RIT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RIT2
Entrez Gene ID	6014
Full Name	Ras like without CAAX 2
Synonyms	RIBA,RIN,ROC2
General protein information	Preferred Names Ras like without CAAX 2 Names GTP-binding protein Rit2 GTP-binding protein Roc2 Ric-like, expressed in neurons ras-like protein expressed in neurons ras-like without CAAX protein 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.3
Summary	RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008].
Disorder MIM:	609592

mRNA and Protein(s)

mRNA	Protein	Name
NM_001272077.1	NP_001259006.1	GTP-binding protein Rit2 isoform 2
NM_002930.4	NP_002921.1	GTP-binding protein Rit2 isoform 1
NM_002930.3	NP_002921.1	GTP-binding protein Rit2 isoform 1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Rit2	NP_001013078.1
Homo sapiens (human)	RIT2	NP_002921.1
Canis lupus familiaris (dog)	RIT2	XP_547597.3
Mus musculus (house mouse)	Rit2	NP_033091.1
Gallus gallus (chicken)	RIT2	XP_001233997.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005159	XP_314049.4
	RIT2	XP_001083497.1
Drosophila melanogaster (fruit fly)	Ric	NP_001163165.1

Gene Ontology
Bibliography

Related articles in PubMed

Ras-like without CAAX 2 (RIT2): a susceptibility gene for autism spectrum disorder.
Hamedani SY, Gharesouran J, Noroozi R, Sayad A, Omrani MD, Mir A, Afjeh SSA, Toghi M, Manoochehrabadi S, Ghafouri-Fard S, Taheri M
Metabolic brain disease32(3)751-755(2017 Jun)

The human RIT2 core promoter short tandem repeat predominant allele is species-specific in length: a selective advantage for human evolution?
Emamalizadeh B, Movafagh A, Darvish H, Kazeminasab S, Andarva M, Namdar-Aligoodarzi P, Ohadi M
Molecular genetics and genomics : MGG292(3)611-617(2017 Jun)

Genetic association study between RIT2 and Parkinson's disease in a Han Chinese population.
Li JY, Zhang JH, Li NN, Wang L, Lu ZJ, Cheng L, Sun XY, Peng R
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology38(2)343-347(2017 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Findings indicate for the first time, selective advantage for a human-specific allele at an short tandem repeat locus in the human RIT2 core promoter.
Title: The human RIT2 core promoter short tandem repeat predominant allele is species-specific in length: a selective advantage for human evolution?

RIT2 rs12456492 do not increase the risk of developing Parkinson's in Han Chinese.
Title: Genetic association study between RIT2 and Parkinson's disease in a Han Chinese population.

The current meta-analysis suggested that rs12456492 might be associated with increased PD risk in Asian populations, but studies using larger sample sizes and different ethnic populations will be needed to further confirm this association.
Title: Genetic association of RIT2 rs12456492 polymorphism and Parkinson's disease susceptibility in Asian populations: a meta-analysis.

the G allele, GG and GA genotype of rs12456492(A/G) polymorphism may increase the risk of Parkinson disease. [meta-analysis]
Title: RIT2 rs12456492 polymorphism and the risk of Parkinson's disease: A meta-analysis.

performed a case-control replication study in this population and investigated RIT2 rs12456492 variant in a large cohort of Chinese Han individuals
Title: Assessment of RIT2 rs12456492 association with Parkinson's disease in Mainland China.

