KCNK12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNK12
Entrez Gene ID	56660
Full Name	potassium two pore domain channel subfamily K member 12
Synonyms	K2p12.1,THIK-2,THIK2
General protein information	Preferred Names potassium two pore domain channel subfamily K member 12 Names potassium channel subfamily K member 12 potassium channel, subfamily K, member 12 potassium channel, two pore domain subfamily K, member 12 tandem pore domain halothane-inhibited potassium channel 2 tandem pore domain potassium channel THIK-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p16.3
Summary	This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel, however, it may require other non-pore-forming proteins for activity. [provided by RefSeq, Jul 2008].
Disorder MIM:	607366

mRNA and Protein(s)

mRNA	Protein	Name
NM_022055.2	NP_071338.1	potassium channel subfamily K member 12
NM_022055.1	NP_071338.1	potassium channel subfamily K member 12

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	KCNK12	XP_515460.2
Homo sapiens (human)	KCNK12	NP_071338.1
	KCNK12	XP_001113593.1
Bos taurus (cattle)	KCNK12	NP_001192819.1
Gallus gallus (chicken)	KCNK12	XP_003640952.2
Canis lupus familiaris (dog)	KCNK12	XP_538483.2
Mus musculus (house mouse)	Kcnk12	NP_954859.1
Rattus norvegicus (Norway rat)	Kcnk12	NP_071628.1
Danio rerio (zebrafish)	LOC559153	XP_687561.2
Caenorhabditis elegans (roundworm)	twk-14	NP_001256414.1
Xenopus tropicalis (tropical clawed frog)	kcnk12	XP_002935426.2

Gene Ontology
Bibliography

Related articles in PubMed

Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.
Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D
The Journal of biological chemistry289(41)28202-12(2014 Oct)

Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.
Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F
The Journal of biological chemistry288(49)35081-92(2013 Dec)

Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.
Birlea SA, Gowan K, Fain PR, Spritz RA
The Journal of investigative dermatology130(3)798-803(2010 Mar)

A high-density association screen of 155 ion transport genes for involvement with common migraine.
Nyholt DR, LaForge KS, Kallela M, Alakurtti K, Anttila V, F?rkkil? M, H?mal?inen E, Kaprio J, Kaunisto MA, Heath AC, Montgomery GW, G?bel H, Todt U, Ferrari MD, Launer LJ, Frants RR, Terwindt GM, de Vries B, Verschuren WM, Brand J, Freilinger T, Pfaffenrath V, Straube A, Ballinger DG, Zhan Y, Daly MJ, Cox DR, Dichgans M, van den Maagdenberg AM, Kubisch C, Martin NG, Wessman M, Peltonen L, Palotie A
Human molecular genetics17(21)3318-31(2008 Nov)

Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
Theilig F, Goranova I, Hirsch JR, Wieske M, Unsal S, Bachmann S, Veh RW, Derst C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology21(1-3)63-74(2008)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In cell and tissues co-expressing THIK1 and THIK2, heterodimeric channels may contribute to cell excitability.
Title: Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.

The cytoplasmic amino-terminal region of THIK2 (Nt-THIK2) contains an arginine-rich motif (RRSRRR) that acts as a retention/retrieval signal.
Title: Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: A high-density association screen of 155 ion transport genes for involvement with common migraine.

THIK-1 and THIK-2 are abundantly expressed in the proximal and distal nephron of the mammalian kidney.
Title: Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.

The following KCNK12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNK12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01067	NM_022055.2 Latest version!	Homo sapiens potassium two pore domain channel subfamily K member 12 (KCNK12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu01067	NM_022055.1	Homo sapiens potassium two pore domain channel subfamily K member 12 (KCNK12), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$251.30 $359.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNK12 ( NM_022055.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_071338.1 Homo sapiens potassium two pore domain channel subfamily K member 12 (KCNK12), mRNA.

