NDUFA13 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NDUFA13
Entrez Gene ID	51079
Full Name	NADH:ubiquinone oxidoreductase subunit A13
Synonyms	B16.6,CDA016,CGI-39,GRIM-19,GRIM19
General protein information	Preferred Names NADH:ubiquinone oxidoreductase subunit A13 Names NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 CI-B16.6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 NADH-ubiquinone oxidoreductase B16.6 subunit cell death regulatory protein GRIM-19 cell death-regulatory protein GRIM19 complex I B16.6 subunit complex I-B16.6 gene associated with retinoic and IFN-induced mortality 19 protein gene associated with retinoic and interferon-induced mortality 19 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.11
Summary	This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined. [provided by RefSeq, Oct 2009].
Disorder MIM:	609435
Disorder Html:	{Thyroid carcinoma, Hurthle cell}, 607464 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_015965.6	NP_057049.5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
NM_015965.7	NP_057049.5	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

Pathways from BioSystems

Homologies

	LOC716666	XP_002801516.1
Canis lupus familiaris (dog)	NDUFA13	XP_005632708.1
Bos taurus (cattle)	NDUFA13	NP_788845.1
Arabidopsis thaliana (thale cress)	MEE4	NP_171957.2
Xenopus tropicalis (tropical clawed frog)	ndufa13	NP_988900.1
Pan troglodytes (chimpanzee)	NDUFA13	NP_001065256.1
Rattus norvegicus (Norway rat)	LOC100911483	NP_001264151.1
Homo sapiens (human)	NDUFA13	NP_057049.5
Mus musculus (house mouse)	Ndufa13	NP_075801.1
Danio rerio (zebrafish)	ndufa13	NP_957008.1
Arabidopsis thaliana (thale cress)	AT2G33220	NP_565761.1
Rattus norvegicus (Norway rat)	Ndufa13	XP_235062.3
Oryza sativa (rice)	Os03g0192400	NP_001049239.1

Gene Ontology
Bibliography

Related articles in PubMed

Expression of NDUFA13 in asthenozoospermia and possible pathogenesis.
Yang Y, Cheng L, Wang Y, Han Y, Liu J, Deng X, Chao L
Reproductive biomedicine online34(1)66-74(2017 Jan)

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Stroud DA, Surgenor EE, Formosa LE, Reljic B, Frazier AE, Dibley MG, Osellame LD, Stait T, Beilharz TH, Thorburn DR, Salim A, Ryan MT
Nature538(7623)123-126(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NDUFA13 deficiency may be associated with asthenozoospermia through the disturbance of spermatozoa mitochondrial membrane potential and by increasing apoptosis and intracellular reactive oxygen species
Title: Expression of NDUFA13 in asthenozoospermia and possible pathogenesis.

GRIM-19 expression in cervical cancer cells could inhibit telomerase activity by inhibiting the transactivation of the hTERT promoter by E6, thereby promoting cervical cancer cell senescence.
Title: GRIM-19 Restores Cervical Cancer Cell Senescence by Repressing hTERT Transcription.

Mitochondrial GRIM-19 could not only serve as an valuable prognostic biomarker for gastric cancer development, but also as a potential therapeutic target for STAT3-dependent carcinogenesis of Gastric cancer.
Title: Mitochondrial GRIM-19 as a potential therapeutic target for STAT3-dependent carcinogenesis of gastric cancer.

Low GRIM-19 expression is associated with paclitaxel resistance in cervical cancer.
Title: GRIM-19 inhibition induced autophagy through activation of ERK and HIF-1? not STAT3 in Hela cells.

activation of AMPKalpha by metformin was associated with a reversal of the suppressed GRIM-19 expression in H9C2 cells, the fold of changes in GRIM-19 expression by metformin were much less in HeLa cells
Title: High Glucose Induces Down-Regulated GRIM-19 Expression to Activate STAT3 Signaling and Promote Cell Proliferation in Cell Culture.

The following NDUFA13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDUFA13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18025	NM_015965.7 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase subunit A13 (NDUFA13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
View Old Accession Versions >>
OHu18025	NM_015965.6	Homo sapiens NADH:ubiquinone oxidoreductase subunit A13 (NDUFA13), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NDUFA13 ( NM_015965.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_057049.5 Homo sapiens NADH:ubiquinone oxidoreductase subunit A13 (NDUFA13), mRNA.

Price & Availability↑

CloneID	OHu18025
Clone ID Related Accession (Same CDS sequence)	NM_015965.6 , NM_015965.7
Accession Version	NM_015965.6	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BM839920.1, BC009189.2 and BG705222.1. This sequence is a reference standard in the RefSeqGene project. On Oct 8, 2009 this sequence version replaced NM_015965.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG705222.1, AF261134.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 12611891, 17928352; reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGT CAAAGGTGAA GCAGGACATG CCTCCGCCGG GGGGCTATGG GCCCATCGAC 
TACAAACGGA ACTTGCCGCG TCGAGGACTG TCGGGCTACA GCATGCTGGC CATAGGGATT 
GGAACCCTGA TCTACGGGCA CTGGAGCATA ATGAAGTGGA ACCGTGAGCG CAGGCGCCTA 
CAAATCGAGG ACTTCGAGGC TCGCATCGCG CTGTTGCCAC TGTTACAGGC AGAAACCGAC 
CGGAGGACCT TGCAGATGCT TCGGGAGAAC CTGGAGGAGG AGGCCATCAT CATGAAGGAC 
GTGCCCGACT GGAAGGTGGG GGAGTCTGTG TTCCACACAA CCCGCTGGGT GCCCCCCTTG 
ATCGGGGAGC TGTACGGGCT GCGCACCACA GAGGAGGCTC TCCATGCCAG CCACGGCTTC 
ATGTGGTACA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057049.5
CDS	30..464
Translation	MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT

Target ORF information:

RefSeq Version	NM_015965.6
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit A13 (NDUFA13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015965.6

ORF Insert Sequence:

ATGGCGGCGT CAAAGGTGAA GCAGGACATG CCTCCGCCGG GGGGCTATGG GCCCATCGAC 
TACAAACGGA ACTTGCCGCG TCGAGGACTG TCGGGCTACA GCATGCTGGC CATAGGGATT 
GGAACCCTGA TCTACGGGCA CTGGAGCATA ATGAAGTGGA ACCGTGAGCG CAGGCGCCTA 
CAAATCGAGG ACTTCGAGGC TCGCATCGCG CTGTTGCCAC TGTTACAGGC AGAAACCGAC 
CGGAGGACCT TGCAGATGCT TCGGGAGAAC CTGGAGGAGG AGGCCATCAT CATGAAGGAC 
GTGCCCGACT GGAAGGTGGG GGAGTCTGTG TTCCACACAA CCCGCTGGGT GCCCCCCTTG 
ATCGGGGAGC TGTACGGGCT GCGCACCACA GAGGAGGCTC TCCATGCCAG CCACGGCTTC 
ATGTGGTACA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFA13 ( NM_015965.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_057049.5 Homo sapiens NADH:ubiquinone oxidoreductase subunit A13 (NDUFA13), mRNA.

Price & Availability↑

CloneID	OHu18025
Clone ID Related Accession (Same CDS sequence)	NM_015965.6 , NM_015965.7
Accession Version	NM_015965.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 435bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC009189.2 and BG705222.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_015965.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF261134.1, SRR5189667.105639.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: PMID: 12611891, 17928352; reported by MitoCarta MANE Ensembl match :: ENST00000507754.9/ ENSP00000423673.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGT CAAAGGTGAA GCAGGACATG CCTCCGCCGG GGGGCTATGG GCCCATCGAC 
TACAAACGGA ACTTGCCGCG TCGAGGACTG TCGGGCTACA GCATGCTGGC CATAGGGATT 
GGAACCCTGA TCTACGGGCA CTGGAGCATA ATGAAGTGGA ACCGTGAGCG CAGGCGCCTA 
CAAATCGAGG ACTTCGAGGC TCGCATCGCG CTGTTGCCAC TGTTACAGGC AGAAACCGAC 
CGGAGGACCT TGCAGATGCT TCGGGAGAAC CTGGAGGAGG AGGCCATCAT CATGAAGGAC 
GTGCCCGACT GGAAGGTGGG GGAGTCTGTG TTCCACACAA CCCGCTGGGT GCCCCCCTTG 
ATCGGGGAGC TGTACGGGCT GCGCACCACA GAGGAGGCTC TCCATGCCAG CCACGGCTTC 
ATGTGGTACA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_057049.5
CDS	15..449
Translation	MAASKVKQDMPPPGGYGPIDYKRNLPRRGLSGYSMLAIGIGTLIYGHWSIMKWNRERRRLQIEDFEARIALLPLLQAETDRRTLQMLRENLEEEAIIMKDVPDWKVGESVFHTTRWVPPLIGELYGLRTTEEALHASHGFMWYT

Target ORF information:

RefSeq Version	NM_015965.7
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase subunit A13 (NDUFA13), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_015965.7

ORF Insert Sequence:

ATGGCGGCGT CAAAGGTGAA GCAGGACATG CCTCCGCCGG GGGGCTATGG GCCCATCGAC 
TACAAACGGA ACTTGCCGCG TCGAGGACTG TCGGGCTACA GCATGCTGGC CATAGGGATT 
GGAACCCTGA TCTACGGGCA CTGGAGCATA ATGAAGTGGA ACCGTGAGCG CAGGCGCCTA 
CAAATCGAGG ACTTCGAGGC TCGCATCGCG CTGTTGCCAC TGTTACAGGC AGAAACCGAC 
CGGAGGACCT TGCAGATGCT TCGGGAGAAC CTGGAGGAGG AGGCCATCAT CATGAAGGAC 
GTGCCCGACT GGAAGGTGGG GGAGTCTGTG TTCCACACAA CCCGCTGGGT GCCCCCCTTG 
ATCGGGGAGC TGTACGGGCT GCGCACCACA GAGGAGGCTC TCCATGCCAG CCACGGCTTC 
ATGTGGTACA CGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Expression of NDUFA13 in asthenozoospermia and possible pathogenesis.
Reproductive biomedicine online34(1)66-74(2017 Jan)
Yang Y,Cheng L,Wang Y,Han Y,Liu J,Deng X,Chao L

Accessory subunits are integral for assembly and function of human mitochondrial complex I.
Nature538(7623)123-126(2016 Oct)
Stroud DA,Surgenor EE,Formosa LE,Reljic B,Frazier AE,Dibley MG,Osellame LD,Stait T,Beilharz TH,Thorburn DR,Salim A,Ryan MT

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NDUFA13 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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