Rbp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rbp2
Entrez Gene ID	24710
Full Name	retinol binding protein 2
General protein information	Preferred Names retinol binding protein 2 Names retinol-binding protein 2 CRBP-II Retinol-binding protein 2, cellular cellular retinol-binding protein II retinol binding protein 2, cellular
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 8 Map Location: 8q31
Summary	expressed in neonatal interphotoreceptor matrix; may play a role in retinal development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006243607.1	XP_006243669.1	retinol-binding protein 2 isoform X1
NM_012640.2	NP_036772.2	retinol-binding protein 2
XM_017595475.1	XP_017450964.1	retinol-binding protein 2 isoform X1

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	RBP2	XP_534284.1
Bos taurus (cattle)	RBP2	NP_001094729.1
Pan troglodytes (chimpanzee)	RBP2	XP_001158239.1
Mus musculus (house mouse)	Rbp2	NP_033060.3
Rattus norvegicus (Norway rat)	Rbp2	NP_036772.2
Gallus gallus (chicken)	RBP2	NP_001264346.1
Homo sapiens (human)	RBP2	NP_004155.2
	RBP2	XP_001113494.1
Danio rerio (zebrafish)	rbp2a	NP_694549.1
Xenopus tropicalis (tropical clawed frog)	rbp2	XP_002933389.1

Gene Ontology
Bibliography

Related articles in PubMed

Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats.
Cottin SC, Gambling L, Hayes HE, Stevens VJ, McArdle HJ
The Journal of nutritional biochemistry3255-63(2016 06)

Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats.
Hebiguchi T, Mezaki Y, Morii M, Watanabe R, Yoshikawa K, Miura M, Imai K, Senoo H, Yoshino H
International journal of molecular medicine35(3)724-30(2015 Mar)

Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.
Harrison EH
Biochimica et biophysica acta1821(1)70-7(2012 Jan)

New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers.
Franzoni L, Cavazzini D, Rossi GL, L?cke C
Journal of lipid research51(6)1332-43(2010 Jun)

Induction of histone acetylation on the CRBPII gene in perinatal rat small intestine.
Ogura Y, Mochizuki K, Goda T
Biochimica et biophysica acta1770(9)1289-96(2007 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that, as compared to controls, CrbpII expression in liver is up-regulated by pregnancy and further increased by iron deficiency; maternal iron deficiency has little impact on vitamin A levels and gene expression in placenta, but increases retinol storage in fetal liver; regulation of CrbpII expression in liver may play important roles in vitamin A metabolism in pregnant females and in fetal development.
Title: Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats.

These results suggest that the elevated mRNA expression levels of Rbp2 and Apoa4 in the rats with SB contribute to the effective esterification and transport of vitamin A.
Title: Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats.

protein-ligand interaction differences between CRBP-I and CRBP-II
Title: New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers.

results suggest that CRBPII gene expression during the perinatal period is associated with abrupt acetylation of histones H3 and H4 followed by the binding of CBP/p300 and RXRalpha.
Title: Induction of histone acetylation on the CRBPII gene in perinatal rat small intestine.

analysis of conformational flexibility of rat cellular retinol-binding protein I (CRBP I) and cellular retinol-binding protein II (CRBP II)
Title: Two homologous rat cellular retinol-binding proteins differ in local conformational flexibility.

The following Rbp2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rbp2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa00523	NM_012640.2 Latest version!	Rattus norvegicus retinol binding protein 2 (Rbp2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa31484	XM_017595475.1 Latest version!	Rattus norvegicus retinol binding protein 2 (Rbp2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
ORa31484	XM_006243607.1 Latest version!	Rattus norvegicus retinol binding protein 2 (Rbp2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rbp2 ( NM_012640.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_036772.2 Rattus norvegicus retinol binding protein 2 (Rbp2), mRNA.

