NDUFV2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NDUFV2
Entrez Gene ID	4729
Full Name	NADH:ubiquinone oxidoreductase core subunit V2
Synonyms	CI-24k
General protein information	Preferred Names NADH:ubiquinone oxidoreductase core subunit V2 Names NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa NADH dehydrogenase ubiquinone flavoprotein 2, mitochondrial NADH-ubiquinone oxidoreductase 24 kDa subunit NADH-ubiquinone oxidoreductase flavoprotein 2 complex I 24kDa subunit complex I, mitochondrial respitory chain, 24 kD subunit nuclear-encoded mitochondrial NADH-ubiquinone reductase 24Kd subunit
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18p11.22
Summary	The NADH-ubiquinone oxidoreductase complex (complex I) of the mitochondrial respiratory chain catalyzes the transfer of electrons from NADH to ubiquinone, and consists of at least 43 subunits. The complex is located in the inner mitochondrial membrane. This gene encodes the 24 kDa subunit of complex I, and is involved in electron transfer. Mutations in this gene are implicated in Parkinson's disease, bipolar disorder, schizophrenia, and have been found in one case of early onset hypertrophic cardiomyopathy and encephalopathy. A non-transcribed pseudogene of this locus is found on chromosome 19. [provided by RefSeq, Oct 2009].
Disorder MIM:	600532
Disorder Html:	Mitochondrial complex I deficiency, 252010 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_017025782.1	XP_016881271.1	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1
NM_021074.4	NP_066552.2	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor
NM_021074.5	NP_066552.2	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NDUFV2	NP_776990.1
Gallus gallus (chicken)	NDUFV2	XP_424129.3
Caenorhabditis elegans (roundworm)	CELE_F53F4.10	NP_506376.1
Magnaporthe oryzae (rice blast fungus)	MGG_07301	XP_003715530.1
Arabidopsis thaliana (thale cress)	AT4G02580	NP_567244.1
	NDUFV2	XP_001099724.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP002170	XP_308018.4
Neurospora crassa	NCU01169	XP_961535.1
Xenopus tropicalis (tropical clawed frog)	ndufv2	NP_001017166.1
Pan troglodytes (chimpanzee)	NDUFV2	NP_001065254.1
	LOC713739	XP_001108313.1
Drosophila melanogaster (fruit fly)	CG5703	NP_573228.1
Oryza sativa (rice)	Os05g0509200	NP_001056000.1
Homo sapiens (human)	NDUFV2	NP_066552.2
Canis lupus familiaris (dog)	NDUFV2	XP_537328.2
Mus musculus (house mouse)	Ndufv2	NP_082664.1
Rattus norvegicus (Norway rat)	Ndufv2	NP_112326.1
Danio rerio (zebrafish)	ndufv2	NP_957041.1

Gene Ontology
Bibliography

Related articles in PubMed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
Maio N, Kim KS, Singh A, Rouault TA
Cell metabolism25(4)945-953.e6(2017 Apr)

A haplotype in the 5'-upstream region of the NDUFV2 gene is associated with major depressive disorder in Han Chinese.
Zhang Z, Ni J, Zhang J, Tang W, Li X, Wu Z, Zhang C
Journal of affective disorders190329-332(2016 Jan)

Exome sequencing identifies complex I NDUFV2 mutations as a novel cause of Leigh syndrome.
Cameron JM, MacKay N, Feigenbaum A, Tarnopolsky M, Blaser S, Robinson BH, Schulze A
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society19(5)525-32(2015 Sep)

Mitochondrial targeting of human NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy.
Liu HY, Liao PC, Chuang KT, Kao MC
Journal of biomedical science1829(2011 May)

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.
Loeffen JL, Triepels RH, van den Heuvel LP, Schuelke M, Buskens CA, Smeets RJ, Trijbels JM, Smeitink JA
Biochemical and biophysical research communications253(2)415-22(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

haplotype T-C consisting of rs12457810 and rs12964485 in the 5'-upstream region of NDUFV2 may be a protective factor for the development of MDD in Han Chinese
Title: A haplotype in the 5'-upstream region of the NDUFV2 gene is associated with major depressive disorder in Han Chinese.

We have identified NDUFV2 mutations in two families with Complex I deficiency, including a novel mutation.
Title: Exome sequencing identifies complex I NDUFV2 mutations as a novel cause of Leigh syndrome.

The mitochondrial targeting sequence of NDUFV2 is located at the N-terminus of the precursor protein. Impairment of mitochondrial localization of NDUFV2 as a mechanistic basis for early-onset hypertrophic cardiomyopathy and encephalopathy was established.
Title: Mitochondrial targeting of human NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association study of polymorphisms in the autosomal mitochondrial complex I subunit gene, NADH dehydrogenase (ubiquinone) flavoprotein 2, and bipolar disorder.

