KIR2DL4 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	KIR2DL4
Entrez Gene ID	722782
Full Name	killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Synonyms	KIR2DL4.1,Mamu-KIR
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001042661.1	NP_001036126.1	killer cell immunoglobulin-like receptor 2DL4 precursor
XM_028838563.1	XP_028694396.1	killer cell immunoglobulin-like receptor 2DL4 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	KIR2DL5A	NP_777165.1
Pan troglodytes (chimpanzee)	KIR2DL4	NP_001181862.1
	KIR2DL4	NP_001036126.1
Homo sapiens (human)	KIR2DL4	NP_002246.5

Gene Ontology
Bibliography

Related articles in PubMed

KIR3DL01 upregulation on gut natural killer cells in response to SIV infection of KIR- and MHC class I-defined rhesus macaques.
Ries M, Reynolds MR, Bashkueva K, Crosno K, Capuano S 3rd, Prall TM, Wiseman R, O'Connor DH, Rakasz EG, Uno H, Lifson JD, Evans DT
PLoS pathogens13(7)e1006506(2017 Jul)

KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Hellmann I, Letvin NL, Schmitz JE
Journal of virology87(9)5305-10(2013 May)

KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.
Colantonio AD, Bimber BN, Neidermyer WJ Jr, Reeves RK, Alter G, Altfeld M, Johnson RP, Carrington M, O'Connor DH, Evans DT
PLoS pathogens7(3)e1001316(2011 Mar)

The mosaic of KIR haplotypes in rhesus macaques.
Blokhuis JH, van der Wiel MK, Doxiadis GG, Bontrop RE
Immunogenetics62(5)295-306(2010 May)

Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques.
Chaichompoo P, Bostik P, Stephenson S, Udompunturuk S, Kobkitjaroen J, Pattanapanyasat K, Ansari AA
Cellular immunology263(2)176-87(2010)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Title: KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.

In the Indian population, two different KIR2DL4 entities are encountered, which differ in their intra-cellular signalling motifs. One genotype contains a complex mutation in the distal region of exon 9, which negates a serine/threonine kinase site.
Title: Evidence for balancing selection acting on KIR2DL4 genotypes in rhesus macaques of Indian origin.

The following KIR2DL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KIR2DL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb24106	NM_001042661.1 Latest version!	Macaca mulatta killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OMb75628	XM_028838563.1 Latest version!	Macaca mulatta killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KIR2DL4 ( NM_001042661.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001036126.1 Macaca mulatta killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), mRNA.

Price & Availability↑

CloneID	OMb24106
Clone ID Related Accession (Same CDS sequence)	NM_001042661.1
Accession Version	NM_001042661.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1128bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-27
Organism	Macaca mulatta(Rhesus monkey)
Product	killer cell immunoglobulin-like receptor 2DL4 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF361088.1. On Aug 5, 2006 this sequence version replaced XM_001118880.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF361088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688397, SAMN10394827 [ECO:0000348] ##Evidence-Data-END##

