LORICRIN cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LORICRIN
Entrez Gene ID	4014
Full Name	loricrin
General protein information	Preferred Names loricrin Names loricrin
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q21.3
Summary	This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008].
Disorder MIM:	152445
Disorder Html:	Vohwinkel syndrome with ichthyosis, 604117 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000427.2	NP_000418.2	loricrin
XM_024447049.1	XP_024302817.1	loricrin isoform X1
NM_000427.3	NP_000418.2	loricrin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1?, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.
Sakai T, Hatano Y, Zhang W, Fujiwara S, Nishiyori R
Journal of dermatological science80(2)158-60(2015 Nov)

Novel autosomal dominant mutation in loricrin presenting as prominent ichthyosis.
Pohler E, Cunningham F, Sandilands A, Cole C, Digby S, McMillan JR, Aristodemou S, McGrath JA, Smith FJ, McLean WH, Munro CS, Zamiri M
The British journal of dermatology173(5)1291-4(2015 Nov)

Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes.
Ghatak S, Chan YC, Khanna S, Banerjee J, Weist J, Roy S, Sen CK
Molecular therapy : the journal of the American Society of Gene Therapy23(7)1201-1210(2015 Jul)

Two novel mutations in the LOR gene in three families with loricrin keratoderma.
Hotz A, Bourrat E, Hausser I, Haftek M, da Silva MV, Fischer J
The British journal of dermatology172(4)1158-62(2015 Apr)

A novel microdeletion in LOR causing autosomal dominant loricrin keratoderma.
Kinsler VA, Drury S, Khan A, Waelchli R, Rukaite G, Barnicoat A, Lench N, Harper JI, O'Shaughnessy RF
The British journal of dermatology172(1)262-4(2015 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Letter: Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1alpha, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.
Title: Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1?, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.

Authors report a multi-generation family with prominent ichthyosis and palmoplantar involvement due to a novel mutation in loricrin.
Title: Novel autosomal dominant mutation in loricrin presenting as prominent ichthyosis.

Studies on human keratinocytes recognized that loricrin expression was inversely related to the expression of the cyclin-dependent kinase inhibitor p21
Title: Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes.

two novel heterozygous frameshift mutations in exon 2 - c.646_647insGCAGCAGGTC, p.Gln216Argfs*123 and c.798_799dupT, p.Gly267Trpfs*69 in loricrin keratoderma patients
Title: Two novel mutations in the LOR gene in three families with loricrin keratoderma.

Results describe a novel frameshift mutation leading to loricrin keratoderma presenting with colloidion membrane
Title: A novel microdeletion in LOR causing autosomal dominant loricrin keratoderma.

The following LORICRIN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LORICRIN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19272	NM_000427.3 Latest version!	Homo sapiens loricrin cornified envelope precursor protein (LORICRIN), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu58761	XM_024447049.1 Latest version!	Homo sapiens loricrin cornified envelope precursor protein (LORICRIN), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu19272	NM_000427.2	Homo sapiens loricrin (LOR), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LORICRIN ( NM_000427.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000418.2 Homo sapiens loricrin (LOR), mRNA.

