MMP15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMP15
Entrez Gene ID	4324
Full Name	matrix metallopeptidase 15
Synonyms	MMP-15,MT2-MMP,MT2MMP,MTMMP2,SMCP-2
General protein information	Preferred Names matrix metallopeptidase 15 Names matrix metalloproteinase-15 MT-MMP 2 matrix metallopeptidase 15 (membrane-inserted) matrix metalloproteinase 15 (membrane-inserted) membrane-type matrix metalloproteinase 2 membrane-type-2 matrix metalloproteinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16q21
Summary	This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016].
Disorder MIM:	602261

mRNA and Protein(s)

mRNA	Protein	Name
NM_002428.4	NP_002419.1	matrix metalloproteinase-15 preproprotein
NM_002428.3	NP_002419.1	matrix metalloproteinase-15 preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MMP15	XP_544383.3
Gallus gallus (chicken)	MMP15	XP_413995.3
Danio rerio (zebrafish)	LOC100332426	XP_002662954.2
Pan troglodytes (chimpanzee)	MMP15	XP_001150678.2
Bos taurus (cattle)	MMP15	NP_001178363.1
	MMP15	XP_001101050.1
Mus musculus (house mouse)	Mmp15	NP_032635.1
Rattus norvegicus (Norway rat)	Mmp15	NP_001099638.1
Homo sapiens (human)	MMP15	NP_002419.1
Xenopus tropicalis (tropical clawed frog)	mmp15	NP_001015921.1

Gene Ontology
Bibliography

Related articles in PubMed

E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine.
G?mez-Escudero J, Moreno V, Mart?n-Alonso M, Hern?ndez-Riquer MV, Feinberg T, Colmenar ?, Calvo E, Camafeita E, Mart?nez F, Oudhoff MJ, Weiss SJ, Arroyo AG
Journal of cell science130(23)4013-4027(2017 Dec)

MT2-MMP induces proteolysis and leads to EMT in carcinomas.
Liu Y, Sun X, Feng J, Deng LL, Liu Y, Li B, Zhu M, Lu C, Zhou L
Oncotarget7(30)48193-48205(2016 Jul)

T cell factor-4 functions as a co-activator to promote NF-?B-dependent MMP-15 expression in lung carcinoma cells.
Liu Y, Xu Y, Guo S, Chen H
Scientific reports624025(2016 Apr)

Increased MT2-MMP expression in gastric cancer patients is associated with poor prognosis.
Xu X, Chen L, Xu B, Xie Q, Sun M, Deng X, Wu C, Jiang J
International journal of clinical and experimental pathology8(2)1985-90(2015)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TCF-4 is a co-activator of NF-kappaB p65 that promotes MMP-15 transcription and potentiate the migration activity of the lung cancer cells
Title: T cell factor-4 functions as a co-activator to promote NF-?B-dependent MMP-15 expression in lung carcinoma cells.

In conclusion, MT2-MMP is involved in gastric cancer invasion and metastasis and may serve as an independent prognostic factor for gastric cancer patients.
Title: Increased MT2-MMP expression in gastric cancer patients is associated with poor prognosis.

our data suggest that MT2-MMP expression positively involves in non-small cell lung cancer and might play an important role in promoting the tumor progression and intra-tumoral angiogenesis
Title: MT2-MMP expression associates with tumor progression and angiogenesis in human lung cancer.

HLA-G expression involved in tumor invasiveness or metastasis may rely on the NK cytotoxicity inhibition and induction of MMP-15 expression in ovarian cancer.
Title: Multiple steps of HLA-G in ovarian carcinoma metastasis: alter NK cytotoxicity and induce matrix metalloproteinase-15 (MMP-15) expression.

MMP-15 is up-regulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin.
Title: MMP-15 is upregulated in preeclampsia, but does not cleave endoglin to produce soluble endoglin.

