PSMB1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSMB1
Entrez Gene ID	5689
Full Name	proteasome subunit beta 1
Synonyms	HC5,PMSB1,PSC5
General protein information	Preferred Names proteasome subunit beta 1 Names proteasome subunit beta type-1 macropain subunit C5 multicatalytic endopeptidase complex subunit C5 proteasome (prosome, macropain) subunit, beta type, 1 proteasome beta 1 subunit proteasome component C5 proteasome gamma chain proteasome subunit HC5 testicular secretory protein Li 45
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q27
Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is tightly linked to the TBP (TATA-binding protein) gene in human and in mouse, and is transcribed in the opposite orientation in both species. [provided by RefSeq, Jul 2008].
Disorder MIM:	602017

mRNA and Protein(s)

mRNA	Protein	Name
NM_002793.4	NP_002784.1	proteasome subunit beta type-1
NM_002793.3	NP_002784.1	proteasome subunit beta type-1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	psmb1	NP_001003889.1
Drosophila melanogaster (fruit fly)	Pros26	NP_524115.1
Schizosaccharomyces pombe (fission yeast)	pam1	NP_594729.1
Magnaporthe oryzae (rice blast fungus)	MGG_04622	XP_003710882.1
Neurospora crassa	NCU09366	XP_963776.2
Homo sapiens (human)	PSMB1	NP_002784.1
Mus musculus (house mouse)	Psmb1	NP_035315.1
Caenorhabditis elegans (roundworm)	pbs-6	NP_498806.1
	PSMB1	XP_001084784.1
Bos taurus (cattle)	PSMB1	NP_001033628.1
Gallus gallus (chicken)	PSMB1	NP_001007906.1
Kluyveromyces lactis	KLLA0E05633g	XP_454200.1
Oryza sativa (rice)	Os08g0529100	NP_001062318.1
Canis lupus familiaris (dog)	PSMB1	XP_532275.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004991	XP_315096.4
Xenopus tropicalis (tropical clawed frog)	psmb1	NP_988993.1
Pan troglodytes (chimpanzee)	PSMB1	XP_003311646.1
Rattus norvegicus (Norway rat)	Psmb1	NP_446042.1
Saccharomyces cerevisiae (baker's yeast)	PRE7	NP_009512.1
Eremothecium gossypii	AGOS_AGL324W	NP_986343.2
Arabidopsis thaliana (thale cress)	PBF1	NP_001030905.1
Oryza sativa (rice)	Os09g0505600	NP_001063603.1

Gene Ontology
Bibliography

Related articles in PubMed

Proteasome Subunit Beta Type 1 P11A Polymorphism Is a New Prognostic Marker in Multiple Myeloma.
Varga G, Mikala G, Kiss KP, Kos?czki ?, Szab? E, Meggyesi N, Balassa K, K?vy P, Tegze B, Szombath G, Tordai A, Andrikovics H, Homolya L, Masszi T
Clinical lymphoma, myeloma & leukemia17(11)734-742(2017 Nov)

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

A novel role of proteasomal ?1 subunit in tumorigenesis.
Yuan F, Ma Y, You P, Lin W, Lu H, Yu Y, Wang X, Jiang J, Yang P, Ma Q, Tao T
Bioscience reports33(4)(2013 Jul)

Role of nuclear localization of PSMB1 in transcriptional activation.
Yamauchi J, Sekiguchi M, Shirai T, Yamada M, Ishimi Y
Bioscience, biotechnology, and biochemistry77(8)1785-7(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The proteasome beta1 subunit plays a novel role in tumorigenesis by degrading p27Kip1.
Title: A novel role of proteasomal ?1 subunit in tumorigenesis.

The proteasome was found to be activated in primary sjogren syndrome, with upregulation of gene expression of catalytic proteasome subunits.
Title: Gene expression of catalytic proteasome subunits and resistance toward proteasome inhibition of B lymphocytes from patients with primary sjogren syndrome.

Follicular lymphoma patients with PSMB1 P11A (G allele) and low CD68 expression have significantly longer progression free survival with bortezomib-rituximab versus rituximab.
Title: Prespecified candidate biomarkers identify follicular lymphoma patients who achieved longer progression-free survival with bortezomib-rituximab versus rituximab.

PSMB1 is part of the transcriptional machinery required for gastrin stimulated expression of PAI-2 and Reg1.
Title: The role of proteasome beta subunits in gastrin-mediated transcription of plasminogen activator inhibitor-2 and regenerating protein1.

The mutated form of PSMB1 displayed increased nuclear translocation, resulting in activation of transcription in adipocytes.
Title: Role of nuclear localization of PSMB1 in transcriptional activation.

The following PSMB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSMB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17652	NM_002793.4 Latest version!	Homo sapiens proteasome 20S subunit beta 1 (PSMB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu17652	NM_002793.3	Homo sapiens proteasome subunit beta 1 (PSMB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSMB1 ( NM_002793.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002784.1 Homo sapiens proteasome 20S subunit beta 1 (PSMB1), mRNA.

