Gene Symbol | NFKB2 |
Entrez Gene ID | 4791 |
Full Name | nuclear factor kappa B subunit 2 |
Synonyms | CVID10,H2TF1,LYT-10,LYT10,NF-kB2,p100,p49/p100,p52 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]. |
Disorder MIM: | |
Disorder Html: | Immunodeficiency, common variable, 10, 615577 (3) |