SUMO4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SUMO4
Entrez Gene ID	387082
Full Name	small ubiquitin-like modifier 4
Synonyms	IDDM5,SMT3H4,SUMO-4,dJ281H8.4
General protein information	Preferred Names small ubiquitin-like modifier 4 Names small ubiquitin-related modifier 4 SMT3 suppressor of mif two 3 homolog 2 SMT3 suppressor of mif two 3 homolog 4 insulin-dependent diabetes mellitus 5 small ubiquitin-like modifier 4 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6q25.1
Summary	This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism. [provided by RefSeq, Jul 2008].
Disorder MIM:	608829
Disorder Html:	{Diabetes mellitus, insulin-dependent, 5}, 600320 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001002255.2	NP_001002255.1	small ubiquitin-related modifier 4
NM_001002255.1	NP_001002255.1	small ubiquitin-related modifier 4

Pathways from BioSystems

Homologies

Homo sapiens (human)	SUMO4	NP_001002255.1
Pan troglodytes (chimpanzee)	SUMO4	XP_001173140.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of donor small ubiquitin-like modifier 4 rs237025 genetic variant with tacrolimus elimination in the early period after liver transplantation.
Zhang T, Liu Y, Zeng R, Ling Q, Wen P, Fan J, Peng Z
Liver international : official journal of the International Association for the Study of the Liver(2017 Sep)

Association of donor and recipient SUMO4 rs237025 genetic variant with new-onset diabetes mellitus after liver transplantation in a Chinese population.
Zhang T, Liu Y, Hu Y, Zhang X, Zhong L, Fan J, Peng Z
Gene627428-433(2017 Sep)

Association between the SUMO4 M55V Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Meta-analysis.
Zhang Q, Liu D, Zhao ZY, Sun Q, Ding LX, Wang YX
Biomedical and environmental sciences : BES30(4)288-295(2017 Apr)

SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery.
Baczyk D, Audette MC, Drewlo S, Levytska K, Kingdom JC
PloS one12(5)e0178056(2017)

SUMO4 163 G>A variation is associated with kidney disease in Indian subjects with type 2 diabetes.
Sinha N, Yadav AK, Kumar V, Dutta P, Bhansali A, Jha V
Molecular biology reports43(5)345-8(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Both donor and recipient SUMO4 rs237025 polymorphisms contribute to the development of new-onset diabetes mellitus after liver transplantation.
Title: Association of donor and recipient SUMO4 rs237025 genetic variant with new-onset diabetes mellitus after liver transplantation in a Chinese population.

meta-analysis demonstrated that the G allele of the SUMO4 M55V polymorphism could be a susceptible risk locus to type 2 diabetes mellitus, mainly in the Chinese population, while the association in other ethnic population needs to be further validated
Title: Association between the SUMO4 M55V Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Meta-analysis.

Results show that SUMO-4 is expressed in normal placental development. SUMO-4 expression was increased in pre-eclamptic placentas and in models of oxidative stress and hypoxic injury suggesting that SUMO-4 hyper-SUMOylation may be a potential post-translational mechanism in the stressed pre-eclamptic placenta.
Title: SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery.

study suggests that SUMO4 c.163 G to A polymorphism is associated with the susceptibility to diabetic nephropathy in north Indian subjects with type 2 diabetes
Title: SUMO4 163 G>A variation is associated with kidney disease in Indian subjects with type 2 diabetes.

SUMO4 M55V polymorphism and type-2 diabetes were significantly associated with a possible SUMO4 region to type-2 diabetes susceptibility.
Title: Association of SUMO4 M55V and -94ins/del gene variants with type-2 diabetes.

The following SUMO4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SUMO4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17772	NM_001002255.2 Latest version!	Homo sapiens small ubiquitin like modifier 4 (SUMO4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu17772	NM_001002255.1	Homo sapiens small ubiquitin like modifier 4 (SUMO4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SUMO4 ( NM_001002255.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002255.1 Homo sapiens small ubiquitin like modifier 4 (SUMO4), mRNA.

Price & Availability↑

CloneID	OHu17772
Clone ID Related Accession (Same CDS sequence)	NM_001002255.2 , NM_001002255.1
Accession Version	NM_001002255.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-24
Organism	Homo sapiens(human)
Product	small ubiquitin-related modifier 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL031133.1 and AY340238.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_001002255.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: SRR7346977.1902974.1, SRR7346977.815715.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000326669.6/ ENSP00000318635.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCCAACG AAAAGCCCAC AGAAGAAGTC AAGACTGAGA ACAACAATCA TATTAATTTG 
AAGGTGGCGG GACAGGATGG TTCTGTGGTG CAGTTTAAGA TTAAGAGGCA GACACCACTT 
AGTAAACTAA TGAAAGCCTA TTGTGAACCA CGGGGATTGT CAGTGAAGCA GATCAGATTC 
CGATTTGGTG GGCAACCAAT CAGTGGAACA GACAAACCTG CACAGTTGGA AATGGAAGAT 
GAAGATACAA TTGATGTGTT TCAACAGCCT ACGGGAGGTG TCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002255.1
CDS	131..418
Translation	MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCEPRGLSVKQIRFRFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY

Target ORF information:

RefSeq Version	NM_001002255.2
Organism	Homo sapiens(human)
Definition	Homo sapiens small ubiquitin like modifier 4 (SUMO4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002255.2

ORF Insert Sequence:

ATGGCCAACG AAAAGCCCAC AGAAGAAGTC AAGACTGAGA ACAACAATCA TATTAATTTG 
AAGGTGGCGG GACAGGATGG TTCTGTGGTG CAGTTTAAGA TTAAGAGGCA GACACCACTT 
AGTAAACTAA TGAAAGCCTA TTGTGAACCA CGGGGATTGT CAGTGAAGCA GATCAGATTC 
CGATTTGGTG GGCAACCAAT CAGTGGAACA GACAAACCTG CACAGTTGGA AATGGAAGAT 
GAAGATACAA TTGATGTGTT TCAACAGCCT ACGGGAGGTG TCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SUMO4 ( NM_001002255.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001002255.1 Homo sapiens small ubiquitin like modifier 4 (SUMO4), mRNA.

Price & Availability↑

CloneID	OHu17772
Clone ID Related Accession (Same CDS sequence)	NM_001002255.2 , NM_001002255.1
Accession Version	NM_001002255.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 288bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-19
Organism	Homo sapiens(human)
Product	small ubiquitin-related modifier 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY340238.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AY340238.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCCAACG AAAAGCCCAC AGAAGAAGTC AAGACTGAGA ACAACAATCA TATTAATTTG 
AAGGTGGCGG GACAGGATGG TTCTGTGGTG CAGTTTAAGA TTAAGAGGCA GACACCACTT 
AGTAAACTAA TGAAAGCCTA TTGTGAACCA CGGGGATTGT CAGTGAAGCA GATCAGATTC 
CGATTTGGTG GGCAACCAAT CAGTGGAACA GACAAACCTG CACAGTTGGA AATGGAAGAT 
GAAGATACAA TTGATGTGTT TCAACAGCCT ACGGGAGGTG TCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001002255.1
CDS	34..321
Translation	MANEKPTEEVKTENNNHINLKVAGQDGSVVQFKIKRQTPLSKLMKAYCEPRGLSVKQIRFRFGGQPISGTDKPAQLEMEDEDTIDVFQQPTGGVY

Target ORF information:

RefSeq Version	NM_001002255.1
Organism	Homo sapiens(human)
Definition	Homo sapiens small ubiquitin like modifier 4 (SUMO4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001002255.1

ORF Insert Sequence:

ATGGCCAACG AAAAGCCCAC AGAAGAAGTC AAGACTGAGA ACAACAATCA TATTAATTTG 
AAGGTGGCGG GACAGGATGG TTCTGTGGTG CAGTTTAAGA TTAAGAGGCA GACACCACTT 
AGTAAACTAA TGAAAGCCTA TTGTGAACCA CGGGGATTGT CAGTGAAGCA GATCAGATTC 
CGATTTGGTG GGCAACCAAT CAGTGGAACA GACAAACCTG CACAGTTGGA AATGGAAGAT 
GAAGATACAA TTGATGTGTT TCAACAGCCT ACGGGAGGTG TCTACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of donor small ubiquitin-like modifier 4 rs237025 genetic variant with tacrolimus elimination in the early period after liver transplantation.
Liver international : official journal of the International Association for the Study of the Liver(2017 Sep)
Zhang T,Liu Y,Zeng R,Ling Q,Wen P,Fan J,Peng Z

Association of donor and recipient SUMO4 rs237025 genetic variant with new-onset diabetes mellitus after liver transplantation in a Chinese population.
Gene627428-433(2017 Sep)
Zhang T,Liu Y,Hu Y,Zhang X,Zhong L,Fan J,Peng Z

Association between the SUMO4 M55V Polymorphism and Susceptibility to Type 2 Diabetes Mellitus: A Meta-analysis.
Biomedical and environmental sciences : BES30(4)288-295(2017 Apr)
Zhang Q,Liu D,Zhao ZY,Sun Q,Ding LX,Wang YX

SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery.
PloS one12(5)e0178056(2017)
Baczyk D,Audette MC,Drewlo S,Levytska K,Kingdom JC

SUMO4 163 G>A variation is associated with kidney disease in Indian subjects with type 2 diabetes.
Molecular biology reports43(5)345-8(2016 May)
Sinha N,Yadav AK,Kumar V,Dutta P,Bhansali A,Jha V

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SUMO4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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