Price & Availability↑

CloneID	OHu17652
Clone ID Related Accession (Same CDS sequence)	NM_002793.4 , NM_002793.3
Accession Version	NM_002793.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	proteasome subunit beta type-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP369175.1, BC020807.1 and BQ685374.1. On Nov 22, 2018 this sequence version replaced NM_002793.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.404183.1, HM005585.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153733, SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000262193.7/ ENSP00000262193.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTGTCCT CTACAGCCAT GTATTCGGCT CCTGGCAGAG ACTTGGGGAT GGAACCGCAC 
AGAGCCGCGG GCCCTTTGCA GCTGCGATTT TCGCCCTACG TTTTCAACGG AGGTACTATA 
CTGGCAATTG CTGGAGAAGA TTTTGCAATT GTTGCTTCTG ATACTCGATT GAGTGAAGGG 
TTTTCAATTC ATACGCGGGA TAGCCCCAAA TGTTACAAAT TAACAGACAA AACAGTCATT 
GGATGCAGCG GTTTTCATGG AGACTGTCTT ACGCTGACAA AGATTATTGA AGCAAGACTA 
AAGATGTATA AGCATTCCAA TAATAAGGCC ATGACTACGG GGGCAATTGC TGCAATGCTG 
TCTACAATCC TGTATTCAAG GCGCTTCTTT CCATACTATG TTTACAACAT CATCGGTGGA 
CTTGATGAAG AAGGAAAGGG GGCTGTATAC AGCTTTGATC CAGTAGGGTC TTACCAGAGA 
GACTCCTTCA AGGCTGGAGG CTCAGCAAGT GCCATGCTAC AGCCCCTGCT TGACAACCAG 
GTTGGTTTTA AGAACATGCA GAATGTGGAG CATGTTCCGC TGTCCTTGGA CAGAGCCATG 
CGGCTGGTGA AAGATGTCTT CATTTCTGCG GCTGAGAGAG ATGTGTACAC TGGGGACGCA 
CTCCGGATCT GCATAGTGAC CAAAGAGGGC ATCAGGGAGG AAACTGTTTC CTTAAGGAAG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002784.1
CDS	66..791
Translation	MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD

Target ORF information:

RefSeq Version	NM_002793.4
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome 20S subunit beta 1 (PSMB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002793.4

ORF Insert Sequence:

ATGTTGTCCT CTACAGCCAT GTATTCGGCT CCTGGCAGAG ACTTGGGGAT GGAACCGCAC 
AGAGCCGCGG GCCCTTTGCA GCTGCGATTT TCGCCCTACG TTTTCAACGG AGGTACTATA 
CTGGCAATTG CTGGAGAAGA TTTTGCAATT GTTGCTTCTG ATACTCGATT GAGTGAAGGG 
TTTTCAATTC ATACGCGGGA TAGCCCCAAA TGTTACAAAT TAACAGACAA AACAGTCATT 
GGATGCAGCG GTTTTCATGG AGACTGTCTT ACGCTGACAA AGATTATTGA AGCAAGACTA 
AAGATGTATA AGCATTCCAA TAATAAGGCC ATGACTACGG GGGCAATTGC TGCAATGCTG 
TCTACAATCC TGTATTCAAG GCGCTTCTTT CCATACTATG TTTACAACAT CATCGGTGGA 
CTTGATGAAG AAGGAAAGGG GGCTGTATAC AGCTTTGATC CAGTAGGGTC TTACCAGAGA 
GACTCCTTCA AGGCTGGAGG CTCAGCAAGT GCCATGCTAC AGCCCCTGCT TGACAACCAG 
GTTGGTTTTA AGAACATGCA GAATGTGGAG CATGTTCCGC TGTCCTTGGA CAGAGCCATG 
CGGCTGGTGA AAGATGTCTT CATTTCTGCG GCTGAGAGAG ATGTGTACAC TGGGGACGCA 
CTCCGGATCT GCATAGTGAC CAAAGAGGGC ATCAGGGAGG AAACTGTTTC CTTAAGGAAG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSMB1 ( NM_002793.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002784.1 Homo sapiens proteasome subunit beta 1 (PSMB1), mRNA.

