NME8 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NME8
Entrez Gene ID	51314
Full Name	NME/NM23 family member 8
Synonyms	CILD6,HEL-S-99,NM23-H8,SPTRX2,TXNDC3,sptrx-2
General protein information	Preferred Names NME/NM23 family member 8 Names thioredoxin domain-containing protein 3 epididymis secretory protein Li 99 sperm-specific thioredoxin 2 spermatid-specific thioredoxin-2 thioredoxin domain containing 3 (spermatozoa)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p14.1
Summary	This gene encodes a protein with an N-terminal thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer dynein arms, and the protein is implicated in ciliary function. Mutations in this gene are implicated in primary ciliary dyskinesia type 6.[provided by RefSeq, Nov 2009].
Disorder MIM:	607421
Disorder Html:	Ciliary dyskinesia, primary, 6, 610852 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_016616.5	NP_057700.3	thioredoxin domain-containing protein 3
NM_016616.4	NP_057700.3	thioredoxin domain-containing protein 3

Pathways from BioSystems

Homologies

Homo sapiens (human)	NME8	NP_057700.3
Pan troglodytes (chimpanzee)	TXNDC3	XP_527723.3
	TXNDC3	XP_001101594.1
Gallus gallus (chicken)	TXNDC3	XP_426021.3
Danio rerio (zebrafish)	nme8	NP_001082944.1
Canis lupus familiaris (dog)	NME8	XP_851794.1
Mus musculus (house mouse)	Nme8	NP_853622.2
Rattus norvegicus (Norway rat)	Nme8	NP_942087.2
Xenopus tropicalis (tropical clawed frog)	nme9	NP_001121456.1

Gene Ontology
Bibliography

Related articles in PubMed

Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study.
Bressler J, Mosley TH, Penman A, Gottesman RF, Windham BG, Knopman DS, Wruck LM, Boerwinkle E
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics174(3)269-282(2017 Apr)

NME8 rs2718058 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.
Liu SL, Wang XC, Tan MS, Wang HF, Zhang W, Wang ZX, Yu JT, Tan L
Oncotarget7(24)36014-36020(2016 Jun)

A genome-wide association study of periodontitis in a Japanese population.
Shimizu S, Momozawa Y, Takahashi A, Nagasawa T, Ashikawa K, Terada Y, Izumi Y, Kobayashi H, Tsuji M, Kubo M, Furuichi Y
Journal of dental research94(4)555-61(2015 Apr)

Association between NME8 locus polymorphism and cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease.
Liu Y, Yu JT, Wang HF, Hao XK, Yang YF, Jiang T, Zhu XC, Cao L, Zhang DQ, Tan L
PloS one9(12)e114777(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Addition of the minor allele for rs670139 (MS4A4E), rs9331896 (CLU), and rs12155159 (NME8) was nominally associated with change on the DWRT, DSST, and WFT, respectively, in whites.
Title: Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study.

Studies suggest that the rs2718058 near gene NME8 on chromosome 7p14.1 might not play a major role in the genetic predisposition to late-onset Alzheimer's disease (LOAD) in the North Han Chinese.
Title: NME8 rs2718058 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.

GPR141-NME8 locus had strong genetic effect on the susceptibility to generalized periodontitis in Japanese individuals with history of smoking. identified 2 suggestive loci for periodontitis in a Japanese population.
Title: A genome-wide association study of periodontitis in a Japanese population.

NME8 locus polymorphism is associated with cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease.
Title: Association between NME8 locus polymorphism and cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following NME8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NME8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu27090	NM_016616.5 Latest version!	Homo sapiens NME/NM23 family member 8 (NME8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu27090	NM_016616.4	Homo sapiens NME/NM23 family member 8 (NME8), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NME8 ( NM_016616.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_057700.3 Homo sapiens NME/NM23 family member 8 (NME8), mRNA.

