POU5F1B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	POU5F1B
Entrez Gene ID	5462
Full Name	POU class 5 homeobox 1B
Synonyms	OCT4-PG1,OCT4PG1,OTF3C,OTF3P1,POU5F1P1,POU5F1P4,POU5FLC20,POU5FLC8
General protein information	Preferred Names POU class 5 homeobox 1B Names putative POU domain, class 5, transcription factor 1B POU 5 domain protein POU class 5 homeobox 1 pseudogene 1 POU domain transcription factor OCT4-pg1 POU domain transcription factor Oct-4 POU domain, class 5, transcription factor 1 pseudogene 1 octamer binding protein 3_like sequence
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8q24.21
Summary	This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009].
Disorder MIM:	615739

mRNA and Protein(s)

mRNA	Protein	Name
NM_001159542.2	NP_001153014.1	putative POU domain, class 5, transcription factor 1B
NM_001159542.1	NP_001153014.1	putative POU domain, class 5, transcription factor 1B

Pathways from BioSystems

Homologies

Homo sapiens (human)	POU5F1B	NP_001153014.1
Pan troglodytes (chimpanzee)	POU5F1B	XP_528230.1

Gene Ontology
Bibliography

Related articles in PubMed

Prospective study of DNA methylation at chromosome 8q24 in peripheral blood and prostate cancer risk.
Barry KH, Moore LE, Sampson JN, Koutros S, Yan L, Meyer A, Reddy M, Oler AJ, Cook MB, Fraumeni JF Jr, Yeager M, Amundadottir LT, Berndt SI
British journal of cancer116(11)1470-1479(2017 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We identified eight specific CpG sites at 8q24, including six correlated sites in the POU5F1B gene, as well as two CpG sites in intergenic regions, whose DNA methylation levels were associated with prostate cancer risk.
Title: Prospective study of DNA methylation at chromosome 8q24 in peripheral blood and prostate cancer risk.

The POU5F1B pseudogene is amplified and expressed at a high level in, as well as confers an aggressive phenotype on, GC, and that POU5F1B amplification is associated with a poor prognosis in GC patients.
Title: The OCT4 pseudogene POU5F1B is amplified and promotes an aggressive phenotype in gastric cancer.

POU5F1P1 rs10505477 is correlated with survival of gastric cancer patients who receving cisplatin-based chemotherapy after gastrectomy.
Title: Clinical significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection.

Association of rs7014346 in POU5F1P1, rs989902 in PTPN13, and rs7003146 in TCF7L2 with variations in the risk of breast cancer in a Chinese Han population.
Title: Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population.

Data suggest that expression of Oct4 and NANOG (Nanog homeobox protein) is up-regulated in visceral adipose tissue stem cells in type 2 diabetes as compared to control; expression is also up-regulated in hyperglycemic conditions.
Title: A diabetic milieu promotes OCT4 and NANOG production in human visceral-derived adipose stem cells.

The following POU5F1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU5F1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26333	NM_001159542.2 Latest version!	Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu26333	NM_001159542.1	Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

POU5F1B ( NM_001159542.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001153014.1 Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA.