Price & Availability↑

CloneID	OHu17652
Clone ID Related Accession (Same CDS sequence)	NM_002793.4 , NM_002793.3
Accession Version	NM_002793.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	proteasome subunit beta type-1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP369175.1, BC020807.1 and BQ685374.1. On Oct 3, 2008 this sequence version replaced NM_002793.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005585.1, SRR1163655.404183.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153733, SAMEA2467144 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGTTGTCCT CTACAGCCAT GTATTCGGCT CCTGGCAGAG ACTTGGGGAT GGAACCGCAC 
AGAGCCGCGG GCCCTTTGCA GCTGCGATTT TCGCCCTACG TTTTCAACGG AGGTACTATA 
CTGGCAATTG CTGGAGAAGA TTTTGCAATT GTTGCTTCTG ATACTCGATT GAGTGAAGGG 
TTTTCAATTC ATACGCGGGA TAGCCCCAAA TGTTACAAAT TAACAGACAA AACAGTCATT 
GGATGCAGCG GTTTTCATGG AGACTGTCTT ACGCTGACAA AGATTATTGA AGCAAGACTA 
AAGATGTATA AGCATTCCAA TAATAAGGCC ATGACTACGG GGGCAATTGC TGCAATGCTG 
TCTACAATCC TGTATTCAAG GCGCTTCTTT CCATACTATG TTTACAACAT CATCGGTGGA 
CTTGATGAAG AAGGAAAGGG GGCTGTATAC AGCTTTGATC CAGTAGGGTC TTACCAGAGA 
GACTCCTTCA AGGCTGGAGG CTCAGCAAGT GCCATGCTAC AGCCCCTGCT TGACAACCAG 
GTTGGTTTTA AGAACATGCA GAATGTGGAG CATGTTCCGC TGTCCTTGGA CAGAGCCATG 
CGGCTGGTGA AAGATGTCTT CATTTCTGCG GCTGAGAGAG ATGTGTACAC TGGGGACGCA 
CTCCGGATCT GCATAGTGAC CAAAGAGGGC ATCAGGGAGG AAACTGTTTC CTTAAGGAAG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002784.1
CDS	88..813
Translation	MLSSTAMYSAPGRDLGMEPHRAAGPLQLRFSPYVFNGGTILAIAGEDFAIVASDTRLSEGFSIHTRDSPKCYKLTDKTVIGCSGFHGDCLTLTKIIEARLKMYKHSNNKAMTTGAIAAMLSTILYSRRFFPYYVYNIIGGLDEEGKGAVYSFDPVGSYQRDSFKAGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDRAMRLVKDVFISAAERDVYTGDALRICIVTKEGIREETVSLRKD

Target ORF information:

RefSeq Version	NM_002793.3
Organism	Homo sapiens(human)
Definition	Homo sapiens proteasome subunit beta 1 (PSMB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002793.3

ORF Insert Sequence:

ATGTTGTCCT CTACAGCCAT GTATTCGGCT CCTGGCAGAG ACTTGGGGAT GGAACCGCAC 
AGAGCCGCGG GCCCTTTGCA GCTGCGATTT TCGCCCTACG TTTTCAACGG AGGTACTATA 
CTGGCAATTG CTGGAGAAGA TTTTGCAATT GTTGCTTCTG ATACTCGATT GAGTGAAGGG 
TTTTCAATTC ATACGCGGGA TAGCCCCAAA TGTTACAAAT TAACAGACAA AACAGTCATT 
GGATGCAGCG GTTTTCATGG AGACTGTCTT ACGCTGACAA AGATTATTGA AGCAAGACTA 
AAGATGTATA AGCATTCCAA TAATAAGGCC ATGACTACGG GGGCAATTGC TGCAATGCTG 
TCTACAATCC TGTATTCAAG GCGCTTCTTT CCATACTATG TTTACAACAT CATCGGTGGA 
CTTGATGAAG AAGGAAAGGG GGCTGTATAC AGCTTTGATC CAGTAGGGTC TTACCAGAGA 
GACTCCTTCA AGGCTGGAGG CTCAGCAAGT GCCATGCTAC AGCCCCTGCT TGACAACCAG 
GTTGGTTTTA AGAACATGCA GAATGTGGAG CATGTTCCGC TGTCCTTGGA CAGAGCCATG 
CGGCTGGTGA AAGATGTCTT CATTTCTGCG GCTGAGAGAG ATGTGTACAC TGGGGACGCA 
CTCCGGATCT GCATAGTGAC CAAAGAGGGC ATCAGGGAGG AAACTGTTTC CTTAAGGAAG 
GACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Proteasome Subunit Beta Type 1 P11A Polymorphism Is a New Prognostic Marker in Multiple Myeloma.
Clinical lymphoma, myeloma & leukemia17(11)734-742(2017 Nov)
Varga G,Mikala G,Kiss KP,Kos?czki ?,Szab? E,Meggyesi N,Balassa K,K?vy P,Tegze B,Szombath G,Tordai A,Andrikovics H,Homolya L,Masszi T

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

A novel role of proteasomal ?1 subunit in tumorigenesis.
Bioscience reports33(4)(2013 Jul)
Yuan F,Ma Y,You P,Lin W,Lu H,Yu Y,Wang X,Jiang J,Yang P,Ma Q,Tao T

Role of nuclear localization of PSMB1 in transcriptional activation.
Bioscience, biotechnology, and biochemistry77(8)1785-7(2013)
Yamauchi J,Sekiguchi M,Shirai T,Yamada M,Ishimi Y

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PSMB1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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