Price & Availability↑

CloneID	OHu27090
Clone ID Related Accession (Same CDS sequence)	NM_016616.5 , NM_016616.4
Accession Version	NM_016616.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1767bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	thioredoxin domain-containing protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC036816.1 and AF202051.2. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_016616.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: GQ472221.1, BC036816.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119, SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000199447.9/ ENSP00000199447.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAAGCA AAAAACGAGA AGTCCAGTTA CAGACAGTCA TCAATAATCA AAGCCTGTGG 
GATGAGATGT TGCAGAACAA AGGCTTAACA GTGATTGATG TTTACCAAGC CTGGTGTGGA 
CCTTGCAGAG CAATGCAACC TTTATTCAGA AAATTGAAAA ATGAACTGAA CGAAGACGAA 
ATTCTGCATT TTGCTGTCGC AGAAGCTGAC AACATTGTGA CTTTGCAGCC ATTTAGAGAT 
AAATGTGAAC CTGTTTTTCT CTTTAGTGTT AATGGCAAAA TTATCGAAAA GATTCAGGGT 
GCAAATGCAC CGCTTGTTAA TAAAAAAGTT ATTAATTTGA TCGATGAGGA GAGAAAAATT 
GCAGCAGGTG AAATGGCTCG ACCTCAGTAT CCTGAAATTC CATTAGTAGA CTCAGATTCA 
GAAGTTAGTG AAGAATCACC ATGTGAAAGT GTTCAGGAAT TATACAGTAT TGCTATTATC 
AAACCGGATG CTGTGATTAG TAAAAAAGTT CTAGAAATTA AAAGAAAAAT TACCAAAGCT 
GGATTTATTA TAGAAGCAGA GCATAAGACA GTGCTCACTG AAGAACAAGT TGTCAACTTC 
TATAGTCGAA TAGCAGACCA GTGTGACTTC GAAGAGTTTG TCTCTTTTAT GACAAGTGGC 
TTAAGCTATA TTCTAGTTGT ATCTCAAGGA AGTAAACACA ATCCTCCCTC TGAAGAAACC 
GAACCACAGA CTGACACCGA ACCTAACGAA CGATCTGAGG ATCAACCTGA GGTCGAAGCC 
CAGGTTACAC CTGGAATGAT GAAGAACAAA CAAGACAGTT TACAAGAATA TCTGGAAAGA 
CAACATTTAG CTCAGCTCTG TGACATTGAA GAGGATGCAG CTAATGTTGC TAAGTTCATG 
GATGCTTTCT TCCCCGATTT TAAAAAAATG AAAAGCATGA AATTAGAAAA GACATTGGCA 
TTACTTCGAC CAAATCTCTT TCATGAAAGG AAAGATGATG TTTTGCGTAT TATTAAAGAT 
GAAGACTTCA AAATACTGGA GCAAAGACAA GTAGTATTAT CGGAAAAAGA AGCACAAGCA 
CTGTGCAAGG AATATGAAAA TGAAGACTAT TTTAATAAAC TTATAGAAAA CATGACCAGT 
GGTCCATCTC TAGCCCTTGT TTTATTGAGA GACAATGGCT TGCAATACTG GAAACAATTA 
CTGGGACCAA GAACTGTTGA AGAAGCCATT GAATATTTTC CAGAGAGTTT ATGTGCACAG 
TTTGCGATGG ACAGTTTGCC GGTCAACCAG TTGTATGGCA GCGATTCATT AGAAACCGCT 
GAAAGGGAAA TACAGCATTT CTTTCCTCTT CAAAGCACTT TAGGCTTGAT TAAACCTCAT 
GCAACAAGTG AACAAAGAGA GCAGATCCTG AAGATAGTTA AGGAGGCTGG ATTTGATCTG 
ACACAGGTGA AGAAAATGTT CCTAACTCCT GAGCAAATAG AGAAAATTTA TCCAAAAGTA 
ACAGGAAAAG ACTTTTATAA AGATTTATTG GAAATGTTAT CTGTGGGTCC ATCTATGGTC 
ATGATTCTGA CCAAGTGGAA TGCTGTTGCA GAATGGAGAC GATTGATGGG CCCAACAGAC 
CCAGAAGAAG CAAAATTACT TTCCCCTGAC TCCATCCGAG CCCAGTTTGG AATAAGTAAA 
TTGAAAAACA TTGTCCATGG AGCATCTAAC GCCTATGAAG CAAAAGAGGT TGTTAATAGA 
CTCTTTGAGG ATCCTGAGGA AAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057700.3
CDS	373..2139
Translation	MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKIAAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFMDAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN

Target ORF information:

RefSeq Version	NM_016616.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NME/NM23 family member 8 (NME8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016616.5

ORF Insert Sequence:

ATGGCAAGCA AAAAACGAGA AGTCCAGTTA CAGACAGTCA TCAATAATCA AAGCCTGTGG 
GATGAGATGT TGCAGAACAA AGGCTTAACA GTGATTGATG TTTACCAAGC CTGGTGTGGA 
CCTTGCAGAG CAATGCAACC TTTATTCAGA AAATTGAAAA ATGAACTGAA CGAAGACGAA 
ATTCTGCATT TTGCTGTCGC AGAAGCTGAC AACATTGTGA CTTTGCAGCC ATTTAGAGAT 
AAATGTGAAC CTGTTTTTCT CTTTAGTGTT AATGGCAAAA TTATCGAAAA GATTCAGGGT 
GCAAATGCAC CGCTTGTTAA TAAAAAAGTT ATTAATTTGA TCGATGAGGA GAGAAAAATT 
GCAGCAGGTG AAATGGCTCG ACCTCAGTAT CCTGAAATTC CATTAGTAGA CTCAGATTCA 
GAAGTTAGTG AAGAATCACC ATGTGAAAGT GTTCAGGAAT TATACAGTAT TGCTATTATC 
AAACCGGATG CTGTGATTAG TAAAAAAGTT CTAGAAATTA AAAGAAAAAT TACCAAAGCT 
GGATTTATTA TAGAAGCAGA GCATAAGACA GTGCTCACTG AAGAACAAGT TGTCAACTTC 
TATAGTCGAA TAGCAGACCA GTGTGACTTC GAAGAGTTTG TCTCTTTTAT GACAAGTGGC 
TTAAGCTATA TTCTAGTTGT ATCTCAAGGA AGTAAACACA ATCCTCCCTC TGAAGAAACC 
GAACCACAGA CTGACACCGA ACCTAACGAA CGATCTGAGG ATCAACCTGA GGTCGAAGCC 
CAGGTTACAC CTGGAATGAT GAAGAACAAA CAAGACAGTT TACAAGAATA TCTGGAAAGA 
CAACATTTAG CTCAGCTCTG TGACATTGAA GAGGATGCAG CTAATGTTGC TAAGTTCATG 
GATGCTTTCT TCCCCGATTT TAAAAAAATG AAAAGCATGA AATTAGAAAA GACATTGGCA 
TTACTTCGAC CAAATCTCTT TCATGAAAGG AAAGATGATG TTTTGCGTAT TATTAAAGAT 
GAAGACTTCA AAATACTGGA GCAAAGACAA GTAGTATTAT CGGAAAAAGA AGCACAAGCA 
CTGTGCAAGG AATATGAAAA TGAAGACTAT TTTAATAAAC TTATAGAAAA CATGACCAGT 
GGTCCATCTC TAGCCCTTGT TTTATTGAGA GACAATGGCT TGCAATACTG GAAACAATTA 
CTGGGACCAA GAACTGTTGA AGAAGCCATT GAATATTTTC CAGAGAGTTT ATGTGCACAG 
TTTGCGATGG ACAGTTTGCC GGTCAACCAG TTGTATGGCA GCGATTCATT AGAAACCGCT 
GAAAGGGAAA TACAGCATTT CTTTCCTCTT CAAAGCACTT TAGGCTTGAT TAAACCTCAT 
GCAACAAGTG AACAAAGAGA GCAGATCCTG AAGATAGTTA AGGAGGCTGG ATTTGATCTG 
ACACAGGTGA AGAAAATGTT CCTAACTCCT GAGCAAATAG AGAAAATTTA TCCAAAAGTA 
ACAGGAAAAG ACTTTTATAA AGATTTATTG GAAATGTTAT CTGTGGGTCC ATCTATGGTC 
ATGATTCTGA CCAAGTGGAA TGCTGTTGCA GAATGGAGAC GATTGATGGG CCCAACAGAC 
CCAGAAGAAG CAAAATTACT TTCCCCTGAC TCCATCCGAG CCCAGTTTGG AATAAGTAAA 
TTGAAAAACA TTGTCCATGG AGCATCTAAC GCCTATGAAG CAAAAGAGGT TGTTAATAGA 
CTCTTTGAGG ATCCTGAGGA AAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NME8 ( NM_016616.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_057700.3 Homo sapiens NME/NM23 family member 8 (NME8), mRNA.

