KIR2DL4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KIR2DL4
Entrez Gene ID	3805
Full Name	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Synonyms	CD158D,G9P,KIR-103AS,KIR-2DL4,KIR103,KIR103AS
General protein information	Preferred Names killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 Names killer cell immunoglobulin-like receptor 2DL4 CD158 antigen-like family member D MHC class I NK cell receptor KIR103AS killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 killer cell inhibitory receptor 103AS
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.42
Summary	Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016].
Disorder MIM:	604945

mRNA and Protein(s)

mRNA	Protein	Name
NM_002255.6	NP_002246.5	killer cell immunoglobulin-like receptor 2DL4 isoform a precursor
NM_002255.5	NP_002246.5	killer cell immunoglobulin-like receptor 2DL4 isoform a precursor
NM_001080772.1	NP_001074241.1	killer cell immunoglobulin-like receptor 2DL4 isoform b precursor
NM_001080770.1	NP_001074239.1	killer cell immunoglobulin-like receptor 2DL4 isoform c precursor
NM_001080772.2	NP_001074241.1	killer cell immunoglobulin-like receptor 2DL4 isoform b precursor
NM_001080770.2	NP_001074239.1	killer cell immunoglobulin-like receptor 2DL4 isoform c precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KIR2DL5A	NP_777165.1
Pan troglodytes (chimpanzee)	KIR2DL4	NP_001181862.1
	KIR2DL4	NP_001036126.1
Homo sapiens (human)	KIR2DL4	NP_002246.5

Gene Ontology
Bibliography

Related articles in PubMed

The Influence of Cytomegalovirus on Expression of HLA-G and its Ligand KIR2DL4 by Human Peripheral Blood Leucocyte Subsets.
Albayati Z, Alyami A, Alomar S, Middleton D, Bonnett L, Aleem S, Flanagan BF, Christmas SE
Scandinavian journal of immunology86(5)396-407(2017 Nov)

Killer cell immunoglobulin-like receptor 2DL4 is expressed in and suppresses the cell growth of Langerhans cell histiocytosis.
Takei Y, Ueshima C, Kataoka TR, Hirata M, Sugimoto A, Rokutan-Kurata M, Moriyoshi K, Ono K, Murakami I, Iwamoto S, Haga H
Oncotarget8(23)36964-36972(2017 Jun)

KIR 2D (L1, L3, L4, S4) and KIR 3DL1 protein expression in non-small cell lung cancer.
He Y, Bunn PA, Zhou C, Chan D
Oncotarget7(50)82104-82111(2016 Dec)

ADOMA: A Command Line Tool to Modify ClustalW Multiple Alignment Output.
Zaal D, Nota B
Molecular informatics35(1)42-4(2016 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Serum levels of soluble HLA-G were similar in CMV- and CMV+ subjects but levels in culture supernatants were significantly higher in cells from CMV+ than from CMV- subjects stimulated with CMV antigens. The HLA-G ligand KIR2DL4 was mainly expressed on NK cells and CD56+ T cells with no differences between CMV+ and CMV- subjects.
Title: The Influence of Cytomegalovirus on Expression of HLA-G and its Ligand KIR2DL4 by Human Peripheral Blood Leucocyte Subsets.

a woman's heterozygosity in HLA-G and LILRB1 might be an advantage for a success of reproduction, but the partner's heterozygosity in 9A/10A KIR2DL4 alleles might not
Title: Possible Role of HLA-G, LILRB1 and KIR2DL4 Gene Polymorphisms in Spontaneous Miscarriage.

The 9620 9A/10A (rs11410751) polymorphism in exon 7 did not influence the risk of NSCLC.
Title: Genetic polymorphisms and expression of HLA-G and its receptors, KIR2DL4 and LILRB1, in non-small cell lung cancer.

Among 438 Polish people, a weak difference was seen between males and females in 9769 C/A genotypes and alleles. Fertile women had a high frequency of homozygosity for the defective 9A variant, so KIR2DL4 is not absolutely necessary for reproduction.
Title: Genetic polymorphism of KIR2DL4 in the Polish population.

Decreased level of KIR2DL4 rather than its single nucleotide polymorphism is correlated with the susceptibility of pre-eclampsia
Title: KIR2DL4 expression rather than its single nucleotide polymorphisms correlates with pre-eclampsia.

