Pou4f3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Pou4f3
Entrez Gene ID	364855
Full Name	POU class 4 homeobox 3
General protein information	Preferred Names POU class 4 homeobox 3 Names POU domain, class 4, transcription factor 3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 18 Map Location: 18p11

mRNA and Protein(s)

mRNA	Protein	Name
NM_001108889.1	NP_001102359.1	POU domain, class 4, transcription factor 3

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	POU4F3	NP_990090.1
Pan troglodytes (chimpanzee)	POU4F3	XP_527063.1
Canis lupus familiaris (dog)	POU4F3	XP_544328.1
Bos taurus (cattle)	POU4F3	NP_001178964.1
Rattus norvegicus (Norway rat)	Pou4f3	NP_001102359.1
Danio rerio (zebrafish)	pou4f3	NP_571353.1
Drosophila melanogaster (fruit fly)	acj6	NP_524876.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002172	XP_308015.5
	POU4F3	XP_001100319.1
Mus musculus (house mouse)	Pou4f3	NP_620395.2
Xenopus tropicalis (tropical clawed frog)	pou4f3	XP_002935313.1
Homo sapiens (human)	POU4F3	NP_002691.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss.
Lin YH, Lin YH, Lu YC, Liu TC, Chen CY, Hsu CJ, Chen PL, Wu CC
Scientific reports7(1)7551(2017 Aug)

Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.
Tornari C, Towers ER, Gale JE, Dawson SJ
PloS one9(11)e112247(2014)

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.
Zhang L, Wahlin K, Li Y, Masuda T, Yang Z, Zack DJ, Esumi N
Molecular vision191371-86(2013)

Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity.
Clough RL, Sud R, Davis-Silberman N, Hertzano R, Avraham KB, Holley M, Dawson SJ
Biochemical and biophysical research communications324(1)372-81(2004 Nov)

Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation.
Xiang M, Maklad A, Pirvola U, Fritzsch B
BMC neuroscience42(2003 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These data demonstrate that Nr2f2 is a direct target of POU4F3 in vitro and that this regulatory relationship may be relevant to hair cell development and survival.
Title: Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.

The following Pou4f3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pou4f3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08574	NM_001108889.1 Latest version!	Rattus norvegicus POU class 4 homeobox 3 (Pou4f3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Pou4f3 ( NM_001108889.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001102359.1 Rattus norvegicus POU class 4 homeobox 3 (Pou4f3), mRNA.

Price & Availability↑

CloneID	ORa08574
Clone ID Related Accession (Same CDS sequence)	NM_001108889.1
Accession Version	NM_001108889.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1017bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Rattus norvegicus(Norway rat)
Product	POU domain, class 4, transcription factor 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from CH473974.1. On or before Oct 4, 2007 this sequence version replaced XM_344675.3, XM_001069878.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGATGGCCA TGAACGCCAA GCAGCCTTTC GGCATGCACC CCGTACTGCA AGAACCCAAA 
TTCTCCAGCC TGCACTCCGG CTCTGAGGCC ATGCGCCGAG TTTGTCTCCC AGCCCCGCAG 
CTGCAGGGTA ATATATTTGG AAGCTTTGAT GAGAGCCTGC TGGCACGCGC CGAAGCTCTG 
GCGGCGGTGG ATATCGTCTC CCACGGCAAG AACCATCCGT TCAAGCCCGA CGCCACCTAC 
CATACCATGA GCAGCGTGCC CTGCACGTCC ACCTCGCCCA CGGTGCCCAT CTCCCACCCG 
GCTGCACTCA CCTCGCACCC GCATCACCCG GTACATCAGG GCCTCGAGGG CGACTTACTG 
GAGCACATCT CGCCCACGCT GAGCGTGAGC GGCCTAGGGG CCCCGGAGCA CTCCGTGATG 
CCGGCGCAGA TCCACCCGCA TCATCTAGGC GCCATGGGCC ACTTGCATCA GGCCATGGGC 
ATGAGTCACC CGCATGCCGT AGCACCTCAC AGTGCCATGC CTGCGTGTCT CAGCGATGTG 
GAGTCAGACC CTCGAGAGCT GGAGGCGTTC GCCGAGCGCT TCAAGCAGAG GCGCATCAAG 
TTGGGGGTAA CCCAGGCGGA CGTGGGCGCG GCTTTAGCCA ATCTTAAGAT CCCCGGCGTG 
GGCTCTCTCA GCCAGAGCAC CATCTGCAGG TTCGAGTCTC TTACCCTGTC GCACAACAAC 
ATGATCGCGC TCAAGCCAGT CCTCCAGGCC TGGCTGGAGG AGGCCGAGGC CGCCTACCGA 
GAGAAGAACA GCAAGCCGGA GCTCTTCAAC GGCAGTGAGC GTAAGCGCAA ACGCACGTCC 
ATCGCCGCGC CAGAGAAGCG CTCACTCGAA GCCTATTTCG CCATCCAGCC ACGTCCTTCA 
TCTGAAAAGA TCGCGGCCAT CGCTGAGAAA CTGGACCTTA AAAAGAATGT GGTGAGGGTC 
TGGTTCTGTA ACCAGAGACA GAAACAGAAA CGAATGAAGT ACTCTGCTGT CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001102359.1
CDS	1..1017
Translation	MMAMNAKQPFGMHPVLQEPKFSSLHSGSEAMRRVCLPAPQLQGNIFGSFDESLLARAEALAAVDIVSHGKNHPFKPDATYHTMSSVPCTSTSPTVPISHPAALTSHPHHPVHQGLEGDLLEHISPTLSVSGLGAPEHSVMPAQIHPHHLGAMGHLHQAMGMSHPHAVAPHSAMPACLSDVESDPRELEAFAERFKQRRIKLGVTQADVGAALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPVLQAWLEEAEAAYREKNSKPELFNGSERKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAVH

Target ORF information:

RefSeq Version	NM_001108889.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus POU class 4 homeobox 3 (Pou4f3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001108889.1

ORF Insert Sequence:

ATGATGGCCA TGAACGCCAA GCAGCCTTTC GGCATGCACC CCGTACTGCA AGAACCCAAA 
TTCTCCAGCC TGCACTCCGG CTCTGAGGCC ATGCGCCGAG TTTGTCTCCC AGCCCCGCAG 
CTGCAGGGTA ATATATTTGG AAGCTTTGAT GAGAGCCTGC TGGCACGCGC CGAAGCTCTG 
GCGGCGGTGG ATATCGTCTC CCACGGCAAG AACCATCCGT TCAAGCCCGA CGCCACCTAC 
CATACCATGA GCAGCGTGCC CTGCACGTCC ACCTCGCCCA CGGTGCCCAT CTCCCACCCG 
GCTGCACTCA CCTCGCACCC GCATCACCCG GTACATCAGG GCCTCGAGGG CGACTTACTG 
GAGCACATCT CGCCCACGCT GAGCGTGAGC GGCCTAGGGG CCCCGGAGCA CTCCGTGATG 
CCGGCGCAGA TCCACCCGCA TCATCTAGGC GCCATGGGCC ACTTGCATCA GGCCATGGGC 
ATGAGTCACC CGCATGCCGT AGCACCTCAC AGTGCCATGC CTGCGTGTCT CAGCGATGTG 
GAGTCAGACC CTCGAGAGCT GGAGGCGTTC GCCGAGCGCT TCAAGCAGAG GCGCATCAAG 
TTGGGGGTAA CCCAGGCGGA CGTGGGCGCG GCTTTAGCCA ATCTTAAGAT CCCCGGCGTG 
GGCTCTCTCA GCCAGAGCAC CATCTGCAGG TTCGAGTCTC TTACCCTGTC GCACAACAAC 
ATGATCGCGC TCAAGCCAGT CCTCCAGGCC TGGCTGGAGG AGGCCGAGGC CGCCTACCGA 
GAGAAGAACA GCAAGCCGGA GCTCTTCAAC GGCAGTGAGC GTAAGCGCAA ACGCACGTCC 
ATCGCCGCGC CAGAGAAGCG CTCACTCGAA GCCTATTTCG CCATCCAGCC ACGTCCTTCA 
TCTGAAAAGA TCGCGGCCAT CGCTGAGAAA CTGGACCTTA AAAAGAATGT GGTGAGGGTC 
TGGTTCTGTA ACCAGAGACA GAAACAGAAA CGAATGAAGT ACTCTGCTGT CCACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel missense variant in the nuclear localization signal of POU4F3 causes autosomal dominant non-syndromic hearing loss.
Scientific reports7(1)7551(2017 Aug)
Lin YH,Lin YH,Lu YC,Liu TC,Chen CY,Hsu CJ,Chen PL,Wu CC

Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3.
PloS one9(11)e112247(2014)
Tornari C,Towers ER,Gale JE,Dawson SJ

RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors.
Molecular vision191371-86(2013)
Zhang L,Wahlin K,Li Y,Masuda T,Yang Z,Zack DJ,Esumi N

Brn-3c (POU4F3) regulates BDNF and NT-3 promoter activity.
Biochemical and biophysical research communications324(1)372-81(2004 Nov)
Clough RL,Sud R,Davis-Silberman N,Hertzano R,Avraham KB,Holley M,Dawson SJ

Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation.
BMC neuroscience42(2003 Jan)
Xiang M,Maklad A,Pirvola U,Fritzsch B

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Pou4f3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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