PPM1G cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPM1G
Entrez Gene ID	5496
Full Name	protein phosphatase, Mg2+/Mn2+ dependent 1G
Synonyms	PP2CG,PP2CGAMMA,PPP2CG
General protein information	Preferred Names protein phosphatase, Mg2+/Mn2+ dependent 1G Names protein phosphatase 1G PP2C-gamma protein phosphatase 1C protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform protein phosphatase 2, catalytic subunit, gamma isoform protein phosphatase 2C gamma isoform protein phosphatase 2C isoform gamma protein phosphatase magnesium-dependent 1 gamma
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p23.3
Summary	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010].
Disorder MIM:	605119

mRNA and Protein(s)

mRNA	Protein	Name
NM_177983.3	NP_817092.1	protein phosphatase 1G
NM_177983.2	NP_817092.1	protein phosphatase 1G

Pathways from BioSystems

Homologies

Homo sapiens (human)	PPM1G	NP_817092.1
Pan troglodytes (chimpanzee)	PPM1G	NP_001233384.1
Mus musculus (house mouse)	Ppm1g	NP_032040.1
Rattus norvegicus (Norway rat)	Ppm1g	NP_671742.1
Danio rerio (zebrafish)	ppm1g	NP_958896.1
Drosophila melanogaster (fruit fly)	CG10417	NP_610169.1
Oryza sativa (rice)	Os09g0558000	NP_001063908.1
	PPM1G	XP_001096179.1
Gallus gallus (chicken)	PPM1G	XP_003641098.1
Canis lupus familiaris (dog)	PPM1G	XP_532910.2
Xenopus tropicalis (tropical clawed frog)	ppm1g	NP_001015840.1
Bos taurus (cattle)	PPM1G	NP_777226.2

Gene Ontology
Bibliography

Related articles in PubMed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Yadav L, Tamene F, G??s H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M
Cell systems4(4)430-444.e5(2017 Apr)

PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.
Gudipaty SA, McNamara RP, Morton EL, D'Orso I
Molecular and cellular biology35(22)3810-28(2015 Nov)

Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis.
Ruggeri B, Nymberg C, Vuoksimaa E, Lourdusamy A, Wong CP, Carvalho FM, Jia T, Cattrell A, Macare C, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, B?chel C, Conrod PJ, Fauth-B?hler M, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Nees F, Pausova Z, Paus T, Rietschel M, Robbins T, Smolka MN, Spanagel R, Bakalkin G, Mill J, Sommer WH, Rose RJ, Yan J, Aliev F, Dick D, Kaprio J, Desrivi?res S, Schumann G,
The American journal of psychiatry172(6)543-52(2015 Jun)

WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ?Np73 levels.
Chaudhary N, Maddika S
Molecular and cellular biology34(19)3754-64(2014 Oct)

Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.
McNamara RP, McCann JL, Gudipaty SA, D'Orso I
Cell reports5(5)1256-68(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 once P-TEFb has been released from the 7SK snRNP.
Title: PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.

Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder.
Title: Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis.

PPM1G inactivates monomeric WWP2 and promotes the assembly of WWP2-WWP1 heterodimeric complex.
Title: WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ?Np73 levels.

PPM1G dephosphorylates the P-TEFb kinase T loop to disassemble the 7SK snRNP.
Title: Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.

study has identified protein phosphatase PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosphorylation of 4E-BP1.
Title: Protein phosphatase PPM1G regulates protein translation and cell growth by dephosphorylating 4E binding protein 1 (4E-BP1).

The following PPM1G gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPM1G cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27573	NM_177983.3 Latest version!	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu27573	NM_177983.2	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPM1G ( NM_177983.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_817092.1 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G), mRNA.

