Mmp15 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Mmp15
Entrez Gene ID	17388
Full Name	matrix metallopeptidase 15
Synonyms	AI503551,MT-MMP 2,MT2-MMP
General protein information	Preferred Names matrix metallopeptidase 15 Names matrix metalloproteinase-15 Membrane type 2-MMP membrane-type-2 matrix metalloproteinase
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8 C5\|8 47.12 cM
Summary	This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. A deficiency of the encoded protein in mice is compatible with normal development and postnatal growth. [provided by RefSeq, Feb 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_008609.3	NP_032635.1	matrix metalloproteinase-15 precursor
NM_008609.4	NP_032635.1	matrix metalloproteinase-15 preproprotein

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	MMP15	XP_544383.3
Gallus gallus (chicken)	MMP15	XP_413995.3
Danio rerio (zebrafish)	LOC100332426	XP_002662954.2
Pan troglodytes (chimpanzee)	MMP15	XP_001150678.2
Bos taurus (cattle)	MMP15	NP_001178363.1
	MMP15	XP_001101050.1
Mus musculus (house mouse)	Mmp15	NP_032635.1
Rattus norvegicus (Norway rat)	Mmp15	NP_001099638.1
Homo sapiens (human)	MMP15	NP_002419.1
Xenopus tropicalis (tropical clawed frog)	mmp15	NP_001015921.1

Gene Ontology
Bibliography

Related articles in PubMed

Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage.
Pelosi E, D'Ignazio L, Michel M, Beyer M, Thompson K, Forabosco A, Schlessinger D
Biology of reproduction(2018 Jan)

MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.
Sanz RL, Ferraro GB, Kacervosky J, Salesse C, Gowing E, Hua L, Rambaldi I, Beaubien F, Holmbeck K, Cloutier JF, L?vesque M, Murai K, Fournier AE
The Journal of neuroscience : the official journal of the Society for Neuroscience38(3)518-529(2018 Jan)

Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.
Feinberg TY, Rowe RG, Saunders TL, Weiss SJ
Development (Cambridge, England)143(21)3956-3968(2016 11)

High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Although neither proteinase is required for branching morphogenesis, transcriptome profiling reveals a key role for MMP14 and MMP15 in regulating mammary gland adipocyte differentiation. Whereas MMP14 promotes the generation of white fat depots crucial for energy storage, MMP15 differentially controls the formation of thermogenic brown fat.
Title: Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.

Data indicate that Snai1 is sufficient to promote mmp15 expression, cell transformation, and mesenchymal cell migration and invasion.
Title: Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development.

The following Mmp15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mmp15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu02338	NM_008609.4 Latest version!	Mus musculus matrix metallopeptidase 15 (Mmp15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$384.30 $549.00
View Old Accession Versions >>
OMu02338	NM_008609.3	Mus musculus matrix metallopeptidase 15 (Mmp15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$384.30 $549.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Mmp15 ( NM_008609.3 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032635.1 Mus musculus matrix metallopeptidase 15 (Mmp15), mRNA.

Price & Availability↑

CloneID	OMu02338
Clone ID Related Accession (Same CDS sequence)	NM_008609.3 , NM_008609.4
Accession Version	NM_008609.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1974bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-14
Organism	Mus musculus(House mouse)
Product	matrix metalloproteinase-15 precursor
Comment

