MYOZ1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYOZ1
Entrez Gene ID	58529
Full Name	myozenin 1
Synonyms	CS-2,FATZ,MYOZ
General protein information	Preferred Names myozenin 1 Names myozenin-1 calsarcin-2 filamin-, actinin- and telethonin-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q22.2
Summary	The protein encoded by this gene is primarily expressed in the skeletal muscle, and belongs to the myozenin family. Members of this family function as calcineurin-interacting proteins that help tether calcineurin to the sarcomere of cardiac and skeletal muscle. They play an important role in modulation of calcineurin signaling. [provided by RefSeq, Apr 2012].
Disorder MIM:	605603

mRNA and Protein(s)

mRNA	Protein	Name
NM_021245.3	NP_067068.1	myozenin-1
NM_021245.4	NP_067068.1	myozenin-1

Pathways from BioSystems

Homologies

Xenopus tropicalis (tropical clawed frog)	myoz1	NP_001006717.1
Pan troglodytes (chimpanzee)	MYOZ1	XP_001143094.1
Mus musculus (house mouse)	Myoz1	NP_067483.1
Homo sapiens (human)	MYOZ1	NP_067068.1
	MYOZ1	XP_001100978.1
Bos taurus (cattle)	MYOZ1	NP_776822.1
Rattus norvegicus (Norway rat)	Myoz1	NP_001102567.1
Gallus gallus (chicken)	MYOZ1	XP_421619.3
Danio rerio (zebrafish)	myoz1b	NP_001002447.1
Canis lupus familiaris (dog)	MYOZ1	NP_001041560.1
Danio rerio (zebrafish)	myoz1a	NP_991241.1

Gene Ontology
Bibliography

Related articles in PubMed

Gene expression and genetic variation in human atria.
Lin H, Dolmatova EV, Morley MP, Lunetta KL, McManus DD, Magnani JW, Margulies KB, Hakonarson H, del Monte F, Benjamin EJ, Cappola TP, Ellinor PT
Heart rhythm11(2)266-71(2014 Feb)

Candidate-gene testing for orphan limb-girdle muscular dystrophies.
Aurino S, Piluso G, Saccone V, Cacciottolo M, D'Amico F, Dionisi M, Totaro A, Belsito A, Di Vicino U, Nigro V
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology2790-7(2008 Dec)

Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation.
Frey N, Frank D, Lippl S, Kuhn C, K?gler H, Barrientos T, Rohr C, Will R, M?ller OJ, Weiler H, Bassel-Duby R, Katus HA, Olson EN
The Journal of clinical investigation118(11)3598-608(2008 Nov)

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.
Witt CC, Witt SH, Lerche S, Labeit D, Back W, Labeit S
The EMBO journal27(2)350-60(2008 Jan)

Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy.
Posch MG, Perrot A, Dietz R, Ozcelik C, Pankuweit S, Ruppert V, Richter A, Maisch B
Molecular genetics and metabolism91(2)207-8(2007 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our results implicate MYOZ1 as the causative gene at the chromosome 10q22 locus for AF.
Title: Gene expression and genetic variation in human atria.

Observational study of gene-disease association. (HuGE Navigator)
Title: Candidate-gene testing for orphan limb-girdle muscular dystrophies.

Mutations in MYOZ1 and MYOZ2 are at least very rare events as an underlying disease mechanism for idiopathic or familial DCM
Title: Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy.

Mutations in PDLIM3 and MYOZ1, encoding myocyte Z line proteins, do not play any significant role in the genetic etiology of idiopathic DCM.
Title: Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy.

Our findings provide evidence for a novel connection between the Z-disc protein calsarcin-2 and the sarcolemma via filamins and beta1 integrins.
Title: The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.

The following MYOZ1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYOZ1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19834	NM_021245.4 Latest version!	Homo sapiens myozenin 1 (MYOZ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu19834	NM_021245.3	Homo sapiens myozenin 1 (MYOZ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYOZ1 ( NM_021245.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_067068.1 Homo sapiens myozenin 1 (MYOZ1), mRNA.

