PYY cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PYY
Entrez Gene ID	5697
Full Name	peptide YY
Synonyms	PYY-I,PYY1
General protein information	Preferred Names peptide YY Names peptide YY peptide tyrosine tyrosine prepro-PYY
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.31
Summary	This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016].
Disorder MIM:	600781

mRNA and Protein(s)

mRNA	Protein	Name
NM_004160.5	NP_004151.3	peptide YY preproprotein
XM_011525035.1	XP_011523337.1	peptide YY isoform X1

Pathways from BioSystems

Homologies

	PYY	XP_001113958.1
Bos taurus (cattle)	PYY	NP_001035677.1
Rattus norvegicus (Norway rat)	Pyy	NP_001029252.1
Xenopus tropicalis (tropical clawed frog)	pyy	NP_001072427.1
Homo sapiens (human)	PYY	NP_004151.3
Pan troglodytes (chimpanzee)	PYY	XP_523780.3
Danio rerio (zebrafish)	pyya	NP_001157843.1
Canis lupus familiaris (dog)	PYY	XP_005624470.1
Mus musculus (house mouse)	Pyy	NP_663410.1
Danio rerio (zebrafish)	pyyb	XP_001333222.2

Gene Ontology
Bibliography

Related articles in PubMed

Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.
Pendharkar SA, Singh RG, Petrov MS
Cytokine90161-168(2017 Feb)

The role of gut hormone peptide YY in energy and glucose homeostasis: twelve years on.
Manning S, Batterham RL
Annual review of physiology76585-608(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after acute pancreatitis and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFalpha. Future research is warranted to investigate the signaling pathways that underlie these associations.
Title: Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.

Data suggest that dose/intensity-response relationships exist between exercise intensity and total plasma PYY levels, though the effects on total plasma GLP1 levels and hunger perceptions seem unclear. (PYY = peptide YY ; GLP1 = glucagon-like peptide 1)
Title: Total PYY and GLP-1 responses to submaximal continuous and supramaximal sprint interval cycling in men.

expression of PYY and its NPY receptors on mouse islets and immortalised rodent and human beta-cells was examined.
Title: Islet distribution of Peptide YY and its regulatory role in primary mouse islets and immortalised rodent and human beta-cell function and survival.

In extremely obese patients, fasting PYY3-36 concentrations were linked to systolic blood pressure, but not to other components of metabolic syndrome, suggesting divergence between pathways of blood pressure and glucose/body weight regulation.
Title: Associations of Circulating PYY

Angiotensin II stimulates PYY secretion, in turn inhibiting epithelial anion fluxes, thereby reducing net fluid secretion into the colonic lumen.
Title: Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans.

The following PYY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PYY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu20777	NM_004160.5 Latest version!	Homo sapiens peptide YY (PYY), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu59986	XM_011525035.1 Latest version!	Homo sapiens peptide YY (PYY), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PYY ( NM_004160.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004151.3 Homo sapiens peptide YY (PYY), mRNA.

Price & Availability↑

CloneID	OHu20777
Clone ID Related Accession (Same CDS sequence)	NM_004160.5
Accession Version	NM_004160.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	peptide YY preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC041057.1, AC007993.15 and AI654355.1. This sequence is a reference standard in the RefSeqGene project. On Feb 20, 2016 this sequence version replaced NM_004160.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041057.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGTTCG TGCGCAGGCC GTGGCCCGCC TTGACCACAG TGCTTCTGGC CCTGCTCGTC 
TGCCTAGGGG CGCTGGTCGA CGCCTACCCC ATCAAACCCG AGGCTCCCGG CGAAGACGCC 
TCGCCGGAGG AGCTGAACCG CTACTACGCC TCCCTGCGCC ACTACCTCAA CCTGGTCACC 
CGGCAGCGGT ATGGGAAAAG AGACGGCCCG GACACGCTTC TTTCCAAAAC GTTCTTCCCC 
GACGGCGAGG ACCGCCCCGT CAGGTCGCGG TCGGAGGGCC CAGACCTGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004151.3
CDS	542..835
Translation	MVFVRRPWPALTTVLLALLVCLGALVDAYPIKPEAPGEDASPEELNRYYASLRHYLNLVTRQRYGKRDGPDTLLSKTFFPDGEDRPVRSRSEGPDLW

Target ORF information:

RefSeq Version	NM_004160.5
Organism	Homo sapiens(human)
Definition	Homo sapiens peptide YY (PYY), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004160.5

ORF Insert Sequence:

ATGGTGTTCG TGCGCAGGCC GTGGCCCGCC TTGACCACAG TGCTTCTGGC CCTGCTCGTC 
TGCCTAGGGG CGCTGGTCGA CGCCTACCCC ATCAAACCCG AGGCTCCCGG CGAAGACGCC 
TCGCCGGAGG AGCTGAACCG CTACTACGCC TCCCTGCGCC ACTACCTCAA CCTGGTCACC 
CGGCAGCGGT ATGGGAAAAG AGACGGCCCG GACACGCTTC TTTCCAAAAC GTTCTTCCCC 
GACGGCGAGG ACCGCCCCGT CAGGTCGCGG TCGGAGGGCC CAGACCTGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PYY ( XM_011525035.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523337.1 Homo sapiens peptide YY (PYY), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59986
Clone ID Related Accession (Same CDS sequence)	XM_011525035.1
Accession Version	XM_011525035.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	peptide YY isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGTTCG TGCGCAGGCC GTGGCCCGCC TTGACCACAG TGCTTCTGGC CCTGCTCGTC 
TGCCTAGGGG CGCTGGTCGA CGCCTACCCC ATCAAACCCG AGGCTCCCCG CGAAGACGCC 
TCGCCGGAGG AGCTGAACCG CTACTACGCC TCCCTGCGCC ACTACCTCAA CCTGGTCACC 
CGGCAGCGGT ATGGGAAAAG AGACGGCCCG GACACGCTTC TTTCCAAAAC GTTCTTCCCC 
GACGGCGAGG ACCGCCCCGT CAGGTCGCGG TCGGAGGGCC CAGACCTGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523337.1
CDS	1152..1445
Translation	MVFVRRPWPALTTVLLALLVCLGALVDAYPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRYGKRDGPDTLLSKTFFPDGEDRPVRSRSEGPDLW

Target ORF information:

RefSeq Version	XM_011525035.1
Organism	Homo sapiens(human)
Definition	Homo sapiens peptide YY (PYY), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525035.1

ORF Insert Sequence:

ATGGTGTTCG TGCGCAGGCC GTGGCCCGCC TTGACCACAG TGCTTCTGGC CCTGCTCGTC 
TGCCTAGGGG CGCTGGTCGA CGCCTACCCC ATCAAACCCG AGGCTCCCCG CGAAGACGCC 
TCGCCGGAGG AGCTGAACCG CTACTACGCC TCCCTGCGCC ACTACCTCAA CCTGGTCACC 
CGGCAGCGGT ATGGGAAAAG AGACGGCCCG GACACGCTTC TTTCCAAAAC GTTCTTCCCC 
GACGGCGAGG ACCGCCCCGT CAGGTCGCGG TCGGAGGGCC CAGACCTGTG GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.
Cytokine90161-168(2017 Feb)
Pendharkar SA,Singh RG,Petrov MS

The role of gut hormone peptide YY in energy and glucose homeostasis: twelve years on.
Annual review of physiology76585-608(2014)
Manning S,Batterham RL

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PYY cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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