The following MMP15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29446	NM_002428.4 Latest version!	Homo sapiens matrix metallopeptidase 15 (MMP15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu29446	NM_002428.3	Homo sapiens matrix metallopeptidase 15 (MMP15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMP15 ( NM_002428.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002419.1 Homo sapiens matrix metallopeptidase 15 (MMP15), mRNA.

Price & Availability↑

CloneID	OHu29446
Clone ID Related Accession (Same CDS sequence)	NM_002428.4 , NM_002428.3
Accession Version	NM_002428.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2010bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	matrix metalloproteinase-15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC055428.1, AW161057.1, Z48482.1 and BC006412.1. On Nov 22, 2018 this sequence version replaced NM_002428.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036495.1, Z48482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000219271.4/ ENSP00000219271.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCAGCG ACCCGAGCGC GCCCGGACGG CCGGGCTGGA CGGGCAGCCT CCTCGGCGAC 
CGGGAGGAGG CGGCGCGGCC GCGACTGCTG CCGCTGCTCC TGGTGCTTCT GGGCTGCCTG 
GGCCTTGGCG TAGCGGCCGA AGACGCGGAG GTCCATGCCG AGAACTGGCT GCGGCTTTAT 
GGCTACCTGC CTCAGCCCAG CCGCCATATG TCCACCATGC GTTCCGCCCA GATCTTGGCC 
TCGGCCCTTG CAGAGATGCA GCGCTTCTAC GGGATCCCAG TCACCGGTGT GCTCGACGAA 
GAGACCAAGG AGTGGATGAA GCGGCCCCGC TGTGGGGTGC CAGACCAGTT CGGGGTACGA 
GTGAAAGCCA ACCTGCGGCG GCGTCGGAAG CGCTACGCCC TCACCGGGAG GAAGTGGAAC 
AACCACCATC TGACCTTTAG CATCCAGAAC TACACGGAGA AGTTGGGCTG GTACCACTCG 
ATGGAGGCGG TGCGCAGGGC CTTCCGCGTG TGGGAGCAGG CCACGCCCCT GGTCTTCCAG 
GAGGTGCCCT ATGAGGACAT CCGGCTGCGG CGACAGAAGG AGGCCGACAT CATGGTACTC 
TTTGCCTCTG GCTTCCACGG CGACAGCTCG CCGTTTGATG GCACCGGTGG CTTTCTGGCC 
CACGCCTATT TCCCTGGCCC CGGCCTAGGC GGGGACACCC ATTTTGACGC AGATGAGCCC 
TGGACCTTCT CCAGCACTGA CCTGCATGGA AACAACCTCT TCCTGGTGGC AGTGCATGAG 
CTGGGCCACG CGCTGGGGCT GGAGCACTCC AGCAACCCCA ATGCCATCAT GGCGCCGTTC 
TACCAGTGGA AGGACGTTGA CAACTTCAAG CTGCCCGAGG ACGATCTCCG TGGCATCCAG 
CAGCTCTACG GTACCCCAGA CGGTCAGCCA CAGCCTACCC AGCCTCTCCC CACTGTGACG 
CCACGGCGGC CAGGCCGGCC TGACCACCGG CCGCCCCGGC CTCCCCAGCC ACCACCCCCA 
GGTGGGAAGC CAGAGCGGCC CCCAAAGCCG GGCCCCCCAG TCCAGCCCCG AGCCACAGAG 
CGGCCCGACC AGTATGGCCC CAACATCTGC GACGGGGACT TTGACACAGT GGCCATGCTT 
CGCGGGGAGA TGTTCGTGTT CAAGGGCCGC TGGTTCTGGC GAGTCCGGCA CAACCGCGTC 
CTGGACAACT ATCCCATGCC CATCGGGCAC TTCTGGCGTG GTCTGCCCGG TGACATCAGT 
GCTGCCTACG AGCGCCAAGA CGGTCGTTTT GTCTTTTTCA AAGGTGACCG CTACTGGCTC 
TTTCGAGAAG CGAACCTGGA GCCCGGCTAC CCACAGCCGC TGACCAGCTA TGGCCTGGGC 
ATCCCCTATG ACCGCATTGA CACGGCCATC TGGTGGGAGC CCACAGGCCA CACCTTCTTC 
TTCCAAGAGG ACAGGTACTG GCGCTTCAAC GAGGAGACAC AGCGTGGAGA CCCTGGGTAC 
CCCAAGCCCA TCAGTGTCTG GCAGGGGATC CCTGCCTCCC CTAAAGGGGC CTTCCTGAGC 
AATGACGCAG CCTACACCTA CTTCTACAAG GGCACCAAAT ACTGGAAATT CGACAATGAG 
CGCCTGCGGA TGGAGCCCGG CTACCCCAAG TCCATCCTGC GGGACTTCAT GGGCTGCCAG 
GAGCACGTGG AGCCAGGCCC CCGATGGCCC GACGTGGCCC GGCCGCCCTT CAACCCCCAC 
GGGGGTGCAG AGCCCGGGGC GGACAGCGCA GAGGGCGACG TGGGGGATGG GGATGGGGAC 
TTTGGGGCCG GGGTCAACAA GGACGGGGGC AGCCGCGTGG TGGTGCAGAT GGAGGAGGTG 
GCACGGACGG TGAACGTGGT GATGGTGCTG GTGCCACTGC TGCTGCTGCT CTGCGTCCTG 
GGCCTCACCT ACGCGCTGGT GCAGATGCAG CGCAAGGGTG CGCCACGTGT CCTGCTTTAC 
TGCAAGCGCT CGCTGCAGGA GTGGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002419.1
CDS	598..2607
Translation	MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV

Target ORF information:

RefSeq Version	NM_002428.4
Organism	Homo sapiens(human)
Definition	Homo sapiens matrix metallopeptidase 15 (MMP15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002428.4

ORF Insert Sequence:

ATGGGCAGCG ACCCGAGCGC GCCCGGACGG CCGGGCTGGA CGGGCAGCCT CCTCGGCGAC 
CGGGAGGAGG CGGCGCGGCC GCGACTGCTG CCGCTGCTCC TGGTGCTTCT GGGCTGCCTG 
GGCCTTGGCG TAGCGGCCGA AGACGCGGAG GTCCATGCCG AGAACTGGCT GCGGCTTTAT 
GGCTACCTGC CTCAGCCCAG CCGCCATATG TCCACCATGC GTTCCGCCCA GATCTTGGCC 
TCGGCCCTTG CAGAGATGCA GCGCTTCTAC GGGATCCCAG TCACCGGTGT GCTCGACGAA 
GAGACCAAGG AGTGGATGAA GCGGCCCCGC TGTGGGGTGC CAGACCAGTT CGGGGTACGA 
GTGAAAGCCA ACCTGCGGCG GCGTCGGAAG CGCTACGCCC TCACCGGGAG GAAGTGGAAC 
AACCACCATC TGACCTTTAG CATCCAGAAC TACACGGAGA AGTTGGGCTG GTACCACTCG 
ATGGAGGCGG TGCGCAGGGC CTTCCGCGTG TGGGAGCAGG CCACGCCCCT GGTCTTCCAG 
GAGGTGCCCT ATGAGGACAT CCGGCTGCGG CGACAGAAGG AGGCCGACAT CATGGTACTC 
TTTGCCTCTG GCTTCCACGG CGACAGCTCG CCGTTTGATG GCACCGGTGG CTTTCTGGCC 
CACGCCTATT TCCCTGGCCC CGGCCTAGGC GGGGACACCC ATTTTGACGC AGATGAGCCC 
TGGACCTTCT CCAGCACTGA CCTGCATGGA AACAACCTCT TCCTGGTGGC AGTGCATGAG 
CTGGGCCACG CGCTGGGGCT GGAGCACTCC AGCAACCCCA ATGCCATCAT GGCGCCGTTC 
TACCAGTGGA AGGACGTTGA CAACTTCAAG CTGCCCGAGG ACGATCTCCG TGGCATCCAG 
CAGCTCTACG GTACCCCAGA CGGTCAGCCA CAGCCTACCC AGCCTCTCCC CACTGTGACG 
CCACGGCGGC CAGGCCGGCC TGACCACCGG CCGCCCCGGC CTCCCCAGCC ACCACCCCCA 
GGTGGGAAGC CAGAGCGGCC CCCAAAGCCG GGCCCCCCAG TCCAGCCCCG AGCCACAGAG 
CGGCCCGACC AGTATGGCCC CAACATCTGC GACGGGGACT TTGACACAGT GGCCATGCTT 
CGCGGGGAGA TGTTCGTGTT CAAGGGCCGC TGGTTCTGGC GAGTCCGGCA CAACCGCGTC 
CTGGACAACT ATCCCATGCC CATCGGGCAC TTCTGGCGTG GTCTGCCCGG TGACATCAGT 
GCTGCCTACG AGCGCCAAGA CGGTCGTTTT GTCTTTTTCA AAGGTGACCG CTACTGGCTC 
TTTCGAGAAG CGAACCTGGA GCCCGGCTAC CCACAGCCGC TGACCAGCTA TGGCCTGGGC 
ATCCCCTATG ACCGCATTGA CACGGCCATC TGGTGGGAGC CCACAGGCCA CACCTTCTTC 
TTCCAAGAGG ACAGGTACTG GCGCTTCAAC GAGGAGACAC AGCGTGGAGA CCCTGGGTAC 
CCCAAGCCCA TCAGTGTCTG GCAGGGGATC CCTGCCTCCC CTAAAGGGGC CTTCCTGAGC 
AATGACGCAG CCTACACCTA CTTCTACAAG GGCACCAAAT ACTGGAAATT CGACAATGAG 
CGCCTGCGGA TGGAGCCCGG CTACCCCAAG TCCATCCTGC GGGACTTCAT GGGCTGCCAG 
GAGCACGTGG AGCCAGGCCC CCGATGGCCC GACGTGGCCC GGCCGCCCTT CAACCCCCAC 
GGGGGTGCAG AGCCCGGGGC GGACAGCGCA GAGGGCGACG TGGGGGATGG GGATGGGGAC 
TTTGGGGCCG GGGTCAACAA GGACGGGGGC AGCCGCGTGG TGGTGCAGAT GGAGGAGGTG 
GCACGGACGG TGAACGTGGT GATGGTGCTG GTGCCACTGC TGCTGCTGCT CTGCGTCCTG 
GGCCTCACCT ACGCGCTGGT GCAGATGCAG CGCAAGGGTG CGCCACGTGT CCTGCTTTAC 
TGCAAGCGCT CGCTGCAGGA GTGGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MMP15 ( NM_002428.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002419.1 Homo sapiens matrix metallopeptidase 15 (MMP15), mRNA.