Price & Availability↑

CloneID	OHu27090
Clone ID Related Accession (Same CDS sequence)	NM_016616.5 , NM_016616.4
Accession Version	NM_016616.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1767bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-21
Organism	Homo sapiens(human)
Product	thioredoxin domain-containing protein 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC036816.1, AF202051.2 and AF305596.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced XM_005249764.1, NM_016616.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036816.1, GQ472221.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151119, SAMEA2161674 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCAAGCA AAAAACGAGA AGTCCAGTTA CAGACAGTCA TCAATAATCA AAGCCTGTGG 
GATGAGATGT TGCAGAACAA AGGCTTAACA GTGATTGATG TTTACCAAGC CTGGTGTGGA 
CCTTGCAGAG CAATGCAACC TTTATTCAGA AAATTGAAAA ATGAACTGAA CGAAGACGAA 
ATTCTGCATT TTGCTGTCGC AGAAGCTGAC AACATTGTGA CTTTGCAGCC ATTTAGAGAT 
AAATGTGAAC CTGTTTTTCT CTTTAGTGTT AATGGCAAAA TTATCGAAAA GATTCAGGGT 
GCAAATGCAC CGCTTGTTAA TAAAAAAGTT ATTAATTTGA TCGATGAGGA GAGAAAAATT 
GCAGCAGGTG AAATGGCTCG ACCTCAGTAT CCTGAAATTC CATTAGTAGA CTCAGATTCA 
GAAGTTAGTG AAGAATCACC ATGTGAAAGT GTTCAGGAAT TATACAGTAT TGCTATTATC 
AAACCGGATG CTGTGATTAG TAAAAAAGTT CTAGAAATTA AAAGAAAAAT TACCAAAGCT 
GGATTTATTA TAGAAGCAGA GCATAAGACA GTGCTCACTG AAGAACAAGT TGTCAACTTC 
TATAGTCGAA TAGCAGACCA GTGTGACTTC GAAGAGTTTG TCTCTTTTAT GACAAGTGGC 
TTAAGCTATA TTCTAGTTGT ATCTCAAGGA AGTAAACACA ATCCTCCCTC TGAAGAAACC 
GAACCACAGA CTGACACCGA ACCTAACGAA CGATCTGAGG ATCAACCTGA GGTCGAAGCC 
CAGGTTACAC CTGGAATGAT GAAGAACAAA CAAGACAGTT TACAAGAATA TCTGGAAAGA 
CAACATTTAG CTCAGCTCTG TGACATTGAA GAGGATGCAG CTAATGTTGC TAAGTTCATG 
