POU4F3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	POU4F3
Entrez Gene ID	5459
Full Name	POU class 4 homeobox 3
Synonyms	BRN3C,DFNA15,DFNA42,DFNA52
General protein information	Preferred Names POU class 4 homeobox 3 Names POU domain, class 4, transcription factor 3 brain-3C brain-specific homeobox/POU domain protein 3C brn-3C deafness, autosomal dominant 42
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q32
Summary	This gene encodes a member of the POU-domain family of transcription factors. POU-domain proteins have been observed to play important roles in control of cell identity in several systems. This protein is found in the retina and may play a role in determining or maintaining the identities of a small subset of visual system neurons. Defects in this gene are the cause of non-syndromic sensorineural deafness autosomal dominant type 15. [provided by RefSeq, Mar 2009].
Disorder MIM:	602460
Disorder Html:	Deafness, autosomal dominant 15, 602459 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_002700.2	NP_002691.1	POU domain, class 4, transcription factor 3
NM_002700.3	NP_002691.1	POU domain, class 4, transcription factor 3

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	POU4F3	NP_990090.1
Pan troglodytes (chimpanzee)	POU4F3	XP_527063.1
Canis lupus familiaris (dog)	POU4F3	XP_544328.1
Bos taurus (cattle)	POU4F3	NP_001178964.1
Rattus norvegicus (Norway rat)	Pou4f3	NP_001102359.1
Danio rerio (zebrafish)	pou4f3	NP_571353.1
Drosophila melanogaster (fruit fly)	acj6	NP_524876.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002172	XP_308015.5
	POU4F3	XP_001100319.1
Mus musculus (house mouse)	Pou4f3	NP_620395.2
Xenopus tropicalis (tropical clawed frog)	pou4f3	XP_002935313.1
Homo sapiens (human)	POU4F3	NP_002691.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss.
Lin YH, Lin YH, Lu YC, Liu TC, Chen CY, Hsu CJ, Chen PL, Wu CC
Scientific reports7(1)7551(2017 Aug)

POU4F3 mutation screening in Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis identified novel variants associated with autosomal dominant hearing loss.
Kitano T, Miyagawa M, Nishio SY, Moteki H, Oda K, Ohyama K, Miyazaki H, Hidaka H, Nakamura KI, Murata T, Matsuoka R, Ohta Y, Nishiyama N, Kumakawa K, Furutate S, Iwasaki S, Yamada T, Ohta Y, Uehara N, Noguchi Y, Usami SI
PloS one12(5)e0177636(2017)

A Novel Nonsense Mutation of
Zhang C, Wang M, Xiao Y, Zhang F, Zhou Y, Li J, Zheng Q, Bai X, Wang H
Neural plasticity20161512831(2016)

Mutation in the Hair Cell Specific Gene
He L, Pang X, Chen P, Wu H, Yang T
Neural plasticity20169890827(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study identified a novel heterozygous mutation (c.602delT, p.L201fs) in the gene POU4F3 within a large hearing impaired Chinese family.
Title: Exome sequencing identifies POU4F3 as the causative gene for a large Chinese family with non-syndromic hearing loss.

Novel 12 POU4F3 likely pathogenic variants (six missense variants, three frameshift variants, and three nonsense variants) were successfully identified in 15 probands (2.5%) among 602 families exhibiting autosomal dominant hearing loss, whereas no variants were detected in the other 1,947 probands with autosomal recessive or inheritance pattern unknown hearing loss.
Title: POU4F3 mutation screening in Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis identified novel variants associated with autosomal dominant hearing loss.

results indicated GRHL2 might be a noise-induced hearing loss (NIHL) susceptibility gene, but the effect of POU4F3 on NIHL could only be detected when taking noise exposure into account and their effects were enhanced by higher levels of noise exposure
Title: Genetic Variation in POU4F3 and GRHL2 Associated with Noise-Induced Hearing Loss in Chinese Population: A Case-Control Study.

report the first nonsense mutation of POU4F3 associated with progressive hearing loss and explored the possible underlying mechanism
Title: A Novel Nonsense Mutation of

Mutations in POU4F3 are a relatively common cause of autosomal dominant nonsyndromic hearing loss in Chinese Hans.
Title: Mutation in the Hair Cell Specific Gene

The following POU4F3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU4F3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21794	NM_002700.3 Latest version!	Homo sapiens POU class 4 homeobox 3 (POU4F3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
View Old Accession Versions >>
OHu21794	NM_002700.2	Homo sapiens POU class 4 homeobox 3 (POU4F3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

POU4F3 ( NM_002700.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002691.1 Homo sapiens POU class 4 homeobox 3 (POU4F3), mRNA.