ATGGGCAGCG ACCGGAGCGC ACTCGGACGT CCAGGCTGCA CTGGCAGCTG CCTCAGCAGC 
CGAGCTTCGC TGCTCCCGCT GCTACTGGTG CTTCTGGACT GTCTGGGCCA TGGTACAGCG 
TCTAAAGACG CCGAAGTGTA CGCCGCGGAG AACTGGCTGC GGCTCTATGG CTACCTACCC 
CAGCCCAGCC GCCACATGTC CACCATGCGC TCTGCCCAGA TCCTGGCCTC CGCCCTTGCC 
GAGATGCAGA GTTTCTATGG GATCCCTGTC ACGGGTGTGC TTGATGAAGA GACGAAAACG 
TGGATGAAGC GGCCCCGATG TGGGGTTCCT GATCAGTTTG GGGTACATGT GAAAGCCAAC 
CTGCGTCGAC GGCGGAAACG TTACACCCTG ACAGGAAAGG CATGGAACAA TTACCACCTG 
ACCTTCAGCA TCCAGAACTA CACTGAGAAG CTGGGCTGGT ACAACTCCAT GGAGGCGGTG 
CGCAGGGCTT TCCAAGTGTG GGAGCAGGTC ACACCATTGG TCTTCCAGGA AGTATCCTAT 
GATGACATTC GGCTACGAAG GCGAGCGGAG GCTGACATCA TGGTACTCTT TGCCTCTGGC 
TTCCATGGCG ACAGCTCACC GTTTGATGGC GTGGGTGGCT TTCTGGCCCA CGCTTATTTC 
CCCGGCCCTG GTCTGGGTGG GGACACCCAT TTCGACGCAG ATGAACCCTG GACCTTCTCC 
AGCACTGACC TGCATGGAAT CAGCCTCTTT CTGGTGGCCG TGCATGAGCT GGGCCATGCC 
CTGGGGCTAG AACACTCAAG TAACCCCAGC GCTATTATGG CACCCTTCTA CCAGTGGATG 
GATACCGACA ACTTCCAGCT GCCCGAAGAT GACCTTCGGG GCATCCAGCA GCTGTATGGC 
TCCCCAGATG GTAAGCCACA GCCCACCCGG CCTCTCCCCA CTGTGAGGCC CCGGCGGCCA 
GGACGGCCAG ATCACCAGCC ACCTCGGCCT CCCCAGCCAC CACATCCAGG TGGGAAGCCA 
GAAAGGCCCC CCAAACCAGG GCCCCCACCC CAGCCCCGAG CCACAGAGAG GCCTGACCAG 
TATGGCCCCA ACATCTGCGA TGGCAACTTC GACACAGTGG CTGTGCTCCG CGGAGAGATG 
TTTGTGTTCA AGGGCCGCTG GTTCTGGCGA GTCAGGCACA ACCGCGTTCT AGACAACTAC 
CCCATGCCAA TTGGCCACTT CTGGCGCGGT CTGCCGGGGA ACATCAGTGC TGCCTACGAG 
CGCCAGGATG GACATTTTGT CTTCTTCAAA GGTAACCGCT ACTGGCTTTT CCGAGAAGCC 
AATCTGGAGC CCGGCTACCC ACAGCCGCTG AGCAGCTATG GCACAGACAT CCCCTATGAC 
CGCATTGACA CAGCCATCTG GTGGGAGCCC ACAGGTCACA CCTTCTTCTT TCAAGCAGAC 
AGGTACTGGC GCTTCAACGA GGAGACACAG CATGGAGACC CTGGCTACCC CAAGCCCATC 
AGTGTCTGGC AGGGGATCCC CACCTCTCCC AAAGGGGCCT TCCTCAGCAA CGATGCAGCC 
TACACCTACT TCTACAAGGG CACCAAGTAC TGGAAATTCA ACAACGAACG CCTACGGATG 
GAACCCGGCC ACCCCAAATC CATCCTGCGG GACTTCATGG GCTGCCAGGA GCACGTGGAG 
CCCCGATCGC GATGGCCCGA TGTGGCTCGT CCACCCTTCA ACCCCAACGG GGGTGCCGAG 
CCTGAGGCAG ATGGTGACAG CAAGGAAGAG AACGCGGGTG ACAAGGATGA GGGCAGCCGC 
GTGGTGGTGC AGATGGAGGA GGTGGTCCGG ACAGTGAACG TGGTGATGGT GTTGGTCCCC 
TTGCTGCTGT TGCTCTGTAT TCTGGGCCTG GCCTTTGCTC TGGTGCAGAT GCAGCGCAAG 
GGCGCCCCTC GCATGCTGCT CTACTGCAAG CGCTCACTGC AGGAGTGGGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_032635.1