GATGCTTTCT TCCCCGATTT TAAAAAAATG AAAAGCATGA AATTAGAAAA GACATTGGCA 
TTACTTCGAC CAAATCTCTT TCATGAAAGG AAAGATGATG TTTTGCGTAT TATTAAAGAT 
GAAGACTTCA AAATACTGGA GCAAAGACAA GTAGTATTAT CGGAAAAAGA AGCACAAGCA 
CTGTGCAAGG AATATGAAAA TGAAGACTAT TTTAATAAAC TTATAGAAAA CATGACCAGT 
GGTCCATCTC TAGCCCTTGT TTTATTGAGA GACAATGGCT TGCAATACTG GAAACAATTA 
CTGGGACCAA GAACTGTTGA AGAAGCCATT GAATATTTTC CAGAGAGTTT ATGTGCACAG 
TTTGCGATGG ACAGTTTGCC GGTCAACCAG TTGTATGGCA GCGATTCATT AGAAACCGCT 
GAAAGGGAAA TACAGCATTT CTTTCCTCTT CAAAGCACTT TAGGCTTGAT TAAACCTCAT 
GCAACAAGTG AACAAAGAGA GCAGATCCTG AAGATAGTTA AGGAGGCTGG ATTTGATCTG 
ACACAGGTGA AGAAAATGTT CCTAACTCCT GAGCAAATAG AGAAAATTTA TCCAAAAGTA 
ACAGGAAAAG ACTTTTATAA AGATTTATTG GAAATGTTAT CTGTGGGTCC ATCTATGGTC 
ATGATTCTGA CCAAGTGGAA TGCTGTTGCA GAATGGAGAC GATTGATGGG CCCAACAGAC 
CCAGAAGAAG CAAAATTACT TTCCCCTGAC TCCATCCGAG CCCAGTTTGG AATAAGTAAA 
TTGAAAAACA TTGTCCATGG AGCATCTAAC GCCTATGAAG CAAAAGAGGT TGTTAATAGA 
CTCTTTGAGG ATCCTGAGGA AAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057700.3
CDS	373..2139
Translation	MASKKREVQLQTVINNQSLWDEMLQNKGLTVIDVYQAWCGPCRAMQPLFRKLKNELNEDEILHFAVAEADNIVTLQPFRDKCEPVFLFSVNGKIIEKIQGANAPLVNKKVINLIDEERKIAAGEMARPQYPEIPLVDSDSEVSEESPCESVQELYSIAIIKPDAVISKKVLEIKRKITKAGFIIEAEHKTVLTEEQVVNFYSRIADQCDFEEFVSFMTSGLSYILVVSQGSKHNPPSEETEPQTDTEPNERSEDQPEVEAQVTPGMMKNKQDSLQEYLERQHLAQLCDIEEDAANVAKFMDAFFPDFKKMKSMKLEKTLALLRPNLFHERKDDVLRIIKDEDFKILEQRQVVLSEKEAQALCKEYENEDYFNKLIENMTSGPSLALVLLRDNGLQYWKQLLGPRTVEEAIEYFPESLCAQFAMDSLPVNQLYGSDSLETAEREIQHFFPLQSTLGLIKPHATSEQREQILKIVKEAGFDLTQVKKMFLTPEQIEKIYPKVTGKDFYKDLLEMLSVGPSMVMILTKWNAVAEWRRLMGPTDPEEAKLLSPDSIRAQFGISKLKNIVHGASNAYEAKEVVNRLFEDPEEN

