ASIP cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ASIP
Entrez Gene ID	434
Full Name	agouti signaling protein
Synonyms	AGSW,AGTI,AGTIL,ASP,SHEP9
General protein information	Preferred Names agouti signaling protein Names agouti-signaling protein agouti signaling protein, nonagouti homolog agouti switch protein nonagouti homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20q11.22
Summary	In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008].
Disorder MIM:	600201
Disorder Html:	[Skin/hair/eye pigmentation 9, dark/light hair], 611742 (3); [Skin/hair/eye pigmentation 9, brown/nonbrown eyes], 611742 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011528822.1	XP_011527124.1	agouti-signaling protein isoform X1
XM_011528823.1	XP_011527125.1	agouti-signaling protein isoform X1
XM_011528821.1	XP_011527123.1	agouti-signaling protein isoform X2
NM_001672.2	NP_001663.2	agouti-signaling protein precursor
XM_011528820.2	XP_011527122.1	agouti-signaling protein isoform X2
XM_011528820.1	XP_011527122.1	agouti-signaling protein isoform X1
XM_005260412.3	XP_005260469.1	agouti-signaling protein isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	ASIP	NP_996674.1
Mus musculus (house mouse)	a	NP_056585.2
Pan troglodytes (chimpanzee)	ASIP	NP_001129099.1
	LOC709156	XP_001097667.1
Homo sapiens (human)	ASIP	NP_001663.2
Canis lupus familiaris (dog)	ASIP	NP_001007264.1
Rattus norvegicus (Norway rat)	Asip	NP_443211.1

Gene Ontology
Bibliography

Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.
Jacobs LC, Hamer MA, Gunn DA, Deelen J, Lall JS, van Heemst D, Uh HW, Hofman A, Uitterlinden AG, Griffiths CEM, Beekman M, Slagboom PE, Kayser M, Liu F, Nijsten T
The Journal of investigative dermatology135(7)1735-1742(2015 Jul)

SLC24A5 and ASIP as phenotypic predictors in Brazilian population for forensic purposes.
Lima FA, de Ara?jo Lima F, Gon?alves FT, de Toledo Gon?alves F, Fridman C, Fridman C
Legal medicine (Tokyo, Japan)17(4)261-6(2015 Jul)

Inherited variation at MC1R and ASIP and association with melanoma-specific survival.
Taylor NJ, Reiner AS, Begg CB, Cust AE, Busam KJ, Anton-Culver H, Dwyer T, From L, Gallagher RP, Gruber SB, Rosso S, White KA, Zanetti R, Orlow I, Thomas NE, Rebbeck TR, Berwick M, Kanetsky PA,
International journal of cancer136(11)2659-67(2015 Jun)

Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
Zhang M, Song F, Liang L, Nan H, Zhang J, Liu H, Wang LE, Wei Q, Lee JE, Amos CI, Kraft P, Qureshi AA, Han J
Human molecular genetics22(14)2948-59(2013 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ASIP expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

ASIP gene mutation is involved in the development of facial pigmented lesions.
Title: A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.

Polymorphisms of ASIP were found to be associated with skin, hair, and eye color in a phenotypically diverse Brazilian population. More research is needed to determine its usefulness in forensic science.
Title: SLC24A5 and ASIP as phenotypic predictors in Brazilian population for forensic purposes.

Data show that ASIP TG/TG diplotype, which is known to be associated with melanoma risk, was linked to a 5-fold increase in hazard of death from melanoma.
Title: Inherited variation at MC1R and ASIP and association with melanoma-specific survival.

An increased risk of melanoma (odds ratio [OR] 1.27, 95% confidence interval [95% CI] 1.03-1.57) in carriers of the rs4911414 variant, located 120 kb upstream of ASIP.
Title: Variants at chromosome 20 (ASIP locus) and melanoma risk.

The following ASIP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ASIP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18304	NM_001672.2 Latest version!	Homo sapiens agouti signaling protein (ASIP), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18304	XM_011528823.1 Latest version!	Homo sapiens agouti signaling protein (ASIP), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18304	XM_011528822.1 Latest version!	Homo sapiens agouti signaling protein (ASIP), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18304	XM_011528821.1 Latest version!	Homo sapiens agouti signaling protein (ASIP), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu18304	XM_011528820.2 Latest version!	Homo sapiens agouti signaling protein (ASIP), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu53010	XM_005260412.3 Latest version!	Homo sapiens agouti signaling protein (ASIP), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu18304	XM_011528820.1	Homo sapiens agouti signaling protein (ASIP), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ASIP ( NM_001672.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001663.2 Homo sapiens agouti signaling protein (ASIP), mRNA.

