COLCA1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	COLCA1
Entrez Gene ID	399948
Full Name	colorectal cancer associated 1
Synonyms	C11orf92,CASC12,LOH11CR1F
General protein information	Preferred Names colorectal cancer associated 1 Names colorectal cancer-associated protein 1 cancer susceptibility candidate 12
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 11 Map Location: 11q23.1
Summary	This gene encodes a transmembrane protein that localizes to granular structures, including crystalloid eosinophilic granules and other granular organelles. This gene, along with an overlapping opposite strand gene, has been implicated as a susceptibility locus for colorectal cancer. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2014].
Disorder MIM:	615693

mRNA and Protein(s)

mRNA	Protein	Name
NM_001302644.1	NP_001289573.1	colorectal cancer-associated protein 1
NM_207429.3	NP_997312.1	colorectal cancer-associated protein 1
NM_001302646.1	NP_001289575.1	colorectal cancer-associated protein 1
NM_001302647.1	NP_001289576.1	colorectal cancer-associated protein 1
NM_001302645.1	NP_001289574.1	colorectal cancer-associated protein 1
NM_001302648.1	NP_001289577.1	colorectal cancer-associated protein 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis.
Closa A, Cordero D, Sanz-Pamplona R, Sol? X, Crous-Bou M, Par?-Brunet L, Berenguer A, Guino E, Lopez-Doriga A, Guardiola J, Biondo S, Salazar R, Moreno V
Carcinogenesis35(9)2039-46(2014 Sep)

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Zhang B, Jia WH, Matsuda K, Kweon SS, Matsuo K, Xiang YB, Shin A, Jee SH, Kim DH, Cai Q, Long J, Shi J, Wen W, Yang G, Zhang Y, Li C, Li B, Guo Y, Ren Z, Ji BT, Pan ZZ, Takahashi A, Shin MH, Matsuda F, Gao YT, Oh JH, Kim S, Ahn YO, , Chan AT, Chang-Claude J, Slattery ML, , Gruber SB, Schumacher FR, Stenzel SL, , Casey G, Kim HR, Jeong JY, Park JW, Li HL, Hosono S, Cho SH, Kubo M, Shu XO, Zeng YX, Zheng W
Nature genetics46(6)533-42(2014 Jun)

Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.
Peltekova VD, Lemire M, Qazi AM, Zaidi SH, Trinh QM, Bielecki R, Rogers M, Hodgson L, Wang M, D'Souza DJ, Zandi S, Chong T, Kwan JY, Kozak K, De Borja R, Timms L, Rangrej J, Volar M, Chan-Seng-Yue M, Beck T, Ash C, Lee S, Wang J, Boutros PC, Stein LD, Dick JE, Gryfe R, McPherson JD, Zanke BW, Pollett A, Gallinger S, Hudson TJ
International journal of cancer134(10)2330-41(2014 May)

Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1.
Biancolella M, Fortini BK, Tring S, Plummer SJ, Mendoza-Fandino GA, Hartiala J, Hitchler MJ, Yan C, Schumacher FR, Conti DV, Edlund CK, Noushmehr H, Coetzee SG, Bresalier RS, Ahnen DJ, Barry EL, Berman BP, Rice JC, Coetzee GA, Casey G
Human molecular genetics23(8)2198-209(2014 Apr)

Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population.
Duan X, Li X, Lou H, Geng T, Jin T, Liang P, Li S, Long Y, Chen C
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine35(3)1813-7(2014 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data implicate COLCA1 and COLCA2 in the pathogenesis of colon cancer.
Title: Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.

We found PLCE1, C11orf92-C11orf93, and NOC3L associated with colorectal cancer susceptibility
Title: Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Susceptibility genetic variants associated with colorectal cancer risk correlate with cancer phenotype.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association studies on 11 published colorectal cancer risk loci.

Observational study of gene-disease association. (HuGE Navigator)
Title: Risk of genome-wide association study-identified genetic variants for colorectal cancer in a Chinese population.

The following COLCA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COLCA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu80097	NM_001302646.1 Latest version!	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu80097	NM_001302645.1 Latest version!	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu80097	NM_207429.3 Latest version!	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu80097	NM_001302648.1 Latest version!	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 6, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu80097	NM_001302644.1 Latest version!	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu80097	NM_001302647.1 Latest version!	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

COLCA1 ( NM_001302644.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289573.1 Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu80097
Clone ID Related Accession (Same CDS sequence)	NM_001302644.1 , NM_207429.3 , NM_001302646.1 , NM_001302647.1 , NM_001302645.1 , NM_001302648.1
Accession Version	NM_001302644.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	colorectal cancer-associated protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from KF728566.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 3. All variants (1 through 6) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KF728566.1, CR936778.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289573.1
CDS	2410..2784
Translation	MESCSVAQAGVLTSPFMWRWTGMAGALSALDNTIEDDADDQLPCGEGRPGWVRGELLGSQGVCKDSKDLFVPTSSSLYGCFCVGLVSGMAISVLLLASDFRKLDFSRPEPCFEKEASLWFVAQH

