LECT2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	LECT2
Entrez Gene ID	3950
Full Name	leukocyte cell derived chemotaxin 2
Synonyms	chm-II,chm2
General protein information	Preferred Names leukocyte cell derived chemotaxin 2 Names leukocyte cell-derived chemotaxin-2 chondromodulin-II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q31.1
Summary	This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008].
Disorder MIM:	602882

mRNA and Protein(s)

mRNA	Protein	Name
NM_002302.2	NP_002293.2	leukocyte cell-derived chemotaxin-2 precursor
NM_002302.3	NP_002293.2	leukocyte cell-derived chemotaxin-2 precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Lect2	NP_001101875.1
Gallus gallus (chicken)	LECT2	NP_990809.1
Danio rerio (zebrafish)	lect2l	NP_001041520.1
Danio rerio (zebrafish)	LOC567149	XP_695533.1
	LECT2	XP_001111039.1
Danio rerio (zebrafish)	LOC793246	XP_001332975.2
Homo sapiens (human)	LECT2	NP_002293.2
Pan troglodytes (chimpanzee)	LECT2	XP_517944.2
Canis lupus familiaris (dog)	LECT2	XP_531913.1
Mus musculus (house mouse)	Lect2	NP_034832.2
Bos taurus (cattle)	LECT2	NP_776805.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis.
Yoo HJ, Hwang SY, Choi JH, Lee HJ, Chung HS, Seo JA, Kim SG, Kim NH, Baik SH, Choi DS, Choi KM
PloS one12(4)e0174717(2017)

Visceral fat area is a strong predictor of leukocyte cell-derived chemotaxin 2, a potential biomarker of dyslipidemia.
Tanisawa K, Taniguchi H, Sun X, Ito T, Kawakami R, Sakamoto S, Higuchi M
PloS one12(3)e0173310(2017)

Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy.
Okumura A, Unoki-Kubota H, Yoshida-Hata N, Yamamoto-Honda R, Yamashita S, Iwata M, Tobe K, Kajio H, Noda M, Katai N, Yamagoe S, Kaburagi Y
Clinica chimica acta; international journal of clinical chemistry463145-149(2016 Dec)

New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study.
Sonmez FC, Yildiz P, Akhtar MS, Aydin C, Sonmez O, Ay N, Vatankulu MA
Medical science monitor : international medical journal of experimental and clinical research225234-5239(2016 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Circulating LECT2 concentrations were increased in individuals with NAFLD and those with MetS, but not in those with atherosclerosis. The relationship between LECT2 and both NAFLD and MetS might be mediated by its association with abdominal obesity and lipid metabolism.
Title: Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis.

VFA was the strongest predictor of plasma LECT2 that is a potential biomarker linking visceral obesity to dyslipidemia
Title: Visceral fat area is a strong predictor of leukocyte cell-derived chemotaxin 2, a potential biomarker of dyslipidemia.

findings indicated that serum LECT2 level is negatively associated with the presence of diabetic retinopathy and suggest that low circulating LECT2 level is a risk factor for diabetic retinopathy
Title: Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy.

the tissue levels of THBS2 and LECT-2 may correlate with the stage of atherosclerosis.
Title: New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study.

LECT2 was found to be catalytically inactive as a metalloendopeptidase against various types of peptide sequences, including pentaglycine.
Title: Crystal Structure of Human Leukocyte Cell-derived Chemotaxin 2 (LECT2) Reveals a Mechanistic Basis of Functional Evolution in a Mammalian Protein with an M23 Metalloendopeptidase Fold.

The following LECT2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LECT2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu23789	NM_002302.3 Latest version!	Homo sapiens leukocyte cell derived chemotaxin 2 (LECT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu23789	NM_002302.2	Homo sapiens leukocyte cell derived chemotaxin 2 (LECT2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

LECT2 ( NM_002302.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002293.2 Homo sapiens leukocyte cell derived chemotaxin 2 (LECT2), mRNA.