There is no statistical significance between NDUFV2 gene promoter variants and susceptibility to schizophrenia in Han Chinese.
Title: Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese.

The following NDUFV2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NDUFV2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18965	NM_021074.5 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu87896	XM_017025782.1 Latest version!	Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu18965	NM_021074.4	Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NDUFV2 ( NM_021074.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_066552.2 Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), mRNA.

Price & Availability↑

CloneID	OHu18965
Clone ID Related Accession (Same CDS sequence)	NM_021074.4 , NM_021074.5
Accession Version	NM_021074.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG742948.1, BC001632.1 and AW051350.1. This sequence is a reference standard in the RefSeqGene project. On Oct 3, 2009 this sequence version replaced NM_021074.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.619101.1, SRR1163658.75149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTTCTTCT CCGCGGCGCT CCGGGCCCGG GCGGCTGGCC TCACCGCCCA CTGGGGAAGA 
CATGTAAGGA ATTTGCATAA GACAGTTATG CAAAATGGAG CTGGAGGAGC TTTATTTGTG 
CACAGAGATA CTCCTGAGAA TAACCCTGAT ACTCCATTTG ATTTCACACC AGAAAACTAT 
AAGAGGATAG AGGCAATTGT AAAAAACTAT CCAGAAGGCC ATAAAGCAGC AGCTGTTCTT 
CCAGTCCTGG ATTTAGCCCA AAGGCAGAAT GGGTGGTTGC CCATCTCTGC TATGAACAAG 
GTTGCAGAAG TTTTACAAGT ACCTCCAATG AGAGTATATG AAGTAGCAAC TTTTTATACA 
ATGTATAATC GAAAGCCAGT TGGAAAGTAT CACATTCAGG TCTGCACTAC TACACCCTGC 
ATGCTTCGAA ACTCTGACAG CATACTGGAG GCCATTCAGA AAAAGCTTGG AATAAAGGTT 
GGGGAGACTA CACCTGACAA ACTTTTCACT CTTATAGAAG TGGAATGTTT AGGGGCCTGT 
GTGAACGCAC CAATGGTTCA AATAAATGAC AATTACTATG AGGATTTGAC AGCTAAGGAT 
ATTGAAGAAA TTATTGATGA GCTCAAGGCT GGCAAAATCC CAAAACCAGG GCCAAGGAGT 
GGACGCTTCT CTTGTGAGCC AGCTGGAGGT CTTACCTCTT TGACTGAACC ACCCAAGGGA 
CCTGGATTTG GTGTACAAGC AGGCCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066552.2
CDS	115..864
Translation	MFFSAALRARAAGLTAHWGRHVRNLHKTVMQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL

Target ORF information:

RefSeq Version	NM_021074.4
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021074.4

ORF Insert Sequence:

ATGTTCTTCT CCGCGGCGCT CCGGGCCCGG GCGGCTGGCC TCACCGCCCA CTGGGGAAGA 
CATGTAAGGA ATTTGCATAA GACAGTTATG CAAAATGGAG CTGGAGGAGC TTTATTTGTG 
CACAGAGATA CTCCTGAGAA TAACCCTGAT ACTCCATTTG ATTTCACACC AGAAAACTAT 
AAGAGGATAG AGGCAATTGT AAAAAACTAT CCAGAAGGCC ATAAAGCAGC AGCTGTTCTT 
CCAGTCCTGG ATTTAGCCCA AAGGCAGAAT GGGTGGTTGC CCATCTCTGC TATGAACAAG 
GTTGCAGAAG TTTTACAAGT ACCTCCAATG AGAGTATATG AAGTAGCAAC TTTTTATACA 
ATGTATAATC GAAAGCCAGT TGGAAAGTAT CACATTCAGG TCTGCACTAC TACACCCTGC 
ATGCTTCGAA ACTCTGACAG CATACTGGAG GCCATTCAGA AAAAGCTTGG AATAAAGGTT 
GGGGAGACTA CACCTGACAA ACTTTTCACT CTTATAGAAG TGGAATGTTT AGGGGCCTGT 
GTGAACGCAC CAATGGTTCA AATAAATGAC AATTACTATG AGGATTTGAC AGCTAAGGAT 
ATTGAAGAAA TTATTGATGA GCTCAAGGCT GGCAAAATCC CAAAACCAGG GCCAAGGAGT 
GGACGCTTCT CTTGTGAGCC AGCTGGAGGT CTTACCTCTT TGACTGAACC ACCCAAGGGA 
CCTGGATTTG GTGTACAAGC AGGCCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFV2 ( NM_021074.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_066552.2 Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), mRNA.

