THAP12 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	THAP12
Entrez Gene ID	5612
Full Name	THAP domain containing 12
Synonyms	DAP4,P52rIPK,PRKRIR,THAP0
General protein information	Preferred Names THAP domain containing 12 Names 52 kDa repressor of the inhibitor of the protein kinase 58 kDa interferon-induced protein kinase-interacting protein P58IPK-regulatory protein THAP domain-containing protein 0 THAP domain-containing protein 12 death-associated protein 4 inhibitor of protein kinase PKR p58IPK-interacting protein protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) testicular tissue protein Li 133
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q13.5
Disorder MIM:	607374

mRNA and Protein(s)

mRNA	Protein	Name
NM_004705.4	NP_004696.2	52 kDa repressor of the inhibitor of the protein kinase
NM_004705.3	NP_004696.2	52 kDa repressor of the inhibitor of the protein kinase

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Prkrir	NP_001178559.1
Gallus gallus (chicken)	PRKRIR	XP_425679.3
Pan troglodytes (chimpanzee)	PRKRIR	XP_003313264.1
	PRKRIR	XP_001086430.1
Bos taurus (cattle)	PRKRIR	NP_001179132.1
Mus musculus (house mouse)	Prkrir	NP_082686.1
Danio rerio (zebrafish)	prkrirb	NP_001002680.1
Homo sapiens (human)	PRKRIR	NP_004696.2
Canis lupus familiaris (dog)	PRKRIR	XP_542300.2
Xenopus tropicalis (tropical clawed frog)	prkrir	NP_989053.1

Gene Ontology
Bibliography

Related articles in PubMed

A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein.
Now H, Yoo JY
Biochemical and biophysical research communications413(3)487-93(2011 Sep)

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF, Goddard KA, Barreto ML, Reis MG, Teixeira MG
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
Johnatty SE, Beesley J, Chen X, Macgregor S, Duffy DL, Spurdle AB, deFazio A, Gava N, Webb PM, Rossing MA, Doherty JA, Goodman MT, Lurie G, Thompson PJ, Wilkens LR, Ness RB, Moysich KB, Chang-Claude J, Wang-Gohrke S, Cramer DW, Terry KL, Hankinson SE, Tworoger SS, Garcia-Closas M, Yang H, Lissowska J, Chanock SJ, Pharoah PD, Song H, Whitemore AS, Pearce CL, Stram DO, Wu AH, Pike MC, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Anton-Culver H, Ziogas A, Hogdall E, Kjaer SK, Hogdall C, Berchuck A, Schildkraut JM, Iversen ES, Moorman PG, Phelan CM, Sellers TA, Cunningham JM, Vierkant RA, Rider DN, Goode EL, Haviv I, Chenevix-Trench G, , ,
PLoS genetics6(7)e1001016(2010 Jul)

A census of human transcription factors: function, expression and evolution.
Vaquerizas JM, Kummerfeld SK, Teichmann SA, Luscombe NM
Nature reviews. Genetics10(4)252-63(2009 04)

The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity.
Clouaire T, Roussigne M, Ecochard V, Mathe C, Amalric F, Girard JP
Proceedings of the National Academy of Sciences of the United States of America102(19)6907-12(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PRKRIR provides a novel positive regulator controlling the RIG-I-IFN production system through protein stability control.
Title: A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein.

Observational study of gene-disease association. (HuGE Navigator)
Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1.

Meta-analysis of gene-disease association. (HuGE Navigator)
Title: Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".

role in promoting MST1-induced apoptosis by enabling colocalization of MST with p53
Title: Death-associated protein 4 binds MST1 and augments MST1-induced apoptosis.