Price & Availability↑

CloneID	OHu26333
Clone ID Related Accession (Same CDS sequence)	NM_001159542.2 , NM_001159542.1
Accession Version	NM_001159542.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-08
Organism	Homo sapiens(human)
Product	putative POU domain, class 5, transcription factor 1B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ486513.1. On Jun 2, 2019 this sequence version replaced NM_001159542.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DQ486513.1, HQ122885.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGAC ACCTGGCTTC GGATTTCGCC TTCTCGCCCC CTCCAGGCGG TGGGGGTGAT 
GGGCCATGGG GGGCGGAGCC GGGCTGGGTT GATCCTCTGA CCTGGCTAAG CTTCCAAGGC 
CCTCCTGGAG GGCCAGGAAT CGGGCCGGGG GTTGGGCCAG GCTCTGAGGT GTGGGGGATT 
CCCCCTTGCC CCCCGCCGTA TGAGTTATGT GGGGGGATGG CGTACTGTGG GCCTCAGGTT 
GGAGTGGGGC TAGTGCCCCA AGGCGGCTTG GAGACCTCTC AGCCTGAGAG CGAAGCAGGA 
GTCGGGGTGG AGAGCAACTC CAATGGGGCC TCCCCGGAAC CCTGCACCGT CCCCCCTGGT 
GCCGTGAAGC TGGAGAAGGA GAAGCTAGAG CAAAACCCGG AGAAGTCCCA GGACATCAAA 
GCTCTGCAGA AAGAACTCGA GCAATTTGCC AAGCTCCTGA AGCAGAAGAG GATCACCCTG 
GGATATACAC AGGCCGATGT GGGGCTCATC CTGGGGGTTC TATTTGGGAA GGTGTTCAGC 
CAAAAGACCA TCTGCCGCTT TGAGGCTCTG CAGCTTAGCT TCAAGAACAT GTGTAAGCTG 
CGGCCCTTGC TGCAGAAGTG GGTGGAGGAA GCTGACAACA ATGAAAATCT TCAGGAGATA 
TGCAAAGCAG AAACCCTCAT GCAGGCCCGA AAGAGAAAGC GAACCAGTAT CGAGAACCGA 
GTGAGAGGCA ACCTGGAGAA TTTGTTCCTG CAGTGCCCGA AACCCACACT GCAGATCAGC 
CACATCGCCC AGCAGCTTGG GCTCGAGAAG GATGTGGTCC GAGTGTGGTT CTGTAACCGG 
CGCCAGAAGG GCAAGCGATC AAGCAGCGAC TATGCACAAC GAGAGGATTT TGAGGCTGCT 
GGGTCTCCTT TCTCAGGGGG ACCAGTGTCC TTTCCTCCGG CCCCAGGGCC CCATTTTGGT 
ACCCCAGGCT ATGGGAGCCC TCACTTCACT GCACTGTACT CCTCAGTCCC TTTCCCTGAG 
GGGGAAGTCT TTCCCCCAGT CTCCGTCATC ACTCTGGGCT CTCCCATGCA TTCAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153014.1
CDS	43..1122
Translation	MAGHLASDFAFSPPPGGGGDGPWGAEPGWVDPLTWLSFQGPPGGPGIGPGVGPGSEVWGIPPCPPPYELCGGMAYCGPQVGVGLVPQGGLETSQPESEAGVGVESNSNGASPEPCTVPPGAVKLEKEKLEQNPEKSQDIKALQKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQKTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLMQARKRKRTSIENRVRGNLENLFLQCPKPTLQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPPAPGPHFGTPGYGSPHFTALYSSVPFPEGEVFPPVSVITLGSPMHSN

Target ORF information:

RefSeq Version	NM_001159542.2
Organism	Homo sapiens(human)
Definition	Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159542.2

ORF Insert Sequence:

ATGGCGGGAC ACCTGGCTTC GGATTTCGCC TTCTCGCCCC CTCCAGGCGG TGGGGGTGAT 
GGGCCATGGG GGGCGGAGCC GGGCTGGGTT GATCCTCTGA CCTGGCTAAG CTTCCAAGGC 
CCTCCTGGAG GGCCAGGAAT CGGGCCGGGG GTTGGGCCAG GCTCTGAGGT GTGGGGGATT 
CCCCCTTGCC CCCCGCCGTA TGAGTTATGT GGGGGGATGG CGTACTGTGG GCCTCAGGTT 
GGAGTGGGGC TAGTGCCCCA AGGCGGCTTG GAGACCTCTC AGCCTGAGAG CGAAGCAGGA 
GTCGGGGTGG AGAGCAACTC CAATGGGGCC TCCCCGGAAC CCTGCACCGT CCCCCCTGGT 
GCCGTGAAGC TGGAGAAGGA GAAGCTAGAG CAAAACCCGG AGAAGTCCCA GGACATCAAA 
GCTCTGCAGA AAGAACTCGA GCAATTTGCC AAGCTCCTGA AGCAGAAGAG GATCACCCTG 
GGATATACAC AGGCCGATGT GGGGCTCATC CTGGGGGTTC TATTTGGGAA GGTGTTCAGC 
CAAAAGACCA TCTGCCGCTT TGAGGCTCTG CAGCTTAGCT TCAAGAACAT GTGTAAGCTG 
CGGCCCTTGC TGCAGAAGTG GGTGGAGGAA GCTGACAACA ATGAAAATCT TCAGGAGATA 
TGCAAAGCAG AAACCCTCAT GCAGGCCCGA AAGAGAAAGC GAACCAGTAT CGAGAACCGA 
GTGAGAGGCA ACCTGGAGAA TTTGTTCCTG CAGTGCCCGA AACCCACACT GCAGATCAGC 
CACATCGCCC AGCAGCTTGG GCTCGAGAAG GATGTGGTCC GAGTGTGGTT CTGTAACCGG 
CGCCAGAAGG GCAAGCGATC AAGCAGCGAC TATGCACAAC GAGAGGATTT TGAGGCTGCT 
GGGTCTCCTT TCTCAGGGGG ACCAGTGTCC TTTCCTCCGG CCCCAGGGCC CCATTTTGGT 
ACCCCAGGCT ATGGGAGCCC TCACTTCACT GCACTGTACT CCTCAGTCCC TTTCCCTGAG 
GGGGAAGTCT TTCCCCCAGT CTCCGTCATC ACTCTGGGCT CTCCCATGCA TTCAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POU5F1B ( NM_001159542.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001153014.1 Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA.

Price & Availability↑

CloneID	OHu26333
Clone ID Related Accession (Same CDS sequence)	NM_001159542.2 , NM_001159542.1
Accession Version	NM_001159542.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-20
Organism	Homo sapiens(human)
Product	putative POU domain, class 5, transcription factor 1B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ486513.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DQ486513.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGGAC ACCTGGCTTC GGATTTCGCC TTCTCGCCCC CTCCAGGCGG TGGGGGTGAT 
GGGCCATGGG GGGCGGAGCC GGGCTGGGTT GATCCTCTGA CCTGGCTAAG CTTCCAAGGC 
CCTCCTGGAG GGCCAGGAAT CGGGCCGGGG GTTGGGCCAG GCTCTGAGGT GTGGGGGATT 
CCCCCTTGCC CCCCGCCGTA TGAGTTATGT GGGGGGATGG CGTACTGTGG GCCTCAGGTT 
GGAGTGGGGC TAGTGCCCCA AGGCGGCTTG GAGACCTCTC AGCCTGAGAG CGAAGCAGGA 
GTCGGGGTGG AGAGCAACTC CAATGGGGCC TCCCCGGAAC CCTGCACCGT CCCCCCTGGT 
GCCGTGAAGC TGGAGAAGGA GAAGCTAGAG CAAAACCCGG AGAAGTCCCA GGACATCAAA 
GCTCTGCAGA AAGAACTCGA GCAATTTGCC AAGCTCCTGA AGCAGAAGAG GATCACCCTG 
GGATATACAC AGGCCGATGT GGGGCTCATC CTGGGGGTTC TATTTGGGAA GGTGTTCAGC 
CAAAAGACCA TCTGCCGCTT TGAGGCTCTG CAGCTTAGCT TCAAGAACAT GTGTAAGCTG 
CGGCCCTTGC TGCAGAAGTG GGTGGAGGAA GCTGACAACA ATGAAAATCT TCAGGAGATA 
TGCAAAGCAG AAACCCTCAT GCAGGCCCGA AAGAGAAAGC GAACCAGTAT CGAGAACCGA 
GTGAGAGGCA ACCTGGAGAA TTTGTTCCTG CAGTGCCCGA AACCCACACT GCAGATCAGC 
CACATCGCCC AGCAGCTTGG GCTCGAGAAG GATGTGGTCC GAGTGTGGTT CTGTAACCGG 
CGCCAGAAGG GCAAGCGATC AAGCAGCGAC TATGCACAAC GAGAGGATTT TGAGGCTGCT 
GGGTCTCCTT TCTCAGGGGG ACCAGTGTCC TTTCCTCCGG CCCCAGGGCC CCATTTTGGT 
ACCCCAGGCT ATGGGAGCCC TCACTTCACT GCACTGTACT CCTCAGTCCC TTTCCCTGAG 
GGGGAAGTCT TTCCCCCAGT CTCCGTCATC ACTCTGGGCT CTCCCATGCA TTCAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001153014.1
CDS	256..1335
Translation	MAGHLASDFAFSPPPGGGGDGPWGAEPGWVDPLTWLSFQGPPGGPGIGPGVGPGSEVWGIPPCPPPYELCGGMAYCGPQVGVGLVPQGGLETSQPESEAGVGVESNSNGASPEPCTVPPGAVKLEKEKLEQNPEKSQDIKALQKELEQFAKLLKQKRITLGYTQADVGLILGVLFGKVFSQKTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLMQARKRKRTSIENRVRGNLENLFLQCPKPTLQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPPAPGPHFGTPGYGSPHFTALYSSVPFPEGEVFPPVSVITLGSPMHSN