Target ORF information:

RefSeq Version	NM_016616.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NME/NM23 family member 8 (NME8), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_016616.4

ORF Insert Sequence:

ATGGCAAGCA AAAAACGAGA AGTCCAGTTA CAGACAGTCA TCAATAATCA AAGCCTGTGG 
GATGAGATGT TGCAGAACAA AGGCTTAACA GTGATTGATG TTTACCAAGC CTGGTGTGGA 
CCTTGCAGAG CAATGCAACC TTTATTCAGA AAATTGAAAA ATGAACTGAA CGAAGACGAA 
ATTCTGCATT TTGCTGTCGC AGAAGCTGAC AACATTGTGA CTTTGCAGCC ATTTAGAGAT 
AAATGTGAAC CTGTTTTTCT CTTTAGTGTT AATGGCAAAA TTATCGAAAA GATTCAGGGT 
GCAAATGCAC CGCTTGTTAA TAAAAAAGTT ATTAATTTGA TCGATGAGGA GAGAAAAATT 
GCAGCAGGTG AAATGGCTCG ACCTCAGTAT CCTGAAATTC CATTAGTAGA CTCAGATTCA 
GAAGTTAGTG AAGAATCACC ATGTGAAAGT GTTCAGGAAT TATACAGTAT TGCTATTATC 
AAACCGGATG CTGTGATTAG TAAAAAAGTT CTAGAAATTA AAAGAAAAAT TACCAAAGCT 
GGATTTATTA TAGAAGCAGA GCATAAGACA GTGCTCACTG AAGAACAAGT TGTCAACTTC 
TATAGTCGAA TAGCAGACCA GTGTGACTTC GAAGAGTTTG TCTCTTTTAT GACAAGTGGC 
TTAAGCTATA TTCTAGTTGT ATCTCAAGGA AGTAAACACA ATCCTCCCTC TGAAGAAACC 
GAACCACAGA CTGACACCGA ACCTAACGAA CGATCTGAGG ATCAACCTGA GGTCGAAGCC 
CAGGTTACAC CTGGAATGAT GAAGAACAAA CAAGACAGTT TACAAGAATA TCTGGAAAGA 
CAACATTTAG CTCAGCTCTG TGACATTGAA GAGGATGCAG CTAATGTTGC TAAGTTCATG 
GATGCTTTCT TCCCCGATTT TAAAAAAATG AAAAGCATGA AATTAGAAAA GACATTGGCA 
TTACTTCGAC CAAATCTCTT TCATGAAAGG AAAGATGATG TTTTGCGTAT TATTAAAGAT 
GAAGACTTCA AAATACTGGA GCAAAGACAA GTAGTATTAT CGGAAAAAGA AGCACAAGCA 
CTGTGCAAGG AATATGAAAA TGAAGACTAT TTTAATAAAC TTATAGAAAA CATGACCAGT 
GGTCCATCTC TAGCCCTTGT TTTATTGAGA GACAATGGCT TGCAATACTG GAAACAATTA 
CTGGGACCAA GAACTGTTGA AGAAGCCATT GAATATTTTC CAGAGAGTTT ATGTGCACAG 
TTTGCGATGG ACAGTTTGCC GGTCAACCAG TTGTATGGCA GCGATTCATT AGAAACCGCT 
GAAAGGGAAA TACAGCATTT CTTTCCTCTT CAAAGCACTT TAGGCTTGAT TAAACCTCAT 
GCAACAAGTG AACAAAGAGA GCAGATCCTG AAGATAGTTA AGGAGGCTGG ATTTGATCTG 
ACACAGGTGA AGAAAATGTT CCTAACTCCT GAGCAAATAG AGAAAATTTA TCCAAAAGTA 
ACAGGAAAAG ACTTTTATAA AGATTTATTG GAAATGTTAT CTGTGGGTCC ATCTATGGTC 
ATGATTCTGA CCAAGTGGAA TGCTGTTGCA GAATGGAGAC GATTGATGGG CCCAACAGAC 
CCAGAAGAAG CAAAATTACT TTCCCCTGAC TCCATCCGAG CCCAGTTTGG AATAAGTAAA 
TTGAAAAACA TTGTCCATGG AGCATCTAAC GCCTATGAAG CAAAAGAGGT TGTTAATAGA 
CTCTTTGAGG ATCCTGAGGA AAACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genetic variants associated with risk of Alzheimer's disease contribute to cognitive change in midlife: The Atherosclerosis Risk in Communities Study.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics174(3)269-282(2017 Apr)
Bressler J,Mosley TH,Penman A,Gottesman RF,Windham BG,Knopman DS,Wruck LM,Boerwinkle E

NME8 rs2718058 polymorphism with Alzheimer's disease risk: a replication and meta-analysis.
Oncotarget7(24)36014-36020(2016 Jun)
Liu SL,Wang XC,Tan MS,Wang HF,Zhang W,Wang ZX,Yu JT,Tan L

A genome-wide association study of periodontitis in a Japanese population.
Journal of dental research94(4)555-61(2015 Apr)
Shimizu S,Momozawa Y,Takahashi A,Nagasawa T,Ashikawa K,Terada Y,Izumi Y,Kobayashi H,Tsuji M,Kubo M,Furuichi Y

Association between NME8 locus polymorphism and cognitive decline, cerebrospinal fluid and neuroimaging biomarkers in Alzheimer's disease.
PloS one9(12)e114777(2014)
Liu Y,Yu JT,Wang HF,Hao XK,Yang YF,Jiang T,Zhu XC,Cao L,Zhang DQ,Tan L

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NME8 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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