Price & Availability↑

CloneID	OHu29446
Clone ID Related Accession (Same CDS sequence)	NM_002428.4 , NM_002428.3
Accession Version	NM_002428.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2010bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	matrix metalloproteinase-15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC055428.1, AW161057.1, Z48482.1 and BC006412.1. On Jan 20, 2016 this sequence version replaced NM_002428.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036495.1, Z48482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCG ACCCGAGCGC GCCCGGACGG CCGGGCTGGA CGGGCAGCCT CCTCGGCGAC 
CGGGAGGAGG CGGCGCGGCC GCGACTGCTG CCGCTGCTCC TGGTGCTTCT GGGCTGCCTG 
GGCCTTGGCG TAGCGGCCGA AGACGCGGAG GTCCATGCCG AGAACTGGCT GCGGCTTTAT 
GGCTACCTGC CTCAGCCCAG CCGCCATATG TCCACCATGC GTTCCGCCCA GATCTTGGCC 
TCGGCCCTTG CAGAGATGCA GCGCTTCTAC GGGATCCCAG TCACCGGTGT GCTCGACGAA 
GAGACCAAGG AGTGGATGAA GCGGCCCCGC TGTGGGGTGC CAGACCAGTT CGGGGTACGA 
GTGAAAGCCA ACCTGCGGCG GCGTCGGAAG CGCTACGCCC TCACCGGGAG GAAGTGGAAC 
AACCACCATC TGACCTTTAG CATCCAGAAC TACACGGAGA AGTTGGGCTG GTACCACTCG 
ATGGAGGCGG TGCGCAGGGC CTTCCGCGTG TGGGAGCAGG CCACGCCCCT GGTCTTCCAG 
GAGGTGCCCT ATGAGGACAT CCGGCTGCGG CGACAGAAGG AGGCCGACAT CATGGTACTC 
TTTGCCTCTG GCTTCCACGG CGACAGCTCG CCGTTTGATG GCACCGGTGG CTTTCTGGCC 
CACGCCTATT TCCCTGGCCC CGGCCTAGGC GGGGACACCC ATTTTGACGC AGATGAGCCC 
TGGACCTTCT CCAGCACTGA CCTGCATGGA AACAACCTCT TCCTGGTGGC AGTGCATGAG 
CTGGGCCACG CGCTGGGGCT GGAGCACTCC AGCAACCCCA ATGCCATCAT GGCGCCGTTC 
TACCAGTGGA AGGACGTTGA CAACTTCAAG CTGCCCGAGG ACGATCTCCG TGGCATCCAG 
CAGCTCTACG GTACCCCAGA CGGTCAGCCA CAGCCTACCC AGCCTCTCCC CACTGTGACG 
CCACGGCGGC CAGGCCGGCC TGACCACCGG CCGCCCCGGC CTCCCCAGCC ACCACCCCCA 
GGTGGGAAGC CAGAGCGGCC CCCAAAGCCG GGCCCCCCAG TCCAGCCCCG AGCCACAGAG 
CGGCCCGACC AGTATGGCCC CAACATCTGC GACGGGGACT TTGACACAGT GGCCATGCTT 
