ATP5PB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATP5PB
Entrez Gene ID	515
Full Name	ATP synthase peripheral stalk-membrane subunit b
Synonyms	ATP5F1,PIG47
General protein information	Preferred Names ATP synthase peripheral stalk-membrane subunit b Names ATP synthase F(0) complex subunit B1, mitochondrial ATP synthase B chain, mitochondrial ATP synthase proton-transporting mitochondrial F(0) complex subunit B1 ATP synthase subunit b, mitochondrial ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b ATP synthase, H+ transporting, mitochondrial Fo complex subunit B1 ATPase subunit b H+-ATP synthase subunit b cell proliferation-inducing protein 47
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p13.2
Summary	This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008].
Disorder MIM:	603270

mRNA and Protein(s)

mRNA	Protein	Name
NM_001688.4	NP_001679.2	ATP synthase F(0) complex subunit B1, mitochondrial precursor
NM_001688.5	NP_001679.2	ATP synthase F(0) complex subunit B1, mitochondrial precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	ATP5F1	XP_513639.1
Drosophila melanogaster (fruit fly)	ATPsyn-b	NP_524011.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP001138	XP_322024.4
Xenopus tropicalis (tropical clawed frog)	atp5f1	NP_989118.1
Bos taurus (cattle)	ATP5F1	NP_001033590.1
Mus musculus (house mouse)	Atp5f1	NP_033855.2
Rattus norvegicus (Norway rat)	Atp5f1	NP_599192.1
	ATP5F1	XP_001105535.1
Canis lupus familiaris (dog)	LOC479901	XP_537027.2
Danio rerio (zebrafish)	atp5f1	NP_001005960.1
Homo sapiens (human)	ATP5F1	NP_001679.2
Rattus norvegicus (Norway rat)	LOC100911417	XP_003749420.1
Gallus gallus (chicken)	ATP5F1	XP_417993.3

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Chen S, Lu FF, Seeman P, Liu F
Neurochemical research37(12)2805-13(2012 Dec)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance.
Title: Down-regulation of mitochondrial ATPase by hypermethylation mechanism in chronic myeloid leukemia is associated with multidrug resistance.

Observational study of gene-disease association. (HuGE Navigator)
Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.

Nitration of tyrosine residues 368 and 345 in the beta-subunit elicits FoF1-ATPase activity loss.
Title: Nitration of tyrosine residues 368 and 345 in the beta-subunit elicits FoF1-ATPase activity loss.

Observational study of gene-disease association. (HuGE Navigator)
Title: Polymorphisms in mitochondrial genes and prostate cancer risk.

The following ATP5PB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATP5PB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu21926	NM_001688.5 Latest version!	Homo sapiens ATP synthase peripheral stalk-membrane subunit b (ATP5PB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu21926	NM_001688.4	Homo sapiens ATP synthase peripheral stalk-membrane subunit b (ATP5PB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATP5PB ( NM_001688.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001679.2 Homo sapiens ATP synthase peripheral stalk-membrane subunit b (ATP5PB), mRNA.