Price & Availability↑

CloneID	OHu18965
Clone ID Related Accession (Same CDS sequence)	NM_021074.4 , NM_021074.5
Accession Version	NM_021074.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 750bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG742948.1 and BC001632.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_021074.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.159529.1, SRR5189655.161325.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000318388.11/ ENSP00000327268.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTCTTCT CCGCGGCGCT CCGGGCCCGG GCGGCTGGCC TCACCGCCCA CTGGGGAAGA 
CATGTAAGGA ATTTGCATAA GACAGTTATG CAAAATGGAG CTGGAGGAGC TTTATTTGTG 
CACAGAGATA CTCCTGAGAA TAACCCTGAT ACTCCATTTG ATTTCACACC AGAAAACTAT 
AAGAGGATAG AGGCAATTGT AAAAAACTAT CCAGAAGGCC ATAAAGCAGC AGCTGTTCTT 
CCAGTCCTGG ATTTAGCCCA AAGGCAGAAT GGGTGGTTGC CCATCTCTGC TATGAACAAG 
GTTGCAGAAG TTTTACAAGT ACCTCCAATG AGAGTATATG AAGTAGCAAC TTTTTATACA 
ATGTATAATC GAAAGCCAGT TGGAAAGTAT CACATTCAGG TCTGCACTAC TACACCCTGC 
ATGCTTCGAA ACTCTGACAG CATACTGGAG GCCATTCAGA AAAAGCTTGG AATAAAGGTT 
GGGGAGACTA CACCTGACAA ACTTTTCACT CTTATAGAAG TGGAATGTTT AGGGGCCTGT 
GTGAACGCAC CAATGGTTCA AATAAATGAC AATTACTATG AGGATTTGAC AGCTAAGGAT 
ATTGAAGAAA TTATTGATGA GCTCAAGGCT GGCAAAATCC CAAAACCAGG GCCAAGGAGT 
GGACGCTTCT CTTGTGAGCC AGCTGGAGGT CTTACCTCTT TGACTGAACC ACCCAAGGGA 
CCTGGATTTG GTGTACAAGC AGGCCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_066552.2
CDS	46..795
Translation	MFFSAALRARAAGLTAHWGRHVRNLHKTVMQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL

Target ORF information:

RefSeq Version	NM_021074.5
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_021074.5

ORF Insert Sequence:

ATGTTCTTCT CCGCGGCGCT CCGGGCCCGG GCGGCTGGCC TCACCGCCCA CTGGGGAAGA 
CATGTAAGGA ATTTGCATAA GACAGTTATG CAAAATGGAG CTGGAGGAGC TTTATTTGTG 
CACAGAGATA CTCCTGAGAA TAACCCTGAT ACTCCATTTG ATTTCACACC AGAAAACTAT 
AAGAGGATAG AGGCAATTGT AAAAAACTAT CCAGAAGGCC ATAAAGCAGC AGCTGTTCTT 
CCAGTCCTGG ATTTAGCCCA AAGGCAGAAT GGGTGGTTGC CCATCTCTGC TATGAACAAG 
GTTGCAGAAG TTTTACAAGT ACCTCCAATG AGAGTATATG AAGTAGCAAC TTTTTATACA 
ATGTATAATC GAAAGCCAGT TGGAAAGTAT CACATTCAGG TCTGCACTAC TACACCCTGC 
ATGCTTCGAA ACTCTGACAG CATACTGGAG GCCATTCAGA AAAAGCTTGG AATAAAGGTT 
GGGGAGACTA CACCTGACAA ACTTTTCACT CTTATAGAAG TGGAATGTTT AGGGGCCTGT 
GTGAACGCAC CAATGGTTCA AATAAATGAC AATTACTATG AGGATTTGAC AGCTAAGGAT 
ATTGAAGAAA TTATTGATGA GCTCAAGGCT GGCAAAATCC CAAAACCAGG GCCAAGGAGT 
GGACGCTTCT CTTGTGAGCC AGCTGGAGGT CTTACCTCTT TGACTGAACC ACCCAAGGGA 
CCTGGATTTG GTGTACAAGC AGGCCTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NDUFV2 ( XM_017025782.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881271.1 Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu87896
Clone ID Related Accession (Same CDS sequence)	XM_017025782.1
Accession Version	XM_017025782.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 663bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCAAAATG GAGCTGGAGG AGCTTTATTT GTGCACAGAG ATACTCCTGA GAATAACCCT 
GATACTCCAT TTGATTTCAC ACCAGAAAAC TATAAGAGGA TAGAGGCAAT TGTAAAAAAC 
TATCCAGAAG GCCATAAAGC AGCAGCTGTT CTTCCAGTCC TGGATTTAGC CCAAAGGCAG 
AATGGGTGGT TGCCCATCTC TGCTATGAAC AAGGTTGCAG AAGTTTTACA AGTACCTCCA 
ATGAGAGTAT ATGAAGTAGC AACTTTTTAT ACAATGTATA ATCGAAAGCC AGTTGGAAAG 
TATCACATTC AGGTCTGCAC TACTACACCC TGCATGCTTC GAAACTCTGA CAGCATACTG 
GAGGCCATTC AGAAAAAGCT TGGAATAAAG GTTGGGGAGA CTACACCTGA CAAACTTTTC 
ACTCTTATAG AAGTGGAATG TTTAGGGGCC TGTGTGAACG CACCAATGGT TCAAATAAAT 
GACAATTACT ATGAGGATTT GACAGCTAAG GATATTGAAG AAATTATTGA TGAGCTCAAG 
GCTGGCAAAA TCCCAAAACC AGGGCCAAGG AGTGGACGCT TCTCTTGTGA GCCAGCTGGA 
GGTCTTACCT CTTTGACTGA ACCACCCAAG GGACCTGGAT TTGGTGTACA AGCAGGCCTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881271.1
CDS	392..1054
Translation	MQNGAGGALFVHRDTPENNPDTPFDFTPENYKRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYTMYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGACVNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKGPGFGVQAGL

Target ORF information:

RefSeq Version	XM_017025782.1
Organism	Homo sapiens(human)
Definition	Homo sapiens NADH:ubiquinone oxidoreductase core subunit V2 (NDUFV2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017025782.1

ORF Insert Sequence:

ATGCAAAATG GAGCTGGAGG AGCTTTATTT GTGCACAGAG ATACTCCTGA GAATAACCCT 
GATACTCCAT TTGATTTCAC ACCAGAAAAC TATAAGAGGA TAGAGGCAAT TGTAAAAAAC 
TATCCAGAAG GCCATAAAGC AGCAGCTGTT CTTCCAGTCC TGGATTTAGC CCAAAGGCAG 
AATGGGTGGT TGCCCATCTC TGCTATGAAC AAGGTTGCAG AAGTTTTACA AGTACCTCCA 
ATGAGAGTAT ATGAAGTAGC AACTTTTTAT ACAATGTATA ATCGAAAGCC AGTTGGAAAG 
TATCACATTC AGGTCTGCAC TACTACACCC TGCATGCTTC GAAACTCTGA CAGCATACTG 
GAGGCCATTC AGAAAAAGCT TGGAATAAAG GTTGGGGAGA CTACACCTGA CAAACTTTTC 
ACTCTTATAG AAGTGGAATG TTTAGGGGCC TGTGTGAACG CACCAATGGT TCAAATAAAT 
GACAATTACT ATGAGGATTT GACAGCTAAG GATATTGAAG AAATTATTGA TGAGCTCAAG 
GCTGGCAAAA TCCCAAAACC AGGGCCAAGG AGTGGACGCT TCTCTTGTGA GCCAGCTGGA 
GGTCTTACCT CTTTGACTGA ACCACCCAAG GGACCTGGAT TTGGTGTACA AGCAGGCCTT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.
Cell metabolism25(4)945-953.e6(2017 Apr)
Maio N,Kim KS,Singh A,Rouault TA

A haplotype in the 5'-upstream region of the NDUFV2 gene is associated with major depressive disorder in Han Chinese.
Journal of affective disorders190329-332(2016 Jan)
Zhang Z,Ni J,Zhang J,Tang W,Li X,Wu Z,Zhang C

Exome sequencing identifies complex I NDUFV2 mutations as a novel cause of Leigh syndrome.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society19(5)525-32(2015 Sep)
Cameron JM,MacKay N,Feigenbaum A,Tarnopolsky M,Blaser S,Robinson BH,Schulze A

Mitochondrial targeting of human NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy.
Journal of biomedical science1829(2011 May)
Liu HY,Liao PC,Chuang KT,Kao MC

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.
Biochemical and biophysical research communications253(2)415-22(1998 Dec)
Loeffen JL,Triepels RH,van den Heuvel LP,Schuelke M,Buskens CA,Smeets RJ,Trijbels JM,Smeitink JA

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NDUFV2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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