PTK6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PTK6
Entrez Gene ID	5753
Full Name	protein tyrosine kinase 6
Synonyms	BRK
General protein information	Preferred Names protein tyrosine kinase 6 Names protein-tyrosine kinase 6 PTK6 protein tyrosine kinase 6 breast tumor kinase protein-tyrosine kinase BRK tyrosine-protein kinase BRK
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q13.33
Summary	The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].
Disorder MIM:	602004

mRNA and Protein(s)

mRNA	Protein	Name
NM_001256358.1	NP_001243287.1	protein-tyrosine kinase 6 isoform 2
NM_005975.4	NP_005966.1	protein-tyrosine kinase 6 isoform 1
NM_005975.3	NP_005966.1	protein-tyrosine kinase 6 isoform 1
XM_017027982.1	XP_016883471.1	protein-tyrosine kinase 6 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PTK6	XP_514781.3
Mus musculus (house mouse)	Ptk6	NP_033210.1
Bos taurus (cattle)	PTK6	NP_001179611.1
Danio rerio (zebrafish)	ptk6b	NP_001070140.1
Danio rerio (zebrafish)	ptk6a	XP_682778.4
Xenopus tropicalis (tropical clawed frog)	ptk6	XP_002942429.2
Homo sapiens (human)	PTK6	NP_005966.1
Rattus norvegicus (Norway rat)	Ptk6	NP_001102438.1

Gene Ontology
Bibliography

Related articles in PubMed

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.
Wozniak DJ, Kajdacsy-Balla A, Macias V, Ball-Kell S, Zenner ML, Bie W, Tyner AL
Nature communications8(1)1508(2017 Nov)

PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.
Shin WS, Shim HJ, Lee YH, Pyo M, Park JS, Ahn SY, Lee ST
Journal of cellular biochemistry118(9)2887-2895(2017 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results indicate that plasma-membrane-associated PTK6 phosphorylates Eps8, which promotes cell proliferation, adhesion, and migration
Title: PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.

analysis of recombinant PTK6 kinase domain by x-ray crystallography reveals details of its binding to inhibitors
Title: Co-crystal structures of PTK6: With Dasatinib at 2.24??, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70?? resolution.

The crystal structure of the kinase domain of human PTK6 has been reported.
Title: Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33?? resolution.

PTK6 mRNA and protein levels were elevated in cervical squamous cell cancer and the elevated cytoplasmic expression of PTK6 was associated with tumor grade and short patient survival.
Title: The expression and prognostic value of protein tyrosine kinase 6 in early-stage cervical squamous cell cancer.

Expression of PTK6 in established tumors may maintain the epithelial phenotype, preventing tumor progression.
Title: Kinase-Dependent and -Independent Roles for PTK6 in Colon Cancer.