The following KIR2DL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KIR2DL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20111	NM_002255.6 Latest version!	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu20069	NM_001080772.2 Latest version!	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
OHu20154	NM_001080770.2 Latest version!	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$202.30 $289.00
View Old Accession Versions >>
OHu20111	NM_002255.5	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$265.30 $379.00
OHu20069	NM_001080772.1	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$216.30 $309.00
OHu20154	NM_001080770.1	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$202.30 $289.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KIR2DL4 ( NM_002255.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_002246.5 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20111
Clone ID Related Accession (Same CDS sequence)	NM_002255.6 , NM_002255.5
Accession Version	NM_002255.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-21
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 2DL4 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245128.3, BC041611.1 and BC028137.1. On Oct 31, 2018 this sequence version replaced NM_002255.5. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028137.1, AF002979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031, SAMN01820691 [ECO:0000348] ##Evidence-Data-END##

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGGTAT CGCCAGACAC 
CTGCATGCTG TGATTAGGTA CTCAGTGGCC ATCATCCTCT TTACCATCCT TCCCTTCTTT 
CTCCTTCATC GCTGGTGCTC CAAAAAAAAA AATGCTGCTG TAATGAACCA AGAGCCTGCG 
GGACACAGAA CAGTGAACAG GGAGGACTCT GATGAACAAG ACCCTCAGGA GGTGACATAC 
GCACAGTTGG ATCACTGCAT TTTCACACAG AGAAAAATCA CTGGCCCTTC TCAGAGGAGC 
AAGAGACCCT CAACAGATAC CAGCGTGTGT ATAGAACTTC CAAATGCTGA GCCCAGAGCG 
TTGTCTCCTG CCCATGAGCA CCACAGTCAG GCCTTGATGG GATCTTCTAG GGAGACAACA 
GCCCTGTCTC AAACCCAGCT TGCCAGCTCT AATGTACCAG CAGCTGGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002246.5
CDS	43..1176
Translation	MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLHAVIRYSVAIILFTILPFFLLHRWCSKKKNAAVMNQEPAGHRTVNREDSDEQDPQEVTYAQLDHCIFTQRKITGPSQRSKRPSTDTSVCIELPNAEPRALSPAHEHHSQALMGSSRETTALSQTQLASSNVPAAGI

Target ORF information:

RefSeq Version	NM_002255.6
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002255.6

ORF Insert Sequence:

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGGTAT CGCCAGACAC 
CTGCATGCTG TGATTAGGTA CTCAGTGGCC ATCATCCTCT TTACCATCCT TCCCTTCTTT 
CTCCTTCATC GCTGGTGCTC CAAAAAAAAA AATGCTGCTG TAATGAACCA AGAGCCTGCG 
GGACACAGAA CAGTGAACAG GGAGGACTCT GATGAACAAG ACCCTCAGGA GGTGACATAC 
GCACAGTTGG ATCACTGCAT TTTCACACAG AGAAAAATCA CTGGCCCTTC TCAGAGGAGC 
AAGAGACCCT CAACAGATAC CAGCGTGTGT ATAGAACTTC CAAATGCTGA GCCCAGAGCG 
TTGTCTCCTG CCCATGAGCA CCACAGTCAG GCCTTGATGG GATCTTCTAG GGAGACAACA 
GCCCTGTCTC AAACCCAGCT TGCCAGCTCT AATGTACCAG CAGCTGGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KIR2DL4 ( NM_001080772.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001074241.1 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20069
Clone ID Related Accession (Same CDS sequence)	NM_001080772.1 , NM_001080772.2
Accession Version	NM_001080772.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 2DL4 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC041611.1 and BC028137.1. Transcript Variant: This variant (2) is one nt shorter than variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041611.1, X97229.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031, SAMN01820691 [ECO:0000348] ##Evidence-Data-END##

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGGTAT CGCCAGACAC 
CTGCATGCTG TGATTAGGTA CTCAGTGGCC ATCATCCTCT TTACCATCCT TCCCTTCTTT 
CTCCTTCATC GCTGGTGCTC CAAAAAAAAA ATGCTGCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074241.1
CDS	41..862
Translation	MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLHAVIRYSVAIILFTILPFFLLHRWCSKKKMLL

