAAGTGAAG CCGCAGACAG CAGTCCTTCA GAATTAAAAT ACTTAGGCTT GGATACTCAT 
TCTCGAAAAA AGAGACAACT CTACAGTGCA TTGGCTAATA AATGTTGCCA TGTTGGTTGT 
ACCAAAAGAT CTCTTGCTAG ATTTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RLN2 ( XM_017015011.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016870500.1 Homo sapiens relaxin 2 (RLN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu60275
Clone ID Related Accession (Same CDS sequence)	XM_024447647.1 , XM_017015011.1 , XM_024447646.1
Accession Version	XM_017015011.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	prorelaxin H2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACACAA GCAAAGCAGT CGCGGACTCA TGGATGGAGG AAGTTATTAA ATTATGCGGC 
CGCGAATTAG TTCGCGCGCA GATTGCCATT TGCGGCATGA GCACCTGGAG CAAAAGGTCT 
CTGAGCCAGG AAGATGCTCC TCAGACACCT AGACCAGTGG CAGAAATTGT GCCATCCTTC 
ATCAACAAAG ATACAGAAAC CATAAATATG ATGTCAGAAT TTGTTGCTAA TTTGCCACAG 
GAGCTGAAGT TAACCCTGTC TGAGATGCAG CCAGCATTAC CACAGCTACA ACAACATGTA 
CCTGTATTAA AAGATTCCAG TCTTCTCTTT GAAGAATTTA AGAAACTTAT TCGCAATAGA 
CAAAGTGAAG CCGCAGACAG CAGTCCTTCA GAATTAAAAT ACTTAGGCTT GGATACTCAT 
TCTCGAAAAA AGAGACAACT CTACAGTGCA TTGGCTAATA AATGTTGCCA TGTTGGTTGT 
ACCAAAAGAT CTCTTGCTAG ATTTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016870500.1
CDS	449..958
Translation	MNTSKAVADSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC

Target ORF information:

RefSeq Version	XM_017015011.1
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 2 (RLN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017015011.1

ORF Insert Sequence:

ATGAACACAA GCAAAGCAGT CGCGGACTCA TGGATGGAGG AAGTTATTAA ATTATGCGGC 
CGCGAATTAG TTCGCGCGCA GATTGCCATT TGCGGCATGA GCACCTGGAG CAAAAGGTCT 
CTGAGCCAGG AAGATGCTCC TCAGACACCT AGACCAGTGG CAGAAATTGT GCCATCCTTC 
ATCAACAAAG ATACAGAAAC CATAAATATG ATGTCAGAAT TTGTTGCTAA TTTGCCACAG 
GAGCTGAAGT TAACCCTGTC TGAGATGCAG CCAGCATTAC CACAGCTACA ACAACATGTA 
CCTGTATTAA AAGATTCCAG TCTTCTCTTT GAAGAATTTA AGAAACTTAT TCGCAATAGA 
CAAAGTGAAG CCGCAGACAG CAGTCCTTCA GAATTAAAAT ACTTAGGCTT GGATACTCAT 
TCTCGAAAAA AGAGACAACT CTACAGTGCA TTGGCTAATA AATGTTGCCA TGTTGGTTGT 
ACCAAAAGAT CTCTTGCTAG ATTTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RLN2 ( XM_024447646.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303414.1 Homo sapiens relaxin 2 (RLN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu60275
Clone ID Related Accession (Same CDS sequence)	XM_024447647.1 , XM_017015011.1 , XM_024447646.1
Accession Version	XM_024447646.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 510bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	prorelaxin H2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAACACAA GCAAAGCAGT CGCGGACTCA TGGATGGAGG AAGTTATTAA ATTATGCGGC 
CGCGAATTAG TTCGCGCGCA GATTGCCATT TGCGGCATGA GCACCTGGAG CAAAAGGTCT 
CTGAGCCAGG AAGATGCTCC TCAGACACCT AGACCAGTGG CAGAAATTGT GCCATCCTTC 
ATCAACAAAG ATACAGAAAC CATAAATATG ATGTCAGAAT TTGTTGCTAA TTTGCCACAG 
GAGCTGAAGT TAACCCTGTC TGAGATGCAG CCAGCATTAC CACAGCTACA ACAACATGTA 
CCTGTATTAA AAGATTCCAG TCTTCTCTTT GAAGAATTTA AGAAACTTAT TCGCAATAGA 
CAAAGTGAAG CCGCAGACAG CAGTCCTTCA GAATTAAAAT ACTTAGGCTT GGATACTCAT 
TCTCGAAAAA AGAGACAACT CTACAGTGCA TTGGCTAATA AATGTTGCCA TGTTGGTTGT 
ACCAAAAGAT CTCTTGCTAG ATTTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303414.1
CDS	1365..1874
Translation	MNTSKAVADSWMEEVIKLCGRELVRAQIAICGMSTWSKRSLSQEDAPQTPRPVAEIVPSFINKDTETINMMSEFVANLPQELKLTLSEMQPALPQLQQHVPVLKDSSLLFEEFKKLIRNRQSEAADSSPSELKYLGLDTHSRKKRQLYSALANKCCHVGCTKRSLARFC

Target ORF information:

RefSeq Version	XM_024447646.1
Organism	Homo sapiens(human)
Definition	Homo sapiens relaxin 2 (RLN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447646.1

ORF Insert Sequence:

ATGAACACAA GCAAAGCAGT CGCGGACTCA TGGATGGAGG AAGTTATTAA ATTATGCGGC 
CGCGAATTAG TTCGCGCGCA GATTGCCATT TGCGGCATGA GCACCTGGAG CAAAAGGTCT 
CTGAGCCAGG AAGATGCTCC TCAGACACCT AGACCAGTGG CAGAAATTGT GCCATCCTTC 
ATCAACAAAG ATACAGAAAC CATAAATATG ATGTCAGAAT TTGTTGCTAA TTTGCCACAG 
GAGCTGAAGT TAACCCTGTC TGAGATGCAG CCAGCATTAC CACAGCTACA ACAACATGTA 
CCTGTATTAA AAGATTCCAG TCTTCTCTTT GAAGAATTTA AGAAACTTAT TCGCAATAGA 
CAAAGTGAAG CCGCAGACAG CAGTCCTTCA GAATTAAAAT ACTTAGGCTT GGATACTCAT 
TCTCGAAAAA AGAGACAACT CTACAGTGCA TTGGCTAATA AATGTTGCCA TGTTGGTTGT 
ACCAAAAGAT CTCTTGCTAG ATTTTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Relaxin serum levels in acute heart failure are associated with pulmonary hypertension and right heart overload.
European journal of heart failure19(2)218-225(2017 Feb)
Pintalhao M,Castro-Chaves P,Vasques-Novoa F,Gon?alves F,Mendon?a L,Fontes-Carvalho R,Louren?o P,Almeida P,Leite-Moreira A,Bettencourt P

The Intracellular Effect of Relaxin on Female Anterior Cruciate Ligament Cells.
The American journal of sports medicine44(9)2384-92(2016 Sep)
Konopka JA,DeBaun MR,Chang W,Dragoo JL

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RLN2 cDNA ORF clone, Homo sapiens(human)

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Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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