The following THAP12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the THAP12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04554	NM_004705.4 Latest version!	Homo sapiens THAP domain containing 12 (THAP12), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
View Old Accession Versions >>
OHu04554	NM_004705.3	Homo sapiens THAP domain containing 12 (THAP12), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$279.50-$391.30 $559.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

THAP12 ( NM_004705.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004696.2 Homo sapiens THAP domain containing 12 (THAP12), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04554
Clone ID Related Accession (Same CDS sequence)	NM_004705.4 , NM_004705.3
Accession Version	NM_004705.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2286bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	52 kDa repressor of the inhibitor of the protein kinase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP002360.4, DR005363.1, AF081567.1 and AA765102.1. On Nov 22, 2018 this sequence version replaced NM_004705.3. Transcript Variant: This variant (1) represents the shorter transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110304.1, SRR1803613.154733.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2146411 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000260045.8/ ENSP00000260045.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCCGAACT TCTGCGCTGC CCCCAACTGC ACGCGGAAGA GCACGCAGTC CGACTTGGCC 
TTCTTCAGGT TCCCGCGGGA CCCTGCCAGA TGCCAGAAGT GGGTGGAGAA CTGTAGGAGA 
GCAGACTTAG AAGATAAAAC ACCTGATCAG CTAAATAAAC ATTATCGATT ATGTGCCAAA 
CATTTTGAGA CCTCTATGAT CTGTAGAACT AGTCCTTATA GGACAGTTCT TCGAGATAAT 
GCAATACCAA CAATATTTGA TCTTACCAGT CATTTGAACA ACCCACATAG TAGACACAGA 
AAACGAATAA AAGAACTGAG TGAAGATGAA ATCAGGACAC TGAAACAGAA AAAAATTGAT 
GAAACTTCTG AGCAGGAACA AAAACATAAA GAAACCAACA ATAGCAATGC TCAGAACCCC 
AGCGAAGAAG AGGGTGAAGG GCAAGATGAG GACATTTTAC CTCTAACCCT TGAAGAGAAG 
GAAAACAAAG AATACCTAAA ATCTCTATTT GAAATCTTGA TTCTGATGGG AAAGCAAAAC 
ATACCTCTGG ATGGACATGA GGCTGATGAA ATCCCAGAAG GTCTCTTTAC TCCAGATAAC 
TTTCAGGCAC TGCTGGAGTG TCGGATAAAT TCTGGTGAAG AGGTTCTGAG AAAGCGGTTT 
GAGACAACAG CAGTTAACAC GTTGTTTTGT TCAAAAACAC AGCAGAGGCA GATGCTAGAG 
ATCTGTGAGA GCTGTATTCG AGAAGAAACT CTCAGGGAAG TGAGAGACTC ACACTTCTTT 