Target ORF information:

RefSeq Version	NM_001302644.1
Organism	Homo sapiens(human)
Definition	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302644.1

ORF Insert Sequence:

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLCA1 ( NM_207429.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_997312.1 Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu80097
Clone ID Related Accession (Same CDS sequence)	NM_001302644.1 , NM_207429.3 , NM_001302646.1 , NM_001302647.1 , NM_001302645.1 , NM_001302648.1
Accession Version	NM_207429.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	colorectal cancer-associated protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from KF728568.1. On or before Nov 5, 2014 this sequence version replaced NR_034154.1, NM_207429.2. Transcript Variant: This variant (3) represents the longest transcript. All variants (1 through 6) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KF728568.1, AB096245.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_997312.1
CDS	2492..2866
Translation	MESCSVAQAGVLTSPFMWRWTGMAGALSALDNTIEDDADDQLPCGEGRPGWVRGELLGSQGVCKDSKDLFVPTSSSLYGCFCVGLVSGMAISVLLLASDFRKLDFSRPEPCFEKEASLWFVAQH

Target ORF information:

RefSeq Version	NM_207429.3
Organism	Homo sapiens(human)
Definition	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207429.3

ORF Insert Sequence:

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLCA1 ( NM_001302646.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289575.1 Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 4, mRNA.

Price & Availability↑

CloneID	OHu80097
Clone ID Related Accession (Same CDS sequence)	NM_001302644.1 , NM_207429.3 , NM_001302646.1 , NM_001302647.1 , NM_001302645.1 , NM_001302648.1
Accession Version	NM_001302646.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	colorectal cancer-associated protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from KF728570.1. Transcript Variant: This variant (4) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 3. All variants (1 through 6) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KF728570.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289575.1
CDS	2448..2822
Translation	MESCSVAQAGVLTSPFMWRWTGMAGALSALDNTIEDDADDQLPCGEGRPGWVRGELLGSQGVCKDSKDLFVPTSSSLYGCFCVGLVSGMAISVLLLASDFRKLDFSRPEPCFEKEASLWFVAQH

Target ORF information:

RefSeq Version	NM_001302646.1
Organism	Homo sapiens(human)
Definition	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302646.1

ORF Insert Sequence:

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLCA1 ( NM_001302647.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289576.1 Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 5, mRNA.

Price & Availability↑

CloneID	OHu80097
Clone ID Related Accession (Same CDS sequence)	NM_001302644.1 , NM_207429.3 , NM_001302646.1 , NM_001302647.1 , NM_001302645.1 , NM_001302648.1
Accession Version	NM_001302647.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	colorectal cancer-associated protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY007252.1 and KF728567.1. Transcript Variant: This variant (5) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 3. All variants (1 through 6) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY007252.1, HY051335.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289576.1
CDS	2318..2692
Translation	MESCSVAQAGVLTSPFMWRWTGMAGALSALDNTIEDDADDQLPCGEGRPGWVRGELLGSQGVCKDSKDLFVPTSSSLYGCFCVGLVSGMAISVLLLASDFRKLDFSRPEPCFEKEASLWFVAQH

Target ORF information:

RefSeq Version	NM_001302647.1
Organism	Homo sapiens(human)
Definition	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302647.1

ORF Insert Sequence:

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLCA1 ( NM_001302645.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289574.1 Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu80097
Clone ID Related Accession (Same CDS sequence)	NM_001302644.1 , NM_207429.3 , NM_001302646.1 , NM_001302647.1 , NM_001302645.1 , NM_001302648.1
Accession Version	NM_001302645.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	colorectal cancer-associated protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from KF728567.1. Transcript Variant: This variant (2) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 3. All variants (1 through 6) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KF728567.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267767 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289574.1
CDS	2277..2651
Translation	MESCSVAQAGVLTSPFMWRWTGMAGALSALDNTIEDDADDQLPCGEGRPGWVRGELLGSQGVCKDSKDLFVPTSSSLYGCFCVGLVSGMAISVLLLASDFRKLDFSRPEPCFEKEASLWFVAQH

Target ORF information:

RefSeq Version	NM_001302645.1
Organism	Homo sapiens(human)
Definition	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302645.1

ORF Insert Sequence:

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

COLCA1 ( NM_001302648.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001289577.1 Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 6, mRNA.

