PPY cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPY
Entrez Gene ID	5539
Full Name	pancreatic polypeptide
Synonyms	PNP,PP
General protein information	Preferred Names pancreatic polypeptide Names pancreatic prohormone pancreatic polypeptide Y prepro-PP (prepropancreatic polypeptide)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.31
Summary	This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded 95 aa preproprotein is synthesized in the pancreatic islets of Langerhans and proteolytically processed to generate two peptide products. These products include the active pancreatic hormone of 36 aa and an icosapeptide of unknown function. This hormone acts as a regulator of pancreatic and gastrointestinal functions and may be important in the regulation of food intake. Plasma level of this hormone has been shown to be reduced in conditions associated with increased food intake and elevated in anorexia nervosa. In addition, infusion of this hormone in obese rodents has shown to decrease weight gain. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
Disorder MIM:	167780

mRNA and Protein(s)

mRNA	Protein	Name
NM_001319209.1	NP_001306138.1	pancreatic prohormone isoform 2 precursor
NM_002722.5	NP_002713.1	pancreatic prohormone isoform 1 preproprotein
XM_011524978.3	XP_011523280.1	pancreatic prohormone isoform X1
XM_011524978.2	XP_011523280.1	pancreatic prohormone isoform X1
NM_002722.4	NP_002713.1	pancreatic prohormone isoform 1 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PPY	XP_003315459.1
Bos taurus (cattle)	PPY	NP_776377.2
Mus musculus (house mouse)	Ppy	NP_032944.1
Rattus norvegicus (Norway rat)	Ppy	NP_036758.1
Homo sapiens (human)	PPY	NP_002713.1
Canis lupus familiaris (dog)	PPY	XP_548067.2
	PPY	XP_001113906.1

Gene Ontology
Bibliography

Related articles in PubMed

Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss.
?krha J, Bu?ek P, Uhrov? J, Hrabal P, Kmochov? K, Laclav M, Bungani? B, Fri? P
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]17(1)89-94(2017 Jan - Feb)

Distribution of Pancreatic Polypeptide-secreting Endocrine Cells in Nondiabetic and Diabetic Cases.
?liwi?ska-Mosso? M, Milnerowicz H
Applied immunohistochemistry & molecular morphology : AIMM25(6)422-431(2017 Jul)

Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.
Pendharkar SA, Singh RG, Petrov MS
Cytokine90161-168(2017 Feb)

Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis.
Holzer P, Reichmann F, Farzi A
Neuropeptides46(6)261-74(2012 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GIP and pancreatic polypeptide plasma concentrations are lower in pancreatic cancer irrespective of the degree of glucose intolerance as compared to Type 2 diabetic patients and healthy controls.
Title: Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss.

Peptide YY and PP are associated with circulating innate pro-inflammatory cytokines in patients after acute pancreatitis and cumulatively contribute to nearly half of the variance of IL-6, MCP-1, and TNFalpha. Future research is warranted to investigate the signaling pathways that underlie these associations.
Title: Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.

The most important parameter in diagnosis of HG [Hyperemesis gravidarum ]was plasma PP level
Title: Gut satiety hormones and hyperemesis gravidarum.

Immunohistochemical distribution of this peptide in the epidermal skin (from abdomen, breast and face) of healthy women was analysed.
Title: Immunohistochemical distribution of neuropeptide Y, peptide YY, pancreatic polypeptide-like immunoreactivity and their receptors in the epidermal skin of healthy women.

These data demonstrate glucose-regulated secretion of PP and its effects on glucagon release through PPYR1 receptors expressed by alpha-cells.
Title: Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.

