SIGLEC16 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SIGLEC16
Entrez Gene ID	400709
Full Name	sialic acid binding Ig like lectin 16 (gene/pseudogene)
Synonyms	SIGLECP16,Siglec-P16
General protein information	Preferred Names sialic acid binding Ig like lectin 16 (gene/pseudogene) Names sialic acid-binding Ig-like lectin 16 sialic acid binding Ig-like lectin 16 sialic acid binding Ig-like lectin, pseudogene 16 sialic acid-binding immunoglobulin-like lectin 16 siglec-16
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.33

mRNA and Protein(s)

mRNA	Protein	Name
NM_001348364.1	NP_001335293.1	sialic acid-binding Ig-like lectin 16 precursor
NM_001348364.2	NP_001335293.2	sialic acid-binding Ig-like lectin 16 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.
Schwarz F, Landig CS, Siddiqui S, Secundino I, Olson J, Varki N, Nizet V, Varki A
The EMBO journal36(6)751-760(2017 03)

Evolution of siglec-11 and siglec-16 genes in hominins.
Wang X, Mitra N, Cruz P, Deng L, , Varki N, Angata T, Green ED, Mullikin J, Hayakawa T, Varki A
Molecular biology and evolution29(8)2073-86(2012 Aug)

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.
Cao H, Lakner U, de Bono B, Traherne JA, Trowsdale J, Barrow AD
European journal of immunology38(8)2303-15(2008 Aug)

A human-specific gene in microglia.
Hayakawa T, Angata T, Lewis AL, Mikkelsen TS, Varki NM, Varki A
Science (New York, N.Y.)309(5741)1693(2005 Sep)

The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature428(6982)529-35(2004 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The authors demonstrated that the human-specific pathogen Escherichia coli K1 uses its polysialic acid capsule as a molecular mimic to engage Siglec-11 and escape killing. In contrast, engagement of the activating counterpart Siglec-16 increases elimination of bacteria.
Title: Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.
Title: SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.

The following SIGLEC16 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIGLEC16 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu102337	NM_001348364.1 Latest version!	Homo sapiens sialic acid binding Ig like lectin 16 (gene/pseudogene) (SIGLEC16), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu107133	NM_001348364.2 Latest version!	Homo sapiens sialic acid binding Ig like lectin 16 (gene/pseudogene) (SIGLEC16), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SIGLEC16 ( NM_001348364.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335293.1 Homo sapiens sialic acid binding Ig like lectin 16 (gene/pseudogene) (SIGLEC16), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu102337
Clone ID Related Accession (Same CDS sequence)	NM_001348364.1
Accession Version	NM_001348364.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 16 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK301031.1, BC030222.1 and AC011452.6. Transcript Variant: This variant (1) represents the functional allele encoding the full-length protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK301031.1, BC039008.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 18629938, 22383531 ##RefSeq-Attributes-END##

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGATG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCG TGAACAATTT GTTCTTTCTA AAAGTAACAG CCCTGACTCA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTCCCTG GAACTCCAGG GAAACGTCAT ATATCTGGAA 
GTTCAGAAAG GCCAGTTCCT GCGGCTCCTC TGTGCTGCTG ACAGCCAGCC CCCTGCCACG 
CTGAGCTGGG TCCTGCAGGA CAGAGTCCTC TCCTCGTCCC ACCCCTGGGG CCCCAGAACC 
CTGGGGCTGG AGCTGCGTGG GGTAAGGGCC GGGGATTCAG GGCGCTACAC CTGCCGAGCG 
GAGAACAGGC TTGGCTCCCA GCAGCGAGCC CTGGACCTCT CTGTGCAGTA TCCTCCAGAG 
AACCTGAGAG TGATGGTTTC CCAAGCAAAC AGGACAGTCC TGGAAAACCT GAGGAACGGC 
ACATCCCTCC GGGTCCTGGA GGGCCAAAGC CTGCGTCTGG TCTGTGTCAC ACACAGCAGC 
CCCCCAGCCA GGCTGAGCTG GACCCGGTGG GGACAGACCG TGGGCCCCTC CCAGCCCTCA 
GACCCTGGGG TCCTGGAGCT GCCTCGGGTT CAAATGGAGC ACGAAGGAGA GTTCACCTGC 
CACGCTCGGC ACCCGCTGGG CTCCCAGCGC GTCTCTCTCA GCTTCTCCGT GCACTGCAAA 
TCAGGGCCCA TGACGGGGGT GGTTCTGGTG GCTGTTGGGG AGGTGGCTAT GAAGATCCTG 
CTTCTCTGCC TCTGCCTCAT CCTCCTCAGA GTGAGGTCTT GCAGGAGGAA GGCAGCAAGG 
GCAGCATTGG GCATGGAGGC TGCAGACGCT GTCACGGACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335293.1
CDS	67..1548
Translation	MVPGQAQPQSPEMLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGWTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFVNNLFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVASLELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLRNGTSLRVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPRVQMEHEGEFTCHARHPLGSQRVSLSFSVHCKSGPMTGVVLVAVGEVAMKILLLCLCLILLRVRSCRRKAARAALGMEAADAVTD