Price & Availability↑

CloneID	OHu80097
Clone ID Related Accession (Same CDS sequence)	NM_001302644.1 , NM_207429.3 , NM_001302646.1 , NM_001302647.1 , NM_001302645.1 , NM_001302648.1
Accession Version	NM_001302648.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 375bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-29
Organism	Homo sapiens(human)
Product	colorectal cancer-associated protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY007252.1, AA470052.1 and KF728567.1. Transcript Variant: This variant (6) contains an alternate 5' terminal exon and it thus differs in the 5' UTR, compared to variant 3. All variants (1 through 6) encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX097686.1, AA470052.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148874 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001289577.1
CDS	2283..2657
Translation	MESCSVAQAGVLTSPFMWRWTGMAGALSALDNTIEDDADDQLPCGEGRPGWVRGELLGSQGVCKDSKDLFVPTSSSLYGCFCVGLVSGMAISVLLLASDFRKLDFSRPEPCFEKEASLWFVAQH

Target ORF information:

RefSeq Version	NM_001302648.1
Organism	Homo sapiens(human)
Definition	Homo sapiens colorectal cancer associated 1 (COLCA1), transcript variant 6, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001302648.1

ORF Insert Sequence:

ATGGAGTCTT GCTCAGTCGC CCAGGCTGGA GTGCTAACCT CTCCTTTCAT GTGGAGATGG 
ACAGGGATGG CAGGAGCACT GAGTGCTCTT GACAACACCA TTGAAGATGA TGCTGACGAT 
CAGCTACCCT GTGGAGAAGG CAGGCCAGGC TGGGTGAGAG GGGAGCTCCT TGGAAGTCAG 
GGGGTCTGTA AGGACAGCAA GGATCTCTTT GTCCCAACCT CCAGCAGCCT TTATGGGTGC 
TTCTGTGTTG GCCTTGTTTC TGGGATGGCC ATCTCAGTGC TGTTGCTGGC TAGCGATTTC 
AGAAAACTAG ATTTTTCTAG GCCTGAGCCC TGTTTTGAGA AAGAAGCTTC CCTCTGGTTT 
GTAGCTCAAC ATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of candidate susceptibility genes for colorectal cancer through eQTL analysis.
Carcinogenesis35(9)2039-46(2014 Sep)
Closa A,Cordero D,Sanz-Pamplona R,Sol? X,Crous-Bou M,Par?-Brunet L,Berenguer A,Guino E,Lopez-Doriga A,Guardiola J,Biondo S,Salazar R,Moreno V

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
Nature genetics46(6)533-42(2014 Jun)
Zhang B,Jia WH,Matsuda K,Kweon SS,Matsuo K,Xiang YB,Shin A,Jee SH,Kim DH,Cai Q,Long J,Shi J,Wen W,Yang G,Zhang Y,Li C,Li B,Guo Y,Ren Z,Ji BT,Pan ZZ,Takahashi A,Shin MH,Matsuda F,Gao YT,Oh JH,Kim S,Ahn YO,,Chan AT,Chang-Claude J,Slattery ML,,Gruber SB,Schumacher FR,Stenzel SL,,Casey G,Kim HR,Jeong JY,Park JW,Li HL,Hosono S,Cho SH,Kubo M,Shu XO,Zeng YX,Zheng W

Identification of genes expressed by immune cells of the colon that are regulated by colorectal cancer-associated variants.
International journal of cancer134(10)2330-41(2014 May)
Peltekova VD,Lemire M,Qazi AM,Zaidi SH,Trinh QM,Bielecki R,Rogers M,Hodgson L,Wang M,D'Souza DJ,Zandi S,Chong T,Kwan JY,Kozak K,De Borja R,Timms L,Rangrej J,Volar M,Chan-Seng-Yue M,Beck T,Ash C,Lee S,Wang J,Boutros PC,Stein LD,Dick JE,Gryfe R,McPherson JD,Zanke BW,Pollett A,Gallinger S,Hudson TJ

Identification and characterization of functional risk variants for colorectal cancer mapping to chromosome 11q23.1.
Human molecular genetics23(8)2198-209(2014 Apr)
Biancolella M,Fortini BK,Tring S,Plummer SJ,Mendoza-Fandino GA,Hartiala J,Hitchler MJ,Yan C,Schumacher FR,Conti DV,Edlund CK,Noushmehr H,Coetzee SG,Bresalier RS,Ahnen DJ,Barry EL,Berman BP,Rice JC,Coetzee GA,Casey G

Genetic association of PLCE1, C11orf92-C11orf93, and NOC3L with colorectal cancer risk in the Han population.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine35(3)1813-7(2014 Mar)
Duan X,Li X,Lou H,Geng T,Jin T,Liang P,Li S,Long Y,Chen C

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COLCA1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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