POLE4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	POLE4
Entrez Gene ID	56655
Full Name	DNA polymerase epsilon 4, accessory subunit
Synonyms	YHHQ1,p12
General protein information	Preferred Names DNA polymerase epsilon 4, accessory subunit Names DNA polymerase epsilon subunit 4 DNA polymerase II subunit 4 DNA polymerase epsilon subunit p12 polymerase (DNA) epsilon 4, accessory subunit polymerase (DNA-directed), epsilon 4, accessory subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p12
Summary	POLE4 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM, Apr 2004].
Disorder MIM:	607269

mRNA and Protein(s)

mRNA	Protein	Name
NM_019896.3	NP_063949.2	DNA polymerase epsilon subunit 4
NM_019896.2	NP_063949.2	DNA polymerase epsilon subunit 4
NM_019896.4	NP_063949.2	DNA polymerase epsilon subunit 4

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	POLE4	XP_003949865.1
	POLE4	XP_001111739.1
Bos taurus (cattle)	POLE4	NP_001094695.1
Danio rerio (zebrafish)	zgc:110337	XP_005155767.1
Homo sapiens (human)	POLE4	NP_063949.2
Canis lupus familiaris (dog)	POLE4	XP_540212.3
Mus musculus (house mouse)	Pole4	NP_080158.1
Rattus norvegicus (Norway rat)	Pole4	NP_001102104.1
Xenopus tropicalis (tropical clawed frog)	pole4	NP_001016605.1

Gene Ontology
Bibliography

Related articles in PubMed

Global landscape of HIV-human protein complexes.
J?ger S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M, Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J, Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A, Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK, Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel AD, Krogan NJ
Nature481(7381)365-70(2011 Dec)

Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.
Wang YL, Faiola F, Xu M, Pan S, Martinez E
The Journal of biological chemistry283(49)33808-15(2008 Dec)

Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.
Li Y, Pursell ZF, Linn S
The Journal of biological chemistry275(30)23247-52(2000 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following POLE4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POLE4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29522	NM_019896.4 Latest version!	Homo sapiens DNA polymerase epsilon 4, accessory subunit (POLE4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29522	NM_019896.2	Homo sapiens polymerase (DNA-directed), epsilon 4, accessory subunit (POLE4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu29522	NM_019896.3	Homo sapiens DNA polymerase epsilon 4, accessory subunit (POLE4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

POLE4 ( NM_019896.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_063949.2 Homo sapiens DNA polymerase epsilon 4, accessory subunit (POLE4), mRNA.

Price & Availability↑

CloneID	OHu29522
Clone ID Related Accession (Same CDS sequence)	NM_019896.3 , NM_019896.2 , NM_019896.4
Accession Version	NM_019896.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	DNA polymerase epsilon subunit 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU594966.1, BC031331.1 and AC007400.4. On Jan 19, 2017 this sequence version replaced NM_019896.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.209716.1, SRR1163657.468416.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCGGCGGC AGGAAGCGGG ACGCCCCGAG AGGAGGAGGG ACCTGCTGGG 
GAGGCAGCGG CCTCGCAGCC CCAGGCCCCA ACGAGTGTGC CTGGGGCTCG TCTCTCGAGG 
TTGCCTCTGG CGCGAGTGAA GGCCTTGGTG AAGGCAGATC CCGACGTGAC GCTAGCGGGA 
CAGGAAGCCA TCTTCATTCT GGCACGAGCC GCGGAACTGT TTGTGGAGAC CATTGCAAAA 
GATGCCTACT GTTGCGCTCA GCAGGGAAAA AGGAAAACCC TTCAGAGGAG AGACTTGGAT 
AATGCAATAG AAGCTGTGGA TGAATTTGCT TTTCTGGAAG GTACTTTAGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_063949.2
CDS	38..391
Translation	MAAAAAAGSGTPREEEGPAGEAAASQPQAPTSVPGARLSRLPLARVKALVKADPDVTLAGQEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD

Target ORF information:

RefSeq Version	NM_019896.3
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA polymerase epsilon 4, accessory subunit (POLE4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019896.3

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCGGC AGGAAGCGGG ACGCCCCGAG AGGAGGAGGG ACCTGCTGGG 
GAGGCAGCGG CCTCGCAGCC CCAGGCCCCA ACGAGTGTGC CTGGGGCTCG TCTCTCGAGG 
TTGCCTCTGG CGCGAGTGAA GGCCTTGGTG AAGGCAGATC CCGACGTGAC GCTAGCGGGA 
CAGGAAGCCA TCTTCATTCT GGCACGAGCC GCGGAACTGT TTGTGGAGAC CATTGCAAAA 
GATGCCTACT GTTGCGCTCA GCAGGGAAAA AGGAAAACCC TTCAGAGGAG AGACTTGGAT 
AATGCAATAG AAGCTGTGGA TGAATTTGCT TTTCTGGAAG GTACTTTAGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POLE4 ( NM_019896.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_063949.2 Homo sapiens polymerase (DNA-directed), epsilon 4, accessory subunit (POLE4), mRNA.

