PMCH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PMCH
Entrez Gene ID	5367
Full Name	pro-melanin concentrating hormone
Synonyms	MCH,ppMCH
General protein information	Preferred Names pro-melanin concentrating hormone Names pro-MCH prepro-MCH prepro-melanin-concentrating hormone
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q23.2
Summary	This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include melanin-concentrating hormone (MCH), neuropeptide-glutamic acid-isoleucine (NEI), and neuropeptide-glycine-glutamic acid (NGE). Melanin-concentrating hormone is a 19-amino acid neuropeptide that stimulates hunger and may additionally regulate energy homeostasis, reproductive function, and sleep. Pseudogenes of this gene have been identified on chromosome 5. [provided by RefSeq, Jul 2015].
Disorder MIM:	176795

mRNA and Protein(s)

mRNA	Protein	Name
NM_002674.3	NP_002665.2	pro-MCH preproprotein
XM_017019483.1	XP_016874972.1	pro-MCH isoform X1
XM_017019483.2	XP_016874972.1	pro-MCH isoform X1
NM_002674.4	NP_002665.2	pro-MCH preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	PMCH	NP_001005755.1
Mus musculus (house mouse)	Pmch	NP_084247.1
Homo sapiens (human)	PMCH	NP_002665.2
Pan troglodytes (chimpanzee)	PMCH	NP_001128240.1
Bos taurus (cattle)	PMCH	NP_001073709.1
Rattus norvegicus (Norway rat)	Pmch	NP_036757.1
Gallus gallus (chicken)	PMCH	NP_001182724.1
Xenopus tropicalis (tropical clawed frog)	pmch	XP_002936876.1

Gene Ontology
Bibliography

Related articles in PubMed

Ubiquitous expression and multiple functions of biologically active peptides.
Takahashi K, Ohba K, Kaneko K
Peptides72184-91(2015 Oct)

Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis.
Ziogas DC, Gras-Miralles B, Mustafa S, Geiger BM, Najarian RM, Nagel JM, Flier SN, Popov Y, Tseng YH, Kokkotou E
American journal of physiology. Gastrointestinal and liver physiology304(10)G876-84(2013 May)

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.
Blouin AM, Fried I, Wilson CL, Staba RJ, Behnke EJ, Lam HA, Maidment NT, Karlsson K?, Lapierre JL, Siegel JM
Nature communications41547(2013)

The roles of melanin-concentrating hormone in energy balance and reproductive function: Are they connected?
Naufahu J, Cunliffe AD, Murray JF
Reproduction (Cambridge, England)146(5)R141-50(2013)

Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease.
Schmidt FM, Kratzsch J, Gertz HJ, Tittmann M, Jahn I, Pietsch UC, Kaisers UX, Thiery J, Hegerl U, Sch?nknecht P
PloS one8(5)e63136(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the changes in the levels of two hypothalamic neuropeptides, hypocretin-1 and melanin-concentrating hormone, measured in the human amygdala, are reported.
Title: Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.

MCH is an anabolic neuropeptide with multiple and diverse physiological functions including a key role in energy homoeostasis; evidence suggests that, in the reproductive context, MCH is a modulator rather than a primary regulator.
Title: The roles of melanin-concentrating hormone in energy balance and reproductive function: Are they connected?

Cerebrospinal fluid (CSF) levels were measured in 33 patients with Alzheimer's disease (AD) and 33 healthy subjects, to investigate the role of MCH and HCRT-1 in AD.
Title: Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease.

Melanin-concentrating hormone (MCH) neurons of human hypothalamus, as well as the MCH neurons of mouse hypothalamus, contain IL-6Ralpha.
Title: Interleukin-6 receptor ? is co-localised with melanin-concentrating hormone in human and mouse hypothalamus.

PMCH mRNA expression level was increased 1.85 times (P < 0.01) in vitiligo uninvolved skin and 5.36 times (P < 0.01) in involved skin compared to healthy control skin.
Title: Analysis of the expression profile of CRH-POMC system genes in vitiligo skin biopsies.

The following PMCH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PMCH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23618	NM_002674.4 Latest version!	Homo sapiens pro-melanin concentrating hormone (PMCH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu83896	XM_017019483.2 Latest version!	Homo sapiens pro-melanin concentrating hormone (PMCH), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
View Old Accession Versions >>
OHu83896	XM_017019483.1	Homo sapiens pro-melanin concentrating hormone (PMCH), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$69.30 $99.00
OHu23618	NM_002674.3	Homo sapiens pro-melanin concentrating hormone (PMCH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PMCH ( NM_002674.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002665.2 Homo sapiens pro-melanin concentrating hormone (PMCH), mRNA.