Price & Availability↑

CloneID	OHu19272
Clone ID Related Accession (Same CDS sequence)	NM_000427.2 , NM_000427.3
Accession Version	NM_000427.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	loricrin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC108290.1 and AL161636.21. This sequence is a reference standard in the RefSeqGene project. On Jun 19, 2006 this sequence version replaced NM_000427.1. Sequence Note: Two alleles are present in unaffected individuals. The RefSeq record represents the allele present in the reference genome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC108290.1, ERR279841.8111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCTTATC AGAAAAAGCA GCCCACCCCT CAGCCCCCAG TGGACTGCGT GAAGACCTCT 
GGCGGCGGTG GCGGTGGCGG CGGCAGCGGC GGTGGTGGCT GCGGCTTCTT CGGCGGCGGC 
GGCTCAGGGG GCGGTAGCAG CGGTTCTGGC TGCGGCTACT CCGGCGGCGG TGGCTACTCT 
GGCGGCGGCT GCGGCGGGGG CTCCTCCGGC GGCGGGGGCG GGGGCGGCAT TGGAGGCTGC 
GGAGGGGGCT CCGGTGGGAG CGTCAAGTAC TCCGGAGGCG GCGGCTCCTC CGGCGGGGGC 
TCTGGCTGTT TCTCCAGCGG TGGGGGCGGC TCCGGCTGCT TCTCCTCCGG TGGCGGCGGC 
TCCTCCGGGG GCGGCTCCGG CTGCTTCTCC AGCGGTGGGG GCGGCTCCTC CGGGGGCGGC 
TCCGGCTGCT TCTCCTCCGG CGGCGGCGGC TTCTCGGGCC AGGCGGTCCA GTGCCAGAGC 
TACGGAGGCG TCTCTAGCGG CGGCTCCTCC GGGGGCGGCT CCGGCTGCTT CTCCAGCGGC 
GGGGGCGGCG GCTCTGTCTG CGGCTACTCT GGCGGCGGCT CTGGCTGCGG CGGAGGCTCC 
TCTGGCGGCA GCGGCTCCGG CTACGTCTCC TCGCAGCAGG TCACTCAGAC CTCGTGCGCG 
CCCCAGCCGA GTTACGGAGG GGGGTCGTCC GGCGGCGGCG GCAGCGGCGG AAGCGGCTGC 
TTCTCCAGCG GCGGGGGCGG CGGGAGCTCC GGCTGCGGCG GCGGCTCCTC CGGGATTGGC 
AGCGGCTGCA TCATCAGTGG CGGGGGCTCC GTCTGCGGAG GTGGTTCCTC TGGAGGCGGC 
GGCGGCGGCT CCTCCGTGGG TGGCTCCGGG AGTGGCAAGG GCGTCCCGAT CTGCCACCAG 
ACCCAGCAGA AGCAGGCGCC TACCTGGCCG TCCAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000418.2
CDS	55..993
Translation	MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK

Target ORF information:

RefSeq Version	NM_000427.2
Organism	Homo sapiens(human)
Definition	Homo sapiens loricrin (LOR), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000427.2

ORF Insert Sequence:

ATGTCTTATC AGAAAAAGCA GCCCACCCCT CAGCCCCCAG TGGACTGCGT GAAGACCTCT 
GGCGGCGGTG GCGGTGGCGG CGGCAGCGGC GGTGGTGGCT GCGGCTTCTT CGGCGGCGGC 
GGCTCAGGGG GCGGTAGCAG CGGTTCTGGC TGCGGCTACT CCGGCGGCGG TGGCTACTCT 
GGCGGCGGCT GCGGCGGGGG CTCCTCCGGC GGCGGGGGCG GGGGCGGCAT TGGAGGCTGC 
GGAGGGGGCT CCGGTGGGAG CGTCAAGTAC TCCGGAGGCG GCGGCTCCTC CGGCGGGGGC 
TCTGGCTGTT TCTCCAGCGG TGGGGGCGGC TCCGGCTGCT TCTCCTCCGG TGGCGGCGGC 
TCCTCCGGGG GCGGCTCCGG CTGCTTCTCC AGCGGTGGGG GCGGCTCCTC CGGGGGCGGC 
TCCGGCTGCT TCTCCTCCGG CGGCGGCGGC TTCTCGGGCC AGGCGGTCCA GTGCCAGAGC 
TACGGAGGCG TCTCTAGCGG CGGCTCCTCC GGGGGCGGCT CCGGCTGCTT CTCCAGCGGC 
GGGGGCGGCG GCTCTGTCTG CGGCTACTCT GGCGGCGGCT CTGGCTGCGG CGGAGGCTCC 
TCTGGCGGCA GCGGCTCCGG CTACGTCTCC TCGCAGCAGG TCACTCAGAC CTCGTGCGCG 
CCCCAGCCGA GTTACGGAGG GGGGTCGTCC GGCGGCGGCG GCAGCGGCGG AAGCGGCTGC 
TTCTCCAGCG GCGGGGGCGG CGGGAGCTCC GGCTGCGGCG GCGGCTCCTC CGGGATTGGC 
AGCGGCTGCA TCATCAGTGG CGGGGGCTCC GTCTGCGGAG GTGGTTCCTC TGGAGGCGGC 
GGCGGCGGCT CCTCCGTGGG TGGCTCCGGG AGTGGCAAGG GCGTCCCGAT CTGCCACCAG 
ACCCAGCAGA AGCAGGCGCC TACCTGGCCG TCCAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LORICRIN ( NM_000427.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000418.2 Homo sapiens loricrin cornified envelope precursor protein (LORICRIN), mRNA.