CGCGGGGAGA TGTTCGTGTT CAAGGGCCGC TGGTTCTGGC GAGTCCGGCA CAACCGCGTC 
CTGGACAACT ATCCCATGCC CATCGGGCAC TTCTGGCGTG GTCTGCCCGG TGACATCAGT 
GCTGCCTACG AGCGCCAAGA CGGTCGTTTT GTCTTTTTCA AAGGTGACCG CTACTGGCTC 
TTTCGAGAAG CGAACCTGGA GCCCGGCTAC CCACAGCCGC TGACCAGCTA TGGCCTGGGC 
ATCCCCTATG ACCGCATTGA CACGGCCATC TGGTGGGAGC CCACAGGCCA CACCTTCTTC 
TTCCAAGAGG ACAGGTACTG GCGCTTCAAC GAGGAGACAC AGCGTGGAGA CCCTGGGTAC 
CCCAAGCCCA TCAGTGTCTG GCAGGGGATC CCTGCCTCCC CTAAAGGGGC CTTCCTGAGC 
AATGACGCAG CCTACACCTA CTTCTACAAG GGCACCAAAT ACTGGAAATT CGACAATGAG 
CGCCTGCGGA TGGAGCCCGG CTACCCCAAG TCCATCCTGC GGGACTTCAT GGGCTGCCAG 
GAGCACGTGG AGCCAGGCCC CCGATGGCCC GACGTGGCCC GGCCGCCCTT CAACCCCCAC 
GGGGGTGCAG AGCCCGGGGC GGACAGCGCA GAGGGCGACG TGGGGGATGG GGATGGGGAC 
TTTGGGGCCG GGGTCAACAA GGACGGGGGC AGCCGCGTGG TGGTGCAGAT GGAGGAGGTG 
GCACGGACGG TGAACGTGGT GATGGTGCTG GTGCCACTGC TGCTGCTGCT CTGCGTCCTG 
GGCCTCACCT ACGCGCTGGT GCAGATGCAG CGCAAGGGTG CGCCACGTGT CCTGCTTTAC 
TGCAAGCGCT CGCTGCAGGA GTGGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002419.1
CDS	786..2795
Translation	MGSDPSAPGRPGWTGSLLGDREEAARPRLLPLLLVLLGCLGLGVAAEDAEVHAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQRFYGIPVTGVLDEETKEWMKRPRCGVPDQFGVRVKANLRRRRKRYALTGRKWNNHHLTFSIQNYTEKLGWYHSMEAVRRAFRVWEQATPLVFQEVPYEDIRLRRQKEADIMVLFASGFHGDSSPFDGTGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGNNLFLVAVHELGHALGLEHSSNPNAIMAPFYQWKDVDNFKLPEDDLRGIQQLYGTPDGQPQPTQPLPTVTPRRPGRPDHRPPRPPQPPPPGGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAMLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGYPQPLTSYGLGIPYDRIDTAIWWEPTGHTFFFQEDRYWRFNEETQRGDPGYPKPISVWQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGCQEHVEPGPRWPDVARPPFNPHGGAEPGADSAEGDVGDGDGDFGAGVNKDGGSRVVVQMEEVARTVNVVMVLVPLLLLLCVLGLTYALVQMQRKGAPRVLLYCKRSLQEWV

