NXF5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NXF5
Entrez Gene ID	55998
Full Name	nuclear RNA export factor 5
General protein information	Preferred Names nuclear RNA export factor 5 Names nuclear RNA export factor 5 TAP-like protein 1 TAPL-1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: X Map Location: Xq22.1
Summary	This gene is one member of a family of nuclear RNA export factor genes. The encoded protein can bind RNA, and is implicated in mRNA nuclear export. However, this protein has lost several C-terminal protein domains found in other family members that are required for export activity, and may be an evolving pseudogene. Alternatively spliced transcript variants have been described, but most are candidates for nonsense-mediated decay (NMD) and may not express proteins in vivo. [provided by RefSeq, Jul 2009].
Disorder MIM:	300319

mRNA and Protein(s)

mRNA	Protein	Name
NM_032946.2	NP_116564.2	nuclear RNA export factor 5
XM_024452407.1	XP_024308175.1	nuclear RNA export factor 5 isoform X2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	NXF5	XP_003317625.1
Homo sapiens (human)	NXF5	NP_116564.2

Gene Ontology
Bibliography

Related articles in PubMed

Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene.
Esposito T, Lea RA, Maher BH, Moses D, Cox HC, Magliocca S, Angius A, Nyholt DR, Titus T, Kay T, Gray NA, Rastaldi MP, Parnham A, Gianfrancesco F, Griffiths LR
Human molecular genetics22(18)3654-66(2013 Sep)

An unappreciated role for RNA surveillance.
Hillman RT, Green RE, Brenner SE
Genome biology5(2)R8(2004)

Inv(X)(p21.1;q22.1) in a man with mental retardation, short stature, general muscle wasting, and facial dysmorphism: clinical study and mutation analysis of the NXF5 gene.
Frints SG, Jun L, Fryns JP, Devriendt K, Teulingkx R, Van den Berghe L, De Vos B, Borghgraef M, Chelly J, Des Portes V, Van Bokhoven H, Hamel B, Ropers HH, Kalscheuer V, Raynaud M, Moraine C, Marynen P, Froyen G
American journal of medical genetics. Part A119A(3)367-74(2003 Jun)

NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.
Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G
Current biology : CB11(18)1381-91(2001 Sep)

TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.
Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E
Molecular and cellular biology20(23)8996-9008(2000 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

study of an Australian pedigree in which focal segmental glomerulosclerosis co-segregates with progressive heart block; study found 2 mutations NXF5-R113W and ALG13-T141L segregated with disease phenotype; predicted the NXF5 R113W mutation to be deleterious; cellular studies support a role in the stability and localization of the protein suggesting a causative role
Title: Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene.

Mutations of the NXF5 gene is associated with X-linked mental retardation
Title: Inv(X)(p21.1;q22.1) in a man with mental retardation, short stature, general muscle wasting, and facial dysmorphism: clinical study and mutation analysis of the NXF5 gene.