TCCATTATCA CTGACGATGT AGTGGACATA GCAGGGGAAG AGCACCTACC TGTGTTGGTG 
AGGTTTGTTG ATGAATCTCA TAACCTAAGA GAGGAATTTA TAGGCTTCCT GCCTTATGAA 
GCCGATGCAG AAATTTTGGC TGTGAAATTT CACACTATGA TAACTGAGAA GTGGGGATTA 
AATATGGAGT ATTGTCGTGG CCAGGCTTAC ATTGTCTCTA GTGGATTTTC TTCCAAAATG 
AAAGTTGTTG CTTCTAGACT TTTAGAGAAA TATCCCCAAG CTATCTACAC ACTCTGCTCT 
TCCTGTGCCT TAAATATGTG GTTGGCAAAA TCAGTACCTG TTATGGGAGT ATCTGTTGCA 
TTAGGAACAA TTGAGGAAGT TTGTTCTTTT TTCCATCGAT CACCACAACT GCTTTTAGAA 
CTTGACAACG TAATTTCTGT TCTTTTTCAG AACAGTAAAG AAAGGGGTAA AGAACTGAAG 
GAAATCTGCC ATTCTCAGTG GACAGGCAGG CATGATGCTT TTGAAATTTT AGTGGAACTC 
CTGCAAGCAC TTGTTTTATG TTTAGATGGT ATAAATAGTG ACACAAATAT TAGATGGAAT 
AACTATATAG CTGGCCGAGC ATTTGTACTC TGCAGTGCAG TGTCAGATTT TGATTTCATT 
GTTACTATTG TTGTTCTTAA AAATGTCCTA TCTTTTACAA GAGCCTTTGG GAAAAACCTC 
CAGGGGCAAA CCTCTGATGT CTTCTTTGCG GCCGGTAGCT TGACTGCAGT ACTGCATTCA 
CTCAACGAAG TGATGGAAAA TATTGAAGTT TATCATGAAT TTTGGTTTGA GGAAGCCACA 
AATTTGGCAA CCAAACTTGA TATTCAAATG AAACTCCCTG GGAAATTCCG CAGAGCTCAC 
CAGGGTAACT TGGAATCTCA GCTAACCTCT GAGAGTTACT ATAAAGAAAC CCTAAGTGTC 
CCAACAGTGG AGCACATTAT TCAGGAACTT AAAGATATAT TCTCAGAACA GCACCTCAAA 
GCTCTTAAAT GCTTATCTCT GGTACCCTCA GTCATGGGAC AACTCAAATT CAATACGTCG 
GAGGAACACC ATGCTGACAT GTATAGAAGT GACTTACCCA ATCCTGACAC GCTGTCAGCT 
GAGCTTCATT GTTGGAGAAT CAAATGGAAA CACAGGGGGA AAGATATAGA GCTTCCGTCC 
ACCATCTATG AAGCCCTCCA CCTGCCTGAC ATCAAGTTTT TTCCTAATGT GTATGCATTG 
CTGAAGGTCC TGTGTATTCT TCCTGTGATG AAGGTTGAGA ATGAGCGGTA TGAAAATGGA 
CGAAAGCGTC TTAAAGCATA TTTGAGGAAC ACTTTGACAG ACCAAAGGTC AAGTAACTTG 
GCTTTGCTTA ACATAAATTT TGATATAAAA CACGACCTGG ATTTAATGGT GGACACATAT 
ATTAAACTCT ATACAAGTAA GTCAGAGCTT CCTACAGATA ATTCCGAAAC TGTGGAAAAT 
ACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004696.2
CDS	297..2582
Translation	MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIDETSEQEQKHKETNNSNAQNPSEEEGEGQDEDILPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPEGLFTPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQRQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFHRSPQLLLELDNVISVLFQNSKERGKELKEICHSQWTGRHDAFEILVELLQALVLCLDGINSDTNIRWNNYIAGRAFVLCSAVSDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAAGSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAHQGNLESQLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTSKSELPTDNSETVENT

Target ORF information:

RefSeq Version	NM_004705.4
Organism	Homo sapiens(human)
Definition	Homo sapiens THAP domain containing 12 (THAP12), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004705.4

ORF Insert Sequence:

ATGCCGAACT TCTGCGCTGC CCCCAACTGC ACGCGGAAGA GCACGCAGTC CGACTTGGCC 
TTCTTCAGGT TCCCGCGGGA CCCTGCCAGA TGCCAGAAGT GGGTGGAGAA CTGTAGGAGA 
GCAGACTTAG AAGATAAAAC ACCTGATCAG CTAAATAAAC ATTATCGATT ATGTGCCAAA 
CATTTTGAGA CCTCTATGAT CTGTAGAACT AGTCCTTATA GGACAGTTCT TCGAGATAAT 
GCAATACCAA CAATATTTGA TCTTACCAGT CATTTGAACA ACCCACATAG TAGACACAGA 
AAACGAATAA AAGAACTGAG TGAAGATGAA ATCAGGACAC TGAAACAGAA AAAAATTGAT 
GAAACTTCTG AGCAGGAACA AAAACATAAA GAAACCAACA ATAGCAATGC TCAGAACCCC 
AGCGAAGAAG AGGGTGAAGG GCAAGATGAG GACATTTTAC CTCTAACCCT TGAAGAGAAG 
GAAAACAAAG AATACCTAAA ATCTCTATTT GAAATCTTGA TTCTGATGGG AAAGCAAAAC 
ATACCTCTGG ATGGACATGA GGCTGATGAA ATCCCAGAAG GTCTCTTTAC TCCAGATAAC 
TTTCAGGCAC TGCTGGAGTG TCGGATAAAT TCTGGTGAAG AGGTTCTGAG AAAGCGGTTT 
GAGACAACAG CAGTTAACAC GTTGTTTTGT TCAAAAACAC AGCAGAGGCA GATGCTAGAG 
ATCTGTGAGA GCTGTATTCG AGAAGAAACT CTCAGGGAAG TGAGAGACTC ACACTTCTTT 
TCCATTATCA CTGACGATGT AGTGGACATA GCAGGGGAAG AGCACCTACC TGTGTTGGTG 
AGGTTTGTTG ATGAATCTCA TAACCTAAGA GAGGAATTTA TAGGCTTCCT GCCTTATGAA 
GCCGATGCAG AAATTTTGGC TGTGAAATTT CACACTATGA TAACTGAGAA GTGGGGATTA 
AATATGGAGT ATTGTCGTGG CCAGGCTTAC ATTGTCTCTA GTGGATTTTC TTCCAAAATG 
AAAGTTGTTG CTTCTAGACT TTTAGAGAAA TATCCCCAAG CTATCTACAC ACTCTGCTCT 
TCCTGTGCCT TAAATATGTG GTTGGCAAAA TCAGTACCTG TTATGGGAGT ATCTGTTGCA 
TTAGGAACAA TTGAGGAAGT TTGTTCTTTT TTCCATCGAT CACCACAACT GCTTTTAGAA 
CTTGACAACG TAATTTCTGT TCTTTTTCAG AACAGTAAAG AAAGGGGTAA AGAACTGAAG 
GAAATCTGCC ATTCTCAGTG GACAGGCAGG CATGATGCTT TTGAAATTTT AGTGGAACTC 
CTGCAAGCAC TTGTTTTATG TTTAGATGGT ATAAATAGTG ACACAAATAT TAGATGGAAT 
AACTATATAG CTGGCCGAGC ATTTGTACTC TGCAGTGCAG TGTCAGATTT TGATTTCATT 
GTTACTATTG TTGTTCTTAA AAATGTCCTA TCTTTTACAA GAGCCTTTGG GAAAAACCTC 
CAGGGGCAAA CCTCTGATGT CTTCTTTGCG GCCGGTAGCT TGACTGCAGT ACTGCATTCA 
CTCAACGAAG TGATGGAAAA TATTGAAGTT TATCATGAAT TTTGGTTTGA GGAAGCCACA 
AATTTGGCAA CCAAACTTGA TATTCAAATG AAACTCCCTG GGAAATTCCG CAGAGCTCAC 
CAGGGTAACT TGGAATCTCA GCTAACCTCT GAGAGTTACT ATAAAGAAAC CCTAAGTGTC 
CCAACAGTGG AGCACATTAT TCAGGAACTT AAAGATATAT TCTCAGAACA GCACCTCAAA 
GCTCTTAAAT GCTTATCTCT GGTACCCTCA GTCATGGGAC AACTCAAATT CAATACGTCG 
GAGGAACACC ATGCTGACAT GTATAGAAGT GACTTACCCA ATCCTGACAC GCTGTCAGCT 
GAGCTTCATT GTTGGAGAAT CAAATGGAAA CACAGGGGGA AAGATATAGA GCTTCCGTCC 
ACCATCTATG AAGCCCTCCA CCTGCCTGAC ATCAAGTTTT TTCCTAATGT GTATGCATTG 
CTGAAGGTCC TGTGTATTCT TCCTGTGATG AAGGTTGAGA ATGAGCGGTA TGAAAATGGA 
CGAAAGCGTC TTAAAGCATA TTTGAGGAAC ACTTTGACAG ACCAAAGGTC AAGTAACTTG 
GCTTTGCTTA ACATAAATTT TGATATAAAA CACGACCTGG ATTTAATGGT GGACACATAT 
ATTAAACTCT ATACAAGTAA GTCAGAGCTT CCTACAGATA ATTCCGAAAC TGTGGAAAAT 
ACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