Target ORF information:

RefSeq Version	NM_002428.3
Organism	Homo sapiens(human)
Definition	Homo sapiens matrix metallopeptidase 15 (MMP15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002428.3

ORF Insert Sequence:

ATGGGCAGCG ACCCGAGCGC GCCCGGACGG CCGGGCTGGA CGGGCAGCCT CCTCGGCGAC 
CGGGAGGAGG CGGCGCGGCC GCGACTGCTG CCGCTGCTCC TGGTGCTTCT GGGCTGCCTG 
GGCCTTGGCG TAGCGGCCGA AGACGCGGAG GTCCATGCCG AGAACTGGCT GCGGCTTTAT 
GGCTACCTGC CTCAGCCCAG CCGCCATATG TCCACCATGC GTTCCGCCCA GATCTTGGCC 
TCGGCCCTTG CAGAGATGCA GCGCTTCTAC GGGATCCCAG TCACCGGTGT GCTCGACGAA 
GAGACCAAGG AGTGGATGAA GCGGCCCCGC TGTGGGGTGC CAGACCAGTT CGGGGTACGA 
GTGAAAGCCA ACCTGCGGCG GCGTCGGAAG CGCTACGCCC TCACCGGGAG GAAGTGGAAC 
AACCACCATC TGACCTTTAG CATCCAGAAC TACACGGAGA AGTTGGGCTG GTACCACTCG 
ATGGAGGCGG TGCGCAGGGC CTTCCGCGTG TGGGAGCAGG CCACGCCCCT GGTCTTCCAG 
GAGGTGCCCT ATGAGGACAT CCGGCTGCGG CGACAGAAGG AGGCCGACAT CATGGTACTC 
TTTGCCTCTG GCTTCCACGG CGACAGCTCG CCGTTTGATG GCACCGGTGG CTTTCTGGCC 
CACGCCTATT TCCCTGGCCC CGGCCTAGGC GGGGACACCC ATTTTGACGC AGATGAGCCC 
TGGACCTTCT CCAGCACTGA CCTGCATGGA AACAACCTCT TCCTGGTGGC AGTGCATGAG 
CTGGGCCACG CGCTGGGGCT GGAGCACTCC AGCAACCCCA ATGCCATCAT GGCGCCGTTC 
TACCAGTGGA AGGACGTTGA CAACTTCAAG CTGCCCGAGG ACGATCTCCG TGGCATCCAG 
CAGCTCTACG GTACCCCAGA CGGTCAGCCA CAGCCTACCC AGCCTCTCCC CACTGTGACG 
CCACGGCGGC CAGGCCGGCC TGACCACCGG CCGCCCCGGC CTCCCCAGCC ACCACCCCCA 
GGTGGGAAGC CAGAGCGGCC CCCAAAGCCG GGCCCCCCAG TCCAGCCCCG AGCCACAGAG 
CGGCCCGACC AGTATGGCCC CAACATCTGC GACGGGGACT TTGACACAGT GGCCATGCTT 
CGCGGGGAGA TGTTCGTGTT CAAGGGCCGC TGGTTCTGGC GAGTCCGGCA CAACCGCGTC 
CTGGACAACT ATCCCATGCC CATCGGGCAC TTCTGGCGTG GTCTGCCCGG TGACATCAGT 
GCTGCCTACG AGCGCCAAGA CGGTCGTTTT GTCTTTTTCA AAGGTGACCG CTACTGGCTC 
TTTCGAGAAG CGAACCTGGA GCCCGGCTAC CCACAGCCGC TGACCAGCTA TGGCCTGGGC 
ATCCCCTATG ACCGCATTGA CACGGCCATC TGGTGGGAGC CCACAGGCCA CACCTTCTTC 