Translation

MGSDRSALGRPGCTGSCLSSRASLLPLLLVLLDCLGHGTASKDAEVYAAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQSFYGIPVTGVLDEETKTWMKRPRCGVPDQFGVHVKANLRRRRKRYTLTGKAWNNYHLTFSIQNYTEKLGWYNSMEAVRRAFQVWEQVTPLVFQEVSYDDIRLRRRAEADIMVLFASGFHGDSSPFDGVGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGISLFLVAVHELGHALGLEHSSNPSAIMAPFYQWMDTDNFQLPEDDLRGIQQLYGSPDGKPQPTRPLPTVRPRRPGRPDHQPPRPPQPPHPGGKPERPPKPGPPPQPRATERPDQYGPNICDGNFDTVAVLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGNISAAYERQDGHFVFFKGNRYWLFREANLEPGYPQPLSSYGTDIPYDRIDTAIWWEPTGHTFFFQADRYWRFNEETQHGDPGYPKPISVWQGIPTSPKGAFLSNDAAYTYFYKGTKYWKFNNERLRMEPGHPKSILRDFMGCQEHVEPRSRWPDVARPPFNPNGGAEPEADGDSKEENAGDKDEGSRVVVQMEEVVRTVNVVMVLVPLLLLLCILGLAFALVQMQRKGAPRMLLYCKRSLQEWV

Target ORF information:

RefSeq Version	NM_008609.3
Organism	Mus musculus(House mouse)
Definition	Mus musculus matrix metallopeptidase 15 (Mmp15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008609.3

ORF Insert Sequence:

ATGGGCAGCG ACCGGAGCGC ACTCGGACGT CCAGGCTGCA CTGGCAGCTG CCTCAGCAGC 
CGAGCTTCGC TGCTCCCGCT GCTACTGGTG CTTCTGGACT GTCTGGGCCA TGGTACAGCG 
TCTAAAGACG CCGAAGTGTA CGCCGCGGAG AACTGGCTGC GGCTCTATGG CTACCTACCC 
CAGCCCAGCC GCCACATGTC CACCATGCGC TCTGCCCAGA TCCTGGCCTC CGCCCTTGCC 
GAGATGCAGA GTTTCTATGG GATCCCTGTC ACGGGTGTGC TTGATGAAGA GACGAAAACG 
TGGATGAAGC GGCCCCGATG TGGGGTTCCT GATCAGTTTG GGGTACATGT GAAAGCCAAC 
CTGCGTCGAC GGCGGAAACG TTACACCCTG ACAGGAAAGG CATGGAACAA TTACCACCTG 
ACCTTCAGCA TCCAGAACTA CACTGAGAAG CTGGGCTGGT ACAACTCCAT GGAGGCGGTG 
CGCAGGGCTT TCCAAGTGTG GGAGCAGGTC ACACCATTGG TCTTCCAGGA AGTATCCTAT 
GATGACATTC GGCTACGAAG GCGAGCGGAG GCTGACATCA TGGTACTCTT TGCCTCTGGC 
TTCCATGGCG ACAGCTCACC GTTTGATGGC GTGGGTGGCT TTCTGGCCCA CGCTTATTTC 
CCCGGCCCTG GTCTGGGTGG GGACACCCAT TTCGACGCAG ATGAACCCTG GACCTTCTCC 
AGCACTGACC TGCATGGAAT CAGCCTCTTT CTGGTGGCCG TGCATGAGCT GGGCCATGCC 
CTGGGGCTAG AACACTCAAG TAACCCCAGC GCTATTATGG CACCCTTCTA CCAGTGGATG 
GATACCGACA ACTTCCAGCT GCCCGAAGAT GACCTTCGGG GCATCCAGCA GCTGTATGGC 
TCCCCAGATG GTAAGCCACA GCCCACCCGG CCTCTCCCCA CTGTGAGGCC CCGGCGGCCA 
GGACGGCCAG ATCACCAGCC ACCTCGGCCT CCCCAGCCAC CACATCCAGG TGGGAAGCCA 
GAAAGGCCCC CCAAACCAGG GCCCCCACCC CAGCCCCGAG CCACAGAGAG GCCTGACCAG 
TATGGCCCCA ACATCTGCGA TGGCAACTTC GACACAGTGG CTGTGCTCCG CGGAGAGATG 
TTTGTGTTCA AGGGCCGCTG GTTCTGGCGA GTCAGGCACA ACCGCGTTCT AGACAACTAC 
CCCATGCCAA TTGGCCACTT CTGGCGCGGT CTGCCGGGGA ACATCAGTGC TGCCTACGAG 
CGCCAGGATG GACATTTTGT CTTCTTCAAA GGTAACCGCT ACTGGCTTTT CCGAGAAGCC 
AATCTGGAGC CCGGCTACCC ACAGCCGCTG AGCAGCTATG GCACAGACAT CCCCTATGAC 
CGCATTGACA CAGCCATCTG GTGGGAGCCC ACAGGTCACA CCTTCTTCTT TCAAGCAGAC 
AGGTACTGGC GCTTCAACGA GGAGACACAG CATGGAGACC CTGGCTACCC CAAGCCCATC 
AGTGTCTGGC AGGGGATCCC CACCTCTCCC AAAGGGGCCT TCCTCAGCAA CGATGCAGCC 
TACACCTACT TCTACAAGGG CACCAAGTAC TGGAAATTCA ACAACGAACG CCTACGGATG 
GAACCCGGCC ACCCCAAATC CATCCTGCGG GACTTCATGG GCTGCCAGGA GCACGTGGAG 
CCCCGATCGC GATGGCCCGA TGTGGCTCGT CCACCCTTCA ACCCCAACGG GGGTGCCGAG 
CCTGAGGCAG ATGGTGACAG CAAGGAAGAG AACGCGGGTG ACAAGGATGA GGGCAGCCGC 
GTGGTGGTGC AGATGGAGGA GGTGGTCCGG ACAGTGAACG TGGTGATGGT GTTGGTCCCC 
TTGCTGCTGT TGCTCTGTAT TCTGGGCCTG GCCTTTGCTC TGGTGCAGAT GCAGCGCAAG 
GGCGCCCCTC GCATGCTGCT CTACTGCAAG CGCTCACTGC AGGAGTGGGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Mmp15 ( NM_008609.4 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_032635.1 Mus musculus matrix metallopeptidase 15 (Mmp15), mRNA.

