PRSS1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PRSS1
Entrez Gene ID	5644
Full Name	serine protease 1
Synonyms	TRP1,TRY1,TRY4,TRYP1
General protein information	Preferred Names serine protease 1 Names trypsin-1 TCR V beta 4.1 beta-trypsin cationic trypsinogen digestive zymogen nonfunctional trypsin 1 protease, serine 1 trypsinogen 1 trypsinogen A
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q34
Summary	This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].
Disorder MIM:	276000
Disorder Html:	Pancreatitis, hereditary, 167800 (3); Trypsinogen deficiency, 614044 (1)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002769.4	NP_002760.1	trypsin-1 preproprotein
XM_011516411.1	XP_011514713.1	trypsin-1 isoform X1
NM_002769.5	NP_002760.1	trypsin-1 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	LOC742453	XP_003951210.1
Homo sapiens (human)	PRSS1	NP_002760.1
Mus musculus (house mouse)	Try10	NP_001034085.1
Pan troglodytes (chimpanzee)	LOC100615987	XP_003318897.1
Drosophila melanogaster (fruit fly)	CG10663	NP_001097592.1
	PRSS1	NP_001040586.1

Gene Ontology
Bibliography

Related articles in PubMed

Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.
Campa D, Pastore M, Capurso G, Hackert T, Di Leo M, Izbicki JR, Khaw KT, Gioffreda D, Kupcinskas J, Pasquali C, Macinga P, Kaaks R, Stigliano S, Peeters PH, Key TJ, Talar-Wojnarowska R, Vodicka P, Valente R, Vashist YK, Salvia R, Papaconstantinou I, Shimizu Y, Valsuani C, Zambon CF, Gazouli M, Valantiene I, Niesen W, Mohelnikova-Duchonova B, Hara K, Soucek P, Malecka-Panas E, Bueno-de-Mesquita HBA, Johnson T, Brenner H, Tavano F, Fogar P, Ito H, Sperti C, Butterbach K, Latiano A, Andriulli A, Cavestro GM, Busch ORC, Dijk F, Greenhalf W, Matsuo K, Lombardo C, Strobel O, K?nig AK, Cuk K, Strothmann H, Katzke V, Cantore M, Mambrini A, Oliverius M, Pezzilli R, Landi S, Canzian F
International journal of cancer142(2)290-296(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SNP in the PRSS1-PRSS2-rs10273639 is associated with Chronic pancreatitis.
Title: Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.

Early-onset pancreatitis is associated strongly with PRSS1 or CTRC mutations and family history of pancreatitis.
Title: Early-Onset Acute Recurrent and Chronic Pancreatitis Is Associated with PRSS1 or CTRC Gene Mutations.

These findings suggest that IL-1beta plays a key role in trypsin upregulation and has a pathological role in multiple organ failure in influenza virus infection.
Title: IL-1? is a key cytokine that induces trypsin upregulation in the influenza virus-cytokine-trypsin cycle.

Three types of pathogenic PRSS1 variants was identified in 11 patients, including p.N29I (n=1), p.R122H (n=1), and p.G208A (n=9).
Title: PRSS1, SPINK1, CFTR, and CTRC Pathogenic Variants in Korean Patients With Idiopathic Pancreatitis.

Results identified 3 new rare variants in the proximal promoter region of PRSS1 which along the known c.-30_-28delTCC do not seem to be a risk factors for chronic pancreatitis.
Title: Discovery and Functional Annotation of PRSS1 Promoter Variants in Chronic Pancreatitis.

The following PRSS1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PRSS1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19842	NM_002769.5 Latest version!	Homo sapiens serine protease 1 (PRSS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu59966	XM_011516411.1 Latest version!	Homo sapiens serine protease 1 (PRSS1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu19842	NM_002769.4	Homo sapiens protease, serine 1 (PRSS1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PRSS1 ( NM_002769.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002760.1 Homo sapiens protease, serine 1 (PRSS1), mRNA.