Price & Availability↑

CloneID	OHu01067
Clone ID Related Accession (Same CDS sequence)	NM_022055.2 , NM_022055.1
Accession Version	NM_022055.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC138655.1. On Jul 23, 2019 this sequence version replaced NM_022055.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AF287302.1, BC047749.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCTCCC GCAGCCCCCG GCCCCCGCCC CGCCGTAGCC GCCGCCGCCT GCCGCGCCCC 
TCCTGCTGCT GCTGCTGCTG CCGCCGTTCG CACCTCAACG AGGACACCGG CCGCTTCGTG 
CTGCTGGCGG CGCTCATCGG CCTCTACCTG GTGGCGGGTG CCACAGTCTT CTCGGCGCTC 
GAGAGCCCCG GCGAGGCGGA GGCGCGGGCG CGCTGGGGCG CCACGCTGCG CAACTTCAGC 
GCTGCGCACG GCGTGGCCGA GCCAGAGCTG CGCGCCTTCC TCCGGCACTA CGAGGCCGCG 
CTGGCCGCCG GCGTCCGCGC CGACGCGCTG CGCCCGCGCT GGGACTTCCC CGGCGCCTTC 
TACTTCGTGG GCACCGTGGT GTCAACCATA GGTTTCGGCA TGACCACCCC CGCGACGGTG 
GGCGGGAAGG CCTTCCTCAT CGCCTACGGG CTGTTCGGCT GCGCTGGGAC CATCCTGTTC 
TTCAACCTCT TCCTGGAGCG CATCATCTCG CTGCTGGCCT TCATCATGCG CGCCTGCCGG 
GAGCGCCAGC TGCGCCGCAG CGGCCTGCTG CCCGCCACCT TCCGCCGCGG CTCCGCGCTC 
TCGGAGGCCG ACAGCCTGGC GGGCTGGAAG CCCTCGGTGT ACCACGTGCT GCTCATCCTG 
GGCCTGTTCG CCGTGCTGCT GTCCTGCTGC GCCTCGGCCA TGTACACCAG CGTGGAGGGC 
TGGGACTACG TGGACTCGCT CTACTTCTGC TTCGTCACCT TCAGCACCAT CGGCTTCGGG 
GACCTGGTGA GCAGCCAGCA CGCCGCCTAC CGGAACCAGG GGCTCTACCG CCTGGGCAAC 
TTCCTCTTCA TCCTGCTCGG CGTGTGCTGC ATTTACTCGC TCTTCAACGT CATCTCCATC 
CTCATCAAGC AGGTGCTCAA CTGGATGCTG CGCAAGCTGA GCTGCCGCTG CTGCGCGCGC 
TGCTGCCCGG CTCCTGGCGC GCCCCTGGCC CGGCGCAATG CCATCACCCC AGGCTCCCGG 
CTGCGCCGCC GCCTGGCCGC GCTCGGTGCC GACCCCGCGG CCCGCGACAG CGACGCCGAG 
GGCCGCCGCC TCTCGGGCGA GCTCATCTCC ATGCGCGACC TCACGGCCTC CAACAAGGTG 
TCGCTGGCGC TGCTGCAGAA GCAGCTGTCG GAGACGGCCA ACGGCTACCC GCGCAGCGTG 
TGCGTCAACA CGCGCCAGAA CGGCTTCTCG GGCGGCGTGG GCGCGCTGGG CATCATGAAC 
AACCGGCTGG CCGAGACCAG CGCCTCCAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071338.1
CDS	655..1947
Translation	MSSRSPRPPPRRSRRRLPRPSCCCCCCRRSHLNEDTGRFVLLAALIGLYLVAGATVFSALESPGEAEARARWGATLRNFSAAHGVAEPELRAFLRHYEAALAAGVRADALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILFFNLFLERIISLLAFIMRACRERQLRRSGLLPATFRRGSALSEADSLAGWKPSVYHVLLILGLFAVLLSCCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDLVSSQHAAYRNQGLYRLGNFLFILLGVCCIYSLFNVISILIKQVLNWMLRKLSCRCCARCCPAPGAPLARRNAITPGSRLRRRLAALGADPAARDSDAEGRRLSGELISMRDLTASNKVSLALLQKQLSETANGYPRSVCVNTRQNGFSGGVGALGIMNNRLAETSASR

Target ORF information:

RefSeq Version	NM_022055.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 12 (KCNK12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022055.2

ORF Insert Sequence:

ATGTCCTCCC GCAGCCCCCG GCCCCCGCCC CGCCGTAGCC GCCGCCGCCT GCCGCGCCCC 
TCCTGCTGCT GCTGCTGCTG CCGCCGTTCG CACCTCAACG AGGACACCGG CCGCTTCGTG 
CTGCTGGCGG CGCTCATCGG CCTCTACCTG GTGGCGGGTG CCACAGTCTT CTCGGCGCTC 
GAGAGCCCCG GCGAGGCGGA GGCGCGGGCG CGCTGGGGCG CCACGCTGCG CAACTTCAGC 
GCTGCGCACG GCGTGGCCGA GCCAGAGCTG CGCGCCTTCC TCCGGCACTA CGAGGCCGCG 
CTGGCCGCCG GCGTCCGCGC CGACGCGCTG CGCCCGCGCT GGGACTTCCC CGGCGCCTTC 
TACTTCGTGG GCACCGTGGT GTCAACCATA GGTTTCGGCA TGACCACCCC CGCGACGGTG 
GGCGGGAAGG CCTTCCTCAT CGCCTACGGG CTGTTCGGCT GCGCTGGGAC CATCCTGTTC 
TTCAACCTCT TCCTGGAGCG CATCATCTCG CTGCTGGCCT TCATCATGCG CGCCTGCCGG 
GAGCGCCAGC TGCGCCGCAG CGGCCTGCTG CCCGCCACCT TCCGCCGCGG CTCCGCGCTC 
TCGGAGGCCG ACAGCCTGGC GGGCTGGAAG CCCTCGGTGT ACCACGTGCT GCTCATCCTG 
GGCCTGTTCG CCGTGCTGCT GTCCTGCTGC GCCTCGGCCA TGTACACCAG CGTGGAGGGC 
TGGGACTACG TGGACTCGCT CTACTTCTGC TTCGTCACCT TCAGCACCAT CGGCTTCGGG 
GACCTGGTGA GCAGCCAGCA CGCCGCCTAC CGGAACCAGG GGCTCTACCG CCTGGGCAAC 
TTCCTCTTCA TCCTGCTCGG CGTGTGCTGC ATTTACTCGC TCTTCAACGT CATCTCCATC 
CTCATCAAGC AGGTGCTCAA CTGGATGCTG CGCAAGCTGA GCTGCCGCTG CTGCGCGCGC 
TGCTGCCCGG CTCCTGGCGC GCCCCTGGCC CGGCGCAATG CCATCACCCC AGGCTCCCGG 
CTGCGCCGCC GCCTGGCCGC GCTCGGTGCC GACCCCGCGG CCCGCGACAG CGACGCCGAG 
GGCCGCCGCC TCTCGGGCGA GCTCATCTCC ATGCGCGACC TCACGGCCTC CAACAAGGTG 
TCGCTGGCGC TGCTGCAGAA GCAGCTGTCG GAGACGGCCA ACGGCTACCC GCGCAGCGTG 
TGCGTCAACA CGCGCCAGAA CGGCTTCTCG GGCGGCGTGG GCGCGCTGGG CATCATGAAC 
AACCGGCTGG CCGAGACCAG CGCCTCCAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNK12 ( NM_022055.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_071338.1 Homo sapiens potassium two pore domain channel subfamily K member 12 (KCNK12), mRNA.