Target ORF information:

RefSeq Version	NM_001080772.1
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080772.1

ORF Insert Sequence:

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGGTAT CGCCAGACAC 
CTGCATGCTG TGATTAGGTA CTCAGTGGCC ATCATCCTCT TTACCATCCT TCCCTTCTTT 
CTCCTTCATC GCTGGTGCTC CAAAAAAAAA ATGCTGCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KIR2DL4 ( NM_001080772.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001074241.1 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu20069
Clone ID Related Accession (Same CDS sequence)	NM_001080772.1 , NM_001080772.2
Accession Version	NM_001080772.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-03
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 2DL4 isoform b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245128.3, BC041611.1 and BC028137.1. On Oct 31, 2018 this sequence version replaced NM_001080772.1. Transcript Variant: This variant (2) is one nt shorter than variant 1. It encodes isoform b, which is shorter and has a distinct C-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028137.1, AF002979.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END##

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGGTAT CGCCAGACAC 
CTGCATGCTG TGATTAGGTA CTCAGTGGCC ATCATCCTCT TTACCATCCT TCCCTTCTTT 
CTCCTTCATC GCTGGTGCTC CAAAAAAAAA ATGCTGCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074241.1
CDS	43..864
Translation	MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLHAVIRYSVAIILFTILPFFLLHRWCSKKKMLL

Target ORF information:

RefSeq Version	NM_001080772.2
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080772.2

ORF Insert Sequence:

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGGTAT CGCCAGACAC 
CTGCATGCTG TGATTAGGTA CTCAGTGGCC ATCATCCTCT TTACCATCCT TCCCTTCTTT 
CTCCTTCATC GCTGGTGCTC CAAAAAAAAA ATGCTGCTGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KIR2DL4 ( NM_002255.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002246.5 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu20111
Clone ID Related Accession (Same CDS sequence)	NM_002255.6 , NM_002255.5
Accession Version	NM_002255.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 2DL4 isoform a precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC041611.1 and BC028137.1. On Jan 25, 2007 this sequence version replaced NM_002255.4. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC041611.1, X97229.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153031, SAMN01820691 [ECO:0000348] ##Evidence-Data-END##

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGGTAT CGCCAGACAC 
CTGCATGCTG TGATTAGGTA CTCAGTGGCC ATCATCCTCT TTACCATCCT TCCCTTCTTT 
CTCCTTCATC GCTGGTGCTC CAAAAAAAAA AATGCTGCTG TAATGAACCA AGAGCCTGCG 
GGACACAGAA CAGTGAACAG GGAGGACTCT GATGAACAAG ACCCTCAGGA GGTGACATAC 
GCACAGTTGG ATCACTGCAT TTTCACACAG AGAAAAATCA CTGGCCCTTC TCAGAGGAGC 
AAGAGACCCT CAACAGATAC CAGCGTGTGT ATAGAACTTC CAAATGCTGA GCCCAGAGCG 
TTGTCTCCTG CCCATGAGCA CCACAGTCAG GCCTTGATGG GATCTTCTAG GGAGACAACA 
GCCCTGTCTC AAACCCAGCT TGCCAGCTCT AATGTACCAG CAGCTGGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002246.5
CDS	41..1174
Translation	MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLHAVIRYSVAIILFTILPFFLLHRWCSKKKNAAVMNQEPAGHRTVNREDSDEQDPQEVTYAQLDHCIFTQRKITGPSQRSKRPSTDTSVCIELPNAEPRALSPAHEHHSQALMGSSRETTALSQTQLASSNVPAAGI

Target ORF information:

RefSeq Version	NM_002255.5
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002255.5

ORF Insert Sequence:

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGGTAT CGCCAGACAC 
CTGCATGCTG TGATTAGGTA CTCAGTGGCC ATCATCCTCT TTACCATCCT TCCCTTCTTT 
CTCCTTCATC GCTGGTGCTC CAAAAAAAAA AATGCTGCTG TAATGAACCA AGAGCCTGCG 
GGACACAGAA CAGTGAACAG GGAGGACTCT GATGAACAAG ACCCTCAGGA GGTGACATAC 
GCACAGTTGG ATCACTGCAT TTTCACACAG AGAAAAATCA CTGGCCCTTC TCAGAGGAGC 
AAGAGACCCT CAACAGATAC CAGCGTGTGT ATAGAACTTC CAAATGCTGA GCCCAGAGCG 
TTGTCTCCTG CCCATGAGCA CCACAGTCAG GCCTTGATGG GATCTTCTAG GGAGACAACA 
GCCCTGTCTC AAACCCAGCT TGCCAGCTCT AATGTACCAG CAGCTGGAAT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KIR2DL4 ( NM_001080770.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001074239.1 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu20154
Clone ID Related Accession (Same CDS sequence)	NM_001080770.1 , NM_001080770.2
Accession Version	NM_001080770.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-31
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 2DL4 isoform c precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC041611.1 and BC028137.1. Transcript Variant: This variant (3) lacks an internal exon in the coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF002980.1, Y13054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END##

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGATGC TGCTGTAATG 
AACCAAGAGC CTGCGGGACA CAGAACAGTG AACAGGGAGG ACTCTGATGA ACAAGACCCT 
CAGGAGGTGA CATACGCACA GTTGGATCAC TGCATTTTCA CACAGAGAAA AATCACTGGC 
CCTTCTCAGA GGAGCAAGAG ACCCTCAACA GATACCAGCG TGTGTATAGA ACTTCCAAAT 
GCTGAGCCCA GAGCGTTGTC TCCTGCCCAT GAGCACCACA GTCAGGCCTT GATGGGATCT 
TCTAGGGAGA CAACAGCCCT GTCTCAAACC CAGCTTGCCA GCTCTAATGT ACCAGCAGCT 
GGAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074239.1
CDS	41..1069
Translation	MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTDAAVMNQEPAGHRTVNREDSDEQDPQEVTYAQLDHCIFTQRKITGPSQRSKRPSTDTSVCIELPNAEPRALSPAHEHHSQALMGSSRETTALSQTQLASSNVPAAGI

Target ORF information:

RefSeq Version	NM_001080770.1
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080770.1

ORF Insert Sequence:

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGATGC TGCTGTAATG 
AACCAAGAGC CTGCGGGACA CAGAACAGTG AACAGGGAGG ACTCTGATGA ACAAGACCCT 
CAGGAGGTGA CATACGCACA GTTGGATCAC TGCATTTTCA CACAGAGAAA AATCACTGGC 
CCTTCTCAGA GGAGCAAGAG ACCCTCAACA GATACCAGCG TGTGTATAGA ACTTCCAAAT 
GCTGAGCCCA GAGCGTTGTC TCCTGCCCAT GAGCACCACA GTCAGGCCTT GATGGGATCT 
TCTAGGGAGA CAACAGCCCT GTCTCAAACC CAGCTTGCCA GCTCTAATGT ACCAGCAGCT 
GGAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KIR2DL4 ( NM_001080770.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001074239.1 Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu20154
Clone ID Related Accession (Same CDS sequence)	NM_001080770.1 , NM_001080770.2
Accession Version	NM_001080770.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1029bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Homo sapiens(human)
Product	killer cell immunoglobulin-like receptor 2DL4 isoform c precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245128.3, BC041611.1 and BC028137.1. On Oct 31, 2018 this sequence version replaced NM_001080770.1. Transcript Variant: This variant (3) lacks an internal exon in the coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF002980.1, LS974092.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END##

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGATGC TGCTGTAATG 
AACCAAGAGC CTGCGGGACA CAGAACAGTG AACAGGGAGG ACTCTGATGA ACAAGACCCT 
CAGGAGGTGA CATACGCACA GTTGGATCAC TGCATTTTCA CACAGAGAAA AATCACTGGC 
CCTTCTCAGA GGAGCAAGAG ACCCTCAACA GATACCAGCG TGTGTATAGA ACTTCCAAAT 
GCTGAGCCCA GAGCGTTGTC TCCTGCCCAT GAGCACCACA GTCAGGCCTT GATGGGATCT 
TCTAGGGAGA CAACAGCCCT GTCTCAAACC CAGCTTGCCA GCTCTAATGT ACCAGCAGCT 
GGAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001074239.1
CDS	43..1071
Translation	MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTDAAVMNQEPAGHRTVNREDSDEQDPQEVTYAQLDHCIFTQRKITGPSQRSKRPSTDTSVCIELPNAEPRALSPAHEHHSQALMGSSRETTALSQTQLASSNVPAAGI