THAP12 ( NM_004705.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004696.2 Homo sapiens THAP domain containing 12 (THAP12), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu04554
Clone ID Related Accession (Same CDS sequence)	NM_004705.4 , NM_004705.3
Accession Version	NM_004705.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2286bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	52 kDa repressor of the inhibitor of the protein kinase
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DR005363.1, AF081567.1 and AA765102.1. On Feb 7, 2015 this sequence version replaced NM_004705.2. Transcript Variant: This variant (1) represents the shorter transcript. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC110304.1, SRR1803613.154733.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2142348, SAMEA2146411 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCGAACT TCTGCGCTGC CCCCAACTGC ACGCGGAAGA GCACGCAGTC CGACTTGGCC 
TTCTTCAGGT TCCCGCGGGA CCCTGCCAGA TGCCAGAAGT GGGTGGAGAA CTGTAGGAGA 
GCAGACTTAG AAGATAAAAC ACCTGATCAG CTAAATAAAC ATTATCGATT ATGTGCCAAA 
CATTTTGAGA CCTCTATGAT CTGTAGAACT AGTCCTTATA GGACAGTTCT TCGAGATAAT 
GCAATACCAA CAATATTTGA TCTTACCAGT CATTTGAACA ACCCACATAG TAGACACAGA 
AAACGAATAA AAGAACTGAG TGAAGATGAA ATCAGGACAC TGAAACAGAA AAAAATTGAT 
GAAACTTCTG AGCAGGAACA AAAACATAAA GAAACCAACA ATAGCAATGC TCAGAACCCC 
AGCGAAGAAG AGGGTGAAGG GCAAGATGAG GACATTTTAC CTCTAACCCT TGAAGAGAAG 
GAAAACAAAG AATACCTAAA ATCTCTATTT GAAATCTTGA TTCTGATGGG AAAGCAAAAC 
ATACCTCTGG ATGGACATGA GGCTGATGAA ATCCCAGAAG GTCTCTTTAC TCCAGATAAC 
TTTCAGGCAC TGCTGGAGTG TCGGATAAAT TCTGGTGAAG AGGTTCTGAG AAAGCGGTTT 
GAGACAACAG CAGTTAACAC GTTGTTTTGT TCAAAAACAC AGCAGAGGCA GATGCTAGAG 
ATCTGTGAGA GCTGTATTCG AGAAGAAACT CTCAGGGAAG TGAGAGACTC ACACTTCTTT 
TCCATTATCA CTGACGATGT AGTGGACATA GCAGGGGAAG AGCACCTACC TGTGTTGGTG 
AGGTTTGTTG ATGAATCTCA TAACCTAAGA GAGGAATTTA TAGGCTTCCT GCCTTATGAA 
GCCGATGCAG AAATTTTGGC TGTGAAATTT CACACTATGA TAACTGAGAA GTGGGGATTA 
AATATGGAGT ATTGTCGTGG CCAGGCTTAC ATTGTCTCTA GTGGATTTTC TTCCAAAATG 
AAAGTTGTTG CTTCTAGACT TTTAGAGAAA TATCCCCAAG CTATCTACAC ACTCTGCTCT 
TCCTGTGCCT TAAATATGTG GTTGGCAAAA TCAGTACCTG TTATGGGAGT ATCTGTTGCA 
TTAGGAACAA TTGAGGAAGT TTGTTCTTTT TTCCATCGAT CACCACAACT GCTTTTAGAA 