The following NXF5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NXF5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu19256	NM_032946.2 Latest version!	Homo sapiens nuclear RNA export factor 5 (NXF5), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu69929	XM_024452407.1 Latest version!	Homo sapiens nuclear RNA export factor 5 (NXF5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NXF5 ( NM_032946.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_116564.2 Homo sapiens nuclear RNA export factor 5 (NXF5), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19256
Clone ID Related Accession (Same CDS sequence)	NM_032946.2
Accession Version	NM_032946.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	nuclear RNA export factor 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ277654.1 and BC131708.1. This sequence is a reference standard in the RefSeqGene project. On Jul 17, 2009 this sequence version replaced NM_032946.1. Transcript Variant: This variant (1) represents the shortest transcript and is protein-coding. ##Evidence-Data-START## CDS exon combination :: BC131708.1 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGCGGA ACACACAAGA TGAAAACATG AGGAAATGGT TCAAGGTCAC AATTCCTTAT 
GGGATAAAGT ATGACAAGGC ATGGCTAATG AATTCAATCC AGAGCAATTG CAGTGTCCCC 
TTCACTCCGG TTGATTTCCA CTACATCCGA AATCGGGCAT GCTTCTTTGT CCAGGTTGCT 
AGTGCTGCCT CTGCATTGAA GGATGTCAGT TATAAGATTT ATGATGATGA GAACCAAAAG 
ATATGTATAT TTGTCAGTCA TTTTACTGCG CCCTACTCTG TGAAGAATAA GTTGAAGCCA 
GGCCAAATGG AGATGCTAAA GCTGACCATG AACAAACGGT ACAATGTCTC CCAGCAAGCT 
CTTGATCTCC AGAATCTCCG CTTTGACCCA GACTTGATGG GCCGTGACAT TGATATAATC 
CTGAATCGAA GAAACTGCAT GGCTGCCACC CTGAAGATCA CTGAAAGAAA TTTCCCTGAG 
CTGTTGTCTT TGAACTTGTG CAACAACAAA CTGTACCAGC TGGATGGCCT TTCTGACATT 
ACAGAGAAGG CTCCCAAAGT CAAGACCCTG AATCTCTCCA AAAATAAGCT GGAGTCGGCG 
TGGGAGTTGG GCAAGGTGAA AGGGCTGAAG CTCGAAGAGC TATGGCTAGA AGGGAACCCG 
TTGTGCAGCA CCTTCTCGGA CCAGTCTGCC TATGTAAGTG CCATCCGGGA TTGTTTCCCC 
AAGTTGTTAC GCCTGGACGG CCGAGAGTTA TCCGCACCAG TGATTGTTGA CATTGACAGC 
TCTGAGACAA TGAAACCCTG CAAGGAAAAC TTTACTGGAT CTGAGACCCT AAAGCATTTA 
GTCCTGCAAT TCCTGCAGCA GAGCAACTTG TGCAAGTACT TCAAGGATAG CAGGAATATA 
AAAATTCTCA AAGACCCCTA CCTGCAGAGG AAGCTGCTAA AGCACACAAA ATGTCCACGA 
AACGTGGACT CCCTCAGTGC ATTGCCTGAA ACTCAGCATG ACTTCACCTC CATCCTGGTG 
GACATGTGGT ACCAGACCGT GAACACCTGC TTCCTCCCTC GGGCAGGCCC AGAGAGCCAG 
AGCCTAAGAC CACTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116564.2
CDS	361..1458
Translation	MRRNTQDENMRKWFKVTIPYGIKYDKAWLMNSIQSNCSVPFTPVDFHYIRNRACFFVQVASAASALKDVSYKIYDDENQKICIFVSHFTAPYSVKNKLKPGQMEMLKLTMNKRYNVSQQALDLQNLRFDPDLMGRDIDIILNRRNCMAATLKITERNFPELLSLNLCNNKLYQLDGLSDITEKAPKVKTLNLSKNKLESAWELGKVKGLKLEELWLEGNPLCSTFSDQSAYVSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQSNLCKYFKDSRNIKILKDPYLQRKLLKHTKCPRNVDSLSALPETQHDFTSILVDMWYQTVNTCFLPRAGPESQSLRPL

Target ORF information:

RefSeq Version	NM_032946.2
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear RNA export factor 5 (NXF5), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032946.2

ORF Insert Sequence:

ATGAGGCGGA ACACACAAGA TGAAAACATG AGGAAATGGT TCAAGGTCAC AATTCCTTAT 
GGGATAAAGT ATGACAAGGC ATGGCTAATG AATTCAATCC AGAGCAATTG CAGTGTCCCC 
TTCACTCCGG TTGATTTCCA CTACATCCGA AATCGGGCAT GCTTCTTTGT CCAGGTTGCT 
AGTGCTGCCT CTGCATTGAA GGATGTCAGT TATAAGATTT ATGATGATGA GAACCAAAAG 
ATATGTATAT TTGTCAGTCA TTTTACTGCG CCCTACTCTG TGAAGAATAA GTTGAAGCCA 
GGCCAAATGG AGATGCTAAA GCTGACCATG AACAAACGGT ACAATGTCTC CCAGCAAGCT 
CTTGATCTCC AGAATCTCCG CTTTGACCCA GACTTGATGG GCCGTGACAT TGATATAATC 
CTGAATCGAA GAAACTGCAT GGCTGCCACC CTGAAGATCA CTGAAAGAAA TTTCCCTGAG 
CTGTTGTCTT TGAACTTGTG CAACAACAAA CTGTACCAGC TGGATGGCCT TTCTGACATT 
ACAGAGAAGG CTCCCAAAGT CAAGACCCTG AATCTCTCCA AAAATAAGCT GGAGTCGGCG 
TGGGAGTTGG GCAAGGTGAA AGGGCTGAAG CTCGAAGAGC TATGGCTAGA AGGGAACCCG 
TTGTGCAGCA CCTTCTCGGA CCAGTCTGCC TATGTAAGTG CCATCCGGGA TTGTTTCCCC 
AAGTTGTTAC GCCTGGACGG CCGAGAGTTA TCCGCACCAG TGATTGTTGA CATTGACAGC 
TCTGAGACAA TGAAACCCTG CAAGGAAAAC TTTACTGGAT CTGAGACCCT AAAGCATTTA 
GTCCTGCAAT TCCTGCAGCA GAGCAACTTG TGCAAGTACT TCAAGGATAG CAGGAATATA 
AAAATTCTCA AAGACCCCTA CCTGCAGAGG AAGCTGCTAA AGCACACAAA ATGTCCACGA 
AACGTGGACT CCCTCAGTGC ATTGCCTGAA ACTCAGCATG ACTTCACCTC CATCCTGGTG 
GACATGTGGT ACCAGACCGT GAACACCTGC TTCCTCCCTC GGGCAGGCCC AGAGAGCCAG 
AGCCTAAGAC CACTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NXF5 ( XM_024452407.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024308175.1 Homo sapiens nuclear RNA export factor 5 (NXF5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu69929
Clone ID Related Accession (Same CDS sequence)	XM_024452407.1
Accession Version	XM_024452407.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 723bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	nuclear RNA export factor 5 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000023.11) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCATCTC TTCCTCTGGC CCAATGCCAG GAGCTGGGCC CTCCTTGGGG AGAAACCTGG 
GTTTCCTACG TCAAGGGTCC AGAAGCGGGC CACGTTCCTG AGGCAGGAGT GGAAGGCAGA 
GGGCAGAGGA GGTTGAGAAG ACAGAAGGAC AGGCCTCTCA GGGCACTGCC CCACCTTCCC 
TCCTTCTCCA CCTCACATCG TCCTGCCTGG GCCCTCAGAG GAGCCCTGGG TAGCCCGAGA 
TGGGTAGCAT TCCTCGGTCA AGGCGTCAGC ACAGAGGGGC ACAGGAGTCA GGGACCATCA 
GAAGAGAATG CAGTGGTCTG GAGAGGGGGT CCCCAGACTC TGAACCCCAT GCTGAGCTGG 
GGCCTGACTC TTCACTCCTC CCGGGAGAAG GTCTCCTGTC CCCGTGGCTG CTCTGTTTCC 
CATGCCCAGC TCAGACTGAG CTCACACAGT GCCATCCGGG ATTGTTTCCC CAAGTTGTTA 
CGCCTGGACG GCCGAGAGTT ATCCGCACCA GTGATTGTTG ACATTGACAG CTCTGAGACA 
ATGAAACCCT GCAAGGAAAA CTTTACTGGA TCTGAGACCC TAAAGCATTT AGTCCTGCAA 
TTCCTGCAGC AGTATTACTC GATCTATGAC TCTGGAGATC GACAGGGTCT CCTCGGTGCT 
TACCACGATG AGGCCTGCTT CTCCTTGGCT ATTCCCTTCG ACCCCAAGGA CTCAGCCCCA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024308175.1
CDS	138..860
Translation	MPSLPLAQCQELGPPWGETWVSYVKGPEAGHVPEAGVEGRGQRRLRRQKDRPLRALPHLPSFSTSHRPAWALRGALGSPRWVAFLGQGVSTEGHRSQGPSEENAVVWRGGPQTLNPMLSWGLTLHSSREKVSCPRGCSVSHAQLRLSSHSAIRDCFPKLLRLDGRELSAPVIVDIDSSETMKPCKENFTGSETLKHLVLQFLQQYYSIYDSGDRQGLLGAYHDEACFSLAIPFDPKDSAP