Price & Availability↑

CloneID	OHu19834
Clone ID Related Accession (Same CDS sequence)	NM_021245.3 , NM_021245.4
Accession Version	NM_021245.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	myozenin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025753.1 and AA176752.1. This sequence is a reference standard in the RefSeqGene project. On Apr 17, 2012 this sequence version replaced NM_021245.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC025753.1, AJ278124.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGCTCT CAGGAACCCC GGCCCCTAAT AAGAAGAGGA AATCCAGCAA GCTGATCATG 
GAACTCACTG GAGGTGGACA GGAGAGCTCA GGCTTGAACC TGGGCAAAAA GATCAGTGTC 
CCAAGGGATG TGATGTTGGA GGAACTGTCG CTGCTTACCA ACCGGGGCTC CAAGATGTTC 
AAACTGCGGC AGATGAGGGT GGAGAAGTTT ATTTATGAGA ACCACCCTGA TGTTTTCTCT 
GACAGCTCAA TGGATCACTT CCAGAAGTTC CTTCCAACAG TGGGGGGACA GCTGGGCACA 
GCTGGTCAGG GATTCTCATA CAGCAAGAGC AACGGCAGAG GCGGCAGCCA GGCAGGGGGC 
AGTGGCTCTG CCGGACAGTA TGGCTCTGAT CAGCAGCACC ATCTGGGCTC TGGGTCTGGA 
GCTGGGGGTA CAGGTGGTCC CGCGGGCCAG GCTGGCAGAG GAGGAGCTGC TGGCACAGCA 
GGGGTTGGTG AGACAGGATC AGGAGACCAG GCAGGCGGAG AAGGAAAACA TATCACTGTG 
TTCAAGACCT ATATTTCCCC ATGGGAGCGA GCCATGGGGG TTGACCCCCA GCAAAAAATG 
GAACTTGGCA TTGACCTGCT GGCCTATGGG GCCAAAGCTG AACTTCCCAA ATATAAGTCC 
TTCAACAGGA CGGCAATGCC CTATGGTGGA TATGAGAAGG CCTCCAAACG CATGACCTTC 
CAGATGCCCA AGTTTGACCT GGGGCCCTTG CTGAGTGAAC CCCTGGTCCT CTACAACCAA 
AACCTCTCCA ACAGGCCTTC TTTCAATCGA ACCCCTATTC CCTGGCTGAG CTCTGGGGAG 
CCTGTAGACT ACAACGTGGA TATTGGCATC CCCTTGGATG GAGAAACAGA GGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067068.1
CDS	366..1265
Translation	MPLSGTPAPNKKRKSSKLIMELTGGGQESSGLNLGKKISVPRDVMLEELSLLTNRGSKMFKLRQMRVEKFIYENHPDVFSDSSMDHFQKFLPTVGGQLGTAGQGFSYSKSNGRGGSQAGGSGSAGQYGSDQQHHLGSGSGAGGTGGPAGQAGRGGAAGTAGVGETGSGDQAGGEGKHITVFKTYISPWERAMGVDPQQKMELGIDLLAYGAKAELPKYKSFNRTAMPYGGYEKASKRMTFQMPKFDLGPLLSEPLVLYNQNLSNRPSFNRTPIPWLSSGEPVDYNVDIGIPLDGETEEL

Target ORF information:

RefSeq Version	NM_021245.3
Organism	Homo sapiens(human)
Definition	Homo sapiens myozenin 1 (MYOZ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021245.3

ORF Insert Sequence:

ATGCCGCTCT CAGGAACCCC GGCCCCTAAT AAGAAGAGGA AATCCAGCAA GCTGATCATG 
GAACTCACTG GAGGTGGACA GGAGAGCTCA GGCTTGAACC TGGGCAAAAA GATCAGTGTC 
CCAAGGGATG TGATGTTGGA GGAACTGTCG CTGCTTACCA ACCGGGGCTC CAAGATGTTC 
AAACTGCGGC AGATGAGGGT GGAGAAGTTT ATTTATGAGA ACCACCCTGA TGTTTTCTCT 
GACAGCTCAA TGGATCACTT CCAGAAGTTC CTTCCAACAG TGGGGGGACA GCTGGGCACA 
GCTGGTCAGG GATTCTCATA CAGCAAGAGC AACGGCAGAG GCGGCAGCCA GGCAGGGGGC 
AGTGGCTCTG CCGGACAGTA TGGCTCTGAT CAGCAGCACC ATCTGGGCTC TGGGTCTGGA 
GCTGGGGGTA CAGGTGGTCC CGCGGGCCAG GCTGGCAGAG GAGGAGCTGC TGGCACAGCA 
GGGGTTGGTG AGACAGGATC AGGAGACCAG GCAGGCGGAG AAGGAAAACA TATCACTGTG 
TTCAAGACCT ATATTTCCCC ATGGGAGCGA GCCATGGGGG TTGACCCCCA GCAAAAAATG 
GAACTTGGCA TTGACCTGCT GGCCTATGGG GCCAAAGCTG AACTTCCCAA ATATAAGTCC 
TTCAACAGGA CGGCAATGCC CTATGGTGGA TATGAGAAGG CCTCCAAACG CATGACCTTC 
CAGATGCCCA AGTTTGACCT GGGGCCCTTG CTGAGTGAAC CCCTGGTCCT CTACAACCAA 
AACCTCTCCA ACAGGCCTTC TTTCAATCGA ACCCCTATTC CCTGGCTGAG CTCTGGGGAG 
CCTGTAGACT ACAACGTGGA TATTGGCATC CCCTTGGATG GAGAAACAGA GGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MYOZ1 ( NM_021245.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_067068.1 Homo sapiens myozenin 1 (MYOZ1), mRNA.

Price & Availability↑

CloneID	OHu19834
Clone ID Related Accession (Same CDS sequence)	NM_021245.3 , NM_021245.4
Accession Version	NM_021245.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	myozenin-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC025753.1 and AA176752.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_021245.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.66730.1, SRR5189667.212838.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000359322.5/ ENSP00000352272.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCCGCTCT CAGGAACCCC GGCCCCTAAT AAGAAGAGGA AATCCAGCAA GCTGATCATG 
GAACTCACTG GAGGTGGACA GGAGAGCTCA GGCTTGAACC TGGGCAAAAA GATCAGTGTC 
CCAAGGGATG TGATGTTGGA GGAACTGTCG CTGCTTACCA ACCGGGGCTC CAAGATGTTC 
AAACTGCGGC AGATGAGGGT GGAGAAGTTT ATTTATGAGA ACCACCCTGA TGTTTTCTCT 
GACAGCTCAA TGGATCACTT CCAGAAGTTC CTTCCAACAG TGGGGGGACA GCTGGGCACA 
GCTGGTCAGG GATTCTCATA CAGCAAGAGC AACGGCAGAG GCGGCAGCCA GGCAGGGGGC 
AGTGGCTCTG CCGGACAGTA TGGCTCTGAT CAGCAGCACC ATCTGGGCTC TGGGTCTGGA 
GCTGGGGGTA CAGGTGGTCC CGCGGGCCAG GCTGGCAGAG GAGGAGCTGC TGGCACAGCA 
GGGGTTGGTG AGACAGGATC AGGAGACCAG GCAGGCGGAG AAGGAAAACA TATCACTGTG 
TTCAAGACCT ATATTTCCCC ATGGGAGCGA GCCATGGGGG TTGACCCCCA GCAAAAAATG 
GAACTTGGCA TTGACCTGCT GGCCTATGGG GCCAAAGCTG AACTTCCCAA ATATAAGTCC 
TTCAACAGGA CGGCAATGCC CTATGGTGGA TATGAGAAGG CCTCCAAACG CATGACCTTC 
CAGATGCCCA AGTTTGACCT GGGGCCCTTG CTGAGTGAAC CCCTGGTCCT CTACAACCAA 
AACCTCTCCA ACAGGCCTTC TTTCAATCGA ACCCCTATTC CCTGGCTGAG CTCTGGGGAG 
CCTGTAGACT ACAACGTGGA TATTGGCATC CCCTTGGATG GAGAAACAGA GGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_067068.1
CDS	83..982
Translation	MPLSGTPAPNKKRKSSKLIMELTGGGQESSGLNLGKKISVPRDVMLEELSLLTNRGSKMFKLRQMRVEKFIYENHPDVFSDSSMDHFQKFLPTVGGQLGTAGQGFSYSKSNGRGGSQAGGSGSAGQYGSDQQHHLGSGSGAGGTGGPAGQAGRGGAAGTAGVGETGSGDQAGGEGKHITVFKTYISPWERAMGVDPQQKMELGIDLLAYGAKAELPKYKSFNRTAMPYGGYEKASKRMTFQMPKFDLGPLLSEPLVLYNQNLSNRPSFNRTPIPWLSSGEPVDYNVDIGIPLDGETEEL