Price & Availability↑

CloneID	OHu27573
Clone ID Related Accession (Same CDS sequence)	NM_177983.3 , NM_177983.2
Accession Version	NM_177983.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1641bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	protein phosphatase 1G
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA520893.1 and BC000057.2. On Nov 23, 2018 this sequence version replaced NM_177983.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.55608.1, SRR1803614.275238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000344034.5/ ENSP00000342778.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 
CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 
GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT 
GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 
GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT 
ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA 
CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 
GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 
GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA 
CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT 
TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT 
GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC 
TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 
GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA 
GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG 
GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA 
GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG 
TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA 
GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT 
GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT 
GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC 
CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT 
GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC 
AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG 
GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC 
ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA 
AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG 
AAGAAGGCCA AGCGAGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_817092.1
CDS	170..1810
Translation	MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD

Target ORF information:

RefSeq Version	NM_177983.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177983.3

ORF Insert Sequence:

ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 
CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 
GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT 
GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 
GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT 
ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA 
CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 
GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 
GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA 
CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT 
TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT 
GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC 
TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 
GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA 
GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG 
GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA 
GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG 
TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA 
GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT 
GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT 
GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC 
CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT 
GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC 
AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG 
GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC 
ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA 
AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG 
AAGAAGGCCA AGCGAGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPM1G ( NM_177983.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_817092.1 Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G), mRNA.

Price & Availability↑

CloneID	OHu27573
Clone ID Related Accession (Same CDS sequence)	NM_177983.3 , NM_177983.2
Accession Version	NM_177983.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1641bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-14
Organism	Homo sapiens(human)
Product	protein phosphatase 1G
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA520893.1 and BC000057.2. On May 10, 2012 this sequence version replaced NM_177983.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.55608.1, SRR1803612.255665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 
CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 
GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT 
GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 
GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT 
ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA 
CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 
GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 
GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA 
CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT 
TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT 
GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC 
TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 
GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA 
GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG 
GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA 
GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG 
TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA 
GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT 
GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT 
GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC 
CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT 
GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC 
AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG 
GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC 
ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA 
AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG 
AAGAAGGCCA AGCGAGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_817092.1
CDS	262..1902
Translation	MGAYLSQPNTVKCSGDGVGAPRLPLPYGFSAMQGWRVSMEDAHNCIPELDSETAMFSVYDGHGGEEVALYCAKYLPDIIKDQKAYKEGKLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEEATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTAKAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDSGTTAVVALIRGKQLIVANAGDSRCVVSEAGKALDMSYDHKPEDEVELARIKNAGGKVTMDGRVNGGLNLSRAIGDHFYKRNKNLPPEEQMISALPDIKVLTLTDDHEFMVIACDGIWNVMSSQEVVDFIQSKISQRDENGELRLLSSIVEELLDQCLAPDTSGDGTGCDNMTCIIICFKPRNTAELQPESGKRKLEEVLSTEGAEENGNSDKKKKAKRD

Target ORF information:

RefSeq Version	NM_177983.2
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177983.2

ORF Insert Sequence:

ATGGGTGCCT ACCTCTCCCA GCCCAACACG GTGAAGTGCT CCGGGGACGG GGTCGGCGCC 
CCGCGCCTGC CGCTGCCCTA CGGCTTCTCC GCCATGCAAG GCTGGCGCGT CTCCATGGAG 
GATGCTCACA ACTGTATTCC TGAGCTGGAC AGTGAGACAG CCATGTTTTC TGTCTACGAT 
GGACATGGAG GGGAGGAAGT TGCCTTGTAC TGTGCCAAAT ATCTTCCTGA TATCATCAAA 
GATCAGAAGG CCTACAAGGA AGGCAAGCTA CAGAAGGCTT TAGAAGATGC CTTCTTGGCT 
ATTGACGCCA AATTGACCAC TGAAGAAGTC ATTAAAGAGC TGGCACAGAT TGCAGGGCGA 
CCCACTGAGG ATGAAGATGA AAAAGAAAAA GTAGCTGATG AAGATGATGT GGACAATGAG 
GAGGCTGCAC TGCTGCATGA AGAGGCTACC ATGACTATTG AAGAGCTGCT GACACGCTAC 
GGGCAGAACT GTCACAAGGG CCCTCCCCAC AGCAAATCTG GAGGTGGGAC AGGCGAGGAA 
CCAGGGTCCC AGGGCCTCAA TGGGGAGGCA GGACCTGAGG ACTCAACTAG GGAAACTCCT 
TCACAAGAAA ATGGCCCCAC AGCCAAGGCC TACACAGGCT TTTCCTCCAA CTCGGAACGT 
GGGACTGAGG CAGGCCAAGT TGGTGAGCCT GGCATTCCCA CTGGTGAGGC TGGGCCTTCC 
TGCTCTTCAG CCTCTGACAA GCTGCCTCGA GTTGCTAAGT CCAAGTTCTT TGAGGACAGT 
GAGGATGAGT CAGATGAGGC GGAGGAAGAA GAGGAAGACA GTGAGGAATG CAGCGAGGAA 
GAGGATGGCT ACAGCAGTGA GGAGGCAGAG AATGAGGAAG ATGAGGATGA CACCGAGGAG 
GCTGAAGAGG ACGATGAAGA AGAAGAAGAA GAGATGATGG TGCCAGGGAT GGAAGGCAAA 
GAGGAGCCTG GCTCTGACAG TGGTACAACA GCGGTGGTGG CCCTGATACG AGGGAAGCAG 
TTGATTGTAG CCAACGCAGG AGACTCTCGC TGTGTGGTAT CTGAGGCTGG CAAAGCTTTA 
GACATGTCCT ATGATCACAA ACCAGAGGAT GAAGTAGAAC TAGCACGCAT CAAGAATGCT 
GGTGGCAAGG TCACCATGGA TGGGCGAGTC AACGGGGGCC TCAACCTCTC CAGAGCCATT 
GGGGACCACT TCTATAAGAG AAACAAGAAC CTGCCACCTG AGGAACAGAT GATTTCAGCC 
CTTCCTGACA TCAAGGTGCT GACTCTCACT GACGACCATG AATTCATGGT CATTGCCTGT 
GATGGCATCT GGAATGTGAT GAGCAGCCAG GAAGTTGTAG ATTTCATTCA ATCAAAGATC 
AGCCAGCGTG ATGAAAATGG GGAGCTTCGG TTATTGTCAT CCATTGTGGA AGAGCTGCTG 
GATCAGTGCC TGGCACCAGA CACTTCTGGG GATGGTACAG GGTGTGACAA CATGACCTGC 
ATCATCATTT GCTTCAAGCC CCGAAACACA GCAGAGCTCC AGCCAGAGAG TGGCAAGCGA 
AAACTAGAGG AGGTGCTCTC TACTGAGGGG GCTGAAGAAA ATGGCAACAG CGACAAGAAG 
AAGAAGGCCA AGCGAGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Cell systems4(4)430-444.e5(2017 Apr)
Yadav L,Tamene F,G??s H,van Drogen A,Katainen R,Aebersold R,Gstaiger M,Varjosalo M

PPM1G Binds 7SK RNA and Hexim1 To Block P-TEFb Assembly into the 7SK snRNP and Sustain Transcription Elongation.
Molecular and cellular biology35(22)3810-28(2015 Nov)
Gudipaty SA,McNamara RP,Morton EL,D'Orso I

Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis.
The American journal of psychiatry172(6)543-52(2015 Jun)
Ruggeri B,Nymberg C,Vuoksimaa E,Lourdusamy A,Wong CP,Carvalho FM,Jia T,Cattrell A,Macare C,Banaschewski T,Barker GJ,Bokde AL,Bromberg U,B?chel C,Conrod PJ,Fauth-B?hler M,Flor H,Frouin V,Gallinat J,Garavan H,Gowland P,Heinz A,Ittermann B,Martinot JL,Nees F,Pausova Z,Paus T,Rietschel M,Robbins T,Smolka MN,Spanagel R,Bakalkin G,Mill J,Sommer WH,Rose RJ,Yan J,Aliev F,Dick D,Kaprio J,Desrivi?res S,Schumann G,

WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ?Np73 levels.
Molecular and cellular biology34(19)3754-64(2014 Oct)
Chaudhary N,Maddika S

Transcription factors mediate the enzymatic disassembly of promoter-bound 7SK snRNP to locally recruit P-TEFb for transcription elongation.
Cell reports5(5)1256-68(2013 Dec)
McNamara RP,McCann JL,Gudipaty SA,D'Orso I

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PPM1G cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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