Price & Availability↑

CloneID	OHu23789
Clone ID Related Accession (Same CDS sequence)	NM_002302.2 , NM_002302.3
Accession Version	NM_002302.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-30
Organism	Homo sapiens(human)
Product	leukocyte cell-derived chemotaxin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from D63521.1, AV661075.1 and BI825931.1. On Feb 15, 2005 this sequence version replaced NM_002302.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D63521.1, BG564346.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTTCCA CCAAAGCCCT CCTTTTGGCT GGTCTGATTT CTACCGCACT GGCAGGGCCA 
TGGGCTAATA TATGTGCTGG CAAGTCTTCC AATGAGATCC GGACGTGTGA CCGCCATGGC 
TGTGGACAGT ACTCTGCTCA AAGAAGTCAG AGGCCTCACC AGGGTGTGGA CATCTTGTGC 
TCTGCTGGAT CTACTGTGTA CGCACCATTC ACTGGAATGA TTGTGGGCCA GGAGAAACCT 
TATCAAAACA AGAATGCTAT CAATAATGGT GTTCGAATAT CTGGAAGAGG TTTTTGTGTC 
AAAATGTTCT ACATTAAGCC AATTAAGTAT AAAGGTCCTA TTAAGAAGGG AGAAAAACTT 
GGAACTCTAT TGCCCTTGCA GAAAGTTTAT CCTGGCATAC AATCGCATGT GCACATTGAA 
AACTGTGACT CGAGTGACCC TACTGCATAC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002293.2
CDS	202..657
Translation	MFSTKALLLAGLISTALAGPWANICAGKSSNEIRTCDRHGCGQYSAQRSQRPHQGVDILCSAGSTVYAPFTGMIVGQEKPYQNKNAINNGVRISGRGFCVKMFYIKPIKYKGPIKKGEKLGTLLPLQKVYPGIQSHVHIENCDSSDPTAYL

Target ORF information:

RefSeq Version	NM_002302.2
Organism	Homo sapiens(human)
Definition	Homo sapiens leukocyte cell derived chemotaxin 2 (LECT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002302.2

ORF Insert Sequence:

ATGTTTTCCA CCAAAGCCCT CCTTTTGGCT GGTCTGATTT CTACCGCACT GGCAGGGCCA 
TGGGCTAATA TATGTGCTGG CAAGTCTTCC AATGAGATCC GGACGTGTGA CCGCCATGGC 
TGTGGACAGT ACTCTGCTCA AAGAAGTCAG AGGCCTCACC AGGGTGTGGA CATCTTGTGC 
TCTGCTGGAT CTACTGTGTA CGCACCATTC ACTGGAATGA TTGTGGGCCA GGAGAAACCT 
TATCAAAACA AGAATGCTAT CAATAATGGT GTTCGAATAT CTGGAAGAGG TTTTTGTGTC 
AAAATGTTCT ACATTAAGCC AATTAAGTAT AAAGGTCCTA TTAAGAAGGG AGAAAAACTT 
GGAACTCTAT TGCCCTTGCA GAAAGTTTAT CCTGGCATAC AATCGCATGT GCACATTGAA 
AACTGTGACT CGAGTGACCC TACTGCATAC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

LECT2 ( NM_002302.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002293.2 Homo sapiens leukocyte cell derived chemotaxin 2 (LECT2), mRNA.