The following RIT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RIT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09782	NM_002930.4 Latest version!	Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu10015	NM_001272077.1 Latest version!	Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu09782	NM_002930.3	Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RIT2 ( NM_002930.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002921.1 Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09782
Clone ID Related Accession (Same CDS sequence)	NM_002930.4 , NM_002930.3
Accession Version	NM_002930.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	GTP-binding protein Rit2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Y07565.1. On Nov 22, 2018 this sequence version replaced NM_002930.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y07565.1, SRR5189664.170107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000326695.10/ ENSP00000321805.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGGTAG AAAATGAAGC CAGCTGCTCC CCGGGCAGCG CATCAGGCGG GTCCAGAGAG 
TACAAGGTGG TAATGCTGGG AGCAGGGGGA GTTGGTAAAA GCGCAATGAC AATGCAGTTT 
ATTAGTCATC AGTTCCCTGA TTATCATGAC CCTACTATAG AAGATGCTTA TAAGACCCAG 
GTCAGGATTG ACAATGAGCC AGCTTACTTG GACATCTTGG ACACTGCTGG CCAGGCAGAA 
TTCACAGCCA TGCGGGAGCA GTACATGCGA GGTGGGGAAG GCTTCATCAT CTGCTACTCC 
GTCACTGACC GTCAATCATT TCAGGAGGCT GCCAAGTTTA AAGAGCTCAT TTTTCAGGTC 
CGCCACACCT ATGAAATTCC CCTGGTGCTG GTGGGTAACA AAATTGATCT GGAACAGTTC 
CGCCAGGTTT CTACAGAAGA AGGCTTGAGT CTTGCCCAAG AATATAATTG TGGTTTTTTT 
GAGACCTCTG CAGCCCTCAG ATTCTGTATT GATGATGCTT TTCATGGCTT AGTGAGGGAA 
ATTCGCAAGA AGGAGTCCAT GCCATCCTTG ATGGAAAAGA AACTGAAGAG AAAAGACAGC 
CTGTGGAAGA AGCTCAAAGG TTCTTTGAAG AAGAAGAGAG AAAATATGAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002921.1
CDS	167..820
Translation	MEVENEASCSPGSASGGSREYKVVMLGAGGVGKSAMTMQFISHQFPDYHDPTIEDAYKTQVRIDNEPAYLDILDTAGQAEFTAMREQYMRGGEGFIICYSVTDRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLEQFRQVSTEEGLSLAQEYNCGFFETSAALRFCIDDAFHGLVREIRKKESMPSLMEKKLKRKDSLWKKLKGSLKKKRENMT

Target ORF information:

RefSeq Version	NM_002930.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002930.4

ORF Insert Sequence:

ATGGAGGTAG AAAATGAAGC CAGCTGCTCC CCGGGCAGCG CATCAGGCGG GTCCAGAGAG 
TACAAGGTGG TAATGCTGGG AGCAGGGGGA GTTGGTAAAA GCGCAATGAC AATGCAGTTT 
ATTAGTCATC AGTTCCCTGA TTATCATGAC CCTACTATAG AAGATGCTTA TAAGACCCAG 
GTCAGGATTG ACAATGAGCC AGCTTACTTG GACATCTTGG ACACTGCTGG CCAGGCAGAA 
TTCACAGCCA TGCGGGAGCA GTACATGCGA GGTGGGGAAG GCTTCATCAT CTGCTACTCC 
GTCACTGACC GTCAATCATT TCAGGAGGCT GCCAAGTTTA AAGAGCTCAT TTTTCAGGTC 
CGCCACACCT ATGAAATTCC CCTGGTGCTG GTGGGTAACA AAATTGATCT GGAACAGTTC 
CGCCAGGTTT CTACAGAAGA AGGCTTGAGT CTTGCCCAAG AATATAATTG TGGTTTTTTT 
GAGACCTCTG CAGCCCTCAG ATTCTGTATT GATGATGCTT TTCATGGCTT AGTGAGGGAA 
ATTCGCAAGA AGGAGTCCAT GCCATCCTTG ATGGAAAAGA AACTGAAGAG AAAAGACAGC 
CTGTGGAAGA AGCTCAAAGG TTCTTTGAAG AAGAAGAGAG AAAATATGAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIT2 ( NM_002930.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002921.1 Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu09782
Clone ID Related Accession (Same CDS sequence)	NM_002930.4 , NM_002930.3
Accession Version	NM_002930.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 654bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-08
Organism	Homo sapiens(human)
Product	GTP-binding protein Rit2 isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Y07565.1 and BG188523.1. On Jan 11, 2013 this sequence version replaced NM_002930.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Y07565.1, U78164.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END##

