NNAT cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NNAT
Entrez Gene ID	4826
Full Name	neuronatin
Synonyms	Peg5
General protein information	Preferred Names neuronatin Names neuronatin
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 20 Map Location: 20q11.23
Summary	The protein encoded by this gene is a proteolipid that may be involved in the regulation of ion channels during brain development. The encoded protein may also play a role in forming and maintaining the structure of the nervous system. This gene is found within an intron of another gene, bladder cancer associated protein, but on the opposite strand. This gene is imprinted and is expressed only from the paternal allele. [provided by RefSeq, Apr 2016].
Disorder MIM:	603106

mRNA and Protein(s)

mRNA	Protein	Name
NM_181689.3	NP_859017.1	neuronatin isoform beta
NM_181689.2	NP_859017.1	neuronatin isoform beta
NM_001322802.1	NP_001309731.1	neuronatin isoform gamma
NM_005386.3	NP_005377.1	neuronatin isoform alpha
NM_005386.4	NP_005377.1	neuronatin isoform alpha
NM_001322802.2	NP_001309731.1	neuronatin isoform gamma
NM_005386.2	NP_005377.1	neuronatin isoform alpha

Pathways from BioSystems

Homologies

	NNAT	XP_001091703.1
Canis lupus familiaris (dog)	LOC609195	XP_852537.2
Bos taurus (cattle)	NNAT	NP_001188253.1
Homo sapiens (human)	NNAT	NP_005377.1
Rattus norvegicus (Norway rat)	Nnat	NP_446053.1
Pan troglodytes (chimpanzee)	NNAT	XP_001141473.1
Mus musculus (house mouse)	Nnat	NP_035053.1

Gene Ontology
Bibliography

Related articles in PubMed

Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations.
Oczko-Wojciechowska M, Swierniak M, Krajewska J, Kowalska M, Kowal M, Stokowy T, Wojtas B, Rusinek D, Pawlaczek A, Czarniecka A, Szpak-Ulczok S, Gawlik T, Chmielik E, Tyszkiewicz T, Nikiel B, Lange D, Jarzab M, Wiench M, Jarzab B
Scientific reports742074(2017 Feb)

Neuronatin is a stress-responsive protein of rod photoreceptors.
Shinde V, Pitale PM, Howse W, Gorbatyuk O, Gorbatyuk M
Neuroscience3281-8(2016 07)

Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.
Dugu L, Nakahara T, Wu Z, Uchi H, Liu M, Hirano K, Yokomizo T, Furue M
Journal of dermatological science73(3)225-31(2014 Mar)

Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.
Joseph RM
Genomics103(2-3)183-8(2014 Feb-Mar)

Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas.
Renner M, Wolf T, Meyer H, Hartmann W, Penzel R, Ulrich A, Lehner B, Hovestadt V, Czwan E, Egerer G, Schmitt T, Alldinger I, Renker EK, Ehemann V, Eils R, Wardelmann E, B?ttner R, Lichter P, Brors B, Schirmacher P, Mechtersheimer G
Genome biology14(12)r137(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

indicate that Nnat is related to keratinocyte differentiation by up-regulating involucrin expression
Title: Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.

Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.
Title: Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.

Data suggest NNAT as a potential tumor suppressor in myxoid liposarcomas.
Title: Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas.

Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease
Title: Neuronatin-mediated aberrant calcium signaling and endoplasmic reticulum stress underlie neuropathology in Lafora disease.

methylation status of a not-yet-described regulatory element within the NNAT locus that contains four potential CTCF binding sites determines the expression level of NNAT
Title: Selective methylation of CpGs at regulatory binding sites controls NNAT expression in Wilms tumors.