Price & Availability↑

CloneID	OHu19842
Clone ID Related Accession (Same CDS sequence)	NM_002769.4 , NM_002769.5
Accession Version	NM_002769.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	trypsin-1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP321999.1, BC128226.1 and CA948204.1. This sequence is a reference standard in the RefSeqGene project. On Nov 3, 2010 this sequence version replaced NM_002769.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CA772083.1, CA777765.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAATCCAC TCCTGATCCT TACCTTTGTG GCAGCTGCTC TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACAACTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
CTGAATTCTG GCTACCACTT CTGTGGTGGC TCCCTCATCA ACGAACAGTG GGTGGTATCA 
GCAGGCCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC 
CTGGAGGGGA ATGAGCAGTT CATCAATGCA GCCAAGATCA TCCGCCACCC CCAATACGAC 
AGGAAGACTC TGAACAATGA CATCATGTTA ATCAAGCTCT CCTCACGTGC AGTAATCAAC 
GCCCGCGTGT CCACCATCTC TCTGCCCACC GCCCCTCCAG CCACTGGCAC GAAGTGCCTC 
ATCTCTGGCT GGGGCAACAC TGCGAGCTCT GGCGCCGACT ACCCAGACGA GCTGCAGTGC 
CTGGATGCTC CTGTGCTGAG CCAGGCTAAG TGTGAAGCCT CCTACCCTGG AAAGATTACC 
AGCAACATGT TCTGTGTGGG CTTCCTTGAG GGAGGCAAGG ATTCATGTCA GGGTGATTCT 
GGTGGCCCTG TGGTCTGCAA TGGACAGCTC CAAGGAGTTG TCTCCTGGGG TGATGGCTGT 
GCCCAGAAGA ACAAGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGAA ATGGATTAAG 
AACACCATAG CTGCCAATAG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002760.1
CDS	18..761
Translation	MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS

Target ORF information:

RefSeq Version	NM_002769.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protease, serine 1 (PRSS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002769.4

ORF Insert Sequence:

ATGAATCCAC TCCTGATCCT TACCTTTGTG GCAGCTGCTC TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACAACTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
CTGAATTCTG GCTACCACTT CTGTGGTGGC TCCCTCATCA ACGAACAGTG GGTGGTATCA 
GCAGGCCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC 
CTGGAGGGGA ATGAGCAGTT CATCAATGCA GCCAAGATCA TCCGCCACCC CCAATACGAC 
AGGAAGACTC TGAACAATGA CATCATGTTA ATCAAGCTCT CCTCACGTGC AGTAATCAAC 
GCCCGCGTGT CCACCATCTC TCTGCCCACC GCCCCTCCAG CCACTGGCAC GAAGTGCCTC 
ATCTCTGGCT GGGGCAACAC TGCGAGCTCT GGCGCCGACT ACCCAGACGA GCTGCAGTGC 
CTGGATGCTC CTGTGCTGAG CCAGGCTAAG TGTGAAGCCT CCTACCCTGG AAAGATTACC 
AGCAACATGT TCTGTGTGGG CTTCCTTGAG GGAGGCAAGG ATTCATGTCA GGGTGATTCT 
GGTGGCCCTG TGGTCTGCAA TGGACAGCTC CAAGGAGTTG TCTCCTGGGG TGATGGCTGT 
GCCCAGAAGA ACAAGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGAA ATGGATTAAG 
AACACCATAG CTGCCAATAG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS1 ( NM_002769.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002760.1 Homo sapiens serine protease 1 (PRSS1), mRNA.