Price & Availability↑

CloneID	OMu02338
Clone ID Related Accession (Same CDS sequence)	NM_008609.3 , NM_008609.4
Accession Version	NM_008609.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1974bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Mus musculus(house mouse)
Product	matrix metalloproteinase-15 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BY732226.1 and BC047278.1. On Feb 12, 2016 this sequence version replaced NM_008609.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047278.1, D86332.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAGCG ACCGGAGCGC ACTCGGACGT CCAGGCTGCA CTGGCAGCTG CCTCAGCAGC 
CGAGCTTCGC TGCTCCCGCT GCTACTGGTG CTTCTGGACT GTCTGGGCCA TGGTACAGCG 
TCTAAAGACG CCGAAGTGTA CGCCGCGGAG AACTGGCTGC GGCTCTATGG CTACCTACCC 
CAGCCCAGCC GCCACATGTC CACCATGCGC TCTGCCCAGA TCCTGGCCTC CGCCCTTGCC 
GAGATGCAGA GTTTCTATGG GATCCCTGTC ACGGGTGTGC TTGATGAAGA GACGAAAACG 
TGGATGAAGC GGCCCCGATG TGGGGTTCCT GATCAGTTTG GGGTACATGT GAAAGCCAAC 
CTGCGTCGAC GGCGGAAACG TTACACCCTG ACAGGAAAGG CATGGAACAA TTACCACCTG 
ACCTTCAGCA TCCAGAACTA CACTGAGAAG CTGGGCTGGT ACAACTCCAT GGAGGCGGTG 
CGCAGGGCTT TCCAAGTGTG GGAGCAGGTC ACACCATTGG TCTTCCAGGA AGTATCCTAT 
GATGACATTC GGCTACGAAG GCGAGCGGAG GCTGACATCA TGGTACTCTT TGCCTCTGGC 
TTCCATGGCG ACAGCTCACC GTTTGATGGC GTGGGTGGCT TTCTGGCCCA CGCTTATTTC 
CCCGGCCCTG GTCTGGGTGG GGACACCCAT TTCGACGCAG ATGAACCCTG GACCTTCTCC 
AGCACTGACC TGCATGGAAT CAGCCTCTTT CTGGTGGCCG TGCATGAGCT GGGCCATGCC 
CTGGGGCTAG AACACTCAAG TAACCCCAGC GCTATTATGG CACCCTTCTA CCAGTGGATG 
GATACCGACA ACTTCCAGCT GCCCGAAGAT GACCTTCGGG GCATCCAGCA GCTGTATGGC 
TCCCCAGATG GTAAGCCACA GCCCACCCGG CCTCTCCCCA CTGTGAGGCC CCGGCGGCCA 
GGACGGCCAG ATCACCAGCC ACCTCGGCCT CCCCAGCCAC CACATCCAGG TGGGAAGCCA 
GAAAGGCCCC CCAAACCAGG GCCCCCACCC CAGCCCCGAG CCACAGAGAG GCCTGACCAG 