The following NNAT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NNAT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu100559	NM_001322802.2 Latest version!	Homo sapiens neuronatin (NNAT), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21175	NM_005386.4 Latest version!	Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu25272	NM_181689.3 Latest version!	Homo sapiens neuronatin (NNAT), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu25272	NM_181689.2	Homo sapiens neuronatin (NNAT), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu21175	NM_005386.3	Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu100559	NM_001322802.1	Homo sapiens neuronatin (NNAT), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu21175	NM_005386.2	Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NNAT ( NM_001322802.1 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001309731.1 Homo sapiens neuronatin (NNAT), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu100559
Clone ID Related Accession (Same CDS sequence)	NM_001322802.1 , NM_001322802.2
Accession Version	NM_001322802.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	neuronatin isoform gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY021161.1, CN388981.1 and BC001768.1. Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region compared to variant 1, resulting in a frameshift. The encoded isoform (gamma) has a longer and distinct C-terminus compared to isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR2132849.18506.1, SRR2132857.6869.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GTTCAGGTAC TCCCTGCAGA AGCTGGCATA 
CACGGTGTCG CGGACCGGGC GGCAGGTGTT GGGGGAGCGC AGGCAGCGAG CCCCCAACTG 
AGGCCCCAGC TCCCAGCCCT GGGCGGCCGT ATCATCAGGT GCTCCTGTGC ATCTCGGCCA 
GCACGGGAGC CAGTGCCGCG CAGGAATGTG GGGTCCCCTG TGTTCCCTCG CCAGAGGAGC 
ACTTGGCAAG GTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309731.1
CDS	127..504
Translation	MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSVQVLPAEAGIHGVADRAAGVGGAQAASPQLRPQLPALGGRIIRCSCASRPAREPVPRRNVGSPVFPRQRSTWQGQ

Target ORF information:

RefSeq Version	NM_001322802.1
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronatin (NNAT), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322802.1

ORF Insert Sequence:

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GTTCAGGTAC TCCCTGCAGA AGCTGGCATA 
CACGGTGTCG CGGACCGGGC GGCAGGTGTT GGGGGAGCGC AGGCAGCGAG CCCCCAACTG 
AGGCCCCAGC TCCCAGCCCT GGGCGGCCGT ATCATCAGGT GCTCCTGTGC ATCTCGGCCA 
GCACGGGAGC CAGTGCCGCG CAGGAATGTG GGGTCCCCTG TGTTCCCTCG CCAGAGGAGC 
ACTTGGCAAG GTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NNAT ( NM_001322802.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001309731.1 Homo sapiens neuronatin (NNAT), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu100559
Clone ID Related Accession (Same CDS sequence)	NM_001322802.1 , NM_001322802.2
Accession Version	NM_001322802.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 378bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	neuronatin isoform gamma
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY021161.1, CN388981.1 and BC001768.1. On May 31, 2019 this sequence version replaced NM_001322802.1. Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region compared to variant 1, resulting in a frameshift. The encoded isoform (gamma) has a longer and distinct C-terminus compared to isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410570.663553.1, ERR279837.1657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GTTCAGGTAC TCCCTGCAGA AGCTGGCATA 
CACGGTGTCG CGGACCGGGC GGCAGGTGTT GGGGGAGCGC AGGCAGCGAG CCCCCAACTG 
AGGCCCCAGC TCCCAGCCCT GGGCGGCCGT ATCATCAGGT GCTCCTGTGC ATCTCGGCCA 
GCACGGGAGC CAGTGCCGCG CAGGAATGTG GGGTCCCCTG TGTTCCCTCG CCAGAGGAGC 
ACTTGGCAAG GTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001309731.1
CDS	83..460
Translation	MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSVQVLPAEAGIHGVADRAAGVGGAQAASPQLRPQLPALGGRIIRCSCASRPAREPVPRRNVGSPVFPRQRSTWQGQ

Target ORF information:

RefSeq Version	NM_001322802.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronatin (NNAT), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001322802.2

ORF Insert Sequence:

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GTTCAGGTAC TCCCTGCAGA AGCTGGCATA 
CACGGTGTCG CGGACCGGGC GGCAGGTGTT GGGGGAGCGC AGGCAGCGAG CCCCCAACTG 
AGGCCCCAGC TCCCAGCCCT GGGCGGCCGT ATCATCAGGT GCTCCTGTGC ATCTCGGCCA 
GCACGGGAGC CAGTGCCGCG CAGGAATGTG GGGTCCCCTG TGTTCCCTCG CCAGAGGAGC 
ACTTGGCAAG GTCAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NNAT ( NM_005386.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_005377.1 Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21175
Clone ID Related Accession (Same CDS sequence)	NM_005386.3 , NM_005386.4 , NM_005386.2
Accession Version	NM_005386.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	neuronatin isoform alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY021161.1 and BC001768.1. On Apr 13, 2016 this sequence version replaced NM_005386.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC001768.1, SRR2132850.14214.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GAGGTGTTCA GGTACTCCCT GCAGAAGCTG 
GCATACACGG TGTCGCGGAC CGGGCGGCAG GTGTTGGGGG AGCGCAGGCA GCGAGCCCCC 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005377.1
CDS	127..372
Translation	MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRQVLGERRQRAPN

Target ORF information:

RefSeq Version	NM_005386.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005386.3

ORF Insert Sequence:

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GAGGTGTTCA GGTACTCCCT GCAGAAGCTG 
GCATACACGG TGTCGCGGAC CGGGCGGCAG GTGTTGGGGG AGCGCAGGCA GCGAGCCCCC 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NNAT ( NM_005386.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_005377.1 Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21175
Clone ID Related Accession (Same CDS sequence)	NM_005386.3 , NM_005386.4 , NM_005386.2
Accession Version	NM_005386.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-25
Organism	Homo sapiens(human)
Product	neuronatin isoform alpha
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY021161.1 and BC001768.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_005386.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (alpha). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.1160039.1, SRR3476690.374212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000649451.1/ ENSP00000497164.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GAGGTGTTCA GGTACTCCCT GCAGAAGCTG 
GCATACACGG TGTCGCGGAC CGGGCGGCAG GTGTTGGGGG AGCGCAGGCA GCGAGCCCCC 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005377.1
CDS	83..328
Translation	MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRQVLGERRQRAPN

Target ORF information:

RefSeq Version	NM_005386.4
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005386.4

ORF Insert Sequence:

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GAGGTGTTCA GGTACTCCCT GCAGAAGCTG 
GCATACACGG TGTCGCGGAC CGGGCGGCAG GTGTTGGGGG AGCGCAGGCA GCGAGCCCCC 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NNAT ( NM_005386.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_005377.1 Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu21175
Clone ID Related Accession (Same CDS sequence)	NM_005386.3 , NM_005386.4 , NM_005386.2
Accession Version	NM_005386.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 246bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	neuronatin isoform alpha
Comment

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GAGGTGTTCA GGTACTCCCT GCAGAAGCTG 
GCATACACGG TGTCGCGGAC CGGGCGGCAG GTGTTGGGGG AGCGCAGGCA GCGAGCCCCC 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005377.1
Translation	MAAVAAASAELLIIGWYIFRVLLQVFLECCIYWVGFAFRNPPGTQPIARSEVFRYSLQKLAYTVSRTGRQVLGERRQRAPN

Target ORF information:

RefSeq Version	NM_005386.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens neuronatin (NNAT), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005386.2

ORF Insert Sequence:

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCCT GGAATGCTGC ATTTACTGGG TAGGATTCGC TTTTCGAAAT 
CCTCCAGGGA CACAGCCCAT TGCGAGAAGT GAGGTGTTCA GGTACTCCCT GCAGAAGCTG 
GCATACACGG TGTCGCGGAC CGGGCGGCAG GTGTTGGGGG AGCGCAGGCA GCGAGCCCCC 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NNAT ( NM_181689.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_859017.1 Homo sapiens neuronatin (NNAT), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu25272
Clone ID Related Accession (Same CDS sequence)	NM_181689.3 , NM_181689.2
Accession Version	NM_181689.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	neuronatin isoform beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AI879211.1 and BC001768.1. On May 31, 2019 this sequence version replaced NM_181689.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (beta) that is shorter compared to isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.900224.1, SRR7410570.663455.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCAG GTACTCCCTG CAGAAGCTGG CATACACGGT GTCGCGGACC 
GGGCGGCAGG TGTTGGGGGA GCGCAGGCAG CGAGCCCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_859017.1
CDS	83..247
Translation	MAAVAAASAELLIIGWYIFRVLLQVFRYSLQKLAYTVSRTGRQVLGERRQRAPN