Price & Availability↑

CloneID	OHu19842
Clone ID Related Accession (Same CDS sequence)	NM_002769.4 , NM_002769.5
Accession Version	NM_002769.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 744bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-15
Organism	Homo sapiens(human)
Product	trypsin-1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP321999.1, BC128226.1 and CA948204.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_002769.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC128226.1, M22612.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311737.12/ ENSP00000308720.7 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAATCCAC TCCTGATCCT TACCTTTGTG GCAGCTGCTC TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACAACTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
CTGAATTCTG GCTACCACTT CTGTGGTGGC TCCCTCATCA ACGAACAGTG GGTGGTATCA 
GCAGGCCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC 
CTGGAGGGGA ATGAGCAGTT CATCAATGCA GCCAAGATCA TCCGCCACCC CCAATACGAC 
AGGAAGACTC TGAACAATGA CATCATGTTA ATCAAGCTCT CCTCACGTGC AGTAATCAAC 
GCCCGCGTGT CCACCATCTC TCTGCCCACC GCCCCTCCAG CCACTGGCAC GAAGTGCCTC 
ATCTCTGGCT GGGGCAACAC TGCGAGCTCT GGCGCCGACT ACCCAGACGA GCTGCAGTGC 
CTGGATGCTC CTGTGCTGAG CCAGGCTAAG TGTGAAGCCT CCTACCCTGG AAAGATTACC 
AGCAACATGT TCTGTGTGGG CTTCCTTGAG GGAGGCAAGG ATTCATGTCA GGGTGATTCT 
GGTGGCCCTG TGGTCTGCAA TGGACAGCTC CAAGGAGTTG TCTCCTGGGG TGATGGCTGT 
GCCCAGAAGA ACAAGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGAA ATGGATTAAG 
AACACCATAG CTGCCAATAG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002760.1
CDS	14..757
Translation	MNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS

Target ORF information:

RefSeq Version	NM_002769.5
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 1 (PRSS1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002769.5

ORF Insert Sequence:

ATGAATCCAC TCCTGATCCT TACCTTTGTG GCAGCTGCTC TTGCTGCCCC CTTTGATGAT 
GATGACAAGA TCGTTGGGGG CTACAACTGT GAGGAGAATT CTGTCCCCTA CCAGGTGTCC 
CTGAATTCTG GCTACCACTT CTGTGGTGGC TCCCTCATCA ACGAACAGTG GGTGGTATCA 
GCAGGCCACT GCTACAAGTC CCGCATCCAG GTGAGACTGG GAGAGCACAA CATCGAAGTC 
CTGGAGGGGA ATGAGCAGTT CATCAATGCA GCCAAGATCA TCCGCCACCC CCAATACGAC 
AGGAAGACTC TGAACAATGA CATCATGTTA ATCAAGCTCT CCTCACGTGC AGTAATCAAC 
GCCCGCGTGT CCACCATCTC TCTGCCCACC GCCCCTCCAG CCACTGGCAC GAAGTGCCTC 
ATCTCTGGCT GGGGCAACAC TGCGAGCTCT GGCGCCGACT ACCCAGACGA GCTGCAGTGC 
CTGGATGCTC CTGTGCTGAG CCAGGCTAAG TGTGAAGCCT CCTACCCTGG AAAGATTACC 
AGCAACATGT TCTGTGTGGG CTTCCTTGAG GGAGGCAAGG ATTCATGTCA GGGTGATTCT 
GGTGGCCCTG TGGTCTGCAA TGGACAGCTC CAAGGAGTTG TCTCCTGGGG TGATGGCTGT 
GCCCAGAAGA ACAAGCCTGG AGTCTACACC AAGGTCTACA ACTATGTGAA ATGGATTAAG 
AACACCATAG CTGCCAATAG CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PRSS1 ( XM_011516411.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011514713.1 Homo sapiens serine protease 1 (PRSS1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59966
Clone ID Related Accession (Same CDS sequence)	XM_011516411.1
Accession Version	XM_011516411.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	trypsin-1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTGAGTC TTCTGCTCCT TCTCCTGGGA CTAGGCTCTG TGTTCAGTGC TGTCATCTCT 
CAAAAGCCAA GCAGGGATAT CTGTCAACGT GGAACCTCCC TGACGATCCA GTGTCAAGTC 
GATAGCCAAG TCACCATGAT GTTCTGGTAC CGTCAGCAAC CTGGACAGAG CCTGACACTG 
ATCGCAACTG CAAATCAGGG CTCTGAGGCC ACATATGAGA GTGGATTTGT CATTGACAAG 
TTTCCCATCA GCCGCCCAAA CCTAACATTC TCAACTCTGA CTGTGAGCAA CATGAGCCCT 
GAAGACAGCA GCATATATCT CTGCAGCGTT GAAGACACAG TGCGGGGCAC AGATCAAAGA 
TCTGAGCAAG AACCTCAGCT CTCTCCTACC CAGCTCCTCT CACACGAGCC TGAAGGCCCT 
GCCAAGTATC CTTGCAGGAA ACAGCCGGTC TCGCTCTCTG CTCTCAGAAG GAAAGTTTCC 
TTATCACCTG TGAATCACAA ACCCAGAGAG TGGCCAAACA TAGCCAGGCT GATGCAAGAC 
CCTGGGAAGA GGAAAGCTGC AGGTGTGTTT GTGCTGGGAG GAGTGGTGAC CCTCACCTCA 
CAGTCACCTC CTCTCTGGAT CCTCGTGAGG TATAAAGACG AGTCCTCCAC CACCAGTCAG 
GCACACTCTA CCACCATGAA TCCACTCCTG ATCCTTACCT TTGTGGCAGC TGCTCTTGCT 
GCCCCCTTTG ATGATGATGA CAAGATCGTT GGGGGCTACA ACTGTGAGGA GAATTCTGTC 
CCCTACCAGG TGTCCCTGAA TTCTGGCTAC CACTTCTGTG GTGGCTCCCT CATCAACGAA 
CAGTGGGTGG TATCAGCAGG CCACTGCTAC AAGTCCCGCA TCCAGGTGAG ACTGGGAGAG 
CACAACATCG AAGTCCTGGA GGGGAATGAG CAGTTCATCA ATGCAGCCAA GATCATCCGC 
CACCCCCAAT ACGACAGGAA GACTCTGAAC AATGACATCA TGTTAATCAA GCTCTCCTCA 
CGTGCAGTAA TCAACGCCCG CGTGTCCACC ATCTCTCTGC CCACCGCCCC TCCAGCCACT 
GGCACGAAGT GCCTCATCTC TGGCTGGGGC AACACTGCGA GCTCTGGCGC CGACTACCCA 
GACGAGCTGC AGTGCCTGGA TGCTCCTGTG CTGAGCCAGG CTAAGTGTGA AGCCTCCTAC 
CCTGGAAAGA TTACCAGCAA CATGTTCTGT GTGGGCTTCC TTGAGGGAGG CAAGGATTCA 
TGTCAGGGTG ATTCTGGTGG CCCTGTGGTC TGCAATGGAC AGCTCCAAGG AGTTGTCTCC 
TGGGGTGATG GCTGTGCCCA GAAGAACAAG CCTGGAGTCT ACACCAAGGT CTACAACTAT 
GTGAAATGGA TTAAGAACAC CATAGCTGCC AATAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011514713.1
CDS	39..1457
Translation	MLSLLLLLLGLGSVFSAVISQKPSRDICQRGTSLTIQCQVDSQVTMMFWYRQQPGQSLTLIATANQGSEATYESGFVIDKFPISRPNLTFSTLTVSNMSPEDSSIYLCSVEDTVRGTDQRSEQEPQLSPTQLLSHEPEGPAKYPCRKQPVSLSALRRKVSLSPVNHKPREWPNIARLMQDPGKRKAAGVFVLGGVVTLTSQSPPLWILVRYKDESSTTSQAHSTTMNPLLILTFVAAALAAPFDDDDKIVGGYNCEENSVPYQVSLNSGYHFCGGSLINEQWVVSAGHCYKSRIQVRLGEHNIEVLEGNEQFINAAKIIRHPQYDRKTLNNDIMLIKLSSRAVINARVSTISLPTAPPATGTKCLISGWGNTASSGADYPDELQCLDAPVLSQAKCEASYPGKITSNMFCVGFLEGGKDSCQGDSGGPVVCNGQLQGVVSWGDGCAQKNKPGVYTKVYNYVKWIKNTIAANS

Target ORF information:

RefSeq Version	XM_011516411.1
Organism	Homo sapiens(human)
Definition	Homo sapiens serine protease 1 (PRSS1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011516411.1

ORF Insert Sequence:

ATGCTGAGTC TTCTGCTCCT TCTCCTGGGA CTAGGCTCTG TGTTCAGTGC TGTCATCTCT 
CAAAAGCCAA GCAGGGATAT CTGTCAACGT GGAACCTCCC TGACGATCCA GTGTCAAGTC 
GATAGCCAAG TCACCATGAT GTTCTGGTAC CGTCAGCAAC CTGGACAGAG CCTGACACTG 
ATCGCAACTG CAAATCAGGG CTCTGAGGCC ACATATGAGA GTGGATTTGT CATTGACAAG 
TTTCCCATCA GCCGCCCAAA CCTAACATTC TCAACTCTGA CTGTGAGCAA CATGAGCCCT 
GAAGACAGCA GCATATATCT CTGCAGCGTT GAAGACACAG TGCGGGGCAC AGATCAAAGA 
TCTGAGCAAG AACCTCAGCT CTCTCCTACC CAGCTCCTCT CACACGAGCC TGAAGGCCCT 
GCCAAGTATC CTTGCAGGAA ACAGCCGGTC TCGCTCTCTG CTCTCAGAAG GAAAGTTTCC 
TTATCACCTG TGAATCACAA ACCCAGAGAG TGGCCAAACA TAGCCAGGCT GATGCAAGAC 
CCTGGGAAGA GGAAAGCTGC AGGTGTGTTT GTGCTGGGAG GAGTGGTGAC CCTCACCTCA 
CAGTCACCTC CTCTCTGGAT CCTCGTGAGG TATAAAGACG AGTCCTCCAC CACCAGTCAG 
GCACACTCTA CCACCATGAA TCCACTCCTG ATCCTTACCT TTGTGGCAGC TGCTCTTGCT 
GCCCCCTTTG ATGATGATGA CAAGATCGTT GGGGGCTACA ACTGTGAGGA GAATTCTGTC 
CCCTACCAGG TGTCCCTGAA TTCTGGCTAC CACTTCTGTG GTGGCTCCCT CATCAACGAA 
CAGTGGGTGG TATCAGCAGG CCACTGCTAC AAGTCCCGCA TCCAGGTGAG ACTGGGAGAG 
CACAACATCG AAGTCCTGGA GGGGAATGAG CAGTTCATCA ATGCAGCCAA GATCATCCGC 
CACCCCCAAT ACGACAGGAA GACTCTGAAC AATGACATCA TGTTAATCAA GCTCTCCTCA 
CGTGCAGTAA TCAACGCCCG CGTGTCCACC ATCTCTCTGC CCACCGCCCC TCCAGCCACT 
GGCACGAAGT GCCTCATCTC TGGCTGGGGC AACACTGCGA GCTCTGGCGC CGACTACCCA 
GACGAGCTGC AGTGCCTGGA TGCTCCTGTG CTGAGCCAGG CTAAGTGTGA AGCCTCCTAC 
CCTGGAAAGA TTACCAGCAA CATGTTCTGT GTGGGCTTCC TTGAGGGAGG CAAGGATTCA 
TGTCAGGGTG ATTCTGGTGG CCCTGTGGTC TGCAATGGAC AGCTCCAAGG AGTTGTCTCC 
TGGGGTGATG GCTGTGCCCA GAAGAACAAG CCTGGAGTCT ACACCAAGGT CTACAACTAT 
GTGAAATGGA TTAAGAACAC CATAGCTGCC AATAGCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Do pancreatic cancer and chronic pancreatitis share the same genetic risk factors? A PANcreatic Disease ReseArch (PANDoRA) consortium investigation.
International journal of cancer142(2)290-296(2018 Jan)
Campa D,Pastore M,Capurso G,Hackert T,Di Leo M,Izbicki JR,Khaw KT,Gioffreda D,Kupcinskas J,Pasquali C,Macinga P,Kaaks R,Stigliano S,Peeters PH,Key TJ,Talar-Wojnarowska R,Vodicka P,Valente R,Vashist YK,Salvia R,Papaconstantinou I,Shimizu Y,Valsuani C,Zambon CF,Gazouli M,Valantiene I,Niesen W,Mohelnikova-Duchonova B,Hara K,Soucek P,Malecka-Panas E,Bueno-de-Mesquita HBA,Johnson T,Brenner H,Tavano F,Fogar P,Ito H,Sperti C,Butterbach K,Latiano A,Andriulli A,Cavestro GM,Busch ORC,Dijk F,Greenhalf W,Matsuo K,Lombardo C,Strobel O,K?nig AK,Cuk K,Strothmann H,Katzke V,Cantore M,Mambrini A,Oliverius M,Pezzilli R,Landi S,Canzian F

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PRSS1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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