ATGTCGCCCA CGGTCGTCAT CCTGGCCTGT CTTGGGTTCT TCTTGGACCA GAGGGTGCGG 
GCACACGTGG GTGGTCAGGA CAAGCCCTTC TGCTCTGCCT GGCCCAGCGC TGTGGTGCCT 
CAGGGAGGAC ACGTGACTCT TTGGTGTCAC TATCGTCCTG GGTTTAACAT CTTCACGCTG 
TACAAGGAAG ACGGGGTGCC TGTCCCTGAG CTCTACAAAA GAATATTCTG GAACAGTTTC 
CTCATTAGCC CTGTGACTGC AGCACATGCA GGGACCTACA GATGTCGAGT TTTTCATCCG 
CACTCCCCCA CTGAGTGGTC GGCACCCAGC AACCCCCTGG TGATCATGGT CACAGGTCTA 
TATGAGAAAC CTTCTCTCTC AGCCCAGCCG GGCCCCACGG TTCCCACAGG AGAGAACATG 
ACCTTGTCCT GCAGTTCCCG GCGCTCCTTT GACATGTACC ATCTATCCAG GGAGGGGGAG 
GCCCATGAAC TTAGGCTCCC TGCAGTGCCG AGCGTCAATG GAACATTCCA GGCTGACTTC 
CCTCTGGGCC CTGCCACCCA CGGAGGGAAC TACAGATGCT TCGGCTCTCT CCGTGACTCT 
CCCTACGAGT GGTCAGACCC AAGTGACCCA CTGCCCGTTT CTGTCACAGG AAACCCTTCA 
AGTAGTTGGC CTTCACCCAC TGAACCAAGC TTCAAAACTG GTATCGTCAC ACACCTGCCT 
GCTGTGATTA GGTACTCGGT GGCCACCATC TTCCTCACCA TCCTCCTCTT CTTTCTCCAT 
CGTTGCTGGT GCTCCGACAA AAAGAATGCT GCTGTAATGG ACCCAGAGCC TGCGGGGGAC 
AGAACAGTCA ACAGGGAGGA CCCTGATGAA CAAGACCCTC AGGAGGTGAC ATACACACAG 
TTGGATCACT GCGTTTTCAC ACGGGGAAAA ATCACTCGCC CTTCTCAGAG GCCCAAGACA 
CCCCCAACAG ATACCAGCGT GTACATAGAA CTTCCAAATG CTGAGCCCAG ATTGTTGTCT 
CCTGCCCACG AGCACCACAG ACAGGCCTGG AAGGGGTCTT CTATGGAGAC CACAGCCCTG 
TCTCAAAACC GGCTTCACAG CTCCAATGTA CCAGCAGTTG GAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001036126.1
CDS	39..1166
Translation	MSPTVVILACLGFFLDQRVRAHVGGQDKPFCSAWPSAVVPQGGHVTLWCHYRPGFNIFTLYKEDGVPVPELYKRIFWNSFLISPVTAAHAGTYRCRVFHPHSPTEWSAPSNPLVIMVTGLYEKPSLSAQPGPTVPTGENMTLSCSSRRSFDMYHLSREGEAHELRLPAVPSVNGTFQADFPLGPATHGGNYRCFGSLRDSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIVTHLPAVIRYSVATIFLTILLFFLHRCWCSDKKNAAVMDPEPAGDRTVNREDPDEQDPQEVTYTQLDHCVFTRGKITRPSQRPKTPPTDTSVYIELPNAEPRLLSPAHEHHRQAWKGSSMETTALSQNRLHSSNVPAVGI

Target ORF information:

RefSeq Version	NM_001042661.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001042661.1

ORF Insert Sequence:

ATGTCGCCCA CGGTCGTCAT CCTGGCCTGT CTTGGGTTCT TCTTGGACCA GAGGGTGCGG 
GCACACGTGG GTGGTCAGGA CAAGCCCTTC TGCTCTGCCT GGCCCAGCGC TGTGGTGCCT 
CAGGGAGGAC ACGTGACTCT TTGGTGTCAC TATCGTCCTG GGTTTAACAT CTTCACGCTG 
TACAAGGAAG ACGGGGTGCC TGTCCCTGAG CTCTACAAAA GAATATTCTG GAACAGTTTC 
CTCATTAGCC CTGTGACTGC AGCACATGCA GGGACCTACA GATGTCGAGT TTTTCATCCG 
CACTCCCCCA CTGAGTGGTC GGCACCCAGC AACCCCCTGG TGATCATGGT CACAGGTCTA 
TATGAGAAAC CTTCTCTCTC AGCCCAGCCG GGCCCCACGG TTCCCACAGG AGAGAACATG 
ACCTTGTCCT GCAGTTCCCG GCGCTCCTTT GACATGTACC ATCTATCCAG GGAGGGGGAG 
GCCCATGAAC TTAGGCTCCC TGCAGTGCCG AGCGTCAATG GAACATTCCA GGCTGACTTC 
CCTCTGGGCC CTGCCACCCA CGGAGGGAAC TACAGATGCT TCGGCTCTCT CCGTGACTCT 
CCCTACGAGT GGTCAGACCC AAGTGACCCA CTGCCCGTTT CTGTCACAGG AAACCCTTCA 
AGTAGTTGGC CTTCACCCAC TGAACCAAGC TTCAAAACTG GTATCGTCAC ACACCTGCCT 
GCTGTGATTA GGTACTCGGT GGCCACCATC TTCCTCACCA TCCTCCTCTT CTTTCTCCAT 
CGTTGCTGGT GCTCCGACAA AAAGAATGCT GCTGTAATGG ACCCAGAGCC TGCGGGGGAC 
AGAACAGTCA ACAGGGAGGA CCCTGATGAA CAAGACCCTC AGGAGGTGAC ATACACACAG 
TTGGATCACT GCGTTTTCAC ACGGGGAAAA ATCACTCGCC CTTCTCAGAG GCCCAAGACA 
CCCCCAACAG ATACCAGCGT GTACATAGAA CTTCCAAATG CTGAGCCCAG ATTGTTGTCT 
CCTGCCCACG AGCACCACAG ACAGGCCTGG AAGGGGTCTT CTATGGAGAC CACAGCCCTG 
TCTCAAAACC GGCTTCACAG CTCCAATGTA CCAGCAGTTG GAATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KIR2DL4 ( XM_028838563.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> XP_028694396.1 Macaca mulatta killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMb75628
Clone ID Related Accession (Same CDS sequence)	XM_028838563.1
Accession Version	XM_028838563.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1227bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-25
Organism	Macaca mulatta(Rhesus monkey)
Product	killer cell immunoglobulin-like receptor 2DL4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_041772.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Macaca mulatta Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGCCCA CGGTCGTCAT CCTGGCCTGT CTTGGGTTCT TCTTGGACCA GAGGGTGCGG 
GCACACGTGG GTGGTCAGGA CAAGCCCTTC TGCTCTGCCT GGCCCAGCGC TGTGGTGCCT 
CAGGGAGGAC ACGTGACTCT TTGGTGTCAC TATCGTCCTG GGTTTAACAT CTTCACGCTG 
TACAAGGAAG ACGGGGTGCC TGTCCCTGAG CTCTACAAAA GAATATTCTG GAACAGTTTC 
CTCATTAGCC CTGTGACTGC AGCACATGCA GGGACCTACA GATGTCGAGT TTTTCATCCG 
CACTCCCCCA CTGAGTGGTC GGCACCCAGC AACCCCCTGG TGATCATGGT CACAGGTCTA 
TATGAGAAAC CTTCTCTCTC AGCCCAGCCG GGCCCCACGG TTCCCACAGG AGAGAACATG 
ACCTTGTCCT GCAGTTCCCG GCGCTCCTTT GACATGTACC ATCTATCCAG GGAGGGGGAG 
GCCCATGAAC TTAGGCTCCC TGCAGTGCCG AGCGTCAATG GAACATTCCA GGCTGACTTC 
CCTCTGGGCC CTGCCACCCA CGGAGGGAAC TACAGATGCT TCGGCTCTCT CCGTGACTCT 
CCCTACGAGT GGTCAGACCC AAGTGACCCA CTGCCCGTTT CTGTCACAGG AAACCCTTCA 
AGTAGTTGGC CTTCACCCAC TGAACCAAGC TTCAAAACTG GTATCGTCAC ACACCTGCCT 
GCTGTGATTA GGTACTCGGT GGCCACCATC TTCCTCACCA TCCTCCTCTT CTTTCTCCAT 
CGTTGCTGGT GCTCCGACAA AAAGAATGCT GCTGTAATGG ACCCAGAGCC TGCGGGGGAC 
AGAACAGTCA ACAGGGAGGT AGGCCCTCCT CTCCCCAGCC TCATGGATAT ATTCTTATTC 
CCTACTAGTC CTGAAGAATG TGAGCCCCTC CCTCACTCAA CATTTCCCTC TCTCCAGGAC 
CCTGATGAAC AAGACCCTCA GGAGGTGACA TACACACAGT TGGATCACTG CGTTTTCACA 
CGGGGAAAAA TCACTCGCCC TTCTCAGAGG CCCAAGACAC CCCCAACAGA TACCAGCGTG 
TACATAGAAC TTCCAAATGC TGAGCCCAGA TTGTTGTCTC CTGCCCACGA GCACCACAGA 
CAGGCCTGGA AGGGGTCTTC TATGGAGACC ACAGCCCTGT CTCAAAACCG GCTTCACAGC 
TCCAATGTAC CAGCAGTTGG AATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_028694396.1
CDS	288..1514
Translation	MSPTVVILACLGFFLDQRVRAHVGGQDKPFCSAWPSAVVPQGGHVTLWCHYRPGFNIFTLYKEDGVPVPELYKRIFWNSFLISPVTAAHAGTYRCRVFHPHSPTEWSAPSNPLVIMVTGLYEKPSLSAQPGPTVPTGENMTLSCSSRRSFDMYHLSREGEAHELRLPAVPSVNGTFQADFPLGPATHGGNYRCFGSLRDSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIVTHLPAVIRYSVATIFLTILLFFLHRCWCSDKKNAAVMDPEPAGDRTVNREVGPPLPSLMDIFLFPTSPEECEPLPHSTFPSLQDPDEQDPQEVTYTQLDHCVFTRGKITRPSQRPKTPPTDTSVYIELPNAEPRLLSPAHEHHRQAWKGSSMETTALSQNRLHSSNVPAVGI