Price & Availability↑

CloneID	OHu23618
Clone ID Related Accession (Same CDS sequence)	NM_002674.3 , NM_002674.4
Accession Version	NM_002674.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	pro-MCH preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB047053.1 and CB047052.1. On Jul 24, 2015 this sequence version replaced NM_002674.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CB047052.1, BG706782.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAAAAA TGAATCTCTC TTCCTATATA TTAATACTAA CTTTTTCTTT GTTTTCTCAA 
GGTATTTTAC TTTCAGCATC CAAGTCCATA AGAAATTTAG ATGATGACAT GGTATTTAAT 
ACATTCAGGT TGGGGAAAGG CTTTCAGAAG GAAGACACTG CAGAAAAATC AGTTATTGCT 
CCTTCCCTGG AACAATATAA AAATGATGAG AGCAGTTTCA TGAACGAAGA GGAAAATAAA 
GTTTCAAAGA ACACAGGCTC CAAACATAAT TTCTTAAATC ATGGTCTGCC ACTGAATCTG 
GCTATAAAAC CTTATCTTGC ACTAAAAGGA TCTGTAGCTT TCCCAGCTGA GAATGGAGTT 
CAGAATACTG AATCAACACA AGAAAAGAGA GAAATTGGGG ATGAAGAAAA CTCAGCTAAA 
TTTCCTATAG GAAGGAGAGA TTTTGACATG CTCAGATGTA TGCTGGGAAG AGTCTACCGA 
CCTTGTTGGC AAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002665.2
CDS	76..573
Translation	MAKMNLSSYILILTFSLFSQGILLSASKSIRNLDDDMVFNTFRLGKGFQKEDTAEKSVIAPSLEQYKNDESSFMNEEENKVSKNTGSKHNFLNHGLPLNLAIKPYLALKGSVAFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV

Target ORF information:

RefSeq Version	NM_002674.3
Organism	Homo sapiens(human)
Definition	Homo sapiens pro-melanin concentrating hormone (PMCH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002674.3

ORF Insert Sequence:

ATGGCAAAAA TGAATCTCTC TTCCTATATA TTAATACTAA CTTTTTCTTT GTTTTCTCAA 
GGTATTTTAC TTTCAGCATC CAAGTCCATA AGAAATTTAG ATGATGACAT GGTATTTAAT 
ACATTCAGGT TGGGGAAAGG CTTTCAGAAG GAAGACACTG CAGAAAAATC AGTTATTGCT 
CCTTCCCTGG AACAATATAA AAATGATGAG AGCAGTTTCA TGAACGAAGA GGAAAATAAA 
GTTTCAAAGA ACACAGGCTC CAAACATAAT TTCTTAAATC ATGGTCTGCC ACTGAATCTG 
GCTATAAAAC CTTATCTTGC ACTAAAAGGA TCTGTAGCTT TCCCAGCTGA GAATGGAGTT 
CAGAATACTG AATCAACACA AGAAAAGAGA GAAATTGGGG ATGAAGAAAA CTCAGCTAAA 
TTTCCTATAG GAAGGAGAGA TTTTGACATG CTCAGATGTA TGCTGGGAAG AGTCTACCGA 
CCTTGTTGGC AAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMCH ( NM_002674.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002665.2 Homo sapiens pro-melanin concentrating hormone (PMCH), mRNA.

Price & Availability↑

CloneID	OHu23618
Clone ID Related Accession (Same CDS sequence)	NM_002674.3 , NM_002674.4
Accession Version	NM_002674.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 498bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	pro-MCH preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB047053.1 and CB047052.1. On Nov 22, 2018 this sequence version replaced NM_002674.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018048.1, BG706895.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000329406.5/ ENSP00000332225.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAAAAA TGAATCTCTC TTCCTATATA TTAATACTAA CTTTTTCTTT GTTTTCTCAA 
GGTATTTTAC TTTCAGCATC CAAGTCCATA AGAAATTTAG ATGATGACAT GGTATTTAAT 
ACATTCAGGT TGGGGAAAGG CTTTCAGAAG GAAGACACTG CAGAAAAATC AGTTATTGCT 
CCTTCCCTGG AACAATATAA AAATGATGAG AGCAGTTTCA TGAACGAAGA GGAAAATAAA 
GTTTCAAAGA ACACAGGCTC CAAACATAAT TTCTTAAATC ATGGTCTGCC ACTGAATCTG 
GCTATAAAAC CTTATCTTGC ACTAAAAGGA TCTGTAGCTT TCCCAGCTGA GAATGGAGTT 
CAGAATACTG AATCAACACA AGAAAAGAGA GAAATTGGGG ATGAAGAAAA CTCAGCTAAA 
TTTCCTATAG GAAGGAGAGA TTTTGACATG CTCAGATGTA TGCTGGGAAG AGTCTACCGA 
CCTTGTTGGC AAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002665.2
CDS	64..561
Translation	MAKMNLSSYILILTFSLFSQGILLSASKSIRNLDDDMVFNTFRLGKGFQKEDTAEKSVIAPSLEQYKNDESSFMNEEENKVSKNTGSKHNFLNHGLPLNLAIKPYLALKGSVAFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV

Target ORF information:

RefSeq Version	NM_002674.4
Organism	Homo sapiens(human)
Definition	Homo sapiens pro-melanin concentrating hormone (PMCH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002674.4

ORF Insert Sequence:

ATGGCAAAAA TGAATCTCTC TTCCTATATA TTAATACTAA CTTTTTCTTT GTTTTCTCAA 
GGTATTTTAC TTTCAGCATC CAAGTCCATA AGAAATTTAG ATGATGACAT GGTATTTAAT 
ACATTCAGGT TGGGGAAAGG CTTTCAGAAG GAAGACACTG CAGAAAAATC AGTTATTGCT 
CCTTCCCTGG AACAATATAA AAATGATGAG AGCAGTTTCA TGAACGAAGA GGAAAATAAA 
GTTTCAAAGA ACACAGGCTC CAAACATAAT TTCTTAAATC ATGGTCTGCC ACTGAATCTG 
GCTATAAAAC CTTATCTTGC ACTAAAAGGA TCTGTAGCTT TCCCAGCTGA GAATGGAGTT 
CAGAATACTG AATCAACACA AGAAAAGAGA GAAATTGGGG ATGAAGAAAA CTCAGCTAAA 
TTTCCTATAG GAAGGAGAGA TTTTGACATG CTCAGATGTA TGCTGGGAAG AGTCTACCGA 
CCTTGTTGGC AAGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMCH ( XM_017019483.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016874972.1 Homo sapiens pro-melanin concentrating hormone (PMCH), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu83896
Clone ID Related Accession (Same CDS sequence)	XM_017019483.1 , XM_017019483.2
Accession Version	XM_017019483.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	pro-MCH isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAAAAA TGAATCTCTC TTCCTATATA TTAATACTAA CTTTTTCTTT GTTTTCTCAA 
GGTATTTTAC TTTCAGCATC CAAGTCCATA AGAAATTTAG ATGATGACAT GGTATTTAAT 
ACATTCAGGT TGGGGAAAGG CTTTCAGAAG GAAGACACTG CAGAAAAATC AGTTATTGCT 
CCTTCCCTGG AACAATATAA AAATGATGAG AGCAGTTTCA TGAACGAAGA GGAAAATAAA 
GTTTCAAAGA ACACAGGCTC CAAACATAAT TTCTTAAATC ATGGTCTGCC ACTGAATCTG 
GCTATAAAAC CTTATCTTGC ACTAAAAGGA TCTGTAGCTT TCCCAGCTGA GAATGGAGTT 
CAGAATACTG AATCAACACA AGAAAAGAGA GAAATTGGGG ATGAAGAAAA CTCAGCTAAA 
TTTCCTATAG GAAGGAGAGA TTTTGACAGT GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016874972.1
CDS	1771..2226
Translation	MAKMNLSSYILILTFSLFSQGILLSASKSIRNLDDDMVFNTFRLGKGFQKEDTAEKSVIAPSLEQYKNDESSFMNEEENKVSKNTGSKHNFLNHGLPLNLAIKPYLALKGSVAFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDSE

Target ORF information:

RefSeq Version	XM_017019483.1
Organism	Homo sapiens(human)
Definition	Homo sapiens pro-melanin concentrating hormone (PMCH), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017019483.1

ORF Insert Sequence:

ATGGCAAAAA TGAATCTCTC TTCCTATATA TTAATACTAA CTTTTTCTTT GTTTTCTCAA 
GGTATTTTAC TTTCAGCATC CAAGTCCATA AGAAATTTAG ATGATGACAT GGTATTTAAT 
ACATTCAGGT TGGGGAAAGG CTTTCAGAAG GAAGACACTG CAGAAAAATC AGTTATTGCT 
CCTTCCCTGG AACAATATAA AAATGATGAG AGCAGTTTCA TGAACGAAGA GGAAAATAAA 
GTTTCAAAGA ACACAGGCTC CAAACATAAT TTCTTAAATC ATGGTCTGCC ACTGAATCTG 
GCTATAAAAC CTTATCTTGC ACTAAAAGGA TCTGTAGCTT TCCCAGCTGA GAATGGAGTT 
CAGAATACTG AATCAACACA AGAAAAGAGA GAAATTGGGG ATGAAGAAAA CTCAGCTAAA 
TTTCCTATAG GAAGGAGAGA TTTTGACAGT GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PMCH ( XM_017019483.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016874972.1 Homo sapiens pro-melanin concentrating hormone (PMCH), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu83896
Clone ID Related Accession (Same CDS sequence)	XM_017019483.1 , XM_017019483.2
Accession Version	XM_017019483.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	pro-MCH isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000012.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017019483.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAAAAA TGAATCTCTC TTCCTATATA TTAATACTAA CTTTTTCTTT GTTTTCTCAA 
GGTATTTTAC TTTCAGCATC CAAGTCCATA AGAAATTTAG ATGATGACAT GGTATTTAAT 
ACATTCAGGT TGGGGAAAGG CTTTCAGAAG GAAGACACTG CAGAAAAATC AGTTATTGCT 
CCTTCCCTGG AACAATATAA AAATGATGAG AGCAGTTTCA TGAACGAAGA GGAAAATAAA 
GTTTCAAAGA ACACAGGCTC CAAACATAAT TTCTTAAATC ATGGTCTGCC ACTGAATCTG 
GCTATAAAAC CTTATCTTGC ACTAAAAGGA TCTGTAGCTT TCCCAGCTGA GAATGGAGTT 
CAGAATACTG AATCAACACA AGAAAAGAGA GAAATTGGGG ATGAAGAAAA CTCAGCTAAA 
TTTCCTATAG GAAGGAGAGA TTTTGACAGT GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016874972.1
CDS	1771..2226
Translation	MAKMNLSSYILILTFSLFSQGILLSASKSIRNLDDDMVFNTFRLGKGFQKEDTAEKSVIAPSLEQYKNDESSFMNEEENKVSKNTGSKHNFLNHGLPLNLAIKPYLALKGSVAFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDSE

Target ORF information:

RefSeq Version	XM_017019483.2
Organism	Homo sapiens(human)
Definition	Homo sapiens pro-melanin concentrating hormone (PMCH), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017019483.2

ORF Insert Sequence:

ATGGCAAAAA TGAATCTCTC TTCCTATATA TTAATACTAA CTTTTTCTTT GTTTTCTCAA 
GGTATTTTAC TTTCAGCATC CAAGTCCATA AGAAATTTAG ATGATGACAT GGTATTTAAT 
ACATTCAGGT TGGGGAAAGG CTTTCAGAAG GAAGACACTG CAGAAAAATC AGTTATTGCT 
CCTTCCCTGG AACAATATAA AAATGATGAG AGCAGTTTCA TGAACGAAGA GGAAAATAAA 
GTTTCAAAGA ACACAGGCTC CAAACATAAT TTCTTAAATC ATGGTCTGCC ACTGAATCTG 
GCTATAAAAC CTTATCTTGC ACTAAAAGGA TCTGTAGCTT TCCCAGCTGA GAATGGAGTT 
CAGAATACTG AATCAACACA AGAAAAGAGA GAAATTGGGG ATGAAGAAAA CTCAGCTAAA 
TTTCCTATAG GAAGGAGAGA TTTTGACAGT GAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ubiquitous expression and multiple functions of biologically active peptides.
Peptides72184-91(2015 Oct)
Takahashi K,Ohba K,Kaneko K

Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis.
American journal of physiology. Gastrointestinal and liver physiology304(10)G876-84(2013 May)
Ziogas DC,Gras-Miralles B,Mustafa S,Geiger BM,Najarian RM,Nagel JM,Flier SN,Popov Y,Tseng YH,Kokkotou E

Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction.
Nature communications41547(2013)
Blouin AM,Fried I,Wilson CL,Staba RJ,Behnke EJ,Lam HA,Maidment NT,Karlsson K?,Lapierre JL,Siegel JM

The roles of melanin-concentrating hormone in energy balance and reproductive function: Are they connected?
Reproduction (Cambridge, England)146(5)R141-50(2013)
Naufahu J,Cunliffe AD,Murray JF

Cerebrospinal fluid melanin-concentrating hormone (MCH) and hypocretin-1 (HCRT-1, orexin-A) in Alzheimer's disease.
PloS one8(5)e63136(2013)
Schmidt FM,Kratzsch J,Gertz HJ,Tittmann M,Jahn I,Pietsch UC,Kaisers UX,Thiery J,Hegerl U,Sch?nknecht P

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PMCH cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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