ATGGAGGTAG AAAATGAAGC CAGCTGCTCC CCGGGCAGCG CATCAGGCGG GTCCAGAGAG 
TACAAGGTGG TAATGCTGGG AGCAGGGGGA GTTGGTAAAA GCGCAATGAC AATGCAGTTT 
ATTAGTCATC AGTTCCCTGA TTATCATGAC CCTACTATAG AAGATGCTTA TAAGACCCAG 
GTCAGGATTG ACAATGAGCC AGCTTACTTG GACATCTTGG ACACTGCTGG CCAGGCAGAA 
TTCACAGCCA TGCGGGAGCA GTACATGCGA GGTGGGGAAG GCTTCATCAT CTGCTACTCC 
GTCACTGACC GTCAATCATT TCAGGAGGCT GCCAAGTTTA AAGAGCTCAT TTTTCAGGTC 
CGCCACACCT ATGAAATTCC CCTGGTGCTG GTGGGTAACA AAATTGATCT GGAACAGTTC 
CGCCAGGTTT CTACAGAAGA AGGCTTGAGT CTTGCCCAAG AATATAATTG TGGTTTTTTT 
GAGACCTCTG CAGCCCTCAG ATTCTGTATT GATGATGCTT TTCATGGCTT AGTGAGGGAA 
ATTCGCAAGA AGGAGTCCAT GCCATCCTTG ATGGAAAAGA AACTGAAGAG AAAAGACAGC 
CTGTGGAAGA AGCTCAAAGG TTCTTTGAAG AAGAAGAGAG AAAATATGAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002921.1
CDS	174..827
Translation	MEVENEASCSPGSASGGSREYKVVMLGAGGVGKSAMTMQFISHQFPDYHDPTIEDAYKTQVRIDNEPAYLDILDTAGQAEFTAMREQYMRGGEGFIICYSVTDRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLEQFRQVSTEEGLSLAQEYNCGFFETSAALRFCIDDAFHGLVREIRKKESMPSLMEKKLKRKDSLWKKLKGSLKKKRENMT

Target ORF information:

RefSeq Version	NM_002930.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002930.3

ORF Insert Sequence:

ATGGAGGTAG AAAATGAAGC CAGCTGCTCC CCGGGCAGCG CATCAGGCGG GTCCAGAGAG 
TACAAGGTGG TAATGCTGGG AGCAGGGGGA GTTGGTAAAA GCGCAATGAC AATGCAGTTT 
ATTAGTCATC AGTTCCCTGA TTATCATGAC CCTACTATAG AAGATGCTTA TAAGACCCAG 
GTCAGGATTG ACAATGAGCC AGCTTACTTG GACATCTTGG ACACTGCTGG CCAGGCAGAA 
TTCACAGCCA TGCGGGAGCA GTACATGCGA GGTGGGGAAG GCTTCATCAT CTGCTACTCC 
GTCACTGACC GTCAATCATT TCAGGAGGCT GCCAAGTTTA AAGAGCTCAT TTTTCAGGTC 
CGCCACACCT ATGAAATTCC CCTGGTGCTG GTGGGTAACA AAATTGATCT GGAACAGTTC 
CGCCAGGTTT CTACAGAAGA AGGCTTGAGT CTTGCCCAAG AATATAATTG TGGTTTTTTT 
GAGACCTCTG CAGCCCTCAG ATTCTGTATT GATGATGCTT TTCATGGCTT AGTGAGGGAA 
ATTCGCAAGA AGGAGTCCAT GCCATCCTTG ATGGAAAAGA AACTGAAGAG AAAAGACAGC 
CTGTGGAAGA AGCTCAAAGG TTCTTTGAAG AAGAAGAGAG AAAATATGAC ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RIT2 ( NM_001272077.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001259006.1 Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu10015
Clone ID Related Accession (Same CDS sequence)	NM_001272077.1
Accession Version	NM_001272077.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 462bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	GTP-binding protein Rit2 isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from Y07565.1, U78166.1 and BG188523.1. Transcript Variant: This variant (2) contains an alternate internal exon in the 3' coding region which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U78166.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2142670 [ECO:0000350] ##Evidence-Data-END##