Target ORF information:

RefSeq Version	XM_028838563.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4 (KIR2DL4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_028838563.1

ORF Insert Sequence:

ATGTCGCCCA CGGTCGTCAT CCTGGCCTGT CTTGGGTTCT TCTTGGACCA GAGGGTGCGG 
GCACACGTGG GTGGTCAGGA CAAGCCCTTC TGCTCTGCCT GGCCCAGCGC TGTGGTGCCT 
CAGGGAGGAC ACGTGACTCT TTGGTGTCAC TATCGTCCTG GGTTTAACAT CTTCACGCTG 
TACAAGGAAG ACGGGGTGCC TGTCCCTGAG CTCTACAAAA GAATATTCTG GAACAGTTTC 
CTCATTAGCC CTGTGACTGC AGCACATGCA GGGACCTACA GATGTCGAGT TTTTCATCCG 
CACTCCCCCA CTGAGTGGTC GGCACCCAGC AACCCCCTGG TGATCATGGT CACAGGTCTA 
TATGAGAAAC CTTCTCTCTC AGCCCAGCCG GGCCCCACGG TTCCCACAGG AGAGAACATG 
ACCTTGTCCT GCAGTTCCCG GCGCTCCTTT GACATGTACC ATCTATCCAG GGAGGGGGAG 
GCCCATGAAC TTAGGCTCCC TGCAGTGCCG AGCGTCAATG GAACATTCCA GGCTGACTTC 
CCTCTGGGCC CTGCCACCCA CGGAGGGAAC TACAGATGCT TCGGCTCTCT CCGTGACTCT 
CCCTACGAGT GGTCAGACCC AAGTGACCCA CTGCCCGTTT CTGTCACAGG AAACCCTTCA 
AGTAGTTGGC CTTCACCCAC TGAACCAAGC TTCAAAACTG GTATCGTCAC ACACCTGCCT 
GCTGTGATTA GGTACTCGGT GGCCACCATC TTCCTCACCA TCCTCCTCTT CTTTCTCCAT 
CGTTGCTGGT GCTCCGACAA AAAGAATGCT GCTGTAATGG ACCCAGAGCC TGCGGGGGAC 
AGAACAGTCA ACAGGGAGGT AGGCCCTCCT CTCCCCAGCC TCATGGATAT ATTCTTATTC 
CCTACTAGTC CTGAAGAATG TGAGCCCCTC CCTCACTCAA CATTTCCCTC TCTCCAGGAC 
CCTGATGAAC AAGACCCTCA GGAGGTGACA TACACACAGT TGGATCACTG CGTTTTCACA 
CGGGGAAAAA TCACTCGCCC TTCTCAGAGG CCCAAGACAC CCCCAACAGA TACCAGCGTG 
TACATAGAAC TTCCAAATGC TGAGCCCAGA TTGTTGTCTC CTGCCCACGA GCACCACAGA 
CAGGCCTGGA AGGGGTCTTC TATGGAGACC ACAGCCCTGT CTCAAAACCG GCTTCACAGC 
TCCAATGTAC CAGCAGTTGG AATCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

KIR3DL01 upregulation on gut natural killer cells in response to SIV infection of KIR- and MHC class I-defined rhesus macaques.
PLoS pathogens13(7)e1006506(2017 Jul)
Ries M,Reynolds MR,Bashkueva K,Crosno K,Capuano S 3rd,Prall TM,Wiseman R,O'Connor DH,Rakasz EG,Uno H,Lifson JD,Evans DT

KIR2DL4 copy number variation is associated with CD4+ T-cell depletion and function of cytokine-producing NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.
Journal of virology87(9)5305-10(2013 May)
Hellmann I,Letvin NL,Schmitz JE

KIR polymorphisms modulate peptide-dependent binding to an MHC class I ligand with a Bw6 motif.
PLoS pathogens7(3)e1001316(2011 Mar)
Colantonio AD,Bimber BN,Neidermyer WJ Jr,Reeves RK,Alter G,Altfeld M,Johnson RP,Carrington M,O'Connor DH,Evans DT

The mosaic of KIR haplotypes in rhesus macaques.
Immunogenetics62(5)295-306(2010 May)
Blokhuis JH,van der Wiel MK,Doxiadis GG,Bontrop RE

Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques.
Cellular immunology263(2)176-87(2010)
Chaichompoo P,Bostik P,Stephenson S,Udompunturuk S,Kobkitjaroen J,Pattanapanyasat K,Ansari AA

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KIR2DL4 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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