NKX1-1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NKX1-1
Entrez Gene ID	54729
Full Name	NK1 homeobox 1
Synonyms	HSPX153,NKX-1.1,SAX2
General protein information	Preferred Names NK1 homeobox 1 Names NK1 transcription factor-related protein 1 HPX-153 homeobox NK1 transcription factor related, locus 1 homeobox protein 153 homeobox protein SAX-2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 4 Map Location: 4p16.3
Summary	This gene encodes a transcription factor that belongs to NKX family of homeodomain-containing proteins which are critical regulators of organ development. In mice, the orthologous gene is expressed predominantly in the brainstem, in the vicinity of serotonergic neurons, and is required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis. Mice with a knockout of the orthologous gene lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue two weeks after birth, and die within three weeks after birth. [provided by RefSeq, Jul 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001290079.1	NP_001277008.1	NK1 transcription factor-related protein 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Ablation of Sax2 gene expression prevents diet-induced obesity.
Simon R, Britsch S, Bergemann A
The FEBS journal278(2)371-82(2011 Jan)

Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis.
Simon R, Lufkin T, Bergemann AD
Developmental dynamics : an official publication of the American Association of Anatomists236(10)2792-9(2007 Oct)

Regulation of organ development by the NKX-homeodomain factors: an NKX code.
Stanfel MN, Moses KA, Schwartz RJ, Zimmer WE
Cellular and molecular biology (Noisy-le-Grand, France)Suppl 51OL785-99(2005 Oct)

Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.
Simon R, Lufkin T
Molecular and cellular biology23(24)9046-60(2003 Dec)

Identification of homeobox genes expressed in human haemopoietic progenitor cells.
Moretti P, Simmons P, Thomas P, Haylock D, Rathjen P, Vadas M, D'Andrea R
Gene144(2)213-9(1994 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following NKX1-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NKX1-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu02185	NM_001290079.1 Latest version!	Homo sapiens NK1 homeobox 1 (NKX1-1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NKX1-1 ( NM_001290079.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001277008.1 Homo sapiens NK1 homeobox 1 (NKX1-1), mRNA.

Price & Availability↑

CloneID	OHu02185
Clone ID Related Accession (Same CDS sequence)	NM_001290079.1
Accession Version	NM_001290079.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-05
Organism	Homo sapiens(human)
Product	NK1 transcription factor-related protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC118281.4. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from alignments. ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGCGCTA GCGGCCCCGA GGCTCCTGGG GACATTCCCG CGCTACCGCC GCCTCCCCAG 
CCAGGTTCGG GGCCCGCACC GCCCGCTCCC GCCGCCGCTG CCCAGGAAGC TATGGACGGG 
CGCGCCGAGC TGCCGGCCTT TCCCCGCGCT GGAGCCCCGC CGCTCGCGGC CAGCGACACT 
GTGCCTGCGG CGCCCGAGGG GGCTGGAGCG GCCCGGCCCG CAGCGCCCCT GCGCCCCACC 
TCCTTCTCGG TACTGGACAT CCTGGACCCC AACAAGTTCA ACAGCAGGAG GCGTCGTTGC 
GTGCTGCTGG GCCCAGTGGC TCCCGCTGCG TGCGCCCCTT GCGCTTCGGC CCCATGCGCC 
CCTGCACCCG CCGCCTCGGG ACGCCCGCCA CGCGCGGAGG AGCTGGAGCG CCGCGCCCTC 
GCCGGCGCCG GGGGAGTCGG AGCCGCCGGA GCTGAGCCGC CGAACGCCGG CGACCCCTTC 
AAGGCAGGGG AGGCCGAGAC CAACGACACC AACGGCTACA GCAGCGGCGG CGGCGGCCAC 
AGCCCGAGCG CGGACAGCGG GGACGAGGTT CCCGACGACG AGGACGACGA CGAGGACGAA 
GCGCCCGAGA CGGAGGCGGC GCGAGGCGCG GAGGAGGCGC GGGGAGGCGG CGGCGGCCTC 
GGGGCCCGCG GGTCGGGTTG CCAGGGCGCG GCTGAGACCG ACGCGTCCCC CGGAGCCACC 
GTCGACGAGG CAGCGGCCCC CGGACCCCGC GAGAACTCGC CCGTTGCCCA GGGCCCACCG 
GGAGGTGCAG CGGCGCCGGG GGGCGCGGGG ACCACCCCGC AGGGCACGGC GACGGCGGCG 
AAGCCCAAGC GGAAGCGCAC GGGGTCCGAC TCCAAGTCCG GGAAGCCGCG GCGAGCGCGC 
ACCGCCTTCA CCTACGAGCA GCTCGTGGCG CTGGAGAACA AGTTCAAGGC CACGCGCTAC 
CTGTCGGTGT GCGAGCGCCT CAACCTGGCG CTGTCGCTCA GCCTCACCGA GACGCAGGTG 
AAGATCTGGT TCCAGAACCG CCGAACCAAG TGGAAGAAGC AGAACCCGGG CGCCGACACC 
AGCGCTCCGA CCGGCGGCGG GGGCGGACCG GGACCGGGGG CCGGGCCTGG CACGGGGCTG 
CCCGGCGGCC TCAGCCCGCT CAGCCCCTCG CCGCCCATGG GCGCCCCGCT CGGCATGCAC 
GGCCCGGCCG GGTACCCGGC GCACGGCCCC GGAGGCCTGG TGTGCGCCGC GCAGCTGCCG 
TTCCTGTCGA GCCCGGCGGT GCTCTCGCCC TTCGTGCTGG GCTCGCAGAC CTACGGGGCG 
CCCGCCTTCT ACGCGCCGCA CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277008.1
CDS	1..1347
Translation	MSASGPEAPGDIPALPPPPQPGSGPAPPAPAAAAQEAMDGRAELPAFPRAGAPPLAASDTVPAAPEGAGAARPAAPLRPTSFSVLDILDPNKFNSRRRRCVLLGPVAPAACAPCASAPCAPAPAASGRPPRAEELERRALAGAGGVGAAGAEPPNAGDPFKAGEAETNDTNGYSSGGGGHSPSADSGDEVPDDEDDDEDEAPETEAARGAEEARGGGGGLGARGSGCQGAAETDASPGATVDEAAAPGPRENSPVAQGPPGGAAAPGGAGTTPQGTATAAKPKRKRTGSDSKSGKPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQNPGADTSAPTGGGGGPGPGAGPGTGLPGGLSPLSPSPPMGAPLGMHGPAGYPAHGPGGLVCAAQLPFLSSPAVLSPFVLGSQTYGAPAFYAPHL

