RAP2A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RAP2A
Entrez Gene ID	5911
Full Name	RAP2A, member of RAS oncogene family
Synonyms	K-REV,KREV,RAP2,RbBP-30
General protein information	Preferred Names RAP2A, member of RAS oncogene family Names ras-related protein Rap-2a RAP2, member of RAS oncogene family (K-rev)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q32.1
Disorder MIM:	179540

mRNA and Protein(s)

mRNA	Protein	Name
NM_021033.7	NP_066361.1	ras-related protein Rap-2a
NM_021033.6	NP_066361.1	ras-related protein Rap-2a precursor

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	rap2a	NP_001030288.1
Canis lupus familiaris (dog)	RAP2A	XP_005634148.1
Mus musculus (house mouse)	Rap2a	NP_083795.2
Homo sapiens (human)	RAP2A	NP_066361.1
Pan troglodytes (chimpanzee)	RAP2A	XP_509705.2
	RAP2A	XP_001088706.1
Gallus gallus (chicken)	RAP2A	XP_001233104.2
Bos taurus (cattle)	RAP2A	NP_001179871.1
Danio rerio (zebrafish)	rap2ab	NP_001139177.1
Caenorhabditis elegans (roundworm)	rap-2	NP_506707.2

Gene Ontology
Bibliography

Related articles in PubMed

Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by
Zhang MY, Zhang Y, Wu XD, Zhang K, Lin P, Bian HJ, Qin MM, Huang W, Wei D, Zhang Z, Wu J, Chen R, Feng F, Wang B, Nan G, Zhu P, Chen ZN
Blood(2018 Jan)

Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Wu JX, Du WQ, Wang XC, Wei LL, Huo FC, Pan YJ, Wu XJ, Pei DS
Scientific reports7(1)6623(2017 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nedd4-1 inhibited Rap2a activity, and promoted the migration and invasion of glioma cells.
Title: Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1.

The small GTPase Ras-related protein 2 (Rap2) was found to bind ArrB1 under resting conditions but dissociated upon formyl-Met-Leu-Phe stimulation.
Title: ?-Arrestin 1-dependent regulation of Rap2 is required for fMLP-stimulated chemotaxis in neutrophil-like HL-60 cells.

The ectopic expression of Rap2a enhances the migration and invasive ability of cancer cells and increases activities of matrix metalloproteinase MMP2 and MMP9.
Title: Rap2a is a novel target gene of p53 and regulates cancer cell migration and invasion.

Single nucleotide polymorphism in RAP2A gene is associated with Peripheral Arterial Disease.
Title: Genome-Wide Association Study of Peripheral Arterial Disease in a Japanese Population.

present review mainly focused on recent studies on the functional and physical interactions between Rap2 and its effectors. We also speculated on the relevance of these pathways to tumorigenesis
Title: Role of Rap2 and its Downstream Effectors in Tumorigenesis.

The following RAP2A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RAP2A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30751	NM_021033.7 Latest version!	Homo sapiens RAP2A, member of RAS oncogene family (RAP2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu30751	NM_021033.6	Homo sapiens RAP2A, member of RAS oncogene family (RAP2A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RAP2A ( NM_021033.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_066361.1 Homo sapiens RAP2A, member of RAS oncogene family (RAP2A), mRNA.

Price & Availability↑

CloneID	OHu30751
Clone ID Related Accession (Same CDS sequence)	NM_021033.7 , NM_021033.6
Accession Version	NM_021033.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2a
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL442067.16, DB480985.1, BC041333.2, DA493957.1, BC022356.1, BC047495.1 and CB215818.1. On Nov 22, 2018 this sequence version replaced NM_021033.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041333.2, SRR1803614.209087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000245304.5/ ENSP00000245304.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCGCGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGGG TAGGCAAATC CGCCCTGACC 
GTGCAGTTCG TGACCGGCAC CTTCATCGAG AAATACGACC CCACCATCGA GGACTTCTAC 
CGCAAGGAGA TCGAGGTGGA TTCGTCGCCG TCGGTGCTGG AGATCCTGGA CACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTC 
GTCTACAGCC TCGTCAACCA GCAGAGCTTC CAGGACATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTATGA GAAAGTGCCA GTCATCTTGG TTGGGAACAA AGTGGACCTG 
GAAAGTGAGA GAGAAGTATC GTCCAGCGAA GGCAGAGCCC TTGCTGAAGA GTGGGGCTGC 
CCCTTTATGG AAACTTCCGC TAAGAGTAAA ACAATGGTGG ACGAACTCTT TGCAGAAATT 
GTGAGGCAGA TGAACTATGC TGCTCAGCCT GACAAAGATG ACCCATGCTG TTCTGCATGT 
AACATACAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066361.1
CDS	303..854
Translation	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSACNIQ

Target ORF information:

RefSeq Version	NM_021033.7
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2A, member of RAS oncogene family (RAP2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021033.7

ORF Insert Sequence:

ATGCGCGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGGG TAGGCAAATC CGCCCTGACC 
GTGCAGTTCG TGACCGGCAC CTTCATCGAG AAATACGACC CCACCATCGA GGACTTCTAC 
CGCAAGGAGA TCGAGGTGGA TTCGTCGCCG TCGGTGCTGG AGATCCTGGA CACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTC 
GTCTACAGCC TCGTCAACCA GCAGAGCTTC CAGGACATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTATGA GAAAGTGCCA GTCATCTTGG TTGGGAACAA AGTGGACCTG 
GAAAGTGAGA GAGAAGTATC GTCCAGCGAA GGCAGAGCCC TTGCTGAAGA GTGGGGCTGC 
CCCTTTATGG AAACTTCCGC TAAGAGTAAA ACAATGGTGG ACGAACTCTT TGCAGAAATT 
GTGAGGCAGA TGAACTATGC TGCTCAGCCT GACAAAGATG ACCCATGCTG TTCTGCATGT 
AACATACAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RAP2A ( NM_021033.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_066361.1 Homo sapiens RAP2A, member of RAS oncogene family (RAP2A), mRNA.

Price & Availability↑

CloneID	OHu30751
Clone ID Related Accession (Same CDS sequence)	NM_021033.7 , NM_021033.6
Accession Version	NM_021033.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 552bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-14
Organism	Homo sapiens(human)
Product	ras-related protein Rap-2a precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB480985.1, BC041333.2, DA493957.1, BC022356.1, BC047495.1 and CB215818.1. On Aug 23, 2008 this sequence version replaced NM_021033.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041333.2, SRR1803614.209087.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGCGCGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGGG TAGGCAAATC CGCCCTGACC 
GTGCAGTTCG TGACCGGCAC CTTCATCGAG AAATACGACC CCACCATCGA GGACTTCTAC 
CGCAAGGAGA TCGAGGTGGA TTCGTCGCCG TCGGTGCTGG AGATCCTGGA CACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTC 
GTCTACAGCC TCGTCAACCA GCAGAGCTTC CAGGACATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTATGA GAAAGTGCCA GTCATCTTGG TTGGGAACAA AGTGGACCTG 
GAAAGTGAGA GAGAAGTATC GTCCAGCGAA GGCAGAGCCC TTGCTGAAGA GTGGGGCTGC 
CCCTTTATGG AAACTTCCGC TAAGAGTAAA ACAATGGTGG ACGAACTCTT TGCAGAAATT 
GTGAGGCAGA TGAACTATGC TGCTCAGCCT GACAAAGATG ACCCATGCTG TTCTGCATGT 
AACATACAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066361.1
CDS	251..802
Translation	MREYKVVVLGSGGVGKSALTVQFVTGTFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYEKVPVILVGNKVDLESEREVSSSEGRALAEEWGCPFMETSAKSKTMVDELFAEIVRQMNYAAQPDKDDPCCSACNIQ

Target ORF information:

RefSeq Version	NM_021033.6
Organism	Homo sapiens(human)
Definition	Homo sapiens RAP2A, member of RAS oncogene family (RAP2A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021033.6

ORF Insert Sequence:

ATGCGCGAGT ACAAAGTGGT GGTGCTGGGC TCGGGCGGGG TAGGCAAATC CGCCCTGACC 
GTGCAGTTCG TGACCGGCAC CTTCATCGAG AAATACGACC CCACCATCGA GGACTTCTAC 
CGCAAGGAGA TCGAGGTGGA TTCGTCGCCG TCGGTGCTGG AGATCCTGGA CACGGCGGGC 
ACCGAGCAGT TCGCGTCCAT GCGGGACCTG TACATCAAGA ACGGCCAGGG CTTCATCCTC 
GTCTACAGCC TCGTCAACCA GCAGAGCTTC CAGGACATCA AGCCCATGCG GGACCAGATC 
ATCCGCGTGA AGCGGTATGA GAAAGTGCCA GTCATCTTGG TTGGGAACAA AGTGGACCTG 
GAAAGTGAGA GAGAAGTATC GTCCAGCGAA GGCAGAGCCC TTGCTGAAGA GTGGGGCTGC 
CCCTTTATGG AAACTTCCGC TAAGAGTAAA ACAATGGTGG ACGAACTCTT TGCAGAAATT 
GTGAGGCAGA TGAACTATGC TGCTCAGCCT GACAAAGATG ACCCATGCTG TTCTGCATGT 
AACATACAAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by
Blood(2018 Jan)
Zhang MY,Zhang Y,Wu XD,Zhang K,Lin P,Bian HJ,Qin MM,Huang W,Wei D,Zhang Z,Wu J,Chen R,Feng F,Wang B,Nan G,Zhu P,Chen ZN

Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt.
Scientific reports7(1)6623(2017 Jul)
Wu JX,Du WQ,Wang XC,Wei LL,Huo FC,Pan YJ,Wu XJ,Pei DS

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RAP2A cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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