The following PTK6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PTK6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu00254	NM_005975.4 Latest version!	Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu11801	NM_001256358.1 Latest version!	Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu93092	XM_017027982.1 Latest version!	Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu00254	NM_005975.3	Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PTK6 ( NM_005975.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005966.1 Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00254
Clone ID Related Accession (Same CDS sequence)	NM_005975.4 , NM_005975.3
Accession Version	NM_005975.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1356bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	protein-tyrosine kinase 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL121829.30, DA762278.1, BC035843.1 and X78549.1. On Nov 23, 2018 this sequence version replaced NM_005975.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X78549.1, BC035843.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000542869.3/ ENSP00000442460.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 
TCCCGGACGG ACGAGGAGCT GAGCTTCCGC GCGGGGGACG TCTTCCACGT GGCCAGGAAG 
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 
TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC GTGGTTCTTT 
GGCTGCATCT CCCGCTCGGA AGCTGTGCGT CGGCTGCAGG CCGAGGGCAA CGCCACGGGC 
GCCTTCCTGA TCAGGGTCAG CGAGAAGCCG AGTGCCGACT ACGTCCTGTC GGTGCGGGAC 
ACGCAGGCTG TGCGGCACTA CAAGATCTGG CGGCGTGCCG GGGGCCGGCT GCACCTGAAC 
GAGGCGGTGT CCTTCCTCAG CCTGCCCGAG CTTGTGAACT ACCACAGGGC CCAGAGCCTG 
TCCCACGGCC TGCGGCTGGC CGCGCCCTGC CGGAAGCACG AGCCTGAGCC CCTGCCCCAT 
TGGGATGACT GGGAGAGGCC GAGGGAGGAG TTCACGCTCT GCAGGAAGCT GGGGTCCGGC 
TACTTTGGGG AGGTCTTCGA GGGGCTCTGG AAAGACCGGG TCCAGGTGGC CATTAAGGTG 
ATTTCTCGAG ACAACCTCCT GCACCAGCAG ATGCTGCAGT CGGAGATCCA GGCCATGAAG 
AAGCTGCGGC ACAAACACAT CCTGGCGCTG TACGCCGTGG TGTCCGTGGG GGACCCCGTG 
TACATCATCA CGGAGCTCAT GGCCAAGGGC AGCCTGCTGG AGCTGCTCCG CGACTCTGAT 
GAGAAAGTCC TGCCCGTTTC GGAGCTGCTG GACATCGCCT GGCAGGTGGC TGAGGGCATG 
TGTTACCTGG AGTCGCAGAA TTACATCCAC CGGGACCTGG CCGCCAGGAA CATCCTCGTC 
GGGGAAAACA CCCTCTGCAA AGTTGGGGAC TTCGGGTTAG CCAGGCTTAT CAAGGAGGAC 
GTCTACCTCT CCCATGACCA CAATATCCCC TACAAGTGGA CGGCCCCTGA AGCGCTCTCC 
CGAGGCCATT ACTCCACCAA ATCCGACGTC TGGTCCTTTG GGATTCTCCT GCATGAGATG 
TTCAGCAGGG GTCAGGTGCC CTACCCAGGC ATGTCCAACC ATGAGGCCTT CCTGAGGGTG 
GACGCCGGCT ACCGCATGCC CTGCCCTCTG GAGTGCCCGC CCAGCGTGCA CAAGCTGATG 
CTGACATGCT GGTGCAGGGA CCCCGAGCAG AGACCCTGCT TCAAGGCCCT GCGGGAGAGG 
CTCTCCAGCT TCACCAGCTA CGAGAACCCG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005966.1
CDS	63..1418
Translation	MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT

Target ORF information:

RefSeq Version	NM_005975.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005975.4

ORF Insert Sequence:

ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 
TCCCGGACGG ACGAGGAGCT GAGCTTCCGC GCGGGGGACG TCTTCCACGT GGCCAGGAAG 
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 
TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC GTGGTTCTTT 
GGCTGCATCT CCCGCTCGGA AGCTGTGCGT CGGCTGCAGG CCGAGGGCAA CGCCACGGGC 
GCCTTCCTGA TCAGGGTCAG CGAGAAGCCG AGTGCCGACT ACGTCCTGTC GGTGCGGGAC 
ACGCAGGCTG TGCGGCACTA CAAGATCTGG CGGCGTGCCG GGGGCCGGCT GCACCTGAAC 
GAGGCGGTGT CCTTCCTCAG CCTGCCCGAG CTTGTGAACT ACCACAGGGC CCAGAGCCTG 
TCCCACGGCC TGCGGCTGGC CGCGCCCTGC CGGAAGCACG AGCCTGAGCC CCTGCCCCAT 
TGGGATGACT GGGAGAGGCC GAGGGAGGAG TTCACGCTCT GCAGGAAGCT GGGGTCCGGC 
TACTTTGGGG AGGTCTTCGA GGGGCTCTGG AAAGACCGGG TCCAGGTGGC CATTAAGGTG 
ATTTCTCGAG ACAACCTCCT GCACCAGCAG ATGCTGCAGT CGGAGATCCA GGCCATGAAG 
AAGCTGCGGC ACAAACACAT CCTGGCGCTG TACGCCGTGG TGTCCGTGGG GGACCCCGTG 
TACATCATCA CGGAGCTCAT GGCCAAGGGC AGCCTGCTGG AGCTGCTCCG CGACTCTGAT 
GAGAAAGTCC TGCCCGTTTC GGAGCTGCTG GACATCGCCT GGCAGGTGGC TGAGGGCATG 
TGTTACCTGG AGTCGCAGAA TTACATCCAC CGGGACCTGG CCGCCAGGAA CATCCTCGTC 
GGGGAAAACA CCCTCTGCAA AGTTGGGGAC TTCGGGTTAG CCAGGCTTAT CAAGGAGGAC 
GTCTACCTCT CCCATGACCA CAATATCCCC TACAAGTGGA CGGCCCCTGA AGCGCTCTCC 
CGAGGCCATT ACTCCACCAA ATCCGACGTC TGGTCCTTTG GGATTCTCCT GCATGAGATG 
TTCAGCAGGG GTCAGGTGCC CTACCCAGGC ATGTCCAACC ATGAGGCCTT CCTGAGGGTG 
GACGCCGGCT ACCGCATGCC CTGCCCTCTG GAGTGCCCGC CCAGCGTGCA CAAGCTGATG 
CTGACATGCT GGTGCAGGGA CCCCGAGCAG AGACCCTGCT TCAAGGCCCT GCGGGAGAGG 
CTCTCCAGCT TCACCAGCTA CGAGAACCCG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTK6 ( NM_005975.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005966.1 Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu00254
Clone ID Related Accession (Same CDS sequence)	NM_005975.4 , NM_005975.3
Accession Version	NM_005975.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1356bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	protein-tyrosine kinase 6 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA762278.1, BC035843.1, X78549.1 and AL121829.30. On Jan 21, 2012 this sequence version replaced NM_005975.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X78549.1, BC035843.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 
TCCCGGACGG ACGAGGAGCT GAGCTTCCGC GCGGGGGACG TCTTCCACGT GGCCAGGAAG 
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 
TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC GTGGTTCTTT 
GGCTGCATCT CCCGCTCGGA AGCTGTGCGT CGGCTGCAGG CCGAGGGCAA CGCCACGGGC 
GCCTTCCTGA TCAGGGTCAG CGAGAAGCCG AGTGCCGACT ACGTCCTGTC GGTGCGGGAC 
ACGCAGGCTG TGCGGCACTA CAAGATCTGG CGGCGTGCCG GGGGCCGGCT GCACCTGAAC 
GAGGCGGTGT CCTTCCTCAG CCTGCCCGAG CTTGTGAACT ACCACAGGGC CCAGAGCCTG 
TCCCACGGCC TGCGGCTGGC CGCGCCCTGC CGGAAGCACG AGCCTGAGCC CCTGCCCCAT 
TGGGATGACT GGGAGAGGCC GAGGGAGGAG TTCACGCTCT GCAGGAAGCT GGGGTCCGGC 
TACTTTGGGG AGGTCTTCGA GGGGCTCTGG AAAGACCGGG TCCAGGTGGC CATTAAGGTG 
ATTTCTCGAG ACAACCTCCT GCACCAGCAG ATGCTGCAGT CGGAGATCCA GGCCATGAAG 
AAGCTGCGGC ACAAACACAT CCTGGCGCTG TACGCCGTGG TGTCCGTGGG GGACCCCGTG 
TACATCATCA CGGAGCTCAT GGCCAAGGGC AGCCTGCTGG AGCTGCTCCG CGACTCTGAT 
GAGAAAGTCC TGCCCGTTTC GGAGCTGCTG GACATCGCCT GGCAGGTGGC TGAGGGCATG 
TGTTACCTGG AGTCGCAGAA TTACATCCAC CGGGACCTGG CCGCCAGGAA CATCCTCGTC 
GGGGAAAACA CCCTCTGCAA AGTTGGGGAC TTCGGGTTAG CCAGGCTTAT CAAGGAGGAC 
GTCTACCTCT CCCATGACCA CAATATCCCC TACAAGTGGA CGGCCCCTGA AGCGCTCTCC 
CGAGGCCATT ACTCCACCAA ATCCGACGTC TGGTCCTTTG GGATTCTCCT GCATGAGATG 
TTCAGCAGGG GTCAGGTGCC CTACCCAGGC ATGTCCAACC ATGAGGCCTT CCTGAGGGTG 
GACGCCGGCT ACCGCATGCC CTGCCCTCTG GAGTGCCCGC CCAGCGTGCA CAAGCTGATG 
CTGACATGCT GGTGCAGGGA CCCCGAGCAG AGACCCTGCT TCAAGGCCCT GCGGGAGAGG 
CTCTCCAGCT TCACCAGCTA CGAGAACCCG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005966.1
CDS	57..1412
Translation	MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSVGDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAARNILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGILLHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKALRERLSSFTSYENPT

Target ORF information:

RefSeq Version	NM_005975.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005975.3

ORF Insert Sequence:

ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 
TCCCGGACGG ACGAGGAGCT GAGCTTCCGC GCGGGGGACG TCTTCCACGT GGCCAGGAAG 
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 
TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC GTGGTTCTTT 
GGCTGCATCT CCCGCTCGGA AGCTGTGCGT CGGCTGCAGG CCGAGGGCAA CGCCACGGGC 
GCCTTCCTGA TCAGGGTCAG CGAGAAGCCG AGTGCCGACT ACGTCCTGTC GGTGCGGGAC 
ACGCAGGCTG TGCGGCACTA CAAGATCTGG CGGCGTGCCG GGGGCCGGCT GCACCTGAAC 
GAGGCGGTGT CCTTCCTCAG CCTGCCCGAG CTTGTGAACT ACCACAGGGC CCAGAGCCTG 
TCCCACGGCC TGCGGCTGGC CGCGCCCTGC CGGAAGCACG AGCCTGAGCC CCTGCCCCAT 
TGGGATGACT GGGAGAGGCC GAGGGAGGAG TTCACGCTCT GCAGGAAGCT GGGGTCCGGC 
TACTTTGGGG AGGTCTTCGA GGGGCTCTGG AAAGACCGGG TCCAGGTGGC CATTAAGGTG 
ATTTCTCGAG ACAACCTCCT GCACCAGCAG ATGCTGCAGT CGGAGATCCA GGCCATGAAG 
AAGCTGCGGC ACAAACACAT CCTGGCGCTG TACGCCGTGG TGTCCGTGGG GGACCCCGTG 
TACATCATCA CGGAGCTCAT GGCCAAGGGC AGCCTGCTGG AGCTGCTCCG CGACTCTGAT 
GAGAAAGTCC TGCCCGTTTC GGAGCTGCTG GACATCGCCT GGCAGGTGGC TGAGGGCATG 
TGTTACCTGG AGTCGCAGAA TTACATCCAC CGGGACCTGG CCGCCAGGAA CATCCTCGTC 
GGGGAAAACA CCCTCTGCAA AGTTGGGGAC TTCGGGTTAG CCAGGCTTAT CAAGGAGGAC 
GTCTACCTCT CCCATGACCA CAATATCCCC TACAAGTGGA CGGCCCCTGA AGCGCTCTCC 
CGAGGCCATT ACTCCACCAA ATCCGACGTC TGGTCCTTTG GGATTCTCCT GCATGAGATG 
TTCAGCAGGG GTCAGGTGCC CTACCCAGGC ATGTCCAACC ATGAGGCCTT CCTGAGGGTG 
GACGCCGGCT ACCGCATGCC CTGCCCTCTG GAGTGCCCGC CCAGCGTGCA CAAGCTGATG 
CTGACATGCT GGTGCAGGGA CCCCGAGCAG AGACCCTGCT TCAAGGCCCT GCGGGAGAGG 
CTCTCCAGCT TCACCAGCTA CGAGAACCCG ACCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTK6 ( NM_001256358.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001243287.1 Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu11801
Clone ID Related Accession (Same CDS sequence)	NM_001256358.1
Accession Version	NM_001256358.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	protein-tyrosine kinase 6 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK301364.1, X78549.1 and AL121829.30. On Aug 31, 2013 this sequence version replaced XR_244124.1. Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in a frameshift and early stop codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. This variant is also known as lambdaM5 and Alt-PTK6. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK301364.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1966682, SAMEA1968540 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 9333026, 21479203 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 
TCCCGGACGG ACGAGGAGCT GAGCTTCCGC GCGGGGGACG TCTTCCACGT GGCCAGGAAG 
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 
TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC TGCGGGACAC 
GCAGGCTGTG CGGCACTACA AGATCTGGCG GCGTGCCGGG GGCCGGCTGC ACCTGAACGA 
GGCGGTGTCC TTCCTCAGCC TGCCCGAGCT TGTGAACTAC CACAGGGCCC AGAGCCTGTC 
CCACGGCCTG CGGCTGGCCG CGCCCTGCCG GAAGCACGAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001243287.1
CDS	57..461
Translation	MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPAGHAGCAALQDLAACRGPAAPERGGVLPQPARACELPQGPEPVPRPAAGRALPEARA

Target ORF information:

RefSeq Version	NM_001256358.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256358.1

ORF Insert Sequence:

ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 
TCCCGGACGG ACGAGGAGCT GAGCTTCCGC GCGGGGGACG TCTTCCACGT GGCCAGGAAG 
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 
TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC TGCGGGACAC 
GCAGGCTGTG CGGCACTACA AGATCTGGCG GCGTGCCGGG GGCCGGCTGC ACCTGAACGA 
GGCGGTGTCC TTCCTCAGCC TGCCCGAGCT TGTGAACTAC CACAGGGCCC AGAGCCTGTC 
CCACGGCCTG CGGCTGGCCG CGCCCTGCCG GAAGCACGAG CCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PTK6 ( XM_017027982.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883471.1 Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu93092
Clone ID Related Accession (Same CDS sequence)	XM_017027982.1
Accession Version	XM_017027982.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 819bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	protein-tyrosine kinase 6 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 
TCCCGGACGG ACGAGGAGCT GAGCTTCCGC GCGGGGGACG TCTTCCACGT GGCCAGGAAG 
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 
TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC GTGGTTCTTT 
GGCTGCATCT CCCGCTCGGA AGCTGTGCGT CGGCTGCAGG CCGAGGGCAA CGCCACGGGC 
GCCTTCCTGA TCAGGGTCAG CGAGAAGCCG AGTGCCGACT ACGTCCTGTC GGTGCGGGAC 
ACGCAGGCTG TGCGGCACTA CAAGATCTGG CGGCGTGCCG GGGGCCGGCT GCACCTGAAC 
GAGGCGGTGT CCTTCCTCAG CCTGCCCGAG CTTGTGAACT ACCACAGGGC CCAGAGCCTG 
TCCCACGGCC TGCGGCTGGC CGCGCCCTGC CGGAAGCACG AGCCTGAGCC CCTGCCCCAT 
TGGGATGACT GGGAGAGGCC GAGGGAGGAG TTCACGCTCT GCAGGAAGCT GGGGTCCGGC 
TACTTTGGGG AGGTCTTCGA GGGGCTCTGG AAAGACCGGG TCCAGGTGGC CATTAAGGTG 
ATTTCTCGAG ATGCTGCAGT CGGAGATCCA GGCCATGAAG AAGCTGCGGC ACAAACACAT 
CCTGGCGCTG TACGCCGTGG TGTCCGTGGG GGACCCCGTG TACATCATCA CGGAGCTCAT 
GGCCAAGGGC AGCCTGCTGG AGCTGCTCCG CGACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883471.1
CDS	57..875
Translation	MVSRDQAHLGPKYVGLWDFKSRTDEELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEPWFFGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHLNEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHWDDWERPREEFTLCRKLGSGYFGEVFEGLWKDRVQVAIKVISRDAAVGDPGHEEAAAQTHPGAVRRGVRGGPRVHHHGAHGQGQPAGAAPRL

Target ORF information:

RefSeq Version	XM_017027982.1
Organism	Homo sapiens(human)
Definition	Homo sapiens protein tyrosine kinase 6 (PTK6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027982.1

ORF Insert Sequence:

ATGGTGTCCC GGGACCAGGC TCACCTGGGC CCCAAGTATG TGGGCCTCTG GGACTTCAAG 
TCCCGGACGG ACGAGGAGCT GAGCTTCCGC GCGGGGGACG TCTTCCACGT GGCCAGGAAG 
GAGGAGCAGT GGTGGTGGGC CACGCTGCTG GACGAGGCGG GTGGGGCCGT GGCCCAGGGC 
TATGTGCCCC ACAACTACCT GGCCGAGAGG GAGACGGTGG AGTCGGAACC GTGGTTCTTT 
GGCTGCATCT CCCGCTCGGA AGCTGTGCGT CGGCTGCAGG CCGAGGGCAA CGCCACGGGC 
GCCTTCCTGA TCAGGGTCAG CGAGAAGCCG AGTGCCGACT ACGTCCTGTC GGTGCGGGAC 
ACGCAGGCTG TGCGGCACTA CAAGATCTGG CGGCGTGCCG GGGGCCGGCT GCACCTGAAC 
GAGGCGGTGT CCTTCCTCAG CCTGCCCGAG CTTGTGAACT ACCACAGGGC CCAGAGCCTG 
TCCCACGGCC TGCGGCTGGC CGCGCCCTGC CGGAAGCACG AGCCTGAGCC CCTGCCCCAT 
TGGGATGACT GGGAGAGGCC GAGGGAGGAG TTCACGCTCT GCAGGAAGCT GGGGTCCGGC 
TACTTTGGGG AGGTCTTCGA GGGGCTCTGG AAAGACCGGG TCCAGGTGGC CATTAAGGTG 
ATTTCTCGAG ATGCTGCAGT CGGAGATCCA GGCCATGAAG AAGCTGCGGC ACAAACACAT 
CCTGGCGCTG TACGCCGTGG TGTCCGTGGG GGACCCCGTG TACATCATCA CGGAGCTCAT 
GGCCAAGGGC AGCCTGCTGG AGCTGCTCCG CGACTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.
Nature communications8(1)1508(2017 Nov)
Wozniak DJ,Kajdacsy-Balla A,Macias V,Ball-Kell S,Zenner ML,Bie W,Tyner AL

PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.
Journal of cellular biochemistry118(9)2887-2895(2017 Sep)
Shin WS,Shim HJ,Lee YH,Pyo M,Park JS,Ahn SY,Lee ST

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PTK6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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