RBP2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RBP2
Entrez Gene ID	5948
Full Name	retinol binding protein 2
Synonyms	CRABP-II,CRBP2,CRBPII,RBPC2
General protein information	Preferred Names retinol binding protein 2 Names retinol-binding protein 2 CRBP-II cellular retinol-binding protein II retinol binding protein 2, cellular
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q23
Summary	This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015].
Disorder MIM:	180280

mRNA and Protein(s)

mRNA	Protein	Name
NM_004164.3	NP_004155.2	retinol-binding protein 2
NM_004164.2	NP_004155.2	retinol-binding protein 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RBP2	XP_534284.1
Bos taurus (cattle)	RBP2	NP_001094729.1
Pan troglodytes (chimpanzee)	RBP2	XP_001158239.1
Mus musculus (house mouse)	Rbp2	NP_033060.3
Rattus norvegicus (Norway rat)	Rbp2	NP_036772.2
Gallus gallus (chicken)	RBP2	NP_001264346.1
Homo sapiens (human)	RBP2	NP_004155.2
	RBP2	XP_001113494.1
Danio rerio (zebrafish)	rbp2a	NP_694549.1
Xenopus tropicalis (tropical clawed frog)	rbp2	XP_002933389.1

Gene Ontology
Bibliography

Related articles in PubMed

Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters.
Zargar ZU, Kimidi MR, Tyagi S
Nucleic acids research46(1)174-188(2018 Jan)

Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation.
Yu X, Chen H, Zuo C, Jin X, Yin Y, Wang H, Jin M, Ozato K, Xu S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Sep)

Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates.
Assar Z, Nossoni Z, Wang W, Santos EM, Kramer K, McCornack C, Vasileiou C, Borhan B, Geiger JH
Structure (London, England : 1993)24(9)1590-8(2016 09)

Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal.
Nossoni Z, Assar Z, Yapici I, Nosrati M, Wang W, Berbasova T, Vasileiou C, Borhan B, Geiger J
Acta crystallographica. Section D, Biological crystallography70(Pt 12)3226-32(2014 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Domain-swapped dimers of RBP2 provides evidence for ordered folding intermediates.
Title: Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates.

miR-34a promotes the osteogenic differentiation of human adipose-derived stem cells via the RBP2/NOTCH1/CYCLIN D1 coregulatory network.
Title: MiR-34a Promotes Osteogenic Differentiation of Human Adipose-Derived Stem Cells via the RBP2/NOTCH1/CYCLIN D1 Coregulatory Network.

Ectopic overexpression of RBP2 can induce cancer stem cell-like (CSC) phenotypes through epithelial to mesenchymal transition in renal cell carcinoma cells by converting them to a more mesenchymal phenotype.
Title: RBP2 induces stem-like cancer cells by promoting EMT and is a prognostic marker for renal cell carcinoma.

promotes overexpression and activation of BCL2 in acute lymphoblastic leukemia development and progression
Title: RBP2 Promotes Adult Acute Lymphoblastic Leukemia by Upregulating BCL2.

RBP2 could induce epithelial-mesenchymal transition in esophageal cancer cells and exert a greater effect on the expression of E-cadherin in lung squamous cells than in esophageal squamous cells.
Title: Retinoblastoma-binding protein 2 induces epithelial-mesenchymal transition in esophageal squamous cancer cells.

The following RBP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RBP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23604	NM_004164.3 Latest version!	Homo sapiens retinol binding protein 2 (RBP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23604	NM_004164.2	Homo sapiens retinol binding protein 2 (RBP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RBP2 ( NM_004164.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004155.2 Homo sapiens retinol binding protein 2 (RBP2), mRNA.

Price & Availability↑

CloneID	OHu23604
Clone ID Related Accession (Same CDS sequence)	NM_004164.3 , NM_004164.2
Accession Version	NM_004164.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	retinol-binding protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC097103.8, BX282005.1 and AW772327.1. On May 17, 2019 this sequence version replaced NM_004164.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AW772327.1, AK291978.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000232217.6/ ENSP00000232217.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACAAGGG ACCAGAATGG AACCTGGGAG ATGGAGAGTA ATGAAAACTT TGAGGGCTAC 
ATGAAGGCCC TGGATATTGA TTTTGCCACC CGCAAGATTG CAGTACGTCT CACTCAGACG 
AAGGTTATTG ATCAAGATGG TGATAACTTC AAGACAAAAA CCACTAGCAC ATTCCGCAAC 
TATGATGTGG ATTTCACTGT TGGAGTAGAG TTTGACGAGT ACACAAAGAG CCTGGATAAC 
CGGCATGTTA AGGCACTGGT CACCTGGGAA GGTGATGTCC TTGTGTGTGT GCAAAAGGGG 
GAGAAGGAGA ACCGCGGCTG GAAGCAGTGG ATTGAGGGGG ACAAGCTGTA CCTGGAGCTG 
ACCTGTGGTG ACCAGGTGTG CCGTCAAGTG TTCAAAAAGA AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004155.2
CDS	58..462
Translation	MTRDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKVIDQDGDNFKTKTTSTFRNYDVDFTVGVEFDEYTKSLDNRHVKALVTWEGDVLVCVQKGEKENRGWKQWIEGDKLYLELTCGDQVCRQVFKKK