Target ORF information:

RefSeq Version	XM_024452407.1
Organism	Homo sapiens(human)
Definition	Homo sapiens nuclear RNA export factor 5 (NXF5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024452407.1

ORF Insert Sequence:

ATGCCATCTC TTCCTCTGGC CCAATGCCAG GAGCTGGGCC CTCCTTGGGG AGAAACCTGG 
GTTTCCTACG TCAAGGGTCC AGAAGCGGGC CACGTTCCTG AGGCAGGAGT GGAAGGCAGA 
GGGCAGAGGA GGTTGAGAAG ACAGAAGGAC AGGCCTCTCA GGGCACTGCC CCACCTTCCC 
TCCTTCTCCA CCTCACATCG TCCTGCCTGG GCCCTCAGAG GAGCCCTGGG TAGCCCGAGA 
TGGGTAGCAT TCCTCGGTCA AGGCGTCAGC ACAGAGGGGC ACAGGAGTCA GGGACCATCA 
GAAGAGAATG CAGTGGTCTG GAGAGGGGGT CCCCAGACTC TGAACCCCAT GCTGAGCTGG 
GGCCTGACTC TTCACTCCTC CCGGGAGAAG GTCTCCTGTC CCCGTGGCTG CTCTGTTTCC 
CATGCCCAGC TCAGACTGAG CTCACACAGT GCCATCCGGG ATTGTTTCCC CAAGTTGTTA 
CGCCTGGACG GCCGAGAGTT ATCCGCACCA GTGATTGTTG ACATTGACAG CTCTGAGACA 
ATGAAACCCT GCAAGGAAAA CTTTACTGGA TCTGAGACCC TAAAGCATTT AGTCCTGCAA 
TTCCTGCAGC AGTATTACTC GATCTATGAC TCTGGAGATC GACAGGGTCT CCTCGGTGCT 
TACCACGATG AGGCCTGCTT CTCCTTGGCT ATTCCCTTCG ACCCCAAGGA CTCAGCCCCA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Unique X-linked familial FSGS with co-segregating heart block disorder is associated with a mutation in the NXF5 gene.
Human molecular genetics22(18)3654-66(2013 Sep)
Esposito T,Lea RA,Maher BH,Moses D,Cox HC,Magliocca S,Angius A,Nyholt DR,Titus T,Kay T,Gray NA,Rastaldi MP,Parnham A,Gianfrancesco F,Griffiths LR

An unappreciated role for RNA surveillance.
Genome biology5(2)R8(2004)
Hillman RT,Green RE,Brenner SE

Inv(X)(p21.1;q22.1) in a man with mental retardation, short stature, general muscle wasting, and facial dysmorphism: clinical study and mutation analysis of the NXF5 gene.
American journal of medical genetics. Part A119A(3)367-74(2003 Jun)
Frints SG,Jun L,Fryns JP,Devriendt K,Teulingkx R,Van den Berghe L,De Vos B,Borghgraef M,Chelly J,Des Portes V,Van Bokhoven H,Hamel B,Ropers HH,Kalscheuer V,Raynaud M,Moraine C,Marynen P,Froyen G

NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation.
Current biology : CB11(18)1381-91(2001 Sep)
Jun L,Frints S,Duhamel H,Herold A,Abad-Rodrigues J,Dotti C,Izaurralde E,Marynen P,Froyen G

TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture.
Molecular and cellular biology20(23)8996-9008(2000 Dec)
Herold A,Suyama M,Rodrigues JP,Braun IC,Kutay U,Carmo-Fonseca M,Bork P,Izaurralde E

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NXF5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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