Price & Availability↑

CloneID	OHu21794
Clone ID Related Accession (Same CDS sequence)	NM_002700.2 , NM_002700.3
Accession Version	NM_002700.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	POU domain, class 4, transcription factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011396.4. This sequence is a reference standard in the RefSeqGene project. On Mar 28, 2009 this sequence version replaced NM_002700.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC104923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153427, SAMEA2158569 [ECO:0000348] ##Evidence-Data-END##

ATGATGGCCA TGAACTCCAA GCAGCCTTTC GGCATGCACC CGGTGCTGCA AGAACCCAAA 
TTCTCCAGTC TGCACTCTGG CTCCGAGGCC ATGCGCCGAG TCTGTCTCCC AGCCCCGCAG 
CTGCAGGGTA ATATATTTGG AAGCTTTGAT GAGAGCCTGC TGGCACGCGC CGAAGCTCTG 
GCGGCGGTGG ATATCGTCTC CCACGGCAAG AACCATCCGT TCAAGCCCGA CGCCACCTAC 
CATACCATGA GCAGCGTGCC CTGCACGTCC ACTTCGTCCA CCGTGCCCAT CTCCCACCCA 
GCTGCGCTCA CCTCACACCC TCACCACGCC GTGCACCAGG GCCTCGAAGG CGACCTGCTG 
GAGCACATCT CGCCCACGCT GAGTGTGAGC GGCCTGGGCG CTCCGGAACA CTCGGTGATG 
CCCGCACAGA TCCATCCACA CCACCTGGGC GCCATGGGCC ACCTGCACCA GGCCATGGGC 
ATGAGTCACC CGCACACCGT GGCCCCTCAT AGCGCCATGC CTGCATGCCT CAGCGACGTG 
GAGTCAGACC CGCGCGAGCT GGAAGCCTTC GCCGAGCGCT TCAAGCAGCG GCGCATCAAG 
CTGGGGGTGA CCCAGGCGGA CGTGGGCGCG GCTCTGGCTA ATCTCAAGAT CCCCGGCGTG 
GGCTCGCTGA GCCAAAGCAC CATCTGCAGG TTCGAGTCTC TCACTCTCTC GCACAACAAC 
ATGATCGCTC TCAAGCCGGT GCTCCAGGCC TGGTTGGAGG AGGCCGAGGC CGCCTACCGA 
GAGAAGAACA GCAAGCCAGA GCTCTTCAAC GGCAGCGAAC GGAAGCGCAA ACGCACGTCC 
ATCGCGGCGC CGGAGAAGCG TTCACTCGAG GCCTATTTCG CTATCCAGCC ACGTCCTTCA 
TCTGAGAAGA TCGCGGCCAT CGCTGAGAAA CTGGACCTTA AAAAGAACGT GGTGAGAGTC 
TGGTTCTGCA ACCAGAGACA GAAACAGAAA CGAATGAAGT ATTCGGCTGT CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002691.1
CDS	90..1106
Translation	MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH

Target ORF information:

RefSeq Version	NM_002700.2
Organism	Homo sapiens(human)
Definition	Homo sapiens POU class 4 homeobox 3 (POU4F3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002700.2

ORF Insert Sequence:

ATGATGGCCA TGAACTCCAA GCAGCCTTTC GGCATGCACC CGGTGCTGCA AGAACCCAAA 
TTCTCCAGTC TGCACTCTGG CTCCGAGGCC ATGCGCCGAG TCTGTCTCCC AGCCCCGCAG 
CTGCAGGGTA ATATATTTGG AAGCTTTGAT GAGAGCCTGC TGGCACGCGC CGAAGCTCTG 
GCGGCGGTGG ATATCGTCTC CCACGGCAAG AACCATCCGT TCAAGCCCGA CGCCACCTAC 
CATACCATGA GCAGCGTGCC CTGCACGTCC ACTTCGTCCA CCGTGCCCAT CTCCCACCCA 
GCTGCGCTCA CCTCACACCC TCACCACGCC GTGCACCAGG GCCTCGAAGG CGACCTGCTG 
GAGCACATCT CGCCCACGCT GAGTGTGAGC GGCCTGGGCG CTCCGGAACA CTCGGTGATG 
CCCGCACAGA TCCATCCACA CCACCTGGGC GCCATGGGCC ACCTGCACCA GGCCATGGGC 
ATGAGTCACC CGCACACCGT GGCCCCTCAT AGCGCCATGC CTGCATGCCT CAGCGACGTG 
GAGTCAGACC CGCGCGAGCT GGAAGCCTTC GCCGAGCGCT TCAAGCAGCG GCGCATCAAG 
CTGGGGGTGA CCCAGGCGGA CGTGGGCGCG GCTCTGGCTA ATCTCAAGAT CCCCGGCGTG 
GGCTCGCTGA GCCAAAGCAC CATCTGCAGG TTCGAGTCTC TCACTCTCTC GCACAACAAC 
ATGATCGCTC TCAAGCCGGT GCTCCAGGCC TGGTTGGAGG AGGCCGAGGC CGCCTACCGA 
GAGAAGAACA GCAAGCCAGA GCTCTTCAAC GGCAGCGAAC GGAAGCGCAA ACGCACGTCC 
ATCGCGGCGC CGGAGAAGCG TTCACTCGAG GCCTATTTCG CTATCCAGCC ACGTCCTTCA 
TCTGAGAAGA TCGCGGCCAT CGCTGAGAAA CTGGACCTTA AAAAGAACGT GGTGAGAGTC 
TGGTTCTGCA ACCAGAGACA GAAACAGAAA CGAATGAAGT ATTCGGCTGT CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

POU4F3 ( NM_002700.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002691.1 Homo sapiens POU class 4 homeobox 3 (POU4F3), mRNA.

Price & Availability↑

CloneID	OHu21794
Clone ID Related Accession (Same CDS sequence)	NM_002700.2 , NM_002700.3
Accession Version	NM_002700.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	POU domain, class 4, transcription factor 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011396.4. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002700.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC104923.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153427, SAMEA2158569 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000646991.2/ ENSP00000495718.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGGCCA TGAACTCCAA GCAGCCTTTC GGCATGCACC CGGTGCTGCA AGAACCCAAA 
TTCTCCAGTC TGCACTCTGG CTCCGAGGCC ATGCGCCGAG TCTGTCTCCC AGCCCCGCAG 
CTGCAGGGTA ATATATTTGG AAGCTTTGAT GAGAGCCTGC TGGCACGCGC CGAAGCTCTG 
GCGGCGGTGG ATATCGTCTC CCACGGCAAG AACCATCCGT TCAAGCCCGA CGCCACCTAC 
CATACCATGA GCAGCGTGCC CTGCACGTCC ACTTCGTCCA CCGTGCCCAT CTCCCACCCA 
GCTGCGCTCA CCTCACACCC TCACCACGCC GTGCACCAGG GCCTCGAAGG CGACCTGCTG 
GAGCACATCT CGCCCACGCT GAGTGTGAGC GGCCTGGGCG CTCCGGAACA CTCGGTGATG 
CCCGCACAGA TCCATCCACA CCACCTGGGC GCCATGGGCC ACCTGCACCA GGCCATGGGC 
ATGAGTCACC CGCACACCGT GGCCCCTCAT AGCGCCATGC CTGCATGCCT CAGCGACGTG 
GAGTCAGACC CGCGCGAGCT GGAAGCCTTC GCCGAGCGCT TCAAGCAGCG GCGCATCAAG 
CTGGGGGTGA CCCAGGCGGA CGTGGGCGCG GCTCTGGCTA ATCTCAAGAT CCCCGGCGTG 
GGCTCGCTGA GCCAAAGCAC CATCTGCAGG TTCGAGTCTC TCACTCTCTC GCACAACAAC 
ATGATCGCTC TCAAGCCGGT GCTCCAGGCC TGGTTGGAGG AGGCCGAGGC CGCCTACCGA 
GAGAAGAACA GCAAGCCAGA GCTCTTCAAC GGCAGCGAAC GGAAGCGCAA ACGCACGTCC 
ATCGCGGCGC CGGAGAAGCG TTCACTCGAG GCCTATTTCG CTATCCAGCC ACGTCCTTCA 
TCTGAGAAGA TCGCGGCCAT CGCTGAGAAA CTGGACCTTA AAAAGAACGT GGTGAGAGTC 
TGGTTCTGCA ACCAGAGACA GAAACAGAAA CGAATGAAGT ATTCGGCTGT CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002691.1
CDS	275..1291
Translation	MMAMNSKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSSTVPISHPAALTSHPHHAVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHTVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH

Target ORF information:

RefSeq Version	NM_002700.3
Organism	Homo sapiens(human)
Definition	Homo sapiens POU class 4 homeobox 3 (POU4F3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002700.3

ORF Insert Sequence:

ATGATGGCCA TGAACTCCAA GCAGCCTTTC GGCATGCACC CGGTGCTGCA AGAACCCAAA 
TTCTCCAGTC TGCACTCTGG CTCCGAGGCC ATGCGCCGAG TCTGTCTCCC AGCCCCGCAG 
CTGCAGGGTA ATATATTTGG AAGCTTTGAT GAGAGCCTGC TGGCACGCGC CGAAGCTCTG 
GCGGCGGTGG ATATCGTCTC CCACGGCAAG AACCATCCGT TCAAGCCCGA CGCCACCTAC 
CATACCATGA GCAGCGTGCC CTGCACGTCC ACTTCGTCCA CCGTGCCCAT CTCCCACCCA 
GCTGCGCTCA CCTCACACCC TCACCACGCC GTGCACCAGG GCCTCGAAGG CGACCTGCTG 
GAGCACATCT CGCCCACGCT GAGTGTGAGC GGCCTGGGCG CTCCGGAACA CTCGGTGATG 
CCCGCACAGA TCCATCCACA CCACCTGGGC GCCATGGGCC ACCTGCACCA GGCCATGGGC 
ATGAGTCACC CGCACACCGT GGCCCCTCAT AGCGCCATGC CTGCATGCCT CAGCGACGTG 
GAGTCAGACC CGCGCGAGCT GGAAGCCTTC GCCGAGCGCT TCAAGCAGCG GCGCATCAAG 
CTGGGGGTGA CCCAGGCGGA CGTGGGCGCG GCTCTGGCTA ATCTCAAGAT CCCCGGCGTG 
GGCTCGCTGA GCCAAAGCAC CATCTGCAGG TTCGAGTCTC TCACTCTCTC GCACAACAAC 
ATGATCGCTC TCAAGCCGGT GCTCCAGGCC TGGTTGGAGG AGGCCGAGGC CGCCTACCGA 
GAGAAGAACA GCAAGCCAGA GCTCTTCAAC GGCAGCGAAC GGAAGCGCAA ACGCACGTCC 
ATCGCGGCGC CGGAGAAGCG TTCACTCGAG GCCTATTTCG CTATCCAGCC ACGTCCTTCA 
TCTGAGAAGA TCGCGGCCAT CGCTGAGAAA CTGGACCTTA AAAAGAACGT GGTGAGAGTC 
TGGTTCTGCA ACCAGAGACA GAAACAGAAA CGAATGAAGT ATTCGGCTGT CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss.
Scientific reports7(1)7551(2017 Aug)
Lin YH,Lin YH,Lu YC,Liu TC,Chen CY,Hsu CJ,Chen PL,Wu CC

POU4F3 mutation screening in Japanese hearing loss patients: Massively parallel DNA sequencing-based analysis identified novel variants associated with autosomal dominant hearing loss.
PloS one12(5)e0177636(2017)
Kitano T,Miyagawa M,Nishio SY,Moteki H,Oda K,Ohyama K,Miyazaki H,Hidaka H,Nakamura KI,Murata T,Matsuoka R,Ohta Y,Nishiyama N,Kumakawa K,Furutate S,Iwasaki S,Yamada T,Ohta Y,Uehara N,Noguchi Y,Usami SI

A Novel Nonsense Mutation of
Neural plasticity20161512831(2016)
Zhang C,Wang M,Xiao Y,Zhang F,Zhou Y,Li J,Zheng Q,Bai X,Wang H

Mutation in the Hair Cell Specific Gene
Neural plasticity20169890827(2016)
He L,Pang X,Chen P,Wu H,Yang T

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POU4F3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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