Target ORF information:

RefSeq Version	NM_001080770.2
Organism	Homo sapiens(human)
Definition	Homo sapiens killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001080770.2

ORF Insert Sequence:

ATGTCCATGT CACCCACGGT CATCATCCTG GCATGTCTTG GGTTCTTCTT GGACCAGAGT 
GTGTGGGCAC ACGTGGGTGG TCAGGACAAG CCCTTCTGCT CTGCCTGGCC CAGCGCTGTG 
GTGCCTCAAG GAGGACACGT GACTCTTCGG TGTCACTATC GTCGTGGGTT TAACATCTTC 
ACGCTGTACA AGAAAGATGG GGTCCCTGTC CCTGAGCTCT ACAACAGAAT ATTCTGGAAC 
AGTTTCCTCA TTAGCCCTGT GACCCCAGCA CACGCAGGGA CCTACAGATG TCGAGGTTTT 
CACCCGCACT CCCCCACTGA GTGGTCGGCA CCCAGCAACC CCCTGGTGAT CATGGTCACA 
GGTCTATATG AGAAACCTTC GCTTACAGCC CGGCCGGGCC CCACGGTTCG CGCAGGAGAG 
AACGTGACCT TGTCCTGCAG CTCCCAGAGC TCCTTTGACA TCTACCATCT ATCCAGGGAG 
GGGGAAGCCC ATGAACTTAG GCTCCCTGCA GTGCCCAGCA TCAATGGAAC ATTCCAGGCC 
GACTTCCCTC TGGGTCCTGC CACCCACGGA GAGACCTACA GATGCTTCGG CTCTTTCCAT 
GGATCTCCCT ACGAGTGGTC AGACCCGAGT GACCCACTGC CTGTTTCTGT CACAGGAAAC 
CCTTCTAGTA GTTGGCCTTC ACCCACTGAA CCAAGCTTCA AAACTGATGC TGCTGTAATG 
AACCAAGAGC CTGCGGGACA CAGAACAGTG AACAGGGAGG ACTCTGATGA ACAAGACCCT 
CAGGAGGTGA CATACGCACA GTTGGATCAC TGCATTTTCA CACAGAGAAA AATCACTGGC 
CCTTCTCAGA GGAGCAAGAG ACCCTCAACA GATACCAGCG TGTGTATAGA ACTTCCAAAT 
GCTGAGCCCA GAGCGTTGTC TCCTGCCCAT GAGCACCACA GTCAGGCCTT GATGGGATCT 
TCTAGGGAGA CAACAGCCCT GTCTCAAACC CAGCTTGCCA GCTCTAATGT ACCAGCAGCT 
GGAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Influence of Cytomegalovirus on Expression of HLA-G and its Ligand KIR2DL4 by Human Peripheral Blood Leucocyte Subsets.
Scandinavian journal of immunology86(5)396-407(2017 Nov)
Albayati Z,Alyami A,Alomar S,Middleton D,Bonnett L,Aleem S,Flanagan BF,Christmas SE

Killer cell immunoglobulin-like receptor 2DL4 is expressed in and suppresses the cell growth of Langerhans cell histiocytosis.
Oncotarget8(23)36964-36972(2017 Jun)
Takei Y,Ueshima C,Kataoka TR,Hirata M,Sugimoto A,Rokutan-Kurata M,Moriyoshi K,Ono K,Murakami I,Iwamoto S,Haga H

KIR 2D (L1, L3, L4, S4) and KIR 3DL1 protein expression in non-small cell lung cancer.
Oncotarget7(50)82104-82111(2016 Dec)
He Y,Bunn PA,Zhou C,Chan D

ADOMA: A Command Line Tool to Modify ClustalW Multiple Alignment Output.
Molecular informatics35(1)42-4(2016 Jan)
Zaal D,Nota B

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KIR2DL4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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