THAP10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	THAP10
Entrez Gene ID	56906
Full Name	THAP domain containing 10
General protein information	Preferred Names THAP domain containing 10 Names THAP domain-containing protein 10
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q23
Summary	This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010].
Disorder MIM:	612538

mRNA and Protein(s)

mRNA	Protein	Name
NM_020147.3	NP_064532.1	THAP domain-containing protein 10
NM_020147.4	NP_064532.1	THAP domain-containing protein 10

Pathways from BioSystems

Homologies

Homo sapiens (human)	THAP10	NP_064532.1
	THAP10	XP_002804892.1
Pan troglodytes (chimpanzee)	THAP10	XP_523207.1
Canis lupus familiaris (dog)	THAP10	XP_853894.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel epigenetic
Li Y, Ning Q, Shi J, Chen Y, Jiang M, Gao L, Huang W, Jing Y, Huang S, Liu A, Hu Z, Liu D, Wang L, Nervi C, Dai Y, Zhang MQ, Yu L
EMBO molecular medicine9(7)933-949(2017 Jul)

Next-generation sequencing to generate interactome datasets.
Yu H, Tardivo L, Tam S, Weiner E, Gebreab F, Fan C, Svrzikapa N, Hirozane-Kishikawa T, Rietman E, Yang X, Sahalie J, Salehi-Ashtiani K, Hao T, Cusick ME, Hill DE, Roth FP, Braun P, Vidal M
Nature methods8(6)478-80(2011 Jun)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer.
De Souza Santos E, De Bessa SA, Netto MM, Nagai MA
International journal of oncology33(1)25-31(2008 Jul)

The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase.
Roussigne M, Kossida S, Lavigne AC, Clouaire T, Ecochard V, Glories A, Amalric F, Girard JP
Trends in biochemical sciences28(2)66-9(2003 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

transcripts of LRRC49/THAP10 bidirectional gene pair are co-regulated by estrogen and that hypermethylation of the bidirectional promoter region simultaneously silences both genes.
Title: Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer.

The following THAP10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THAP10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu12047	NM_020147.4 Latest version!	Homo sapiens THAP domain containing 10 (THAP10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu12047	NM_020147.3	Homo sapiens THAP domain containing 10 (THAP10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

THAP10 ( NM_020147.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_064532.1 Homo sapiens THAP domain containing 10 (THAP10), mRNA.

Price & Availability↑

CloneID	OHu12047
Clone ID Related Accession (Same CDS sequence)	NM_020147.3 , NM_020147.4
Accession Version	NM_020147.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	THAP domain-containing protein 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA272000.1, BC027857.1 and AC090868.4. On Nov 30, 2010 this sequence version replaced NM_020147.2. ##Evidence-Data-START## Transcript exon combination :: BC027857.1, SRR1660807.211441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGGCCC GTTGTGTGGC CGCCCACTGC GGCAACACCA CCAAGTCTGG GAAGTCGCTG 
TTCCGCTTTC CCAAGGACCG GGCCGTGCGG CTGCTCTGGG ACCGCTTCGT GCGGGGTTGC 
CGCGCCGACT GGTACGGAGG CAATGACCGC TCGGTCATCT GCTCTGACCA CTTTGCCCCA 
GCCTGTTTTG ACGTCTCTTC GGTTATCCAG AAGAACCTGC GCTTCTCCCA GCGCCTGAGG 
CTGGTGGCAG GCGCCGTGCC CACCCTGCAC CGGGTGCCCG CCCCGGCACC TAAGAGGGGA 
GAGGAGGGAG ACCAAGCAGG CCGCCTGGAC ACGCGAGGAG AGCTCCAGGC AGCCAGGCAT 
TCTGAGGCTG CCCCAGGTCC AGTCTCCTGT ACACGCCCCC GAGCTGGGAA GCAGGCTGCA 
GCTTCACAGA TTACGTGTGA AAATGAACTT GTGCAAACCC AACCCCATGC TGATAATCCA 
TCTAATACTG TCACTTCAGT ACCTACTCAC TGTGAAGAAG GCCCAGTGCA TAAAAGTACA 
CAAATTTCTT TGAAAAGGCC CCGTCACCGT AGTGTGGGTA TTCAAGCCAA AGTGAAAGCG 
TTTGGAAAAA GACTGTGTAA TGCAACTACT CAGACAGAGG AATTGTGGTC TAGAACTTCC 
TCTCTCTTTG ACATTTACTC CAGTGATTCA GAAACAGATA CAGACTGGGA TATCAAGAGT 
GAACAGAGTG ATTTGTCTTA TATGGCTGTA CAGGTGAAAG AAGAAACATG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064532.1
CDS	162..935
Translation	MPARCVAAHCGNTTKSGKSLFRFPKDRAVRLLWDRFVRGCRADWYGGNDRSVICSDHFAPACFDVSSVIQKNLRFSQRLRLVAGAVPTLHRVPAPAPKRGEEGDQAGRLDTRGELQAARHSEAAPGPVSCTRPRAGKQAAASQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDLSYMAVQVKEETC

Target ORF information:

RefSeq Version	NM_020147.3
Organism	Homo sapiens(human)
Definition	Homo sapiens THAP domain containing 10 (THAP10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020147.3

ORF Insert Sequence:

ATGCCGGCCC GTTGTGTGGC CGCCCACTGC GGCAACACCA CCAAGTCTGG GAAGTCGCTG 
TTCCGCTTTC CCAAGGACCG GGCCGTGCGG CTGCTCTGGG ACCGCTTCGT GCGGGGTTGC 
CGCGCCGACT GGTACGGAGG CAATGACCGC TCGGTCATCT GCTCTGACCA CTTTGCCCCA 
GCCTGTTTTG ACGTCTCTTC GGTTATCCAG AAGAACCTGC GCTTCTCCCA GCGCCTGAGG 
CTGGTGGCAG GCGCCGTGCC CACCCTGCAC CGGGTGCCCG CCCCGGCACC TAAGAGGGGA 
GAGGAGGGAG ACCAAGCAGG CCGCCTGGAC ACGCGAGGAG AGCTCCAGGC AGCCAGGCAT 
TCTGAGGCTG CCCCAGGTCC AGTCTCCTGT ACACGCCCCC GAGCTGGGAA GCAGGCTGCA 
GCTTCACAGA TTACGTGTGA AAATGAACTT GTGCAAACCC AACCCCATGC TGATAATCCA 
TCTAATACTG TCACTTCAGT ACCTACTCAC TGTGAAGAAG GCCCAGTGCA TAAAAGTACA 
CAAATTTCTT TGAAAAGGCC CCGTCACCGT AGTGTGGGTA TTCAAGCCAA AGTGAAAGCG 
TTTGGAAAAA GACTGTGTAA TGCAACTACT CAGACAGAGG AATTGTGGTC TAGAACTTCC 
TCTCTCTTTG ACATTTACTC CAGTGATTCA GAAACAGATA CAGACTGGGA TATCAAGAGT 
GAACAGAGTG ATTTGTCTTA TATGGCTGTA CAGGTGAAAG AAGAAACATG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THAP10 ( NM_020147.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_064532.1 Homo sapiens THAP domain containing 10 (THAP10), mRNA.

Price & Availability↑

CloneID	OHu12047
Clone ID Related Accession (Same CDS sequence)	NM_020147.3 , NM_020147.4
Accession Version	NM_020147.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	THAP domain-containing protein 10
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA272000.1, BC027857.1 and AC090868.4. On Nov 22, 2018 this sequence version replaced NM_020147.3. ##Evidence-Data-START## Transcript exon combination :: BC072414.1, SRR1660807.211441.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000249861.9/ ENSP00000249861.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGGCCC GTTGTGTGGC CGCCCACTGC GGCAACACCA CCAAGTCTGG GAAGTCGCTG 
TTCCGCTTTC CCAAGGACCG GGCCGTGCGG CTGCTCTGGG ACCGCTTCGT GCGGGGTTGC 
CGCGCCGACT GGTACGGAGG CAATGACCGC TCGGTCATCT GCTCTGACCA CTTTGCCCCA 
GCCTGTTTTG ACGTCTCTTC GGTTATCCAG AAGAACCTGC GCTTCTCCCA GCGCCTGAGG 
CTGGTGGCAG GCGCCGTGCC CACCCTGCAC CGGGTGCCCG CCCCGGCACC TAAGAGGGGA 
GAGGAGGGAG ACCAAGCAGG CCGCCTGGAC ACGCGAGGAG AGCTCCAGGC AGCCAGGCAT 
TCTGAGGCTG CCCCAGGTCC AGTCTCCTGT ACACGCCCCC GAGCTGGGAA GCAGGCTGCA 
GCTTCACAGA TTACGTGTGA AAATGAACTT GTGCAAACCC AACCCCATGC TGATAATCCA 
TCTAATACTG TCACTTCAGT ACCTACTCAC TGTGAAGAAG GCCCAGTGCA TAAAAGTACA 
CAAATTTCTT TGAAAAGGCC CCGTCACCGT AGTGTGGGTA TTCAAGCCAA AGTGAAAGCG 
TTTGGAAAAA GACTGTGTAA TGCAACTACT CAGACAGAGG AATTGTGGTC TAGAACTTCC 
TCTCTCTTTG ACATTTACTC CAGTGATTCA GAAACAGATA CAGACTGGGA TATCAAGAGT 
GAACAGAGTG ATTTGTCTTA TATGGCTGTA CAGGTGAAAG AAGAAACATG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_064532.1
CDS	162..935
Translation	MPARCVAAHCGNTTKSGKSLFRFPKDRAVRLLWDRFVRGCRADWYGGNDRSVICSDHFAPACFDVSSVIQKNLRFSQRLRLVAGAVPTLHRVPAPAPKRGEEGDQAGRLDTRGELQAARHSEAAPGPVSCTRPRAGKQAAASQITCENELVQTQPHADNPSNTVTSVPTHCEEGPVHKSTQISLKRPRHRSVGIQAKVKAFGKRLCNATTQTEELWSRTSSLFDIYSSDSETDTDWDIKSEQSDLSYMAVQVKEETC