Price & Availability↑

CloneID	OHu21926
Clone ID Related Accession (Same CDS sequence)	NM_001688.4 , NM_001688.5
Accession Version	NM_001688.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-23
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit B1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF237506.1, AL390195.10, AW778751.1 and AI754631.1. On Jan 27, 2006 this sequence version replaced NM_001688.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279875.3286.1, SRR1803613.222075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCTGTCCC GGGTGGTACT TTCCGCCGCC GCCACAGCGG CCCCCTCTCT GAAGAATGCA 
GCCTTCCTAG GTCCAGGGGT ATTGCAGGCA ACAAGGACCT TTCATACAGG GCAGCCACAC 
CTTGTCCCTG TACCACCTCT TCCTGAATAC GGAGGAAAAG TTCGTTATGG ACTGATCCCT 
GAGGAATTCT TCCAGTTTCT TTATCCTAAA ACTGGTGTAA CAGGACCCTA TGTACTCGGA 
ACTGGGCTTA TCTTGTACGC TTTATCCAAA GAAATATATG TGATTAGCGC AGAGACCTTC 
ACTGCCCTAT CAGTACTAGG TGTAATGGTC TATGGAATTA AAAAATATGG TCCCTTTGTT 
GCAGACTTTG CTGATAAACT CAATGAGCAA AAACTTGCCC AACTAGAAGA GGCGAAGCAG 
GCTTCCATCC AACACATCCA GAATGCAATT GATACGGAGA AGTCACAACA GGCACTGGTT 
CAGAAGCGCC ATTACCTTTT TGATGTGCAA AGGAATAACA TTGCTATGGC TTTGGAAGTT 
ACTTACCGGG AACGACTGTA TAGAGTATAT AAGGAAGTAA AGAATCGCCT GGACTATCAT 
ATATCTGTGC AGAACATGAT GCGTCGAAAG GAACAAGAAC ACATGATAAA TTGGGTGGAG 
AAGCACGTGG TGCAAAGCAT CTCCACACAG CAGGAAAAGG AGACAATTGC CAAGTGCATT 
GCGGACCTAA AGCTGCTGGC AAAGAAGGCT CAAGCACAGC CAGTTATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001679.2
CDS	422..1192
Translation	MLSRVVLSAAATAAPSLKNAAFLGPGVLQATRTFHTGQPHLVPVPPLPEYGGKVRYGLIPEEFFQFLYPKTGVTGPYVLGTGLILYALSKEIYVISAETFTALSVLGVMVYGIKKYGPFVADFADKLNEQKLAQLEEAKQASIQHIQNAIDTEKSQQALVQKRHYLFDVQRNNIAMALEVTYRERLYRVYKEVKNRLDYHISVQNMMRRKEQEHMINWVEKHVVQSISTQQEKETIAKCIADLKLLAKKAQAQPVM

Target ORF information:

RefSeq Version	NM_001688.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase peripheral stalk-membrane subunit b (ATP5PB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001688.4

ORF Insert Sequence:

ATGCTGTCCC GGGTGGTACT TTCCGCCGCC GCCACAGCGG CCCCCTCTCT GAAGAATGCA 
GCCTTCCTAG GTCCAGGGGT ATTGCAGGCA ACAAGGACCT TTCATACAGG GCAGCCACAC 
CTTGTCCCTG TACCACCTCT TCCTGAATAC GGAGGAAAAG TTCGTTATGG ACTGATCCCT 
GAGGAATTCT TCCAGTTTCT TTATCCTAAA ACTGGTGTAA CAGGACCCTA TGTACTCGGA 
ACTGGGCTTA TCTTGTACGC TTTATCCAAA GAAATATATG TGATTAGCGC AGAGACCTTC 
ACTGCCCTAT CAGTACTAGG TGTAATGGTC TATGGAATTA AAAAATATGG TCCCTTTGTT 
GCAGACTTTG CTGATAAACT CAATGAGCAA AAACTTGCCC AACTAGAAGA GGCGAAGCAG 
GCTTCCATCC AACACATCCA GAATGCAATT GATACGGAGA AGTCACAACA GGCACTGGTT 
CAGAAGCGCC ATTACCTTTT TGATGTGCAA AGGAATAACA TTGCTATGGC TTTGGAAGTT 
ACTTACCGGG AACGACTGTA TAGAGTATAT AAGGAAGTAA AGAATCGCCT GGACTATCAT 
ATATCTGTGC AGAACATGAT GCGTCGAAAG GAACAAGAAC ACATGATAAA TTGGGTGGAG 
AAGCACGTGG TGCAAAGCAT CTCCACACAG CAGGAAAAGG AGACAATTGC CAAGTGCATT 
GCGGACCTAA AGCTGCTGGC AAAGAAGGCT CAAGCACAGC CAGTTATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATP5PB ( NM_001688.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001679.2 Homo sapiens ATP synthase peripheral stalk-membrane subunit b (ATP5PB), mRNA.