Target ORF information:

RefSeq Version	NM_001290079.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NK1 homeobox 1 (NKX1-1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290079.1

ORF Insert Sequence:

ATGAGCGCTA GCGGCCCCGA GGCTCCTGGG GACATTCCCG CGCTACCGCC GCCTCCCCAG 
CCAGGTTCGG GGCCCGCACC GCCCGCTCCC GCCGCCGCTG CCCAGGAAGC TATGGACGGG 
CGCGCCGAGC TGCCGGCCTT TCCCCGCGCT GGAGCCCCGC CGCTCGCGGC CAGCGACACT 
GTGCCTGCGG CGCCCGAGGG GGCTGGAGCG GCCCGGCCCG CAGCGCCCCT GCGCCCCACC 
TCCTTCTCGG TACTGGACAT CCTGGACCCC AACAAGTTCA ACAGCAGGAG GCGTCGTTGC 
GTGCTGCTGG GCCCAGTGGC TCCCGCTGCG TGCGCCCCTT GCGCTTCGGC CCCATGCGCC 
CCTGCACCCG CCGCCTCGGG ACGCCCGCCA CGCGCGGAGG AGCTGGAGCG CCGCGCCCTC 
GCCGGCGCCG GGGGAGTCGG AGCCGCCGGA GCTGAGCCGC CGAACGCCGG CGACCCCTTC 
AAGGCAGGGG AGGCCGAGAC CAACGACACC AACGGCTACA GCAGCGGCGG CGGCGGCCAC 
AGCCCGAGCG CGGACAGCGG GGACGAGGTT CCCGACGACG AGGACGACGA CGAGGACGAA 
GCGCCCGAGA CGGAGGCGGC GCGAGGCGCG GAGGAGGCGC GGGGAGGCGG CGGCGGCCTC 
GGGGCCCGCG GGTCGGGTTG CCAGGGCGCG GCTGAGACCG ACGCGTCCCC CGGAGCCACC 
GTCGACGAGG CAGCGGCCCC CGGACCCCGC GAGAACTCGC CCGTTGCCCA GGGCCCACCG 
GGAGGTGCAG CGGCGCCGGG GGGCGCGGGG ACCACCCCGC AGGGCACGGC GACGGCGGCG 
AAGCCCAAGC GGAAGCGCAC GGGGTCCGAC TCCAAGTCCG GGAAGCCGCG GCGAGCGCGC 
ACCGCCTTCA CCTACGAGCA GCTCGTGGCG CTGGAGAACA AGTTCAAGGC CACGCGCTAC 
CTGTCGGTGT GCGAGCGCCT CAACCTGGCG CTGTCGCTCA GCCTCACCGA GACGCAGGTG 
AAGATCTGGT TCCAGAACCG CCGAACCAAG TGGAAGAAGC AGAACCCGGG CGCCGACACC 
AGCGCTCCGA CCGGCGGCGG GGGCGGACCG GGACCGGGGG CCGGGCCTGG CACGGGGCTG 
CCCGGCGGCC TCAGCCCGCT CAGCCCCTCG CCGCCCATGG GCGCCCCGCT CGGCATGCAC 
GGCCCGGCCG GGTACCCGGC GCACGGCCCC GGAGGCCTGG TGTGCGCCGC GCAGCTGCCG 
TTCCTGTCGA GCCCGGCGGT GCTCTCGCCC TTCGTGCTGG GCTCGCAGAC CTACGGGGCG 
CCCGCCTTCT ACGCGCCGCA CCTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ablation of Sax2 gene expression prevents diet-induced obesity.
The FEBS journal278(2)371-82(2011 Jan)
Simon R,Britsch S,Bergemann A

Homeobox gene Sax2 deficiency causes an imbalance in energy homeostasis.
Developmental dynamics : an official publication of the American Association of Anatomists236(10)2792-9(2007 Oct)
Simon R,Lufkin T,Bergemann AD

Regulation of organ development by the NKX-homeodomain factors: an NKX code.
Cellular and molecular biology (Noisy-le-Grand, France)Suppl 51OL785-99(2005 Oct)
Stanfel MN,Moses KA,Schwartz RJ,Zimmer WE

Postnatal lethality in mice lacking the Sax2 homeobox gene homologous to Drosophila S59/slouch: evidence for positive and negative autoregulation.
Molecular and cellular biology23(24)9046-60(2003 Dec)
Simon R,Lufkin T

Identification of homeobox genes expressed in human haemopoietic progenitor cells.
Gene144(2)213-9(1994 Jul)
Moretti P,Simmons P,Thomas P,Haylock D,Rathjen P,Vadas M,D'Andrea R

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NKX1-1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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