CTTGACAACG TAATTTCTGT TCTTTTTCAG AACAGTAAAG AAAGGGGTAA AGAACTGAAG 
GAAATCTGCC ATTCTCAGTG GACAGGCAGG CATGATGCTT TTGAAATTTT AGTGGAACTC 
CTGCAAGCAC TTGTTTTATG TTTAGATGGT ATAAATAGTG ACACAAATAT TAGATGGAAT 
AACTATATAG CTGGCCGAGC ATTTGTACTC TGCAGTGCAG TGTCAGATTT TGATTTCATT 
GTTACTATTG TTGTTCTTAA AAATGTCCTA TCTTTTACAA GAGCCTTTGG GAAAAACCTC 
CAGGGGCAAA CCTCTGATGT CTTCTTTGCG GCCGGTAGCT TGACTGCAGT ACTGCATTCA 
CTCAACGAAG TGATGGAAAA TATTGAAGTT TATCATGAAT TTTGGTTTGA GGAAGCCACA 
AATTTGGCAA CCAAACTTGA TATTCAAATG AAACTCCCTG GGAAATTCCG CAGAGCTCAC 
CAGGGTAACT TGGAATCTCA GCTAACCTCT GAGAGTTACT ATAAAGAAAC CCTAAGTGTC 
CCAACAGTGG AGCACATTAT TCAGGAACTT AAAGATATAT TCTCAGAACA GCACCTCAAA 
GCTCTTAAAT GCTTATCTCT GGTACCCTCA GTCATGGGAC AACTCAAATT CAATACGTCG 
GAGGAACACC ATGCTGACAT GTATAGAAGT GACTTACCCA ATCCTGACAC GCTGTCAGCT 
GAGCTTCATT GTTGGAGAAT CAAATGGAAA CACAGGGGGA AAGATATAGA GCTTCCGTCC 
ACCATCTATG AAGCCCTCCA CCTGCCTGAC ATCAAGTTTT TTCCTAATGT GTATGCATTG 
CTGAAGGTCC TGTGTATTCT TCCTGTGATG AAGGTTGAGA ATGAGCGGTA TGAAAATGGA 
CGAAAGCGTC TTAAAGCATA TTTGAGGAAC ACTTTGACAG ACCAAAGGTC AAGTAACTTG 
GCTTTGCTTA ACATAAATTT TGATATAAAA CACGACCTGG ATTTAATGGT GGACACATAT 
ATTAAACTCT ATACAAGTAA GTCAGAGCTT CCTACAGATA ATTCCGAAAC TGTGGAAAAT 
ACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004696.2
CDS	130..2415
Translation	MPNFCAAPNCTRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAKHFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSRHRKRIKELSEDEIRTLKQKKIDETSEQEQKHKETNNSNAQNPSEEEGEGQDEDILPLTLEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPEGLFTPDNFQALLECRINSGEEVLRKRFETTAVNTLFCSKTQQRQMLEICESCIREETLREVRDSHFFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMITEKWGLNMEYCRGQAYIVSSGFSSKMKVVASRLLEKYPQAIYTLCSSCALNMWLAKSVPVMGVSVALGTIEEVCSFFHRSPQLLLELDNVISVLFQNSKERGKELKEICHSQWTGRHDAFEILVELLQALVLCLDGINSDTNIRWNNYIAGRAFVLCSAVSDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVFFAAGSLTAVLHSLNEVMENIEVYHEFWFEEATNLATKLDIQMKLPGKFRRAHQGNLESQLTSESYYKETLSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFNTSEEHHADMYRSDLPNPDTLSAELHCWRIKWKHRGKDIELPSTIYEALHLPDIKFFPNVYALLKVLCILPVMKVENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDIKHDLDLMVDTYIKLYTSKSELPTDNSETVENT