Target ORF information:

RefSeq Version	NM_020147.4
Organism	Homo sapiens(human)
Definition	Homo sapiens THAP domain containing 10 (THAP10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020147.4

ORF Insert Sequence:

ATGCCGGCCC GTTGTGTGGC CGCCCACTGC GGCAACACCA CCAAGTCTGG GAAGTCGCTG 
TTCCGCTTTC CCAAGGACCG GGCCGTGCGG CTGCTCTGGG ACCGCTTCGT GCGGGGTTGC 
CGCGCCGACT GGTACGGAGG CAATGACCGC TCGGTCATCT GCTCTGACCA CTTTGCCCCA 
GCCTGTTTTG ACGTCTCTTC GGTTATCCAG AAGAACCTGC GCTTCTCCCA GCGCCTGAGG 
CTGGTGGCAG GCGCCGTGCC CACCCTGCAC CGGGTGCCCG CCCCGGCACC TAAGAGGGGA 
GAGGAGGGAG ACCAAGCAGG CCGCCTGGAC ACGCGAGGAG AGCTCCAGGC AGCCAGGCAT 
TCTGAGGCTG CCCCAGGTCC AGTCTCCTGT ACACGCCCCC GAGCTGGGAA GCAGGCTGCA 
GCTTCACAGA TTACGTGTGA AAATGAACTT GTGCAAACCC AACCCCATGC TGATAATCCA 
TCTAATACTG TCACTTCAGT ACCTACTCAC TGTGAAGAAG GCCCAGTGCA TAAAAGTACA 
CAAATTTCTT TGAAAAGGCC CCGTCACCGT AGTGTGGGTA TTCAAGCCAA AGTGAAAGCG 
TTTGGAAAAA GACTGTGTAA TGCAACTACT CAGACAGAGG AATTGTGGTC TAGAACTTCC 
TCTCTCTTTG ACATTTACTC CAGTGATTCA GAAACAGATA CAGACTGGGA TATCAAGAGT 
GAACAGAGTG ATTTGTCTTA TATGGCTGTA CAGGTGAAAG AAGAAACATG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel epigenetic
EMBO molecular medicine9(7)933-949(2017 Jul)
Li Y,Ning Q,Shi J,Chen Y,Jiang M,Gao L,Huang W,Jing Y,Huang S,Liu A,Hu Z,Liu D,Wang L,Nervi C,Dai Y,Zhang MQ,Yu L

Next-generation sequencing to generate interactome datasets.
Nature methods8(6)478-80(2011 Jun)
Yu H,Tardivo L,Tam S,Weiner E,Gebreab F,Fan C,Svrzikapa N,Hirozane-Kishikawa T,Rietman E,Yang X,Sahalie J,Salehi-Ashtiani K,Hao T,Cusick ME,Hill DE,Roth FP,Braun P,Vidal M

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

Silencing of LRRC49 and THAP10 genes by bidirectional promoter hypermethylation is a frequent event in breast cancer.
International journal of oncology33(1)25-31(2008 Jul)
De Souza Santos E,De Bessa SA,Netto MM,Nagai MA

The THAP domain: a novel protein motif with similarity to the DNA-binding domain of P element transposase.
Trends in biochemical sciences28(2)66-9(2003 Feb)
Roussigne M,Kossida S,Lavigne AC,Clouaire T,Ecochard V,Glories A,Amalric F,Girard JP

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THAP10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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