Price & Availability↑

CloneID	OHu23789
Clone ID Related Accession (Same CDS sequence)	NM_002302.2 , NM_002302.3
Accession Version	NM_002302.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 456bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-27
Organism	Homo sapiens(human)
Product	leukocyte cell-derived chemotaxin-2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC002428.1. On Nov 23, 2018 this sequence version replaced NM_002302.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D63521.1, SRR5189664.25165.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000274507.6/ ENSP00000274507.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTTTCCA CCAAAGCCCT CCTTTTGGCT GGTCTGATTT CTACCGCACT GGCAGGGCCA 
TGGGCTAATA TATGTGCTGG CAAGTCTTCC AATGAGATCC GGACGTGTGA CCGCCATGGC 
TGTGGACAGT ACTCTGCTCA AAGAAGTCAG AGGCCTCACC AGGGTGTGGA CATCTTGTGC 
TCTGCTGGAT CTACTGTGTA CGCACCATTC ACTGGAATGA TTGTGGGCCA GGAGAAACCT 
TATCAAAACA AGAATGCTAT CAATAATGGT GTTCGAATAT CTGGAAGAGG TTTTTGTGTC 
AAAATGTTCT ACATTAAGCC AATTAAGTAT AAAGGTCCTA TTAAGAAGGG AGAAAAACTT 
GGAACTCTAT TGCCCTTGCA GAAAGTTTAT CCTGGCATAC AATCGCATGT GCACATTGAA 
AACTGTGACT CGAGTGACCC TACTGCATAC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002293.2
CDS	151..606
Translation	MFSTKALLLAGLISTALAGPWANICAGKSSNEIRTCDRHGCGQYSAQRSQRPHQGVDILCSAGSTVYAPFTGMIVGQEKPYQNKNAINNGVRISGRGFCVKMFYIKPIKYKGPIKKGEKLGTLLPLQKVYPGIQSHVHIENCDSSDPTAYL

Target ORF information:

RefSeq Version	NM_002302.3
Organism	Homo sapiens(human)
Definition	Homo sapiens leukocyte cell derived chemotaxin 2 (LECT2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002302.3

ORF Insert Sequence:

ATGTTTTCCA CCAAAGCCCT CCTTTTGGCT GGTCTGATTT CTACCGCACT GGCAGGGCCA 
TGGGCTAATA TATGTGCTGG CAAGTCTTCC AATGAGATCC GGACGTGTGA CCGCCATGGC 
TGTGGACAGT ACTCTGCTCA AAGAAGTCAG AGGCCTCACC AGGGTGTGGA CATCTTGTGC 
TCTGCTGGAT CTACTGTGTA CGCACCATTC ACTGGAATGA TTGTGGGCCA GGAGAAACCT 
TATCAAAACA AGAATGCTAT CAATAATGGT GTTCGAATAT CTGGAAGAGG TTTTTGTGTC 
AAAATGTTCT ACATTAAGCC AATTAAGTAT AAAGGTCCTA TTAAGAAGGG AGAAAAACTT 
GGAACTCTAT TGCCCTTGCA GAAAGTTTAT CCTGGCATAC AATCGCATGT GCACATTGAA 
AACTGTGACT CGAGTGACCC TACTGCATAC CTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of leukocyte cell-derived chemotaxin 2 (LECT2) with NAFLD, metabolic syndrome, and atherosclerosis.
PloS one12(4)e0174717(2017)
Yoo HJ,Hwang SY,Choi JH,Lee HJ,Chung HS,Seo JA,Kim SG,Kim NH,Baik SH,Choi DS,Choi KM

Visceral fat area is a strong predictor of leukocyte cell-derived chemotaxin 2, a potential biomarker of dyslipidemia.
PloS one12(3)e0173310(2017)
Tanisawa K,Taniguchi H,Sun X,Ito T,Kawakami R,Sakamoto S,Higuchi M

Reduced serum level of leukocyte cell-derived chemotaxin 2 is associated with the presence of diabetic retinopathy.
Clinica chimica acta; international journal of clinical chemistry463145-149(2016 Dec)
Okumura A,Unoki-Kubota H,Yoshida-Hata N,Yamamoto-Honda R,Yamashita S,Iwata M,Tobe K,Kajio H,Noda M,Katai N,Yamagoe S,Kaburagi Y

New Markers in Atherosclerosis: Thrombospondin-2 (THBS-2) and Leukocyte Cell-Derived Chemotaxin-2 (LECT-2); An Immunohistochemical Study.
Medical science monitor : international medical journal of experimental and clinical research225234-5239(2016 Dec)
Sonmez FC,Yildiz P,Akhtar MS,Aydin C,Sonmez O,Ay N,Vatankulu MA

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LECT2 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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