Price & Availability↑

CloneID	OHu29522
Clone ID Related Accession (Same CDS sequence)	NM_019896.3 , NM_019896.2 , NM_019896.4
Accession Version	NM_019896.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	DNA polymerase epsilon subunit 4
Comment

ATGGCGGCGG CGGCGGCGGC AGGAAGCGGG ACGCCCCGAG AGGAGGAGGG ACCTGCTGGG 
GAGGCAGCGG CCTCGCAGCC CCAGGCCCCA ACGAGTGTGC CTGGGGCTCG TCTCTCGAGG 
TTGCCTCTGG CGCGAGTGAA GGCCTTGGTG AAGGCAGATC CCGACGTGAC GCTAGCGGGA 
CAGGAAGCCA TCTTCATTCT GGCACGAGCC GCGGAACTGT TTGTGGAGAC CATTGCAAAA 
GATGCCTACT GTTGCGCTCA GCAGGGAAAA AGGAAAACCC TTCAGAGGAG AGACTTGGAT 
AATGCAATAG AAGCTGTGGA TGAATTTGCT TTTCTGGAAG GTACTTTAGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_063949.2
Translation	MAAAAAAGSGTPREEEGPAGEAAASQPQAPTSVPGARLSRLPLARVKALVKADPDVTLAGQEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD

Target ORF information:

RefSeq Version	NM_019896.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens polymerase (DNA-directed), epsilon 4, accessory subunit (POLE4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019896.2

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCGGC AGGAAGCGGG ACGCCCCGAG AGGAGGAGGG ACCTGCTGGG 
GAGGCAGCGG CCTCGCAGCC CCAGGCCCCA ACGAGTGTGC CTGGGGCTCG TCTCTCGAGG 
TTGCCTCTGG CGCGAGTGAA GGCCTTGGTG AAGGCAGATC CCGACGTGAC GCTAGCGGGA 
CAGGAAGCCA TCTTCATTCT GGCACGAGCC GCGGAACTGT TTGTGGAGAC CATTGCAAAA 
GATGCCTACT GTTGCGCTCA GCAGGGAAAA AGGAAAACCC TTCAGAGGAG AGACTTGGAT 
AATGCAATAG AAGCTGTGGA TGAATTTGCT TTTCTGGAAG GTACTTTAGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POLE4 ( NM_019896.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_063949.2 Homo sapiens DNA polymerase epsilon 4, accessory subunit (POLE4), mRNA.

Price & Availability↑

CloneID	OHu29522
Clone ID Related Accession (Same CDS sequence)	NM_019896.3 , NM_019896.2 , NM_019896.4
Accession Version	NM_019896.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 354bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	DNA polymerase epsilon subunit 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU594966.1, BC031331.1 and AC007400.4. On May 17, 2019 this sequence version replaced NM_019896.3. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.204463.1, SRR7410570.204464.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000483063.2/ ENSP00000420176.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGG CGGCGGCGGC AGGAAGCGGG ACGCCCCGAG AGGAGGAGGG ACCTGCTGGG 
GAGGCAGCGG CCTCGCAGCC CCAGGCCCCA ACGAGTGTGC CTGGGGCTCG TCTCTCGAGG 
TTGCCTCTGG CGCGAGTGAA GGCCTTGGTG AAGGCAGATC CCGACGTGAC GCTAGCGGGA 
CAGGAAGCCA TCTTCATTCT GGCACGAGCC GCGGAACTGT TTGTGGAGAC CATTGCAAAA 
GATGCCTACT GTTGCGCTCA GCAGGGAAAA AGGAAAACCC TTCAGAGGAG AGACTTGGAT 
AATGCAATAG AAGCTGTGGA TGAATTTGCT TTTCTGGAAG GTACTTTAGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_063949.2
CDS	38..391
Translation	MAAAAAAGSGTPREEEGPAGEAAASQPQAPTSVPGARLSRLPLARVKALVKADPDVTLAGQEAIFILARAAELFVETIAKDAYCCAQQGKRKTLQRRDLDNAIEAVDEFAFLEGTLD

Target ORF information:

RefSeq Version	NM_019896.4
Organism	Homo sapiens(human)
Definition	Homo sapiens DNA polymerase epsilon 4, accessory subunit (POLE4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_019896.4

ORF Insert Sequence:

ATGGCGGCGG CGGCGGCGGC AGGAAGCGGG ACGCCCCGAG AGGAGGAGGG ACCTGCTGGG 
GAGGCAGCGG CCTCGCAGCC CCAGGCCCCA ACGAGTGTGC CTGGGGCTCG TCTCTCGAGG 
TTGCCTCTGG CGCGAGTGAA GGCCTTGGTG AAGGCAGATC CCGACGTGAC GCTAGCGGGA 
CAGGAAGCCA TCTTCATTCT GGCACGAGCC GCGGAACTGT TTGTGGAGAC CATTGCAAAA 
GATGCCTACT GTTGCGCTCA GCAGGGAAAA AGGAAAACCC TTCAGAGGAG AGACTTGGAT 
AATGCAATAG AAGCTGTGGA TGAATTTGCT TTTCTGGAAG GTACTTTAGA TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Global landscape of HIV-human protein complexes.
Nature481(7381)365-70(2011 Dec)
J?ger S,Cimermancic P,Gulbahce N,Johnson JR,McGovern KE,Clarke SC,Shales M,Mercenne G,Pache L,Li K,Hernandez H,Jang GM,Roth SL,Akiva E,Marlett J,Stephens M,D'Orso I,Fernandes J,Fahey M,Mahon C,O'Donoghue AJ,Todorovic A,Morris JH,Maltby DA,Alber T,Cagney G,Bushman FD,Young JA,Chanda SK,Sundquist WI,Kortemme T,Hernandez RD,Craik CS,Burlingame A,Sali A,Frankel AD,Krogan NJ

Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.
The Journal of biological chemistry283(49)33808-15(2008 Dec)
Wang YL,Faiola F,Xu M,Pan S,Martinez E

Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.
The Journal of biological chemistry275(30)23247-52(2000 Jul)
Li Y,Pursell ZF,Linn S

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POLE4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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