Price & Availability↑

CloneID	OHu19272
Clone ID Related Accession (Same CDS sequence)	NM_000427.2 , NM_000427.3
Accession Version	NM_000427.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 939bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-15
Organism	Homo sapiens(human)
Product	loricrin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL161636.21 and BC108290.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000427.2. Sequence Note: Two alleles are present in unaffected individuals. The RefSeq record represents the allele present in the reference genome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC108290.1, ERR279841.8111.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368742.4/ ENSP00000357731.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCTTATC AGAAAAAGCA GCCCACCCCT CAGCCCCCAG TGGACTGCGT GAAGACCTCT 
GGCGGCGGTG GCGGTGGCGG CGGCAGCGGC GGTGGTGGCT GCGGCTTCTT CGGCGGCGGC 
GGCTCAGGGG GCGGTAGCAG CGGTTCTGGC TGCGGCTACT CCGGCGGCGG TGGCTACTCT 
GGCGGCGGCT GCGGCGGGGG CTCCTCCGGC GGCGGGGGCG GGGGCGGCAT TGGAGGCTGC 
GGAGGGGGCT CCGGTGGGAG CGTCAAGTAC TCCGGAGGCG GCGGCTCCTC CGGCGGGGGC 
TCTGGCTGTT TCTCCAGCGG TGGGGGCGGC TCCGGCTGCT TCTCCTCCGG TGGCGGCGGC 
TCCTCCGGGG GCGGCTCCGG CTGCTTCTCC AGCGGTGGGG GCGGCTCCTC CGGGGGCGGC 
TCCGGCTGCT TCTCCTCCGG CGGCGGCGGC TTCTCGGGCC AGGCGGTCCA GTGCCAGAGC 
TACGGAGGCG TCTCTAGCGG CGGCTCCTCC GGGGGCGGCT CCGGCTGCTT CTCCAGCGGC 
GGGGGCGGCG GCTCTGTCTG CGGCTACTCT GGCGGCGGCT CTGGCTGCGG CGGAGGCTCC 
TCTGGCGGCA GCGGCTCCGG CTACGTCTCC TCGCAGCAGG TCACTCAGAC CTCGTGCGCG 
CCCCAGCCGA GTTACGGAGG GGGGTCGTCC GGCGGCGGCG GCAGCGGCGG AAGCGGCTGC 
TTCTCCAGCG GCGGGGGCGG CGGGAGCTCC GGCTGCGGCG GCGGCTCCTC CGGGATTGGC 
AGCGGCTGCA TCATCAGTGG CGGGGGCTCC GTCTGCGGAG GTGGTTCCTC TGGAGGCGGC 
GGCGGCGGCT CCTCCGTGGG TGGCTCCGGG AGTGGCAAGG GCGTCCCGAT CTGCCACCAG 
ACCCAGCAGA AGCAGGCGCC TACCTGGCCG TCCAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000418.2
CDS	71..1009
Translation	MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGCGGGSSGGGGGGGIGGCGGGSGGSVKYSGGGGSSGGGSGCFSSGGGGSGCFSSGGGGSSGGGSGCFSSGGGGSSGGGSGCFSSGGGGFSGQAVQCQSYGGVSSGGSSGGGSGCFSSGGGGGSVCGYSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK

Target ORF information:

RefSeq Version	NM_000427.3
Organism	Homo sapiens(human)
Definition	Homo sapiens loricrin cornified envelope precursor protein (LORICRIN), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000427.3

ORF Insert Sequence:

ATGTCTTATC AGAAAAAGCA GCCCACCCCT CAGCCCCCAG TGGACTGCGT GAAGACCTCT 
GGCGGCGGTG GCGGTGGCGG CGGCAGCGGC GGTGGTGGCT GCGGCTTCTT CGGCGGCGGC 
GGCTCAGGGG GCGGTAGCAG CGGTTCTGGC TGCGGCTACT CCGGCGGCGG TGGCTACTCT 
GGCGGCGGCT GCGGCGGGGG CTCCTCCGGC GGCGGGGGCG GGGGCGGCAT TGGAGGCTGC 
GGAGGGGGCT CCGGTGGGAG CGTCAAGTAC TCCGGAGGCG GCGGCTCCTC CGGCGGGGGC 
TCTGGCTGTT TCTCCAGCGG TGGGGGCGGC TCCGGCTGCT TCTCCTCCGG TGGCGGCGGC 
TCCTCCGGGG GCGGCTCCGG CTGCTTCTCC AGCGGTGGGG GCGGCTCCTC CGGGGGCGGC 
TCCGGCTGCT TCTCCTCCGG CGGCGGCGGC TTCTCGGGCC AGGCGGTCCA GTGCCAGAGC 
TACGGAGGCG TCTCTAGCGG CGGCTCCTCC GGGGGCGGCT CCGGCTGCTT CTCCAGCGGC 
GGGGGCGGCG GCTCTGTCTG CGGCTACTCT GGCGGCGGCT CTGGCTGCGG CGGAGGCTCC 
TCTGGCGGCA GCGGCTCCGG CTACGTCTCC TCGCAGCAGG TCACTCAGAC CTCGTGCGCG 
CCCCAGCCGA GTTACGGAGG GGGGTCGTCC GGCGGCGGCG GCAGCGGCGG AAGCGGCTGC 
TTCTCCAGCG GCGGGGGCGG CGGGAGCTCC GGCTGCGGCG GCGGCTCCTC CGGGATTGGC 
AGCGGCTGCA TCATCAGTGG CGGGGGCTCC GTCTGCGGAG GTGGTTCCTC TGGAGGCGGC 
GGCGGCGGCT CCTCCGTGGG TGGCTCCGGG AGTGGCAAGG GCGTCCCGAT CTGCCACCAG 
ACCCAGCAGA AGCAGGCGCC TACCTGGCCG TCCAAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LORICRIN ( XM_024447049.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024302817.1 Homo sapiens loricrin cornified envelope precursor protein (LORICRIN), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu58761
Clone ID Related Accession (Same CDS sequence)	XM_024447049.1
Accession Version	XM_024447049.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	loricrin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCTTATC AGAAAAAGCA GCCCACCCCT CAGCCCCCAG TGGACTGCGT GAAGACCTCT 
GGCGGCGGTG GCGGTGGCGG CGGCAGCGGC GGTGGTGGCT GCGGCTTCTT CGGCGGCGGC 
GGCTCAGGGG GCGGTAGCAG CGGTTCTGGC TGCGGCTACT CCGGCGGCGG TGGCTACTCT 
GGCGGCGGCT CTGGCGGCGG CTCTGGCTGC GGCGGAGGCT CCTCTGGCGG CAGCGGCTCC 
GGCTACGTCT CCTCGCAGCA GGTCACTCAG ACCTCGTGCG CGCCCCAGCC GAGTTACGGA 
GGGGGGTCGT CCGGCGGCGG CGGCAGCGGC GGAAGCGGCT GCTTCTCCAG CGGCGGGGGC 
GGCGGGAGCT CCGGCTGCGG CGGCGGCTCC TCCGGGATTG GCAGCGGCTG CATCATCAGT 
GGCGGGGGCT CCGTCTGCGG AGGTGGTTCC TCTGGAGGCG GCGGCGGCGG CTCCTCCGTG 
GGTGGCTCCG GGAGTGGCAA GGGCGTCCCG ATCTGCCACC AGACCCAGCA GAAGCAGGCG 
CCTACCTGGC CGTCCAAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024302817.1
CDS	123..683
Translation	MSYQKKQPTPQPPVDCVKTSGGGGGGGGSGGGGCGFFGGGGSGGGSSGSGCGYSGGGGYSGGGSGGGSGCGGGSSGGSGSGYVSSQQVTQTSCAPQPSYGGGSSGGGGSGGSGCFSSGGGGGSSGCGGGSSGIGSGCIISGGGSVCGGGSSGGGGGGSSVGGSGSGKGVPICHQTQQKQAPTWPSK