Target ORF information:

RefSeq Version	NM_001348364.1
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 16 (gene/pseudogene) (SIGLEC16), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348364.1

ORF Insert Sequence:

ATGGTCCCGG GACAGGCCCA GCCCCAGAGC CCAGAGATGC TGCTGCTGCC CCTGCTGCTG 
CCCGTGCTGG GGGCGGGGTC CCTGAACAAG GATCCCAGTT ACAGTCTTCA AGTGCAGAGG 
CAGGTGCCGG TGCCGGAGGG CCTGTGTGTC ATCGTGTCTT GCAACCTCTC CTACCCCCGG 
GATGGCTGGG ACGAGTCTAC TGCTGCTTAT GGCTACTGGT TCAAAGGATG GACCAGCCCA 
AAGACGGGTG CTCCTGTGGC CACTAACAAC CAGAGTCGAG AGGTGGAAAT GAGCACCCGG 
GACCGATTCC AGCTCACTGG GGATCCCGGC AAAGGGAGCT GCTCCTTGGT GATCAGAGAC 
GCGCAGAGGG AGGATGAGGC ATGGTACTTC TTTCGGGTGG AGAGAGGAAG CCGTGTGAGA 
CATAGTTTCG TGAACAATTT GTTCTTTCTA AAAGTAACAG CCCTGACTCA GAAGCCTGAT 
GTCTACATCC CCGAGACCCT GGAGCCCGGG CAGCCGGTGA CGGTCATCTG TGTGTTTAAC 
TGGGCTTTCA AGAAATGTCC AGCCCCTTCT TTCTCCTGGA CGGGGGCTGC CCTCTCCCCT 
AGAAGAACCA GACCAAGCAC CTCCCACTTC TCAGTGCTCA GCTTCACGCC CAGCCCCCAG 
GACCACGACA CCGACCTCAC CTGCCATGTG GACTTCTCCA GAAAGGGTGT GAGCGCACAG 
AGGACCGTCC GACTCCGTGT GGCCTCCCTG GAACTCCAGG GAAACGTCAT ATATCTGGAA 
GTTCAGAAAG GCCAGTTCCT GCGGCTCCTC TGTGCTGCTG ACAGCCAGCC CCCTGCCACG 
CTGAGCTGGG TCCTGCAGGA CAGAGTCCTC TCCTCGTCCC ACCCCTGGGG CCCCAGAACC 
CTGGGGCTGG AGCTGCGTGG GGTAAGGGCC GGGGATTCAG GGCGCTACAC CTGCCGAGCG 
GAGAACAGGC TTGGCTCCCA GCAGCGAGCC CTGGACCTCT CTGTGCAGTA TCCTCCAGAG 
AACCTGAGAG TGATGGTTTC CCAAGCAAAC AGGACAGTCC TGGAAAACCT GAGGAACGGC 
ACATCCCTCC GGGTCCTGGA GGGCCAAAGC CTGCGTCTGG TCTGTGTCAC ACACAGCAGC 
CCCCCAGCCA GGCTGAGCTG GACCCGGTGG GGACAGACCG TGGGCCCCTC CCAGCCCTCA 
GACCCTGGGG TCCTGGAGCT GCCTCGGGTT CAAATGGAGC ACGAAGGAGA GTTCACCTGC 
CACGCTCGGC ACCCGCTGGG CTCCCAGCGC GTCTCTCTCA GCTTCTCCGT GCACTGCAAA 
TCAGGGCCCA TGACGGGGGT GGTTCTGGTG GCTGTTGGGG AGGTGGCTAT GAAGATCCTG 
CTTCTCTGCC TCTGCCTCAT CCTCCTCAGA GTGAGGTCTT GCAGGAGGAA GGCAGCAAGG 
GCAGCATTGG GCATGGAGGC TGCAGACGCT GTCACGGACT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SIGLEC16 ( NM_001348364.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001335293.2 Homo sapiens sialic acid binding Ig like lectin 16 (gene/pseudogene) (SIGLEC16), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu107133
Clone ID Related Accession (Same CDS sequence)	NM_001348364.2
Accession Version	NM_001348364.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Homo sapiens(human)