Target ORF information:

RefSeq Version	NM_181689.3
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronatin (NNAT), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181689.3

ORF Insert Sequence:

1
61
121

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCAG GTACTCCCTG CAGAAGCTGG CATACACGGT GTCGCGGACC 
GGGCGGCAGG TGTTGGGGGA GCGCAGGCAG CGAGCCCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NNAT ( NM_181689.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_859017.1 Homo sapiens neuronatin (NNAT), transcript variant 2, mRNA.

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CloneID	OHu25272
Clone ID Related Accession (Same CDS sequence)	NM_181689.3 , NM_181689.2
Accession Version	NM_181689.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 165bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	neuronatin isoform beta
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY021161.1, AI879211.1 and BC001768.1. On Apr 13, 2016 this sequence version replaced NM_181689.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (beta) that is shorter compared to isoform alpha. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR2132857.7756.1, SRR2132849.35829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCAG GTACTCCCTG CAGAAGCTGG CATACACGGT GTCGCGGACC 
GGGCGGCAGG TGTTGGGGGA GCGCAGGCAG CGAGCCCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_859017.1
CDS	127..291
Translation	MAAVAAASAELLIIGWYIFRVLLQVFRYSLQKLAYTVSRTGRQVLGERRQRAPN

Target ORF information:

RefSeq Version	NM_181689.2
Organism	Homo sapiens(human)
Definition	Homo sapiens neuronatin (NNAT), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181689.2

ORF Insert Sequence:

1
61
121

ATGGCGGCAG TGGCGGCGGC CTCGGCTGAA CTGCTCATCA TCGGCTGGTA CATCTTCCGC 
GTGCTGCTGC AGGTGTTCAG GTACTCCCTG CAGAAGCTGG CATACACGGT GTCGCGGACC 
GGGCGGCAGG TGTTGGGGGA GCGCAGGCAG CGAGCCCCCA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations.
Scientific reports742074(2017 Feb)
Oczko-Wojciechowska M,Swierniak M,Krajewska J,Kowalska M,Kowal M,Stokowy T,Wojtas B,Rusinek D,Pawlaczek A,Czarniecka A,Szpak-Ulczok S,Gawlik T,Chmielik E,Tyszkiewicz T,Nikiel B,Lange D,Jarzab M,Wiench M,Jarzab B

Neuronatin is a stress-responsive protein of rod photoreceptors.
Neuroscience3281-8(2016 07)
Shinde V,Pitale PM,Howse W,Gorbatyuk O,Gorbatyuk M

Neuronatin is related to keratinocyte differentiation by up-regulating involucrin.
Journal of dermatological science73(3)225-31(2014 Mar)
Dugu L,Nakahara T,Wu Z,Uchi H,Liu M,Hirano K,Yokomizo T,Furue M

Neuronatin gene: Imprinted and misfolded: Studies in Lafora disease, diabetes and cancer may implicate NNAT-aggregates as a common downstream participant in neuronal loss.
Genomics103(2-3)183-8(2014 Feb-Mar)
Joseph RM

Integrative DNA methylation and gene expression analysis in high-grade soft tissue sarcomas.
Genome biology14(12)r137(2013 Dec)
Renner M,Wolf T,Meyer H,Hartmann W,Penzel R,Ulrich A,Lehner B,Hovestadt V,Czwan E,Egerer G,Schmitt T,Alldinger I,Renker EK,Ehemann V,Eils R,Wardelmann E,B?ttner R,Lichter P,Brors B,Schirmacher P,Mechtersheimer G

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NNAT cDNA ORF clone, Homo sapiens(Human)

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Target ORF information:

ORF Insert Sequence:

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ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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