RAP2B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAP2B
Entrez Gene ID	5912
Full Name	RAP2B, member of RAS oncogene family
General protein information	Preferred Names RAP2B, member of RAS oncogene family Names ras-related protein Rap-2b small GTP binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q25.2
Summary	This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated. [provided by RefSeq, Jul 2008].
Disorder MIM:	179541

mRNA and Protein(s)

mRNA	Protein	Name
NM_002886.3	NP_002877.2	ras-related protein Rap-2b
NM_002886.4	NP_002877.2	ras-related protein Rap-2b

Pathways from BioSystems

Homologies

Homo sapiens (human)	RAP2B	NP_002877.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004769	XP_318045.3
Bos taurus (cattle)	RAP2B	NP_001096001.1
Rattus norvegicus (Norway rat)	Rap2b	NP_596901.1
Drosophila melanogaster (fruit fly)	Rap2l	NP_477402.1
	RAP2B	XP_002803010.1
Mus musculus (house mouse)	Rap2b	NP_082988.1
Xenopus tropicalis (tropical clawed frog)	rap2b	NP_001030287.1
Pan troglodytes (chimpanzee)	RAP2B	XP_003310103.1
Danio rerio (zebrafish)	rap2b	NP_001001729.1

Gene Ontology
Bibliography

Related articles in PubMed

Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway.
Li Y, Li S, Huang L
Oncology research26(1)123-130(2018 Jan)

Rap2B promotes angiogenesis via PI3K/AKT/VEGF signaling pathway in human renal cell carcinoma.
Di J, Gao K, Qu D, Yang J, Zheng J
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317701653(2017 Jul)

Long Non-Coding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b.
Lv GY, Miao J, Zhang XL
Oncology research(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these results revealed that Rap2B promotes renal cell carcinoma angiogenesis via phosphoinositide 3-kinase/AKT/vascular endothelial growth factor signaling pathway, which suggests that Rap2B is a novel therapeutic target for renal cell carcinoma anti-angiogenesis therapy.
Title: Rap2B promotes angiogenesis via PI3K/AKT/VEGF signaling pathway in human renal cell carcinoma.

knockdown of Rap2B inhibits the proliferation and invasion in HCC cells. These findings reveal that Rap2B plays an important role in the regulation of HCC progression.
Title: Knockdown of Rap2B Inhibits the Proliferation and Invasion in Hepatocellular Carcinoma Cells.

our results suggested that Rap2b may be a potential therapeutic target for lung cancer.
Title: Rap2b promotes proliferation, migration, and invasion of lung cancer cells.

Western blot analysis uncovered that elevated Rap2B leads to increased phosphorylation levels of FAK, suggesting that FAK-dependent pathway might be responsible for the effect of Rap2B on PCa cells migration and invasion.
Title: Rap2B promotes cell proliferation, migration and invasion in prostate cancer.

miR-194 is inversely correlated with RAP2B.
Title: MiR-194 inhibits cell proliferation and invasion via repression of RAP2B in bladder cancer.

The following RAP2B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAP2B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20766	NM_002886.4 Latest version!	Homo sapiens RAP2B, member of RAS oncogene family (RAP2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu20766	NM_002886.3	Homo sapiens RAP2B, member of RAS oncogene family (RAP2B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAP2B ( NM_002886.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002877.2 Homo sapiens RAP2B, member of RAS oncogene family (RAP2B), mRNA.

Price & Availability↑

CloneID	OHu20766
Clone ID Related Accession (Same CDS sequence)	NM_002886.3 , NM_002886.4
Accession Version	NM_002886.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BX355341.2, BI551390.1, BU507815.1, BC012362.1, BQ378964.1, HY071303.1, BU860799.1, AW997098.1, CB116910.1, BX116683.1, AI718675.1 and AC117394.10. On Jul 10, 2013 this sequence version replaced NM_002886.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGAGAGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGCG TGGGCAAGTC CGCGCTCACC 
GTGCAGTTCG TGACGGGCTC CTTCATCGAG AAGTACGACC CGACCATCGA AGACTTTTAC 
CGCAAGGAGA TTGAGGTGGA CTCGTCGCCG TCGGTGCTGG AGATCCTGGA TACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTG 
GTCTACAGCC TCGTCAACCA GCAGAGCTTC CAGGACATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTACGA GCGCGTGCCC ATGATCCTGG TGGGCAACAA GGTGGACCTG 
GAGGGTGAGC GCGAGGTCTC GTACGGGGAG GGCAAGGCCC TGGCTGAGGA GTGGAGCTGC 
CCCTTCATGG AGACGTCGGC CAAAAACAAA GCCTCGGTAG ACGAGCTATT TGCCGAGATC 
GTGCGGCAGA TGAACTACGC GGCGCAGCCC AACGGCGATG AGGGCTGCTG CTCGGCCTGC 
GTGATCCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002877.2
CDS	483..1034
Translation	MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSACVIL

Target ORF information:

RefSeq Version	NM_002886.3
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2B, member of RAS oncogene family (RAP2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002886.3

ORF Insert Sequence:

ATGAGAGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGCG TGGGCAAGTC CGCGCTCACC 
GTGCAGTTCG TGACGGGCTC CTTCATCGAG AAGTACGACC CGACCATCGA AGACTTTTAC 
CGCAAGGAGA TTGAGGTGGA CTCGTCGCCG TCGGTGCTGG AGATCCTGGA TACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTG 
GTCTACAGCC TCGTCAACCA GCAGAGCTTC CAGGACATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTACGA GCGCGTGCCC ATGATCCTGG TGGGCAACAA GGTGGACCTG 
GAGGGTGAGC GCGAGGTCTC GTACGGGGAG GGCAAGGCCC TGGCTGAGGA GTGGAGCTGC 
CCCTTCATGG AGACGTCGGC CAAAAACAAA GCCTCGGTAG ACGAGCTATT TGCCGAGATC 
GTGCGGCAGA TGAACTACGC GGCGCAGCCC AACGGCGATG AGGGCTGCTG CTCGGCCTGC 
GTGATCCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAP2B ( NM_002886.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002877.2 Homo sapiens RAP2B, member of RAS oncogene family (RAP2B), mRNA.

Price & Availability↑

CloneID	OHu20766
Clone ID Related Accession (Same CDS sequence)	NM_002886.3 , NM_002886.4
Accession Version	NM_002886.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI551390.1, BU507815.1, BC012362.1, BQ378964.1, HY071303.1, BU860799.1, AW997098.1, CB116910.1, BX116683.1, AI718675.1 and AC117394.10. On May 17, 2019 this sequence version replaced NM_002886.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR6380200.139075.9, AL713766.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000323534.5/ ENSP00000319096.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGAGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGCG TGGGCAAGTC CGCGCTCACC 
GTGCAGTTCG TGACGGGCTC CTTCATCGAG AAGTACGACC CGACCATCGA AGACTTTTAC 
CGCAAGGAGA TTGAGGTGGA CTCGTCGCCG TCGGTGCTGG AGATCCTGGA TACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTG 
GTCTACAGCC TCGTCAACCA GCAGAGCTTC CAGGACATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTACGA GCGCGTGCCC ATGATCCTGG TGGGCAACAA GGTGGACCTG 
GAGGGTGAGC GCGAGGTCTC GTACGGGGAG GGCAAGGCCC TGGCTGAGGA GTGGAGCTGC 
CCCTTCATGG AGACGTCGGC CAAAAACAAA GCCTCGGTAG ACGAGCTATT TGCCGAGATC 
GTGCGGCAGA TGAACTACGC GGCGCAGCCC AACGGCGATG AGGGCTGCTG CTCGGCCTGC 
GTGATCCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002877.2
CDS	469..1020
Translation	MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSACVIL

Target ORF information:

RefSeq Version	NM_002886.4
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2B, member of RAS oncogene family (RAP2B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002886.4

ORF Insert Sequence:

ATGAGAGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGCG TGGGCAAGTC CGCGCTCACC 
GTGCAGTTCG TGACGGGCTC CTTCATCGAG AAGTACGACC CGACCATCGA AGACTTTTAC 
CGCAAGGAGA TTGAGGTGGA CTCGTCGCCG TCGGTGCTGG AGATCCTGGA TACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTG 
GTCTACAGCC TCGTCAACCA GCAGAGCTTC CAGGACATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTACGA GCGCGTGCCC ATGATCCTGG TGGGCAACAA GGTGGACCTG 
GAGGGTGAGC GCGAGGTCTC GTACGGGGAG GGCAAGGCCC TGGCTGAGGA GTGGAGCTGC 
CCCTTCATGG AGACGTCGGC CAAAAACAAA GCCTCGGTAG ACGAGCTATT TGCCGAGATC 
GTGCGGCAGA TGAACTACGC GGCGCAGCCC AACGGCGATG AGGGCTGCTG CTCGGCCTGC 
GTGATCCTCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Knockdown of Rap2B, a Ras Superfamily Protein, Inhibits Proliferation, Migration, and Invasion in Cervical Cancer Cells via Regulating the ERK1/2 Signaling Pathway.
Oncology research26(1)123-130(2018 Jan)
Li Y,Li S,Huang L

Rap2B promotes angiogenesis via PI3K/AKT/VEGF signaling pathway in human renal cell carcinoma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine39(7)1010428317701653(2017 Jul)
Di J,Gao K,Qu D,Yang J,Zheng J

Long Non-Coding RNA XIST Promotes Osteosarcoma Progression by Targeting Ras-Related Protein RAP2B via miR-320b.
Oncology research(2017 Apr)
Lv GY,Miao J,Zhang XL

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RAP2B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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