Price & Availability↑

CloneID	OHu18304
Clone ID Related Accession (Same CDS sequence)	XM_011528822.1 , XM_011528823.1 , XM_011528821.1 , NM_001672.2 , XM_011528820.2 , XM_011528820.1
Accession Version	NM_001672.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	agouti-signaling protein precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L37019.1. This sequence is a reference standard in the RefSeqGene project. On Jun 6, 2002 this sequence version replaced NM_001672.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AI378919.1, BC104238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144333 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001663.2
CDS	11..409
Translation	MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Target ORF information:

RefSeq Version	NM_001672.2
Organism	Homo sapiens(human)
Definition	Homo sapiens agouti signaling protein (ASIP), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001672.2

ORF Insert Sequence:

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASIP ( XM_011528822.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527124.1 Homo sapiens agouti signaling protein (ASIP), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OHu18304
Clone ID Related Accession (Same CDS sequence)	XM_011528822.1 , XM_011528823.1 , XM_011528821.1 , NM_001672.2 , XM_011528820.2 , XM_011528820.1
Accession Version	XM_011528822.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	agouti-signaling protein isoform X1
Comment

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527124.1
Translation	MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Target ORF information:

RefSeq Version	XM_011528822.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens agouti signaling protein (ASIP), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528822.1

ORF Insert Sequence:

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASIP ( XM_011528823.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527125.1 Homo sapiens agouti signaling protein (ASIP), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OHu18304
Clone ID Related Accession (Same CDS sequence)	XM_011528822.1 , XM_011528823.1 , XM_011528821.1 , NM_001672.2 , XM_011528820.2 , XM_011528820.1
Accession Version	XM_011528823.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	agouti-signaling protein isoform X1
Comment

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527125.1
Translation	MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Target ORF information:

RefSeq Version	XM_011528823.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens agouti signaling protein (ASIP), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528823.1

ORF Insert Sequence:

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASIP ( XM_011528821.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527123.1 Homo sapiens agouti signaling protein (ASIP), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu18304
Clone ID Related Accession (Same CDS sequence)	XM_011528822.1 , XM_011528823.1 , XM_011528821.1 , NM_001672.2 , XM_011528820.2 , XM_011528820.1
Accession Version	XM_011528821.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	agouti-signaling protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527123.1
CDS	148..546
Translation	MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Target ORF information:

RefSeq Version	XM_011528821.1
Organism	Homo sapiens(human)
Definition	Homo sapiens agouti signaling protein (ASIP), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528821.1

ORF Insert Sequence:

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASIP ( XM_011528820.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527122.1 Homo sapiens agouti signaling protein (ASIP), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu18304
Clone ID Related Accession (Same CDS sequence)	XM_011528822.1 , XM_011528823.1 , XM_011528821.1 , NM_001672.2 , XM_011528820.2 , XM_011528820.1
Accession Version	XM_011528820.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	agouti-signaling protein isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011528820.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527122.1
CDS	190..588
Translation	MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Target ORF information:

RefSeq Version	XM_011528820.2
Organism	Homo sapiens(human)
Definition	Homo sapiens agouti signaling protein (ASIP), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528820.2

ORF Insert Sequence:

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASIP ( XM_011528820.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011527122.1 Homo sapiens agouti signaling protein (ASIP), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu18304
Clone ID Related Accession (Same CDS sequence)	XM_011528822.1 , XM_011528823.1 , XM_011528821.1 , NM_001672.2 , XM_011528820.2 , XM_011528820.1
Accession Version	XM_011528820.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 399bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	agouti-signaling protein isoform X1
Comment

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011527122.1
Translation	MDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Target ORF information:

RefSeq Version	XM_011528820.1
Organism	Homo sapiens(Human)
Definition	Homo sapiens agouti signaling protein (ASIP), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011528820.1

ORF Insert Sequence:

ATGGATGTCA CCCGCTTACT CCTGGCCACC CTGCTGGTCT TCCTCTGCTT CTTCACTGCC 
AACAGCCACC TGCCACCTGA GGAGAAGCTC CGAGATGACA GGAGCCTGAG AAGCAACTCC 
TCTGTGAACC TACTGGATGT CCCTTCTGTC TCTATTGTGG CGCTGAACAA GAAATCCAAA 
CAGATCGGCA GAAAAGCAGC AGAAAAGAAA AGATCTTCTA AGAAGGAGGC TTCGATGAAG 
AAAGTGGTGC GGCCCCGGAC CCCCCTATCT GCGCCCTGCG TGGCCACCCG CAACAGCTGC 
AAGCCGCCGG CACCCGCCTG CTGCGACCCG TGCGCCTCCT GCCAGTGCCG CTTCTTCCGC 
AGCGCCTGCT CCTGCCGCGT GCTCAGCCTC AACTGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ASIP ( XM_005260412.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005260469.1 Homo sapiens agouti signaling protein (ASIP), transcript variant X1, mRNA.