Target ORF information:

RefSeq Version	NM_001159542.1
Organism	Homo sapiens(human)
Definition	Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001159542.1

ORF Insert Sequence:

ATGGCGGGAC ACCTGGCTTC GGATTTCGCC TTCTCGCCCC CTCCAGGCGG TGGGGGTGAT 
GGGCCATGGG GGGCGGAGCC GGGCTGGGTT GATCCTCTGA CCTGGCTAAG CTTCCAAGGC 
CCTCCTGGAG GGCCAGGAAT CGGGCCGGGG GTTGGGCCAG GCTCTGAGGT GTGGGGGATT 
CCCCCTTGCC CCCCGCCGTA TGAGTTATGT GGGGGGATGG CGTACTGTGG GCCTCAGGTT 
GGAGTGGGGC TAGTGCCCCA AGGCGGCTTG GAGACCTCTC AGCCTGAGAG CGAAGCAGGA 
GTCGGGGTGG AGAGCAACTC CAATGGGGCC TCCCCGGAAC CCTGCACCGT CCCCCCTGGT 
GCCGTGAAGC TGGAGAAGGA GAAGCTAGAG CAAAACCCGG AGAAGTCCCA GGACATCAAA 
GCTCTGCAGA AAGAACTCGA GCAATTTGCC AAGCTCCTGA AGCAGAAGAG GATCACCCTG 
GGATATACAC AGGCCGATGT GGGGCTCATC CTGGGGGTTC TATTTGGGAA GGTGTTCAGC 
CAAAAGACCA TCTGCCGCTT TGAGGCTCTG CAGCTTAGCT TCAAGAACAT GTGTAAGCTG 
CGGCCCTTGC TGCAGAAGTG GGTGGAGGAA GCTGACAACA ATGAAAATCT TCAGGAGATA 
TGCAAAGCAG AAACCCTCAT GCAGGCCCGA AAGAGAAAGC GAACCAGTAT CGAGAACCGA 
GTGAGAGGCA ACCTGGAGAA TTTGTTCCTG CAGTGCCCGA AACCCACACT GCAGATCAGC 
CACATCGCCC AGCAGCTTGG GCTCGAGAAG GATGTGGTCC GAGTGTGGTT CTGTAACCGG 
CGCCAGAAGG GCAAGCGATC AAGCAGCGAC TATGCACAAC GAGAGGATTT TGAGGCTGCT 
GGGTCTCCTT TCTCAGGGGG ACCAGTGTCC TTTCCTCCGG CCCCAGGGCC CCATTTTGGT 
ACCCCAGGCT ATGGGAGCCC TCACTTCACT GCACTGTACT CCTCAGTCCC TTTCCCTGAG 
GGGGAAGTCT TTCCCCCAGT CTCCGTCATC ACTCTGGGCT CTCCCATGCA TTCAAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Prospective study of DNA methylation at chromosome 8q24 in peripheral blood and prostate cancer risk.
British journal of cancer116(11)1470-1479(2017 May)
Barry KH,Moore LE,Sampson JN,Koutros S,Yan L,Meyer A,Reddy M,Oler AJ,Cook MB,Fraumeni JF Jr,Yeager M,Amundadottir LT,Berndt SI

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

POU5F1B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報