TATGGCCCCA ACATCTGCGA TGGCAACTTC GACACAGTGG CTGTGCTCCG CGGAGAGATG 
TTTGTGTTCA AGGGCCGCTG GTTCTGGCGA GTCAGGCACA ACCGCGTTCT AGACAACTAC 
CCCATGCCAA TTGGCCACTT CTGGCGCGGT CTGCCGGGGA ACATCAGTGC TGCCTACGAG 
CGCCAGGATG GACATTTTGT CTTCTTCAAA GGTAACCGCT ACTGGCTTTT CCGAGAAGCC 
AATCTGGAGC CCGGCTACCC ACAGCCGCTG AGCAGCTATG GCACAGACAT CCCCTATGAC 
CGCATTGACA CAGCCATCTG GTGGGAGCCC ACAGGTCACA CCTTCTTCTT TCAAGCAGAC 
AGGTACTGGC GCTTCAACGA GGAGACACAG CATGGAGACC CTGGCTACCC CAAGCCCATC 
AGTGTCTGGC AGGGGATCCC CACCTCTCCC AAAGGGGCCT TCCTCAGCAA CGATGCAGCC 
TACACCTACT TCTACAAGGG CACCAAGTAC TGGAAATTCA ACAACGAACG CCTACGGATG 
GAACCCGGCC ACCCCAAATC CATCCTGCGG GACTTCATGG GCTGCCAGGA GCACGTGGAG 
CCCCGATCGC GATGGCCCGA TGTGGCTCGT CCACCCTTCA ACCCCAACGG GGGTGCCGAG 
CCTGAGGCAG ATGGTGACAG CAAGGAAGAG AACGCGGGTG ACAAGGATGA GGGCAGCCGC 
GTGGTGGTGC AGATGGAGGA GGTGGTCCGG ACAGTGAACG TGGTGATGGT GTTGGTCCCC 
TTGCTGCTGT TGCTCTGTAT TCTGGGCCTG GCCTTTGCTC TGGTGCAGAT GCAGCGCAAG 
GGCGCCCCTC GCATGCTGCT CTACTGCAAG CGCTCACTGC AGGAGTGGGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_032635.1
CDS	574..2547
Translation	MGSDRSALGRPGCTGSCLSSRASLLPLLLVLLDCLGHGTASKDAEVYAAENWLRLYGYLPQPSRHMSTMRSAQILASALAEMQSFYGIPVTGVLDEETKTWMKRPRCGVPDQFGVHVKANLRRRRKRYTLTGKAWNNYHLTFSIQNYTEKLGWYNSMEAVRRAFQVWEQVTPLVFQEVSYDDIRLRRRAEADIMVLFASGFHGDSSPFDGVGGFLAHAYFPGPGLGGDTHFDADEPWTFSSTDLHGISLFLVAVHELGHALGLEHSSNPSAIMAPFYQWMDTDNFQLPEDDLRGIQQLYGSPDGKPQPTRPLPTVRPRRPGRPDHQPPRPPQPPHPGGKPERPPKPGPPPQPRATERPDQYGPNICDGNFDTVAVLRGEMFVFKGRWFWRVRHNRVLDNYPMPIGHFWRGLPGNISAAYERQDGHFVFFKGNRYWLFREANLEPGYPQPLSSYGTDIPYDRIDTAIWWEPTGHTFFFQADRYWRFNEETQHGDPGYPKPISVWQGIPTSPKGAFLSNDAAYTYFYKGTKYWKFNNERLRMEPGHPKSILRDFMGCQEHVEPRSRWPDVARPPFNPNGGAEPEADGDSKEENAGDKDEGSRVVVQMEEVVRTVNVVMVLVPLLLLLCILGLAFALVQMQRKGAPRMLLYCKRSLQEWV