Price & Availability↑

CloneID	OHu21926
Clone ID Related Accession (Same CDS sequence)	NM_001688.4 , NM_001688.5
Accession Version	NM_001688.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 771bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-10
Organism	Homo sapiens(human)
Product	ATP synthase F(0) complex subunit B1, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BF237506.1, AL390195.10, AW778751.1 and AI754631.1. On Nov 23, 2018 this sequence version replaced NM_001688.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291077.1, SRR1803613.81793.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000369722.8/ ENSP00000358737.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTGTCCC GGGTGGTACT TTCCGCCGCC GCCACAGCGG CCCCCTCTCT GAAGAATGCA 
GCCTTCCTAG GTCCAGGGGT ATTGCAGGCA ACAAGGACCT TTCATACAGG GCAGCCACAC 
CTTGTCCCTG TACCACCTCT TCCTGAATAC GGAGGAAAAG TTCGTTATGG ACTGATCCCT 
GAGGAATTCT TCCAGTTTCT TTATCCTAAA ACTGGTGTAA CAGGACCCTA TGTACTCGGA 
ACTGGGCTTA TCTTGTACGC TTTATCCAAA GAAATATATG TGATTAGCGC AGAGACCTTC 
ACTGCCCTAT CAGTACTAGG TGTAATGGTC TATGGAATTA AAAAATATGG TCCCTTTGTT 
GCAGACTTTG CTGATAAACT CAATGAGCAA AAACTTGCCC AACTAGAAGA GGCGAAGCAG 
GCTTCCATCC AACACATCCA GAATGCAATT GATACGGAGA AGTCACAACA GGCACTGGTT 
CAGAAGCGCC ATTACCTTTT TGATGTGCAA AGGAATAACA TTGCTATGGC TTTGGAAGTT 
ACTTACCGGG AACGACTGTA TAGAGTATAT AAGGAAGTAA AGAATCGCCT GGACTATCAT 
ATATCTGTGC AGAACATGAT GCGTCGAAAG GAACAAGAAC ACATGATAAA TTGGGTGGAG 
AAGCACGTGG TGCAAAGCAT CTCCACACAG CAGGAAAAGG AGACAATTGC CAAGTGCATT 
GCGGACCTAA AGCTGCTGGC AAAGAAGGCT CAAGCACAGC CAGTTATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001679.2
CDS	79..849
Translation	MLSRVVLSAAATAAPSLKNAAFLGPGVLQATRTFHTGQPHLVPVPPLPEYGGKVRYGLIPEEFFQFLYPKTGVTGPYVLGTGLILYALSKEIYVISAETFTALSVLGVMVYGIKKYGPFVADFADKLNEQKLAQLEEAKQASIQHIQNAIDTEKSQQALVQKRHYLFDVQRNNIAMALEVTYRERLYRVYKEVKNRLDYHISVQNMMRRKEQEHMINWVEKHVVQSISTQQEKETIAKCIADLKLLAKKAQAQPVM

Target ORF information:

RefSeq Version	NM_001688.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP synthase peripheral stalk-membrane subunit b (ATP5PB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001688.5

ORF Insert Sequence:

ATGCTGTCCC GGGTGGTACT TTCCGCCGCC GCCACAGCGG CCCCCTCTCT GAAGAATGCA 
GCCTTCCTAG GTCCAGGGGT ATTGCAGGCA ACAAGGACCT TTCATACAGG GCAGCCACAC 
CTTGTCCCTG TACCACCTCT TCCTGAATAC GGAGGAAAAG TTCGTTATGG ACTGATCCCT 
GAGGAATTCT TCCAGTTTCT TTATCCTAAA ACTGGTGTAA CAGGACCCTA TGTACTCGGA 
ACTGGGCTTA TCTTGTACGC TTTATCCAAA GAAATATATG TGATTAGCGC AGAGACCTTC 
ACTGCCCTAT CAGTACTAGG TGTAATGGTC TATGGAATTA AAAAATATGG TCCCTTTGTT 
GCAGACTTTG CTGATAAACT CAATGAGCAA AAACTTGCCC AACTAGAAGA GGCGAAGCAG 
GCTTCCATCC AACACATCCA GAATGCAATT GATACGGAGA AGTCACAACA GGCACTGGTT 
CAGAAGCGCC ATTACCTTTT TGATGTGCAA AGGAATAACA TTGCTATGGC TTTGGAAGTT 
ACTTACCGGG AACGACTGTA TAGAGTATAT AAGGAAGTAA AGAATCGCCT GGACTATCAT 
ATATCTGTGC AGAACATGAT GCGTCGAAAG GAACAAGAAC ACATGATAAA TTGGGTGGAG 
AAGCACGTGG TGCAAAGCAT CTCCACACAG CAGGAAAAGG AGACAATTGC CAAGTGCATT 
GCGGACCTAA AGCTGCTGGC AAAGAAGGCT CAAGCACAGC CAGTTATGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.
Neurochemical research37(12)2805-13(2012 Dec)
Chen S,Lu FF,Seeman P,Liu F

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

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ATP5PB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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