Target ORF information:

RefSeq Version	NM_004164.3
Organism	Homo sapiens(human)
Definition	Homo sapiens retinol binding protein 2 (RBP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004164.3

ORF Insert Sequence:

ATGACAAGGG ACCAGAATGG AACCTGGGAG ATGGAGAGTA ATGAAAACTT TGAGGGCTAC 
ATGAAGGCCC TGGATATTGA TTTTGCCACC CGCAAGATTG CAGTACGTCT CACTCAGACG 
AAGGTTATTG ATCAAGATGG TGATAACTTC AAGACAAAAA CCACTAGCAC ATTCCGCAAC 
TATGATGTGG ATTTCACTGT TGGAGTAGAG TTTGACGAGT ACACAAAGAG CCTGGATAAC 
CGGCATGTTA AGGCACTGGT CACCTGGGAA GGTGATGTCC TTGTGTGTGT GCAAAAGGGG 
GAGAAGGAGA ACCGCGGCTG GAAGCAGTGG ATTGAGGGGG ACAAGCTGTA CCTGGAGCTG 
ACCTGTGGTG ACCAGGTGTG CCGTCAAGTG TTCAAAAAGA AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RBP2 ( NM_004164.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004155.2 Homo sapiens retinol binding protein 2 (RBP2), mRNA.

Price & Availability↑

CloneID	OHu23604
Clone ID Related Accession (Same CDS sequence)	NM_004164.3 , NM_004164.2
Accession Version	NM_004164.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-15
Organism	Homo sapiens(human)
Product	retinol-binding protein 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX282005.1, AW772327.1 and AI076320.1. On Dec 24, 2003 this sequence version replaced NM_004164.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279829.4560.1, ERR279872.514.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144835, SAMEA2152474 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAAGGG ACCAGAATGG AACCTGGGAG ATGGAGAGTA ATGAAAACTT TGAGGGCTAC 
ATGAAGGCCC TGGATATTGA TTTTGCCACC CGCAAGATTG CAGTACGTCT CACTCAGACG 
AAGGTTATTG ATCAAGATGG TGATAACTTC AAGACAAAAA CCACTAGCAC ATTCCGCAAC 
TATGATGTGG ATTTCACTGT TGGAGTAGAG TTTGACGAGT ACACAAAGAG CCTGGATAAC 
CGGCATGTTA AGGCACTGGT CACCTGGGAA GGTGATGTCC TTGTGTGTGT GCAAAAGGGG 
GAGAAGGAGA ACCGCGGCTG GAAGCAGTGG ATTGAGGGGG ACAAGCTGTA CCTGGAGCTG 
ACCTGTGGTG ACCAGGTGTG CCGTCAAGTG TTCAAAAAGA AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004155.2
CDS	52..456
Translation	MTRDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKVIDQDGDNFKTKTTSTFRNYDVDFTVGVEFDEYTKSLDNRHVKALVTWEGDVLVCVQKGEKENRGWKQWIEGDKLYLELTCGDQVCRQVFKKK

Target ORF information:

RefSeq Version	NM_004164.2
Organism	Homo sapiens(human)
Definition	Homo sapiens retinol binding protein 2 (RBP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004164.2

ORF Insert Sequence:

ATGACAAGGG ACCAGAATGG AACCTGGGAG ATGGAGAGTA ATGAAAACTT TGAGGGCTAC 
ATGAAGGCCC TGGATATTGA TTTTGCCACC CGCAAGATTG CAGTACGTCT CACTCAGACG 
AAGGTTATTG ATCAAGATGG TGATAACTTC AAGACAAAAA CCACTAGCAC ATTCCGCAAC 
TATGATGTGG ATTTCACTGT TGGAGTAGAG TTTGACGAGT ACACAAAGAG CCTGGATAAC 
CGGCATGTTA AGGCACTGGT CACCTGGGAA GGTGATGTCC TTGTGTGTGT GCAAAAGGGG 
GAGAAGGAGA ACCGCGGCTG GAAGCAGTGG ATTGAGGGGG ACAAGCTGTA CCTGGAGCTG 
ACCTGTGGTG ACCAGGTGTG CCGTCAAGTG TTCAAAAAGA AATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Dynamic site-specific recruitment of RBP2 by pocket protein p130 modulates H3K4 methylation on E2F-responsive promoters.
Nucleic acids research46(1)174-188(2018 Jan)
Zargar ZU,Kimidi MR,Tyagi S

Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology(2017 Sep)
Yu X,Chen H,Zuo C,Jin X,Yin Y,Wang H,Jin M,Ozato K,Xu S

Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates.
Structure (London, England : 1993)24(9)1590-8(2016 09)
Assar Z,Nossoni Z,Wang W,Santos EM,Kramer K,McCornack C,Vasileiou C,Borhan B,Geiger JH

Structures of holo wild-type human cellular retinol-binding protein II (hCRBPII) bound to retinol and retinal.
Acta crystallographica. Section D, Biological crystallography70(Pt 12)3226-32(2014 Dec)
Nossoni Z,Assar Z,Yapici I,Nosrati M,Wang W,Berbasova T,Vasileiou C,Borhan B,Geiger J

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RBP2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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