Target ORF information:

RefSeq Version	NM_008609.4
Organism	Mus musculus(house mouse)
Definition	Mus musculus matrix metallopeptidase 15 (Mmp15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_008609.4

ORF Insert Sequence:

ATGGGCAGCG ACCGGAGCGC ACTCGGACGT CCAGGCTGCA CTGGCAGCTG CCTCAGCAGC 
CGAGCTTCGC TGCTCCCGCT GCTACTGGTG CTTCTGGACT GTCTGGGCCA TGGTACAGCG 
TCTAAAGACG CCGAAGTGTA CGCCGCGGAG AACTGGCTGC GGCTCTATGG CTACCTACCC 
CAGCCCAGCC GCCACATGTC CACCATGCGC TCTGCCCAGA TCCTGGCCTC CGCCCTTGCC 
GAGATGCAGA GTTTCTATGG GATCCCTGTC ACGGGTGTGC TTGATGAAGA GACGAAAACG 
TGGATGAAGC GGCCCCGATG TGGGGTTCCT GATCAGTTTG GGGTACATGT GAAAGCCAAC 
CTGCGTCGAC GGCGGAAACG TTACACCCTG ACAGGAAAGG CATGGAACAA TTACCACCTG 
ACCTTCAGCA TCCAGAACTA CACTGAGAAG CTGGGCTGGT ACAACTCCAT GGAGGCGGTG 
CGCAGGGCTT TCCAAGTGTG GGAGCAGGTC ACACCATTGG TCTTCCAGGA AGTATCCTAT 
GATGACATTC GGCTACGAAG GCGAGCGGAG GCTGACATCA TGGTACTCTT TGCCTCTGGC 
TTCCATGGCG ACAGCTCACC GTTTGATGGC GTGGGTGGCT TTCTGGCCCA CGCTTATTTC 
CCCGGCCCTG GTCTGGGTGG GGACACCCAT TTCGACGCAG ATGAACCCTG GACCTTCTCC 
AGCACTGACC TGCATGGAAT CAGCCTCTTT CTGGTGGCCG TGCATGAGCT GGGCCATGCC 
CTGGGGCTAG AACACTCAAG TAACCCCAGC GCTATTATGG CACCCTTCTA CCAGTGGATG 
GATACCGACA ACTTCCAGCT GCCCGAAGAT GACCTTCGGG GCATCCAGCA GCTGTATGGC 
TCCCCAGATG GTAAGCCACA GCCCACCCGG CCTCTCCCCA CTGTGAGGCC CCGGCGGCCA 
GGACGGCCAG ATCACCAGCC ACCTCGGCCT CCCCAGCCAC CACATCCAGG TGGGAAGCCA 
GAAAGGCCCC CCAAACCAGG GCCCCCACCC CAGCCCCGAG CCACAGAGAG GCCTGACCAG 
TATGGCCCCA ACATCTGCGA TGGCAACTTC GACACAGTGG CTGTGCTCCG CGGAGAGATG 
TTTGTGTTCA AGGGCCGCTG GTTCTGGCGA GTCAGGCACA ACCGCGTTCT AGACAACTAC 
CCCATGCCAA TTGGCCACTT CTGGCGCGGT CTGCCGGGGA ACATCAGTGC TGCCTACGAG 
CGCCAGGATG GACATTTTGT CTTCTTCAAA GGTAACCGCT ACTGGCTTTT CCGAGAAGCC 
AATCTGGAGC CCGGCTACCC ACAGCCGCTG AGCAGCTATG GCACAGACAT CCCCTATGAC 
CGCATTGACA CAGCCATCTG GTGGGAGCCC ACAGGTCACA CCTTCTTCTT TCAAGCAGAC 
AGGTACTGGC GCTTCAACGA GGAGACACAG CATGGAGACC CTGGCTACCC CAAGCCCATC 
AGTGTCTGGC AGGGGATCCC CACCTCTCCC AAAGGGGCCT TCCTCAGCAA CGATGCAGCC 
TACACCTACT TCTACAAGGG CACCAAGTAC TGGAAATTCA ACAACGAACG CCTACGGATG 
GAACCCGGCC ACCCCAAATC CATCCTGCGG GACTTCATGG GCTGCCAGGA GCACGTGGAG 
CCCCGATCGC GATGGCCCGA TGTGGCTCGT CCACCCTTCA ACCCCAACGG GGGTGCCGAG 
CCTGAGGCAG ATGGTGACAG CAAGGAAGAG AACGCGGGTG ACAAGGATGA GGGCAGCCGC 
GTGGTGGTGC AGATGGAGGA GGTGGTCCGG ACAGTGAACG TGGTGATGGT GTTGGTCCCC 
TTGCTGCTGT TGCTCTGTAT TCTGGGCCTG GCCTTTGCTC TGGTGCAGAT GCAGCGCAAG 
GGCGCCCCTC GCATGCTGCT CTACTGCAAG CGCTCACTGC AGGAGTGGGT GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lhx8 ablation leads to massive autophagy of mouse oocytes associated with DNA damage.
Biology of reproduction(2018 Jan)
Pelosi E,D'Ignazio L,Michel M,Beyer M,Thompson K,Forabosco A,Schlessinger D

MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding.
The Journal of neuroscience : the official journal of the Society for Neuroscience38(3)518-529(2018 Jan)
Sanz RL,Ferraro GB,Kacervosky J,Salesse C,Gowing E,Hua L,Rambaldi I,Beaubien F,Holmbeck K,Cloutier JF,L?vesque M,Murai K,Fournier AE

Functional roles of MMP14 and MMP15 in early postnatal mammary gland development.
Development (Cambridge, England)143(21)3956-3968(2016 11)
Feinberg TY,Rowe RG,Saunders TL,Weiss SJ

High-throughput discovery of novel developmental phenotypes.
Nature537(7621)508-514(2016 09)
Dickinson ME,Flenniken AM,Ji X,Teboul L,Wong MD,White JK,Meehan TF,Weninger WJ,Westerberg H,Adissu H,Baker CN,Bower L,Brown JM,Caddle LB,Chiani F,Clary D,Cleak J,Daly MJ,Denegre JM,Doe B,Dolan ME,Edie SM,Fuchs H,Gailus-Durner V,Galli A,Gambadoro A,Gallegos J,Guo S,Horner NR,Hsu CW,Johnson SJ,Kalaga S,Keith LC,Lanoue L,Lawson TN,Lek M,Mark M,Marschall S,Mason J,McElwee ML,Newbigging S,Nutter LM,Peterson KA,Ramirez-Solis R,Rowland DJ,Ryder E,Samocha KE,Seavitt JR,Selloum M,Szoke-Kovacs Z,Tamura M,Trainor AG,Tudose I,Wakana S,Warren J,Wendling O,West DB,Wong L,Yoshiki A,,,,,,,,,MacArthur DG,Tocchini-Valentini GP,Gao X,Flicek P,Bradley A,Skarnes WC,Justice MJ,Parkinson HE,Moore M,Wells S,Braun RE,Svenson KL,de Angelis MH,Herault Y,Mohun T,Mallon AM,Henkelman RM,Brown SD,Adams DJ,Lloyd KC,McKerlie C,Beaudet AL,Bu?an M,Murray SA

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Mmp15 cDNA ORF clone, Mus musculus(house mouse)

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