Product	sialic acid-binding Ig-like lectin 16 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK301031.1, BC030222.1 and AC011452.6. On Nov 3, 2018 this sequence version replaced NM_001348364.1. Transcript Variant: This variant (1) represents the functional allele encoding the full-length protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: EU330985.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2145245 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved polymorphic pseudogene :: PMID: 18629938, 22383531 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGCTGCTGC TGCCCCTGCT GCTGCCCGTG CTGGGGGCGG GGTCCCTGAA CAAGGATCCC 
AGTTACAGTC TTCAAGTGCA GAGGCAGGTG CCGGTGCCGG AGGGCCTGTG TGTCATCGTG 
TCTTGCAACC TCTCCTACCC CCGGGATGGC TGGGACGAGT CTACTGCTGC TTATGGCTAC 
TGGTTCAAAG GATGGACCAG CCCAAAGACG GGTGCTCCTG TGGCCACTAA CAACCAGAGT 
CGAGAGGTGG AAATGAGCAC CCGGGACCGA TTCCAGCTCA CTGGGGATCC CGGCAAAGGG 
AGCTGCTCCT TGGTGATCAG AGACGCGCAG AGGGAGGATG AGGCATGGTA CTTCTTTCGG 
GTGGAGAGAG GAAGCCGTGT GAGACATAGT TTCGTGAACA ATTTGTTCTT TCTAAAAGTA 
ACAGCCCTGA CTCAGAAGCC TGATGTCTAC ATCCCCGAGA CCCTGGAGCC CGGGCAGCCG 
GTGACGGTCA TCTGTGTGTT TAACTGGGCT TTCAAGAAAT GTCCAGCCCC TTCTTTCTCC 
TGGACGGGGG CTGCCCTCTC CCCTAGAAGA ACCAGACCAA GCACCTCCCA CTTCTCAGTG 
CTCAGCTTCA CGCCCAGCCC CCAGGACCAC GACACCGACC TCACCTGCCA TGTGGACTTC 
TCCAGAAAGG GTGTGAGCGC ACAGAGGACC GTCCGACTCC GTGTGGCCTC CCTGGAACTC 
CAGGGAAACG TCATATATCT GGAAGTTCAG AAAGGCCAGT TCCTGCGGCT CCTCTGTGCT 
GCTGACAGCC AGCCCCCTGC CACGCTGAGC TGGGTCCTGC AGGACAGAGT CCTCTCCTCG 
TCCCACCCCT GGGGCCCCAG AACCCTGGGG CTGGAGCTGC GTGGGGTAAG GGCCGGGGAT 
TCAGGGCGCT ACACCTGCCG AGCGGAGAAC AGGCTTGGCT CCCAGCAGCG AGCCCTGGAC 
CTCTCTGTGC AGTATCCTCC AGAGAACCTG AGAGTGATGG TTTCCCAAGC AAACAGGACA 
GTCCTGGAAA ACCTGAGGAA CGGCACATCC CTCCGGGTCC TGGAGGGCCA AAGCCTGCGT 
CTGGTCTGTG TCACACACAG CAGCCCCCCA GCCAGGCTGA GCTGGACCCG GTGGGGACAG 
ACCGTGGGCC CCTCCCAGCC CTCAGACCCT GGGGTCCTGG AGCTGCCTCG GGTTCAAATG 
GAGCACGAAG GAGAGTTCAC CTGCCACGCT CGGCACCCGC TGGGCTCCCA GCGCGTCTCT 
CTCAGCTTCT CCGTGCACTG CAAATCAGGG CCCATGACGG GGGTGGTTCT GGTGGCTGTT 
GGGGAGGTGG CTATGAAGAT CCTGCTTCTC TGCCTCTGCC TCATCCTCCT CAGAGTGAGG 
TCTTGCAGGA GGAAGGCAGC AAGGGCAGCA TTGGGCATGG AGGCTGCAGA CGCTGTCACG 
GACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001335293.2
CDS	39..1484
Translation	MLLLPLLLPVLGAGSLNKDPSYSLQVQRQVPVPEGLCVIVSCNLSYPRDGWDESTAAYGYWFKGWTSPKTGAPVATNNQSREVEMSTRDRFQLTGDPGKGSCSLVIRDAQREDEAWYFFRVERGSRVRHSFVNNLFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFKKCPAPSFSWTGAALSPRRTRPSTSHFSVLSFTPSPQDHDTDLTCHVDFSRKGVSAQRTVRLRVASLELQGNVIYLEVQKGQFLRLLCAADSQPPATLSWVLQDRVLSSSHPWGPRTLGLELRGVRAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLRNGTSLRVLEGQSLRLVCVTHSSPPARLSWTRWGQTVGPSQPSDPGVLELPRVQMEHEGEFTCHARHPLGSQRVSLSFSVHCKSGPMTGVVLVAVGEVAMKILLLCLCLILLRVRSCRRKAARAALGMEAADAVTD