Price & Availability↑

CloneID	ORa00523
Clone ID Related Accession (Same CDS sequence)	NM_012640.2
Accession Version	NM_012640.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-19
Organism	Rattus norvegicus(Norway rat)
Product	retinol-binding protein 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from M13949.1 and CN542437.1. On Oct 26, 2005 this sequence version replaced NM_012640.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M13949.1, CB729037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACGAAGG ACCAGAATGG AACCTGGGAA ATGGAGAGTA ATGAGAACTT TGAAGGCTAC 
ATGAAGGCCC TAGATATTGA TTTTGCCACC CGCAAGATTG CAGTGCGTCT GACTCAGACG 
AAGATCATCG TTCAAGACGG TGATAACTTC AAGACAAAAA CCAACAGCAC GTTCCGCAAC 
TATGACCTAG ATTTCACAGT GGGGGTGGAG TTTGACGAAC ACACAAAGGG TCTGGATGGC 
CGGAACGTCA AGACCCTAGT CACCTGGGAA GGAAACACCC TGGTGTGTGT GCAGAAAGGG 
GAGAAGGAGA ATCGTGGCTG GAAGCAGTGG GTCGAGGGAG ACAAGCTGTA CCTGGAGCTG 
ACCTGCGGTG ACCAGGTGTG TCGACAAGTG TTCAAAAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036772.2
CDS	56..460
Translation	MTKDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKIIVQDGDNFKTKTNSTFRNYDLDFTVGVEFDEHTKGLDGRNVKTLVTWEGNTLVCVQKGEKENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK

Target ORF information:

RefSeq Version	NM_012640.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus retinol binding protein 2 (Rbp2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012640.2

ORF Insert Sequence:

ATGACGAAGG ACCAGAATGG AACCTGGGAA ATGGAGAGTA ATGAGAACTT TGAAGGCTAC 
ATGAAGGCCC TAGATATTGA TTTTGCCACC CGCAAGATTG CAGTGCGTCT GACTCAGACG 
AAGATCATCG TTCAAGACGG TGATAACTTC AAGACAAAAA CCAACAGCAC GTTCCGCAAC 
TATGACCTAG ATTTCACAGT GGGGGTGGAG TTTGACGAAC ACACAAAGGG TCTGGATGGC 
CGGAACGTCA AGACCCTAGT CACCTGGGAA GGAAACACCC TGGTGTGTGT GCAGAAAGGG 
GAGAAGGAGA ATCGTGGCTG GAAGCAGTGG GTCGAGGGAG ACAAGCTGTA CCTGGAGCTG 
ACCTGCGGTG ACCAGGTGTG TCGACAAGTG TTCAAAAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rbp2 ( XM_006243607.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006243669.1 Rattus norvegicus retinol binding protein 2 (Rbp2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa31484
Clone ID Related Accession (Same CDS sequence)	XM_006243607.1 , XM_017595475.1
Accession Version	XM_006243607.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	retinol-binding protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGAAGG ACCAGAATGG AACCTGGGAA ATGGAGAGTA ATGAGAACTT TGAAGGCTAC 
ATGAAGGCCC TAGATATTGA TTTTGCCACC CGCAAGATTG CAGTGCGTCT GACTCAGACG 
AAGATCATCG TTCAAGACGG TGATAACTTC AAGACAAAAA CCAACAGCAC GTTCCGCAAC 
TATGACCTAG ATTTCACAGT GGGGGTGGAG TTTGACGAAC ACACAAAGGG TCTGGATGGC 
CGGAACGTCA AGACCCTAGT CACCTGGGAA GGAAACACCC TGGTGTGCGT GCAGAAAGGG 
GAGAAGGAGA ATCGTGGCTG GAAGCAGTGG GTCGAGGGAG ACAAGCTGTA CCTGGAGCTG 
ACCTGCGGTG ACCAGGTGTG TCGACAAGTG TTCAAAAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006243669.1
CDS	236..640
Translation	MTKDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKIIVQDGDNFKTKTNSTFRNYDLDFTVGVEFDEHTKGLDGRNVKTLVTWEGNTLVCVQKGEKENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK

Target ORF information:

RefSeq Version	XM_006243607.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus retinol binding protein 2 (Rbp2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006243607.1

ORF Insert Sequence:

ATGACGAAGG ACCAGAATGG AACCTGGGAA ATGGAGAGTA ATGAGAACTT TGAAGGCTAC 
ATGAAGGCCC TAGATATTGA TTTTGCCACC CGCAAGATTG CAGTGCGTCT GACTCAGACG 
AAGATCATCG TTCAAGACGG TGATAACTTC AAGACAAAAA CCAACAGCAC GTTCCGCAAC 
TATGACCTAG ATTTCACAGT GGGGGTGGAG TTTGACGAAC ACACAAAGGG TCTGGATGGC 
CGGAACGTCA AGACCCTAGT CACCTGGGAA GGAAACACCC TGGTGTGCGT GCAGAAAGGG 
GAGAAGGAGA ATCGTGGCTG GAAGCAGTGG GTCGAGGGAG ACAAGCTGTA CCTGGAGCTG 
ACCTGCGGTG ACCAGGTGTG TCGACAAGTG TTCAAAAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rbp2 ( XM_017595475.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017450964.1 Rattus norvegicus retinol binding protein 2 (Rbp2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa31484
Clone ID Related Accession (Same CDS sequence)	XM_006243607.1 , XM_017595475.1
Accession Version	XM_017595475.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	retinol-binding protein 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005107.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACGAAGG ACCAGAATGG AACCTGGGAA ATGGAGAGTA ATGAGAACTT TGAAGGCTAC 
ATGAAGGCCC TAGATATTGA TTTTGCCACC CGCAAGATTG CAGTGCGTCT GACTCAGACG 
AAGATCATCG TTCAAGACGG TGATAACTTC AAGACAAAAA CCAACAGCAC GTTCCGCAAC 
TATGACCTAG ATTTCACAGT GGGGGTGGAG TTTGACGAAC ACACAAAGGG TCTGGATGGC 
CGGAACGTCA AGACCCTAGT CACCTGGGAA GGAAACACCC TGGTGTGCGT GCAGAAAGGG 
GAGAAGGAGA ATCGTGGCTG GAAGCAGTGG GTCGAGGGAG ACAAGCTGTA CCTGGAGCTG 
ACCTGCGGTG ACCAGGTGTG TCGACAAGTG TTCAAAAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017450964.1
CDS	230..634
Translation	MTKDQNGTWEMESNENFEGYMKALDIDFATRKIAVRLTQTKIIVQDGDNFKTKTNSTFRNYDLDFTVGVEFDEHTKGLDGRNVKTLVTWEGNTLVCVQKGEKENRGWKQWVEGDKLYLELTCGDQVCRQVFKKK

Target ORF information:

RefSeq Version	XM_017595475.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus retinol binding protein 2 (Rbp2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017595475.1

ORF Insert Sequence:

ATGACGAAGG ACCAGAATGG AACCTGGGAA ATGGAGAGTA ATGAGAACTT TGAAGGCTAC 
ATGAAGGCCC TAGATATTGA TTTTGCCACC CGCAAGATTG CAGTGCGTCT GACTCAGACG 
AAGATCATCG TTCAAGACGG TGATAACTTC AAGACAAAAA CCAACAGCAC GTTCCGCAAC 
TATGACCTAG ATTTCACAGT GGGGGTGGAG TTTGACGAAC ACACAAAGGG TCTGGATGGC 
CGGAACGTCA AGACCCTAGT CACCTGGGAA GGAAACACCC TGGTGTGCGT GCAGAAAGGG 
GAGAAGGAGA ATCGTGGCTG GAAGCAGTGG GTCGAGGGAG ACAAGCTGTA CCTGGAGCTG 
ACCTGCGGTG ACCAGGTGTG TCGACAAGTG TTCAAAAAGA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pregnancy and maternal iron deficiency stimulate hepatic CRBPII expression in rats.
The Journal of nutritional biochemistry3255-63(2016 06)
Cottin SC,Gambling L,Hayes HE,Stevens VJ,McArdle HJ

Massive bowel resection upregulates the intestinal mRNA expression levels of cellular retinol-binding protein II and apolipoprotein A-IV and alters the intestinal vitamin A status in rats.
International journal of molecular medicine35(3)724-30(2015 Mar)
Hebiguchi T,Mezaki Y,Morii M,Watanabe R,Yoshikawa K,Miura M,Imai K,Senoo H,Yoshino H

Mechanisms involved in the intestinal absorption of dietary vitamin A and provitamin A carotenoids.
Biochimica et biophysica acta1821(1)70-7(2012 Jan)
Harrison EH

New insights on the protein-ligand interaction differences between the two primary cellular retinol carriers.
Journal of lipid research51(6)1332-43(2010 Jun)
Franzoni L,Cavazzini D,Rossi GL,L?cke C

Induction of histone acetylation on the CRBPII gene in perinatal rat small intestine.
Biochimica et biophysica acta1770(9)1289-96(2007 Sep)
Ogura Y,Mochizuki K,Goda T

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Rbp2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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