Target ORF information:

RefSeq Version	NM_021245.4
Organism	Homo sapiens(human)
Definition	Homo sapiens myozenin 1 (MYOZ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021245.4

ORF Insert Sequence:

ATGCCGCTCT CAGGAACCCC GGCCCCTAAT AAGAAGAGGA AATCCAGCAA GCTGATCATG 
GAACTCACTG GAGGTGGACA GGAGAGCTCA GGCTTGAACC TGGGCAAAAA GATCAGTGTC 
CCAAGGGATG TGATGTTGGA GGAACTGTCG CTGCTTACCA ACCGGGGCTC CAAGATGTTC 
AAACTGCGGC AGATGAGGGT GGAGAAGTTT ATTTATGAGA ACCACCCTGA TGTTTTCTCT 
GACAGCTCAA TGGATCACTT CCAGAAGTTC CTTCCAACAG TGGGGGGACA GCTGGGCACA 
GCTGGTCAGG GATTCTCATA CAGCAAGAGC AACGGCAGAG GCGGCAGCCA GGCAGGGGGC 
AGTGGCTCTG CCGGACAGTA TGGCTCTGAT CAGCAGCACC ATCTGGGCTC TGGGTCTGGA 
GCTGGGGGTA CAGGTGGTCC CGCGGGCCAG GCTGGCAGAG GAGGAGCTGC TGGCACAGCA 
GGGGTTGGTG AGACAGGATC AGGAGACCAG GCAGGCGGAG AAGGAAAACA TATCACTGTG 
TTCAAGACCT ATATTTCCCC ATGGGAGCGA GCCATGGGGG TTGACCCCCA GCAAAAAATG 
GAACTTGGCA TTGACCTGCT GGCCTATGGG GCCAAAGCTG AACTTCCCAA ATATAAGTCC 
TTCAACAGGA CGGCAATGCC CTATGGTGGA TATGAGAAGG CCTCCAAACG CATGACCTTC 
CAGATGCCCA AGTTTGACCT GGGGCCCTTG CTGAGTGAAC CCCTGGTCCT CTACAACCAA 
AACCTCTCCA ACAGGCCTTC TTTCAATCGA ACCCCTATTC CCTGGCTGAG CTCTGGGGAG 
CCTGTAGACT ACAACGTGGA TATTGGCATC CCCTTGGATG GAGAAACAGA GGAGCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gene expression and genetic variation in human atria.
Heart rhythm11(2)266-71(2014 Feb)
Lin H,Dolmatova EV,Morley MP,Lunetta KL,McManus DD,Magnani JW,Margulies KB,Hakonarson H,del Monte F,Benjamin EJ,Cappola TP,Ellinor PT

Candidate-gene testing for orphan limb-girdle muscular dystrophies.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology2790-7(2008 Dec)
Aurino S,Piluso G,Saccone V,Cacciottolo M,D'Amico F,Dionisi M,Totaro A,Belsito A,Di Vicino U,Nigro V

Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation.
The Journal of clinical investigation118(11)3598-608(2008 Nov)
Frey N,Frank D,Lippl S,Kuhn C,K?gler H,Barrientos T,Rohr C,Will R,M?ller OJ,Weiler H,Bassel-Duby R,Katus HA,Olson EN

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.
The EMBO journal27(2)350-60(2008 Jan)
Witt CC,Witt SH,Lerche S,Labeit D,Back W,Labeit S

Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy.
Molecular genetics and metabolism91(2)207-8(2007 Jun)
Posch MG,Perrot A,Dietz R,Ozcelik C,Pankuweit S,Ruppert V,Richter A,Maisch B

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MYOZ1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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