Target ORF information:

RefSeq Version	NM_001348364.2
Organism	Homo sapiens(human)
Definition	Homo sapiens sialic acid binding Ig like lectin 16 (gene/pseudogene) (SIGLEC16), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001348364.2

ORF Insert Sequence:

ATGCTGCTGC TGCCCCTGCT GCTGCCCGTG CTGGGGGCGG GGTCCCTGAA CAAGGATCCC 
AGTTACAGTC TTCAAGTGCA GAGGCAGGTG CCGGTGCCGG AGGGCCTGTG TGTCATCGTG 
TCTTGCAACC TCTCCTACCC CCGGGATGGC TGGGACGAGT CTACTGCTGC TTATGGCTAC 
TGGTTCAAAG GATGGACCAG CCCAAAGACG GGTGCTCCTG TGGCCACTAA CAACCAGAGT 
CGAGAGGTGG AAATGAGCAC CCGGGACCGA TTCCAGCTCA CTGGGGATCC CGGCAAAGGG 
AGCTGCTCCT TGGTGATCAG AGACGCGCAG AGGGAGGATG AGGCATGGTA CTTCTTTCGG 
GTGGAGAGAG GAAGCCGTGT GAGACATAGT TTCGTGAACA ATTTGTTCTT TCTAAAAGTA 
ACAGCCCTGA CTCAGAAGCC TGATGTCTAC ATCCCCGAGA CCCTGGAGCC CGGGCAGCCG 
GTGACGGTCA TCTGTGTGTT TAACTGGGCT TTCAAGAAAT GTCCAGCCCC TTCTTTCTCC 
TGGACGGGGG CTGCCCTCTC CCCTAGAAGA ACCAGACCAA GCACCTCCCA CTTCTCAGTG 
CTCAGCTTCA CGCCCAGCCC CCAGGACCAC GACACCGACC TCACCTGCCA TGTGGACTTC 
TCCAGAAAGG GTGTGAGCGC ACAGAGGACC GTCCGACTCC GTGTGGCCTC CCTGGAACTC 
CAGGGAAACG TCATATATCT GGAAGTTCAG AAAGGCCAGT TCCTGCGGCT CCTCTGTGCT 
GCTGACAGCC AGCCCCCTGC CACGCTGAGC TGGGTCCTGC AGGACAGAGT CCTCTCCTCG 
TCCCACCCCT GGGGCCCCAG AACCCTGGGG CTGGAGCTGC GTGGGGTAAG GGCCGGGGAT 
TCAGGGCGCT ACACCTGCCG AGCGGAGAAC AGGCTTGGCT CCCAGCAGCG AGCCCTGGAC 
CTCTCTGTGC AGTATCCTCC AGAGAACCTG AGAGTGATGG TTTCCCAAGC AAACAGGACA 
GTCCTGGAAA ACCTGAGGAA CGGCACATCC CTCCGGGTCC TGGAGGGCCA AAGCCTGCGT 
CTGGTCTGTG TCACACACAG CAGCCCCCCA GCCAGGCTGA GCTGGACCCG GTGGGGACAG 
ACCGTGGGCC CCTCCCAGCC CTCAGACCCT GGGGTCCTGG AGCTGCCTCG GGTTCAAATG 
GAGCACGAAG GAGAGTTCAC CTGCCACGCT CGGCACCCGC TGGGCTCCCA GCGCGTCTCT 
CTCAGCTTCT CCGTGCACTG CAAATCAGGG CCCATGACGG GGGTGGTTCT GGTGGCTGTT 
GGGGAGGTGG CTATGAAGAT CCTGCTTCTC TGCCTCTGCC TCATCCTCCT CAGAGTGAGG 
TCTTGCAGGA GGAAGGCAGC AAGGGCAGCA TTGGGCATGG AGGCTGCAGA CGCTGTCACG 
GACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Paired Siglec receptors generate opposite inflammatory responses to a human-specific pathogen.
The EMBO journal36(6)751-760(2017 03)
Schwarz F,Landig CS,Siddiqui S,Secundino I,Olson J,Varki N,Nizet V,Varki A