Target ORF information:

RefSeq Version	NM_004705.3
Organism	Homo sapiens(human)
Definition	Homo sapiens THAP domain containing 12 (THAP12), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004705.3

ORF Insert Sequence:

ATGCCGAACT TCTGCGCTGC CCCCAACTGC ACGCGGAAGA GCACGCAGTC CGACTTGGCC 
TTCTTCAGGT TCCCGCGGGA CCCTGCCAGA TGCCAGAAGT GGGTGGAGAA CTGTAGGAGA 
GCAGACTTAG AAGATAAAAC ACCTGATCAG CTAAATAAAC ATTATCGATT ATGTGCCAAA 
CATTTTGAGA CCTCTATGAT CTGTAGAACT AGTCCTTATA GGACAGTTCT TCGAGATAAT 
GCAATACCAA CAATATTTGA TCTTACCAGT CATTTGAACA ACCCACATAG TAGACACAGA 
AAACGAATAA AAGAACTGAG TGAAGATGAA ATCAGGACAC TGAAACAGAA AAAAATTGAT 
GAAACTTCTG AGCAGGAACA AAAACATAAA GAAACCAACA ATAGCAATGC TCAGAACCCC 
AGCGAAGAAG AGGGTGAAGG GCAAGATGAG GACATTTTAC CTCTAACCCT TGAAGAGAAG 
GAAAACAAAG AATACCTAAA ATCTCTATTT GAAATCTTGA TTCTGATGGG AAAGCAAAAC 
ATACCTCTGG ATGGACATGA GGCTGATGAA ATCCCAGAAG GTCTCTTTAC TCCAGATAAC 
TTTCAGGCAC TGCTGGAGTG TCGGATAAAT TCTGGTGAAG AGGTTCTGAG AAAGCGGTTT 
GAGACAACAG CAGTTAACAC GTTGTTTTGT TCAAAAACAC AGCAGAGGCA GATGCTAGAG 
ATCTGTGAGA GCTGTATTCG AGAAGAAACT CTCAGGGAAG TGAGAGACTC ACACTTCTTT 
TCCATTATCA CTGACGATGT AGTGGACATA GCAGGGGAAG AGCACCTACC TGTGTTGGTG 
AGGTTTGTTG ATGAATCTCA TAACCTAAGA GAGGAATTTA TAGGCTTCCT GCCTTATGAA 
GCCGATGCAG AAATTTTGGC TGTGAAATTT CACACTATGA TAACTGAGAA GTGGGGATTA 
AATATGGAGT ATTGTCGTGG CCAGGCTTAC ATTGTCTCTA GTGGATTTTC TTCCAAAATG 
AAAGTTGTTG CTTCTAGACT TTTAGAGAAA TATCCCCAAG CTATCTACAC ACTCTGCTCT 
TCCTGTGCCT TAAATATGTG GTTGGCAAAA TCAGTACCTG TTATGGGAGT ATCTGTTGCA 
TTAGGAACAA TTGAGGAAGT TTGTTCTTTT TTCCATCGAT CACCACAACT GCTTTTAGAA 
CTTGACAACG TAATTTCTGT TCTTTTTCAG AACAGTAAAG AAAGGGGTAA AGAACTGAAG 
GAAATCTGCC ATTCTCAGTG GACAGGCAGG CATGATGCTT TTGAAATTTT AGTGGAACTC 
CTGCAAGCAC TTGTTTTATG TTTAGATGGT ATAAATAGTG ACACAAATAT TAGATGGAAT 
AACTATATAG CTGGCCGAGC ATTTGTACTC TGCAGTGCAG TGTCAGATTT TGATTTCATT 
GTTACTATTG TTGTTCTTAA AAATGTCCTA TCTTTTACAA GAGCCTTTGG GAAAAACCTC 
CAGGGGCAAA CCTCTGATGT CTTCTTTGCG GCCGGTAGCT TGACTGCAGT ACTGCATTCA 
CTCAACGAAG TGATGGAAAA TATTGAAGTT TATCATGAAT TTTGGTTTGA GGAAGCCACA 
AATTTGGCAA CCAAACTTGA TATTCAAATG AAACTCCCTG GGAAATTCCG CAGAGCTCAC 
CAGGGTAACT TGGAATCTCA GCTAACCTCT GAGAGTTACT ATAAAGAAAC CCTAAGTGTC 
CCAACAGTGG AGCACATTAT TCAGGAACTT AAAGATATAT TCTCAGAACA GCACCTCAAA 
GCTCTTAAAT GCTTATCTCT GGTACCCTCA GTCATGGGAC AACTCAAATT CAATACGTCG 
GAGGAACACC ATGCTGACAT GTATAGAAGT GACTTACCCA ATCCTGACAC GCTGTCAGCT 
GAGCTTCATT GTTGGAGAAT CAAATGGAAA CACAGGGGGA AAGATATAGA GCTTCCGTCC 
ACCATCTATG AAGCCCTCCA CCTGCCTGAC ATCAAGTTTT TTCCTAATGT GTATGCATTG 
CTGAAGGTCC TGTGTATTCT TCCTGTGATG AAGGTTGAGA ATGAGCGGTA TGAAAATGGA 
CGAAAGCGTC TTAAAGCATA TTTGAGGAAC ACTTTGACAG ACCAAAGGTC AAGTAACTTG 
GCTTTGCTTA ACATAAATTT TGATATAAAA CACGACCTGG ATTTAATGGT GGACACATAT 
ATTAAACTCT ATACAAGTAA GTCAGAGCTT CCTACAGATA ATTCCGAAAC TGTGGAAAAT 
ACCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A protein-kinase, IFN-inducible double-stranded RNA dependent inhibitor and repressor of p58 (PRKRIR) enhances type I IFN-mediated antiviral response through the stability control of RIG-I protein.
Biochemical and biophysical research communications413(3)487-93(2011 Sep)
Now H,Yoo JY

Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
European journal of human genetics : EJHG18(11)1221-7(2010 Nov)
Silva LK,Blanton RE,Parrado AR,Melo PS,Morato VG,Reis EA,Dias JP,Castro JM,Vasconcelos PF,Goddard KA,Barreto ML,Reis MG,Teixeira MG

Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
PLoS genetics6(7)e1001016(2010 Jul)
Johnatty SE,Beesley J,Chen X,Macgregor S,Duffy DL,Spurdle AB,deFazio A,Gava N,Webb PM,Rossing MA,Doherty JA,Goodman MT,Lurie G,Thompson PJ,Wilkens LR,Ness RB,Moysich KB,Chang-Claude J,Wang-Gohrke S,Cramer DW,Terry KL,Hankinson SE,Tworoger SS,Garcia-Closas M,Yang H,Lissowska J,Chanock SJ,Pharoah PD,Song H,Whitemore AS,Pearce CL,Stram DO,Wu AH,Pike MC,Gayther SA,Ramus SJ,Menon U,Gentry-Maharaj A,Anton-Culver H,Ziogas A,Hogdall E,Kjaer SK,Hogdall C,Berchuck A,Schildkraut JM,Iversen ES,Moorman PG,Phelan CM,Sellers TA,Cunningham JM,Vierkant RA,Rider DN,Goode EL,Haviv I,Chenevix-Trench G,,,

A census of human transcription factors: function, expression and evolution.
Nature reviews. Genetics10(4)252-63(2009 04)
Vaquerizas JM,Kummerfeld SK,Teichmann SA,Luscombe NM

The THAP domain of THAP1 is a large C2CH module with zinc-dependent sequence-specific DNA-binding activity.
Proceedings of the National Academy of Sciences of the United States of America102(19)6907-12(2005 May)
Clouaire T,Roussigne M,Ecochard V,Mathe C,Amalric F,Girard JP

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THAP12 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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