The following PPY gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPY cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17425	NM_002722.5 Latest version!	Homo sapiens pancreatic polypeptide (PPY), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu59891	XM_011524978.3 Latest version!	Homo sapiens pancreatic polypeptide (PPY), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu100654	NM_001319209.1 Latest version!	Homo sapiens pancreatic polypeptide (PPY), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu59891	XM_011524978.2	Homo sapiens pancreatic polypeptide (PPY), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu17425	NM_002722.4	Homo sapiens pancreatic polypeptide (PPY), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPY ( NM_002722.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002713.1 Homo sapiens pancreatic polypeptide (PPY), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17425
Clone ID Related Accession (Same CDS sequence)	NM_002722.5 , NM_002722.4
Accession Version	NM_002722.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	pancreatic prohormone isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC007993.15, BP394217.1 and BP388331.1. On Jun 2, 2019 this sequence version replaced NM_002722.4. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM918317.1, CA776075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCG CACGCCTCTG CCTCTCCCTG CTGCTCCTGT CCACCTGCGT GGCTCTGTTA 
CTACAGCCAC TGCTGGGTGC CCAGGGAGCC CCACTGGAGC CAGTGTACCC AGGGGACAAT 
GCCACACCAG AGCAGATGGC CCAGTATGCA GCTGATCTCC GTAGATACAT CAACATGCTG 
ACCAGGCCTA GGTATGGGAA AAGACACAAA GAGGACACGC TGGCCTTCTC GGAGTGGGGG 
TCCCCGCATG CTGCTGTCCC CAGGGAGCTC AGCCCGCTGG ACTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002713.1
CDS	57..344
Translation	MAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL

Target ORF information:

RefSeq Version	NM_002722.5
Organism	Homo sapiens(human)
Definition	Homo sapiens pancreatic polypeptide (PPY), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002722.5

ORF Insert Sequence:

ATGGCTGCCG CACGCCTCTG CCTCTCCCTG CTGCTCCTGT CCACCTGCGT GGCTCTGTTA 
CTACAGCCAC TGCTGGGTGC CCAGGGAGCC CCACTGGAGC CAGTGTACCC AGGGGACAAT 
GCCACACCAG AGCAGATGGC CCAGTATGCA GCTGATCTCC GTAGATACAT CAACATGCTG 
ACCAGGCCTA GGTATGGGAA AAGACACAAA GAGGACACGC TGGCCTTCTC GGAGTGGGGG 
TCCCCGCATG CTGCTGTCCC CAGGGAGCTC AGCCCGCTGG ACTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPY ( NM_002722.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002713.1 Homo sapiens pancreatic polypeptide (PPY), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17425
Clone ID Related Accession (Same CDS sequence)	NM_002722.5 , NM_002722.4
Accession Version	NM_002722.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	pancreatic prohormone isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP394217.1 and BP388331.1. On Jan 30, 2016 this sequence version replaced NM_002722.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI833623.1, BP386814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGCCG CACGCCTCTG CCTCTCCCTG CTGCTCCTGT CCACCTGCGT GGCTCTGTTA 
CTACAGCCAC TGCTGGGTGC CCAGGGAGCC CCACTGGAGC CAGTGTACCC AGGGGACAAT 
GCCACACCAG AGCAGATGGC CCAGTATGCA GCTGATCTCC GTAGATACAT CAACATGCTG 
ACCAGGCCTA GGTATGGGAA AAGACACAAA GAGGACACGC TGGCCTTCTC GGAGTGGGGG 
TCCCCGCATG CTGCTGTCCC CAGGGAGCTC AGCCCGCTGG ACTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002713.1
CDS	48..335
Translation	MAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL

Target ORF information:

RefSeq Version	NM_002722.4
Organism	Homo sapiens(human)
Definition	Homo sapiens pancreatic polypeptide (PPY), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002722.4

ORF Insert Sequence:

ATGGCTGCCG CACGCCTCTG CCTCTCCCTG CTGCTCCTGT CCACCTGCGT GGCTCTGTTA 
CTACAGCCAC TGCTGGGTGC CCAGGGAGCC CCACTGGAGC CAGTGTACCC AGGGGACAAT 
GCCACACCAG AGCAGATGGC CCAGTATGCA GCTGATCTCC GTAGATACAT CAACATGCTG 
ACCAGGCCTA GGTATGGGAA AAGACACAAA GAGGACACGC TGGCCTTCTC GGAGTGGGGG 
TCCCCGCATG CTGCTGTCCC CAGGGAGCTC AGCCCGCTGG ACTTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPY ( XM_011524978.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523280.1 Homo sapiens pancreatic polypeptide (PPY), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59891
Clone ID Related Accession (Same CDS sequence)	XM_011524978.3 , XM_011524978.2
Accession Version	XM_011524978.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	pancreatic prohormone isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011524978.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTTTCG TATTTGCTTT GTGGAATATG GCTGCCGCAC GCCTCTGCCT CTCCCTGCTG 
CTCCTGTCCA CCTGCGTGGC TCTGTTACTA CAGCCACTGC TGGGTGCCCA GGGAGCCCCA 
CTGGAGCCAG TGTACCCAGG GGACAATGCC ACACCAGAGC AGATGGCCCA GTATGCAGCT 
GATCTCCGTA GATACATCAA CATGCTGACC AGGCCTAGGT ATGGGAAAAG ACACAAAGAG 
GACACGCTGG CCTTCTCGGA GTGGGGGTCC CCGCATGCTG CTGTCCCCAG GGAGCTCAGC 
CCGCTGGACT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523280.1
CDS	176..490
Translation	MTFVFALWNMAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL

Target ORF information:

RefSeq Version	XM_011524978.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pancreatic polypeptide (PPY), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011524978.3

ORF Insert Sequence:

ATGACTTTCG TATTTGCTTT GTGGAATATG GCTGCCGCAC GCCTCTGCCT CTCCCTGCTG 
CTCCTGTCCA CCTGCGTGGC TCTGTTACTA CAGCCACTGC TGGGTGCCCA GGGAGCCCCA 
CTGGAGCCAG TGTACCCAGG GGACAATGCC ACACCAGAGC AGATGGCCCA GTATGCAGCT 
GATCTCCGTA GATACATCAA CATGCTGACC AGGCCTAGGT ATGGGAAAAG ACACAAAGAG 
GACACGCTGG CCTTCTCGGA GTGGGGGTCC CCGCATGCTG CTGTCCCCAG GGAGCTCAGC 
CCGCTGGACT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPY ( XM_011524978.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011523280.1 Homo sapiens pancreatic polypeptide (PPY), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu59891
Clone ID Related Accession (Same CDS sequence)	XM_011524978.3 , XM_011524978.2
Accession Version	XM_011524978.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 315bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	pancreatic prohormone isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011524978.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACTTTCG TATTTGCTTT GTGGAATATG GCTGCCGCAC GCCTCTGCCT CTCCCTGCTG 
CTCCTGTCCA CCTGCGTGGC TCTGTTACTA CAGCCACTGC TGGGTGCCCA GGGAGCCCCA 
CTGGAGCCAG TGTACCCAGG GGACAATGCC ACACCAGAGC AGATGGCCCA GTATGCAGCT 
GATCTCCGTA GATACATCAA CATGCTGACC AGGCCTAGGT ATGGGAAAAG ACACAAAGAG 
GACACGCTGG CCTTCTCGGA GTGGGGGTCC CCGCATGCTG CTGTCCCCAG GGAGCTCAGC 
CCGCTGGACT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011523280.1
CDS	175..489
Translation	MTFVFALWNMAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL

Target ORF information:

RefSeq Version	XM_011524978.2
Organism	Homo sapiens(human)
Definition	Homo sapiens pancreatic polypeptide (PPY), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011524978.2

ORF Insert Sequence:

ATGACTTTCG TATTTGCTTT GTGGAATATG GCTGCCGCAC GCCTCTGCCT CTCCCTGCTG 
CTCCTGTCCA CCTGCGTGGC TCTGTTACTA CAGCCACTGC TGGGTGCCCA GGGAGCCCCA 
CTGGAGCCAG TGTACCCAGG GGACAATGCC ACACCAGAGC AGATGGCCCA GTATGCAGCT 
GATCTCCGTA GATACATCAA CATGCTGACC AGGCCTAGGT ATGGGAAAAG ACACAAAGAG 
GACACGCTGG CCTTCTCGGA GTGGGGGTCC CCGCATGCTG CTGTCCCCAG GGAGCTCAGC 
CCGCTGGACT TATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPY ( NM_001319209.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001306138.1 Homo sapiens pancreatic polypeptide (PPY), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu100654
Clone ID Related Accession (Same CDS sequence)	NM_001319209.1
Accession Version	NM_001319209.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 306bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	pancreatic prohormone isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP384893.1 and BP388331.1. Transcript Variant: This variant (2) includes an alternate 5' terminal exon, resulting in a different 5' UTR and 5' coding region, and the use of an alternate translation start site compared to variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP384893.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTGTGACT GTGACCTTAT GGCTGCCGCA CGCCTCTGCC TCTCCCTGCT GCTCCTGTCC 
ACCTGCGTGG CTCTGTTACT ACAGCCACTG CTGGGTGCCC AGGGAGCCCC ACTGGAGCCA 
GTGTACCCAG GGGACAATGC CACACCAGAG CAGATGGCCC AGTATGCAGC TGATCTCCGT 
AGATACATCA ACATGCTGAC CAGGCCTAGG TATGGGAAAA GACACAAAGA GGACACGCTG 
GCCTTCTCGG AGTGGGGGTC CCCGCATGCT GCTGTCCCCA GGGAGCTCAG CCCGCTGGAC 
TTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001306138.1
CDS	71..376
Translation	MCDCDLMAAARLCLSLLLLSTCVALLLQPLLGAQGAPLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRYGKRHKEDTLAFSEWGSPHAAVPRELSPLDL

Target ORF information:

RefSeq Version	NM_001319209.1
Organism	Homo sapiens(human)
Definition	Homo sapiens pancreatic polypeptide (PPY), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001319209.1

ORF Insert Sequence:

ATGTGTGACT GTGACCTTAT GGCTGCCGCA CGCCTCTGCC TCTCCCTGCT GCTCCTGTCC 
ACCTGCGTGG CTCTGTTACT ACAGCCACTG CTGGGTGCCC AGGGAGCCCC ACTGGAGCCA 
GTGTACCCAG GGGACAATGC CACACCAGAG CAGATGGCCC AGTATGCAGC TGATCTCCGT 
AGATACATCA ACATGCTGAC CAGGCCTAGG TATGGGAAAA GACACAAAGA GGACACGCTG 
GCCTTCTCGG AGTGGGGGTC CCCGCATGCT GCTGTCCCCA GGGAGCTCAG CCCGCTGGAC 
TTATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lower plasma levels of glucose-dependent insulinotropic peptide (GIP) and pancreatic polypeptide (PP) in patients with ductal adenocarcinoma of the pancreas and their relation to the presence of impaired glucoregulation and weight loss.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]17(1)89-94(2017 Jan - Feb)
?krha J,Bu?ek P,Uhrov? J,Hrabal P,Kmochov? K,Laclav M,Bungani? B,Fri? P

Distribution of Pancreatic Polypeptide-secreting Endocrine Cells in Nondiabetic and Diabetic Cases.
Applied immunohistochemistry & molecular morphology : AIMM25(6)422-431(2017 Jul)
?liwi?ska-Mosso? M,Milnerowicz H

Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.
Cytokine90161-168(2017 Feb)
Pendharkar SA,Singh RG,Petrov MS

Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis.
Neuropeptides46(6)261-74(2012 Dec)
Holzer P,Reichmann F,Farzi A

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PPY cDNA ORF clone, Homo sapiens(human)

Gene

Clones

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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