TPPP3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	TPPP3
Entrez Gene ID	51673
Full Name	tubulin polymerization promoting protein family member 3
Synonyms	CGI-38,TPPP/p20,p20,p25gamma
General protein information	Preferred Names tubulin polymerization promoting protein family member 3 Names tubulin polymerization-promoting protein family member 3 brain specific protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q22.1
Disorder MIM:	616957

mRNA and Protein(s)

mRNA	Protein	Name
NM_016140.3	NP_057224.2	tubulin polymerization-promoting protein family member 3
NM_016140.4	NP_057224.2	tubulin polymerization-promoting protein family member 3
NM_015964.4	NP_057048.2	tubulin polymerization-promoting protein family member 3
NM_015964.3	NP_057048.2	tubulin polymerization-promoting protein family member 3
XM_024450294.1	XP_024306062.1	tubulin polymerization-promoting protein family member 3 isoform X1

Pathways from BioSystems

Homologies

	TPPP3	XP_002802577.1
Bos taurus (cattle)	TPPP3	NP_001029946.1
Mus musculus (house mouse)	Tppp3	NP_080757.1
Rattus norvegicus (Norway rat)	Tppp3	NP_001009639.1
Danio rerio (zebrafish)	LOC559490	XP_687926.1
Xenopus tropicalis (tropical clawed frog)	tppp3	NP_001096466.1
Homo sapiens (human)	TPPP3	NP_057224.2
Canis lupus familiaris (dog)	TPPP3	XP_005620890.1

Gene Ontology
Bibliography

Related articles in PubMed

Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation.
Zhou W, Wang X, Li L, Feng X, Yang Z, Zhang W, Hu R
Molecular and cellular biochemistry333(1-2)91-8(2010 Jan)

Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW
European archives of psychiatry and clinical neuroscience259(3)151-63(2009 Apr)

Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.
Vincze O, T?k?si N, Ol?h J, Hlavanda E, Zotter A, Horv?th I, Lehotzky A, Tiri?n L, Medzihradszky KF, Kov?cs J, Orosz F, Ov?di J
Biochemistry45(46)13818-26(2006 Nov)

p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.
Lindersson E, Lundvig D, Petersen C, Madsen P, Nyengaard JR, H?jrup P, Moos T, Otzen D, Gai WP, Blumbergs PC, Jensen PH
The Journal of biological chemistry280(7)5703-15(2005 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TPPP3 played a crucial role in cell mitosis by regulating centrosomes amplification and/or spindles translocation processes.
Title: Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation.

Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.
Title: Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.

The following TPPP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TPPP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01349	NM_015964.4 Latest version!	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01349	NM_016140.4 Latest version!	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01349	XM_024450294.1 Latest version!	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu01349	NM_016140.3	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu01349	NM_015964.3	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TPPP3 ( NM_016140.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057224.2 Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01349
Clone ID Related Accession (Same CDS sequence)	NM_016140.3 , NM_016140.4 , NM_015964.4 , NM_015964.3 , XM_024450294.1
Accession Version	NM_016140.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	tubulin polymerization-promoting protein family member 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009061.10, BI754230.1, BC000691.2 and AW044067.1. On Dec 27, 2013 this sequence version replaced NM_016140.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: ERR279839.7590.1, CF455847.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057224.2
CDS	254..784
Translation	MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK

Target ORF information:

RefSeq Version	NM_016140.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016140.3

ORF Insert Sequence:

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TPPP3 ( NM_016140.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057224.2 Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu01349
Clone ID Related Accession (Same CDS sequence)	NM_016140.3 , NM_016140.4 , NM_015964.4 , NM_015964.3 , XM_024450294.1
Accession Version	NM_016140.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-31
Organism	Homo sapiens(human)
Product	tubulin polymerization-promoting protein family member 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI754230.1 and BC000691.2. On Jun 1, 2019 this sequence version replaced NM_016140.3. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: ERR279839.7590.1, SRR7410570.624822.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057224.2
CDS	217..747
Translation	MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK

Target ORF information:

RefSeq Version	NM_016140.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016140.4

ORF Insert Sequence:

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TPPP3 ( NM_015964.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057048.2 Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01349
Clone ID Related Accession (Same CDS sequence)	NM_016140.3 , NM_016140.4 , NM_015964.4 , NM_015964.3 , XM_024450294.1
Accession Version	NM_015964.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-01
Organism	Homo sapiens(human)
Product	tubulin polymerization-promoting protein family member 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BQ640401.1 and BC000691.2. On Nov 23, 2018 this sequence version replaced NM_015964.3. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: SRR5189652.8566.1, SRR5189652.63344.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000393957.7/ ENSP00000377529.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057048.2
CDS	126..656
Translation	MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK

Target ORF information:

RefSeq Version	NM_015964.4
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015964.4

ORF Insert Sequence:

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TPPP3 ( NM_015964.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_057048.2 Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu01349
Clone ID Related Accession (Same CDS sequence)	NM_016140.3 , NM_016140.4 , NM_015964.4 , NM_015964.3 , XM_024450294.1
Accession Version	NM_015964.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	tubulin polymerization-promoting protein family member 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009061.10, BQ640401.1, BC000691.2 and AW044067.1. On Dec 27, 2013 this sequence version replaced NM_015964.2. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: ERR279873.1939.1, BM924797.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596, SAMEA2151119 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057048.2
CDS	163..693
Translation	MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK

Target ORF information:

RefSeq Version	NM_015964.3
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015964.3

ORF Insert Sequence:

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TPPP3 ( XM_024450294.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024306062.1 Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu01349
Clone ID Related Accession (Same CDS sequence)	NM_016140.3 , NM_016140.4 , NM_015964.4 , NM_015964.3 , XM_024450294.1
Accession Version	XM_024450294.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	tubulin polymerization-promoting protein family member 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024306062.1
CDS	1091..1621
Translation	MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFSKVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGGAVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK

Target ORF information:

RefSeq Version	XM_024450294.1
Organism	Homo sapiens(human)
Definition	Homo sapiens tubulin polymerization promoting protein family member 3 (TPPP3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024450294.1

ORF Insert Sequence:

ATGGCAGCGA GCACAGACAT GGCTGGGCTG GAGGAGAGCT TCCGCAAGTT TGCCATCCAT 
GGTGACCCCA AGGCCAGTGG GCAAGAGATG AATGGCAAGA ACTGGGCCAA GCTGTGCAAG 
GACTGCAAGG TGGCTGACGG AAAGTCCGTG ACAGGGACCG ATGTGGACAT CGTCTTCTCC 
AAAGTCAAGG GGAAGTCTGC TCGGGTCATC AACTATGAGG AGTTCAAGAA GGCCCTGGAA 
GAGCTGGCGA CCAAGAGATT CAAGGGGAAG AGCAAGGAGG AGGCCTTCGA TGCCATCTGC 
CAGCTGGTGG CAGGCAAAGA GCCAGCCAAT GTGGGCGTCA CTAAAGCAAA AACAGGGGGT 
GCTGTAGACC GGCTGACGGA CACCAGCAGA TACACGGGCT CCCACAAGGA GCGCTTCGAT 
GAGAGCGGCA AGGGCAAGGG CATTGCGGGA CGGCAGGACA TCCTGGACGA CAGTGGCTAC 
GTGAGCGCCT ACAAGAATGC AGGCACCTAC GATGCCAAGG TGAAGAAGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Depletion of tubulin polymerization promoting protein family member 3 suppresses HeLa cell proliferation.
Molecular and cellular biochemistry333(1-2)91-8(2010 Jan)
Zhou W,Wang X,Li L,Feng X,Yang Z,Zhang W,Hu R

Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
European archives of psychiatry and clinical neuroscience259(3)151-63(2009 Apr)
Martins-de-Souza D,Gattaz WF,Schmitt A,Rewerts C,Maccarrone G,Dias-Neto E,Turck CW

Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions.
Biochemistry45(46)13818-26(2006 Nov)
Vincze O,T?k?si N,Ol?h J,Hlavanda E,Zotter A,Horv?th I,Lehotzky A,Tiri?n L,Medzihradszky KF,Kov?cs J,Orosz F,Ov?di J

p25alpha Stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies.
The Journal of biological chemistry280(7)5703-15(2005 Feb)
Lindersson E,Lundvig D,Petersen C,Madsen P,Nyengaard JR,H?jrup P,Moos T,Otzen D,Gai WP,Blumbergs PC,Jensen PH

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TPPP3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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