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CloneID	OHu53010
Clone ID Related Accession (Same CDS sequence)	XM_005260412.3
Accession Version	XM_005260412.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 411bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	agouti-signaling protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005260412.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTCCTG GGATGGATGT CACCCGCTTA CTCCTGGCCA CCCTGCTGGT CTTCCTCTGC 
TTCTTCACTG CCAACAGCCA CCTGCCACCT GAGGAGAAGC TCCGAGATGA CAGGAGCCTG 
AGAAGCAACT CCTCTGTGAA CCTACTGGAT GTCCCTTCTG TCTCTATTGT GGCGCTGAAC 
AAGAAATCCA AACAGATCGG CAGAAAAGCA GCAGAAAAGA AAAGATCTTC TAAGAAGGAG 
GCTTCGATGA AGAAAGTGGT GCGGCCCCGG ACCCCCCTAT CTGCGCCCTG CGTGGCCACC 
CGCAACAGCT GCAAGCCGCC GGCACCCGCC TGCTGCGACC CGTGCGCCTC CTGCCAGTGC 
CGCTTCTTCC GCAGCGCCTG CTCCTGCCGC GTGCTCAGCC TCAACTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005260469.1
CDS	2055..2465
Translation	MPPGMDVTRLLLATLLVFLCFFTANSHLPPEEKLRDDRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC

Target ORF information:

RefSeq Version	XM_005260412.3
Organism	Homo sapiens(human)
Definition	Homo sapiens agouti signaling protein (ASIP), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005260412.3

ORF Insert Sequence:

ATGCCTCCTG GGATGGATGT CACCCGCTTA CTCCTGGCCA CCCTGCTGGT CTTCCTCTGC 
TTCTTCACTG CCAACAGCCA CCTGCCACCT GAGGAGAAGC TCCGAGATGA CAGGAGCCTG 
AGAAGCAACT CCTCTGTGAA CCTACTGGAT GTCCCTTCTG TCTCTATTGT GGCGCTGAAC 
AAGAAATCCA AACAGATCGG CAGAAAAGCA GCAGAAAAGA AAAGATCTTC TAAGAAGGAG 
GCTTCGATGA AGAAAGTGGT GCGGCCCCGG ACCCCCCTAT CTGCGCCCTG CGTGGCCACC 
CGCAACAGCT GCAAGCCGCC GGCACCCGCC TGCTGCGACC CGTGCGCCTC CTGCCAGTGC 
CGCTTCTTCC GCAGCGCCTG CTCCTGCCGC GTGCTCAGCC TCAACTGCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots.
The Journal of investigative dermatology135(7)1735-1742(2015 Jul)
Jacobs LC,Hamer MA,Gunn DA,Deelen J,Lall JS,van Heemst D,Uh HW,Hofman A,Uitterlinden AG,Griffiths CEM,Beekman M,Slagboom PE,Kayser M,Liu F,Nijsten T

SLC24A5 and ASIP as phenotypic predictors in Brazilian population for forensic purposes.
Legal medicine (Tokyo, Japan)17(4)261-6(2015 Jul)
Lima FA,de Ara?jo Lima F,Gon?alves FT,de Toledo Gon?alves F,Fridman C,Fridman C

Inherited variation at MC1R and ASIP and association with melanoma-specific survival.
International journal of cancer136(11)2659-67(2015 Jun)
Taylor NJ,Reiner AS,Begg CB,Cust AE,Busam KJ,Anton-Culver H,Dwyer T,From L,Gallagher RP,Gruber SB,Rosso S,White KA,Zanetti R,Orlow I,Thomas NE,Rebbeck TR,Berwick M,Kanetsky PA,

Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
Human molecular genetics22(14)2948-59(2013 Jul)
Zhang M,Song F,Liang L,Nan H,Zhang J,Liu H,Wang LE,Wei Q,Lee JE,Amos CI,Kraft P,Qureshi AA,Han J

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ASIP cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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