ATGGAGGTAG AAAATGAAGC CAGCTGCTCC CCGGGCAGCG CATCAGGCGG GTCCAGAGAG 
TACAAGGTGG TAATGCTGGG AGCAGGGGGA GTTGGTAAAA GCGCAATGAC AATGCAGTTT 
ATTAGTCATC AGTTCCCTGA TTATCATGAC CCTACTATAG AAGATGCTTA TAAGACCCAG 
GTCAGGATTG ACAATGAGCC AGCTTACTTG GACATCTTGG ACACTGCTGG CCAGGCAGAA 
TTCACAGCCA TGCGGGAGCA GTACATGCGA GGTGGGGAAG GCTTCATCAT CTGCTACTCC 
GTCACTGACC GTCAATCATT TCAGGAGGCT GCCAAGTTTA AAGAGCTCAT TTTTCAGGTC 
CGCCACACCT ATGAAATTCC CCTGGTGCTG GTGGGTAACA AAATTGATCT GGAACAGTTC 
CGCCAGCCTA CACTGAAAGA GTTTGGAAGG GAAGAATTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001259006.1
CDS	174..635
Translation	MEVENEASCSPGSASGGSREYKVVMLGAGGVGKSAMTMQFISHQFPDYHDPTIEDAYKTQVRIDNEPAYLDILDTAGQAEFTAMREQYMRGGEGFIICYSVTDRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLEQFRQPTLKEFGREEF

Target ORF information:

RefSeq Version	NM_001272077.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001272077.1

ORF Insert Sequence:

ATGGAGGTAG AAAATGAAGC CAGCTGCTCC CCGGGCAGCG CATCAGGCGG GTCCAGAGAG 
TACAAGGTGG TAATGCTGGG AGCAGGGGGA GTTGGTAAAA GCGCAATGAC AATGCAGTTT 
ATTAGTCATC AGTTCCCTGA TTATCATGAC CCTACTATAG AAGATGCTTA TAAGACCCAG 
GTCAGGATTG ACAATGAGCC AGCTTACTTG GACATCTTGG ACACTGCTGG CCAGGCAGAA 
TTCACAGCCA TGCGGGAGCA GTACATGCGA GGTGGGGAAG GCTTCATCAT CTGCTACTCC 
GTCACTGACC GTCAATCATT TCAGGAGGCT GCCAAGTTTA AAGAGCTCAT TTTTCAGGTC 
CGCCACACCT ATGAAATTCC CCTGGTGCTG GTGGGTAACA AAATTGATCT GGAACAGTTC 
CGCCAGCCTA CACTGAAAGA GTTTGGAAGG GAAGAATTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ras-like without CAAX 2 (RIT2): a susceptibility gene for autism spectrum disorder.
Metabolic brain disease32(3)751-755(2017 Jun)
Hamedani SY,Gharesouran J,Noroozi R,Sayad A,Omrani MD,Mir A,Afjeh SSA,Toghi M,Manoochehrabadi S,Ghafouri-Fard S,Taheri M

The human RIT2 core promoter short tandem repeat predominant allele is species-specific in length: a selective advantage for human evolution?
Molecular genetics and genomics : MGG292(3)611-617(2017 Jun)
Emamalizadeh B,Movafagh A,Darvish H,Kazeminasab S,Andarva M,Namdar-Aligoodarzi P,Ohadi M

Genetic association study between RIT2 and Parkinson's disease in a Han Chinese population.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology38(2)343-347(2017 Feb)
Li JY,Zhang JH,Li NN,Wang L,Lu ZJ,Cheng L,Sun XY,Peng R

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RIT2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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