Evolution of siglec-11 and siglec-16 genes in hominins.
Molecular biology and evolution29(8)2073-86(2012 Aug)
Wang X,Mitra N,Cruz P,Deng L,,Varki N,Angata T,Green ED,Mullikin J,Hayakawa T,Varki A

SIGLEC16 encodes a DAP12-associated receptor expressed in macrophages that evolved from its inhibitory counterpart SIGLEC11 and has functional and non-functional alleles in humans.
European journal of immunology38(8)2303-15(2008 Aug)
Cao H,Lakner U,de Bono B,Traherne JA,Trowsdale J,Barrow AD

A human-specific gene in microglia.
Science (New York, N.Y.)309(5741)1693(2005 Sep)
Hayakawa T,Angata T,Lewis AL,Mikkelsen TS,Varki NM,Varki A

The DNA sequence and biology of human chromosome 19.
Nature428(6982)529-35(2004 Apr)
Grimwood J,Gordon LA,Olsen A,Terry A,Schmutz J,Lamerdin J,Hellsten U,Goodstein D,Couronne O,Tran-Gyamfi M,Aerts A,Altherr M,Ashworth L,Bajorek E,Black S,Branscomb E,Caenepeel S,Carrano A,Caoile C,Chan YM,Christensen M,Cleland CA,Copeland A,Dalin E,Dehal P,Denys M,Detter JC,Escobar J,Flowers D,Fotopulos D,Garcia C,Georgescu AM,Glavina T,Gomez M,Gonzales E,Groza M,Hammon N,Hawkins T,Haydu L,Ho I,Huang W,Israni S,Jett J,Kadner K,Kimball H,Kobayashi A,Larionov V,Leem SH,Lopez F,Lou Y,Lowry S,Malfatti S,Martinez D,McCready P,Medina C,Morgan J,Nelson K,Nolan M,Ovcharenko I,Pitluck S,Pollard M,Popkie AP,Predki P,Quan G,Ramirez L,Rash S,Retterer J,Rodriguez A,Rogers S,Salamov A,Salazar A,She X,Smith D,Slezak T,Solovyev V,Thayer N,Tice H,Tsai M,Ustaszewska A,Vo N,Wagner M,Wheeler J,Wu K,Xie G,Yang J,Dubchak I,Furey TS,DeJong P,Dickson M,Gordon D,Eichler EE,Pennacchio LA,Richardson P,Stubbs L,Rokhsar DS,Myers RM,Rubin EM,Lucas SM

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SIGLEC16 cDNA ORF clone, Homo sapiens(human)

Gene

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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