Target ORF information:

RefSeq Version	XM_024447049.1
Organism	Homo sapiens(human)
Definition	Homo sapiens loricrin cornified envelope precursor protein (LORICRIN), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447049.1

ORF Insert Sequence:

ATGTCTTATC AGAAAAAGCA GCCCACCCCT CAGCCCCCAG TGGACTGCGT GAAGACCTCT 
GGCGGCGGTG GCGGTGGCGG CGGCAGCGGC GGTGGTGGCT GCGGCTTCTT CGGCGGCGGC 
GGCTCAGGGG GCGGTAGCAG CGGTTCTGGC TGCGGCTACT CCGGCGGCGG TGGCTACTCT 
GGCGGCGGCT CTGGCGGCGG CTCTGGCTGC GGCGGAGGCT CCTCTGGCGG CAGCGGCTCC 
GGCTACGTCT CCTCGCAGCA GGTCACTCAG ACCTCGTGCG CGCCCCAGCC GAGTTACGGA 
GGGGGGTCGT CCGGCGGCGG CGGCAGCGGC GGAAGCGGCT GCTTCTCCAG CGGCGGGGGC 
GGCGGGAGCT CCGGCTGCGG CGGCGGCTCC TCCGGGATTG GCAGCGGCTG CATCATCAGT 
GGCGGGGGCT CCGTCTGCGG AGGTGGTTCC TCTGGAGGCG GCGGCGGCGG CTCCTCCGTG 
GGTGGCTCCG GGAGTGGCAA GGGCGTCCCG ATCTGCCACC AGACCCAGCA GAAGCAGGCG 
CCTACCTGGC CGTCCAAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1?, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes.
Journal of dermatological science80(2)158-60(2015 Nov)
Sakai T,Hatano Y,Zhang W,Fujiwara S,Nishiyori R

Novel autosomal dominant mutation in loricrin presenting as prominent ichthyosis.
The British journal of dermatology173(5)1291-4(2015 Nov)
Pohler E,Cunningham F,Sandilands A,Cole C,Digby S,McMillan JR,Aristodemou S,McGrath JA,Smith FJ,McLean WH,Munro CS,Zamiri M

Barrier Function of the Repaired Skin Is Disrupted Following Arrest of Dicer in Keratinocytes.
Molecular therapy : the journal of the American Society of Gene Therapy23(7)1201-1210(2015 Jul)
Ghatak S,Chan YC,Khanna S,Banerjee J,Weist J,Roy S,Sen CK

Two novel mutations in the LOR gene in three families with loricrin keratoderma.
The British journal of dermatology172(4)1158-62(2015 Apr)
Hotz A,Bourrat E,Hausser I,Haftek M,da Silva MV,Fischer J

A novel microdeletion in LOR causing autosomal dominant loricrin keratoderma.
The British journal of dermatology172(1)262-4(2015 Jan)
Kinsler VA,Drury S,Khan A,Waelchli R,Rukaite G,Barnicoat A,Lench N,Harper JI,O'Shaughnessy RF

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LORICRIN cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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