CCL4L1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CCL4L1
Entrez Gene ID	388372
Full Name	C-C motif chemokine ligand 4 like 1
Synonyms	AT744.2,CCL4L,LAG-1,LAG1,MIP-1-beta,SCYA4L,SCYA4L1,SCYA4L2
General protein information	Preferred Names C-C motif chemokine ligand 4 like 1 Names C-C motif chemokine 4-like CC chemokine ligand 4L1 Lymphocyte activation gene 1 protein Macrophage inflammatory protein 1-beta Monocyte adherence-induced protein 5-alpha Small-inducible cytokine A4-like chemokine (C-C motif) ligand 4-like 1, telomeric macrophage inflammatory protein-1b2 small inducible cytokine A4-like
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q12
Summary	This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014].
Disorder MIM:	603782

mRNA and Protein(s)

mRNA	Protein	Name
NM_207007.3	NP_996890.1	C-C motif chemokine 4-like precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.
Suviolahti E, Ge S, Nast CC, Mirocha J, Karasyov A, White M, Jordan SC, Toyoda M
Transplant immunology32(1)9-17(2015 Jan)

Comparison of a quantitative Real-Time PCR assay and droplet digital PCR for copy number analysis of the CCL4L genes.
Bharuthram A, Paximadis M, Picton AC, Tiemessen CT
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2528-35(2014 Jul)

CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with psoriasis severity.
Pedrosa E, Carretero-Iglesia L, Boada A, Colobran R, Faner R, Pujol-Autonell I, Palou E, Esteve A, Pujol-Borrell R, Ferr?ndiz C, Juan M, Carrascosa JM
The Journal of investigative dermatology131(9)1830-7(2011 Sep)

CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection.
Shao W, Tang J, Song W, Wang C, Li Y, Wilson CM, Kaslow RA
Genes and immunity8(3)224-31(2007 Apr)

Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients.
Colobran R, Adreani P, Ashhab Y, Llano A, Est? JA, Dominguez O, Pujol-Borrell R, Juan M
Journal of immunology (Baltimore, Md. : 1950)174(9)5655-64(2005 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

identified 13 ADCC-activated genes. Six gene expression assays including 8 of the 13 genes (CCL3, CCL4/CCL4L1/CCL4L2, CD160, IFNG, NR4A3 and XCL1/XCL2) were analyzed in 127 kidney biopsies
Title: Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.

PCR results show that lower copy numbers of CCL4L1 are observed in the Caucasian population nd higher copy numbers are observed in the Black population of South Africa.
Title: Comparison of a quantitative Real-Time PCR assay and droplet digital PCR for copy number analysis of the CCL4L genes.

CCL4L1 allele frequency is higher in severe psoriasis, whereas CCL4L2 is more frequent in patients with a milder disease.
Title: CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with psoriasis severity.

multiple copies of CCL3L1 and CCL4L1 present in a single diploid genome are the result of segmental duplication at chromosome 17q12
Title: CCL3L1 and CCL4L1 chemokine genes are located in a segmental duplication at chromosome 17q12.

The following CCL4L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL4L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu16067	NM_207007.3 Latest version!	Homo sapiens C-C motif chemokine ligand 4 like 1 (CCL4L1), transcript variant CCL4L, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CCL4L1 ( NM_207007.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_996890.1 Homo sapiens C-C motif chemokine ligand 4 like 1 (CCL4L1), transcript variant CCL4L, mRNA.

Price & Availability↑

CloneID	OHu16067
Clone ID Related Accession (Same CDS sequence)	NM_207007.3
Accession Version	NM_207007.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	C-C motif chemokine 4-like precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC171857.1, BC070310.1 and BU626856.1. On Apr 16, 2014 this sequence version replaced NM_207007.2. Transcript Variant: This variant (CCL4L) represents the longer transcript and encodes the supported protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY766447.1, SRR1163658.373962.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGCTCT GCGTGACTGT CCTGTCTCTC CTCGTGCTAG TAGCTGCCTT CTGCTCTCTA 
GCACTCTCAG CACCAATGGG CTCAGACCCT CCCACCGCCT GCTGCTTTTC TTACACCGCG 
AGGAAGCTTC CTCGCAACTT TGTGGTAGAT TACTATGAGA CCAGCAGCCT CTGCTCCCAG 
CCAGCTGTGG TATTCCAAAC CAAAAGAGGC AAGCAAGTCT GCGCTGACCC CAGTGAGTCC 
TGGGTCCAGG AGTACGTGTA TGACCTGGAA CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_996890.1
CDS	235..513
Translation	MKLCVTVLSLLVLVAAFCSLALSAPMGSDPPTACCFSYTARKLPRNFVVDYYETSSLCSQPAVVFQTKRGKQVCADPSESWVQEYVYDLELN

Target ORF information:

RefSeq Version	NM_207007.3
Organism	Homo sapiens(human)
Definition	Homo sapiens C-C motif chemokine ligand 4 like 1 (CCL4L1), transcript variant CCL4L, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_207007.3

ORF Insert Sequence:

ATGAAGCTCT GCGTGACTGT CCTGTCTCTC CTCGTGCTAG TAGCTGCCTT CTGCTCTCTA 
GCACTCTCAG CACCAATGGG CTCAGACCCT CCCACCGCCT GCTGCTTTTC TTACACCGCG 
AGGAAGCTTC CTCGCAACTT TGTGGTAGAT TACTATGAGA CCAGCAGCCT CTGCTCCCAG 
CCAGCTGTGG TATTCCAAAC CAAAAGAGGC AAGCAAGTCT GCGCTGACCC CAGTGAGTCC 
TGGGTCCAGG AGTACGTGTA TGACCTGGAA CTGAACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genes associated with antibody-dependent cell activation are overexpressed in renal biopsies from patients with antibody-mediated rejection.
Transplant immunology32(1)9-17(2015 Jan)
Suviolahti E,Ge S,Nast CC,Mirocha J,Karasyov A,White M,Jordan SC,Toyoda M

Comparison of a quantitative Real-Time PCR assay and droplet digital PCR for copy number analysis of the CCL4L genes.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2528-35(2014 Jul)
Bharuthram A,Paximadis M,Picton AC,Tiemessen CT

CCL4L polymorphisms and CCL4/CCL4L serum levels are associated with psoriasis severity.
The Journal of investigative dermatology131(9)1830-7(2011 Sep)
Pedrosa E,Carretero-Iglesia L,Boada A,Colobran R,Faner R,Pujol-Autonell I,Palou E,Esteve A,Pujol-Borrell R,Ferr?ndiz C,Juan M,Carrascosa JM

CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection.
Genes and immunity8(3)224-31(2007 Apr)
Shao W,Tang J,Song W,Wang C,Li Y,Wilson CM,Kaslow RA

Multiple products derived from two CCL4 loci: high incidence of a new polymorphism in HIV+ patients.
Journal of immunology (Baltimore, Md. : 1950)174(9)5655-64(2005 May)
Colobran R,Adreani P,Ashhab Y,Llano A,Est? JA,Dominguez O,Pujol-Borrell R,Juan M

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CCL4L1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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