Price & Availability↑

CloneID	OHu01067
Clone ID Related Accession (Same CDS sequence)	NM_022055.2 , NM_022055.1
Accession Version	NM_022055.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1293bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	potassium channel subfamily K member 12
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF287302.1. ##Evidence-Data-START## Transcript exon combination :: AF287302.1, BC047749.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCCTCCC GCAGCCCCCG GCCCCCGCCC CGCCGTAGCC GCCGCCGCCT GCCGCGCCCC 
TCCTGCTGCT GCTGCTGCTG CCGCCGTTCG CACCTCAACG AGGACACCGG CCGCTTCGTG 
CTGCTGGCGG CGCTCATCGG CCTCTACCTG GTGGCGGGTG CCACAGTCTT CTCGGCGCTC 
GAGAGCCCCG GCGAGGCGGA GGCGCGGGCG CGCTGGGGCG CCACGCTGCG CAACTTCAGC 
GCTGCGCACG GCGTGGCCGA GCCAGAGCTG CGCGCCTTCC TCCGGCACTA CGAGGCCGCG 
CTGGCCGCCG GCGTCCGCGC CGACGCGCTG CGCCCGCGCT GGGACTTCCC CGGCGCCTTC 
TACTTCGTGG GCACCGTGGT GTCAACCATA GGTTTCGGCA TGACCACCCC CGCGACGGTG 
GGCGGGAAGG CCTTCCTCAT CGCCTACGGG CTGTTCGGCT GCGCTGGGAC CATCCTGTTC 
TTCAACCTCT TCCTGGAGCG CATCATCTCG CTGCTGGCCT TCATCATGCG CGCCTGCCGG 
GAGCGCCAGC TGCGCCGCAG CGGCCTGCTG CCCGCCACCT TCCGCCGCGG CTCCGCGCTC 
TCGGAGGCCG ACAGCCTGGC GGGCTGGAAG CCCTCGGTGT ACCACGTGCT GCTCATCCTG 
GGCCTGTTCG CCGTGCTGCT GTCCTGCTGC GCCTCGGCCA TGTACACCAG CGTGGAGGGC 
TGGGACTACG TGGACTCGCT CTACTTCTGC TTCGTCACCT TCAGCACCAT CGGCTTCGGG 
GACCTGGTGA GCAGCCAGCA CGCCGCCTAC CGGAACCAGG GGCTCTACCG CCTGGGCAAC 
TTCCTCTTCA TCCTGCTCGG CGTGTGCTGC ATTTACTCGC TCTTCAACGT CATCTCCATC 
CTCATCAAGC AGGTGCTCAA CTGGATGCTG CGCAAGCTGA GCTGCCGCTG CTGCGCGCGC 
TGCTGCCCGG CTCCTGGCGC GCCCCTGGCC CGGCGCAATG CCATCACCCC AGGCTCCCGG 
CTGCGCCGCC GCCTGGCCGC GCTCGGTGCC GACCCCGCGG CCCGCGACAG CGACGCCGAG 
GGCCGCCGCC TCTCGGGCGA GCTCATCTCC ATGCGCGACC TCACGGCCTC CAACAAGGTG 
TCGCTGGCGC TGCTGCAGAA GCAGCTGTCG GAGACGGCCA ACGGCTACCC GCGCAGCGTG 
TGCGTCAACA CGCGCCAGAA CGGCTTCTCG GGCGGCGTGG GCGCGCTGGG CATCATGAAC 
AACCGGCTGG CCGAGACCAG CGCCTCCAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_071338.1
CDS	1..1293
Translation	MSSRSPRPPPRRSRRRLPRPSCCCCCCRRSHLNEDTGRFVLLAALIGLYLVAGATVFSALESPGEAEARARWGATLRNFSAAHGVAEPELRAFLRHYEAALAAGVRADALRPRWDFPGAFYFVGTVVSTIGFGMTTPATVGGKAFLIAYGLFGCAGTILFFNLFLERIISLLAFIMRACRERQLRRSGLLPATFRRGSALSEADSLAGWKPSVYHVLLILGLFAVLLSCCASAMYTSVEGWDYVDSLYFCFVTFSTIGFGDLVSSQHAAYRNQGLYRLGNFLFILLGVCCIYSLFNVISILIKQVLNWMLRKLSCRCCARCCPAPGAPLARRNAITPGSRLRRRLAALGADPAARDSDAEGRRLSGELISMRDLTASNKVSLALLQKQLSETANGYPRSVCVNTRQNGFSGGVGALGIMNNRLAETSASR

Target ORF information:

RefSeq Version	NM_022055.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium two pore domain channel subfamily K member 12 (KCNK12), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_022055.1

ORF Insert Sequence:

ATGTCCTCCC GCAGCCCCCG GCCCCCGCCC CGCCGTAGCC GCCGCCGCCT GCCGCGCCCC 
TCCTGCTGCT GCTGCTGCTG CCGCCGTTCG CACCTCAACG AGGACACCGG CCGCTTCGTG 
CTGCTGGCGG CGCTCATCGG CCTCTACCTG GTGGCGGGTG CCACAGTCTT CTCGGCGCTC 
GAGAGCCCCG GCGAGGCGGA GGCGCGGGCG CGCTGGGGCG CCACGCTGCG CAACTTCAGC 
GCTGCGCACG GCGTGGCCGA GCCAGAGCTG CGCGCCTTCC TCCGGCACTA CGAGGCCGCG 
CTGGCCGCCG GCGTCCGCGC CGACGCGCTG CGCCCGCGCT GGGACTTCCC CGGCGCCTTC 
TACTTCGTGG GCACCGTGGT GTCAACCATA GGTTTCGGCA TGACCACCCC CGCGACGGTG 
GGCGGGAAGG CCTTCCTCAT CGCCTACGGG CTGTTCGGCT GCGCTGGGAC CATCCTGTTC 
TTCAACCTCT TCCTGGAGCG CATCATCTCG CTGCTGGCCT TCATCATGCG CGCCTGCCGG 
GAGCGCCAGC TGCGCCGCAG CGGCCTGCTG CCCGCCACCT TCCGCCGCGG CTCCGCGCTC 
TCGGAGGCCG ACAGCCTGGC GGGCTGGAAG CCCTCGGTGT ACCACGTGCT GCTCATCCTG 
GGCCTGTTCG CCGTGCTGCT GTCCTGCTGC GCCTCGGCCA TGTACACCAG CGTGGAGGGC 
TGGGACTACG TGGACTCGCT CTACTTCTGC TTCGTCACCT TCAGCACCAT CGGCTTCGGG 
GACCTGGTGA GCAGCCAGCA CGCCGCCTAC CGGAACCAGG GGCTCTACCG CCTGGGCAAC 
TTCCTCTTCA TCCTGCTCGG CGTGTGCTGC ATTTACTCGC TCTTCAACGT CATCTCCATC 
CTCATCAAGC AGGTGCTCAA CTGGATGCTG CGCAAGCTGA GCTGCCGCTG CTGCGCGCGC 
TGCTGCCCGG CTCCTGGCGC GCCCCTGGCC CGGCGCAATG CCATCACCCC AGGCTCCCGG 
CTGCGCCGCC GCCTGGCCGC GCTCGGTGCC GACCCCGCGG CCCGCGACAG CGACGCCGAG 
GGCCGCCGCC TCTCGGGCGA GCTCATCTCC ATGCGCGACC TCACGGCCTC CAACAAGGTG 
TCGCTGGCGC TGCTGCAGAA GCAGCTGTCG GAGACGGCCA ACGGCTACCC GCGCAGCGTG 
TGCGTCAACA CGCGCCAGAA CGGCTTCTCG GGCGGCGTGG GCGCGCTGGG CATCATGAAC 
AACCGGCTGG CCGAGACCAG CGCCTCCAGG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels.
The Journal of biological chemistry289(41)28202-12(2014 Oct)
Blin S,Chatelain FC,Feliciangeli S,Kang D,Lesage F,Bichet D

Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.
The Journal of biological chemistry288(49)35081-92(2013 Dec)
Chatelain FC,Bichet D,Feliciangeli S,Larroque MM,Braud VM,Douguet D,Lesage F

Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.
The Journal of investigative dermatology130(3)798-803(2010 Mar)
Birlea SA,Gowan K,Fain PR,Spritz RA

A high-density association screen of 155 ion transport genes for involvement with common migraine.
Human molecular genetics17(21)3318-31(2008 Nov)
Nyholt DR,LaForge KS,Kallela M,Alakurtti K,Anttila V,F?rkkil? M,H?mal?inen E,Kaprio J,Kaunisto MA,Heath AC,Montgomery GW,G?bel H,Todt U,Ferrari MD,Launer LJ,Frants RR,Terwindt GM,de Vries B,Verschuren WM,Brand J,Freilinger T,Pfaffenrath V,Straube A,Ballinger DG,Zhan Y,Daly MJ,Cox DR,Dichgans M,van den Maagdenberg AM,Kubisch C,Martin NG,Wessman M,Peltonen L,Palotie A

Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology21(1-3)63-74(2008)
Theilig F,Goranova I,Hirsch JR,Wieske M,Unsal S,Bachmann S,Veh RW,Derst C

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KCNK12 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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