TTCCAAGAGG ACAGGTACTG GCGCTTCAAC GAGGAGACAC AGCGTGGAGA CCCTGGGTAC 
CCCAAGCCCA TCAGTGTCTG GCAGGGGATC CCTGCCTCCC CTAAAGGGGC CTTCCTGAGC 
AATGACGCAG CCTACACCTA CTTCTACAAG GGCACCAAAT ACTGGAAATT CGACAATGAG 
CGCCTGCGGA TGGAGCCCGG CTACCCCAAG TCCATCCTGC GGGACTTCAT GGGCTGCCAG 
GAGCACGTGG AGCCAGGCCC CCGATGGCCC GACGTGGCCC GGCCGCCCTT CAACCCCCAC 
GGGGGTGCAG AGCCCGGGGC GGACAGCGCA GAGGGCGACG TGGGGGATGG GGATGGGGAC 
TTTGGGGCCG GGGTCAACAA GGACGGGGGC AGCCGCGTGG TGGTGCAGAT GGAGGAGGTG 
GCACGGACGG TGAACGTGGT GATGGTGCTG GTGCCACTGC TGCTGCTGCT CTGCGTCCTG 
GGCCTCACCT ACGCGCTGGT GCAGATGCAG CGCAAGGGTG CGCCACGTGT CCTGCTTTAC 
TGCAAGCGCT CGCTGCAGGA GTGGGTCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

E-cadherin cleavage by MT2-MMP regulates apical junctional signaling and epithelial homeostasis in the intestine.
Journal of cell science130(23)4013-4027(2017 Dec)
G?mez-Escudero J,Moreno V,Mart?n-Alonso M,Hern?ndez-Riquer MV,Feinberg T,Colmenar ?,Calvo E,Camafeita E,Mart?nez F,Oudhoff MJ,Weiss SJ,Arroyo AG

MT2-MMP induces proteolysis and leads to EMT in carcinomas.
Oncotarget7(30)48193-48205(2016 Jul)
Liu Y,Sun X,Feng J,Deng LL,Liu Y,Li B,Zhu M,Lu C,Zhou L

T cell factor-4 functions as a co-activator to promote NF-?B-dependent MMP-15 expression in lung carcinoma cells.
Scientific reports624025(2016 Apr)
Liu Y,Xu Y,Guo S,Chen H

Increased MT2-MMP expression in gastric cancer patients is associated with poor prognosis.
International journal of clinical and experimental pathology8(2)1985-90(2015)
Xu X,Chen L,Xu B,Xie Q,Sun M,Deng X,Wu C,Jiang J

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MMP15 cDNA ORF clone, Homo sapiens(human)

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ORF Insert Sequence:

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