KCNH1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNH1
Entrez Gene ID	3756
Full Name	potassium voltage-gated channel subfamily H member 1
Synonyms	EAG,EAG1,Kv10.1,TMBTS,ZLS1,h-eag,hEAG1
General protein information	Preferred Names potassium voltage-gated channel subfamily H member 1 Names potassium voltage-gated channel subfamily H member 1 EAG channel 1 ether-a-go-go potassium channel 1 ether-a-go-go, Drosophila, homolog of potassium channel, voltage gated eag related subfamily H, member 1 potassium voltage-gated channel, subfamily H (eag-related), member 1 voltage-gated potassium channel subunit Kv10.1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q32.2
Summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Disorder MIM:	603305
Disorder Html:	Temple-Baraitser syndrome, 611816 (3); Zimmermann-Laband syndrome 1, 135500 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_172362.3	NP_758872.1	potassium voltage-gated channel subfamily H member 1 isoform 1
NM_002238.4	NP_002229.1	potassium voltage-gated channel subfamily H member 1 isoform 2
NM_172362.2	NP_758872.1	potassium voltage-gated channel subfamily H member 1 isoform 1
NM_002238.3	NP_002229.1	potassium voltage-gated channel subfamily H member 1 isoform 2
XM_017001246.1	XP_016856735.1	potassium voltage-gated channel subfamily H member 1 isoform X1

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcnh1	NP_113930.1
Xenopus tropicalis (tropical clawed frog)	kcnh1	XP_002934755.2
Canis lupus familiaris (dog)	LOC490277	XP_005623012.1
Mus musculus (house mouse)	Kcnh1	NP_001033696.1
Gallus gallus (chicken)	KCNH1	XP_419440.4
Homo sapiens (human)	KCNH1	NP_758872.1
Pan troglodytes (chimpanzee)	KCNH1	XP_001169423.2
	KCNH1	XP_001109251.1
Danio rerio (zebrafish)	kcnh1b	NP_001265743.1
Bos taurus (cattle)	KCNH1	NP_776797.1
Danio rerio (zebrafish)	kcnh1a	NP_001038396.1
Oryza sativa (rice)	Os01g0756700	NP_001044290.1

Gene Ontology
Bibliography

Related articles in PubMed

Kv10.1 potassium channel: from the brain to the tumors.
C?zares-Ordo?ez V, Pardo LA
Biochemistry and cell biology = Biochimie et biologie cellulaire95(5)531-536(2017 Oct)

The electric fence to cell-cycle progression: Do local changes in membrane potential facilitate disassembly of the primary cilium?: Timely and localized expression of a potassium channel may set the conditions that allow retraction of the primary cilium.
Urrego D, S?nchez A, Tomczak AP, Pardo LA
BioEssays : news and reviews in molecular, cellular and developmental biology39(6)(2017 Jun)

The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression.
Becchetti A, Crescioli S, Zanieri F, Petroni G, Mercatelli R, Coppola S, Gasparoli L, D'Amico M, Pillozzi S, Crociani O, Stefanini M, Fiore A, Carraresi L, Morello V, Manoli S, Brizzi MF, Ricci D, Rinaldi M, Masi A, Schmidt T, Quercioli F, Defilippi P, Arcangeli A
Science signaling10(473)(2017 Apr)

The involvement of Eag1 potassium channels and miR-34a in rotenone-induced death of dopaminergic SH-SY5Y cells.
Horst CH, Titze-de-Almeida R, Titze-de-Almeida SS
Molecular medicine reports15(4)1479-1488(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

REVIEW: Kv10.1 potassium channel: role from the brain to the tumors
Title: Kv10.1 potassium channel: from the brain to the tumors.

Data show that the interaction of beta1 integrins with hERG1 channels in cancer cells stimulated distinct signaling pathways that depended on the conformational state of hERG1 and affected different aspects of tumor progression.
Title: The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression.

Eag1 potassium channels and miR34a are involved in the response to rotenone-induced injury in SHSY5Y cells.
Title: The involvement of Eag1 potassium channels and miR-34a in rotenone-induced death of dopaminergic SH-SY5Y cells.

Simulations with the inactivation-enhancing mutant Y464A or Na(+) ions lead to trapped water molecules behind the SF, suggesting that these simulations captured early conformational changes linked to C-type inactivation
Title: Dynamics of the EAG1 K

Structural, biochemical, and functional analysis of the calmodulin (CaM) binding sites within the EAG1 channel suggests that the molecular change induced by CaM and underlying channel inhibition occurs locally.
Title: Molecular Insights into the Mechanism of Calmodulin Inhibition of the EAG1 Potassium Channel.

The following KCNH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26359	NM_002238.4 Latest version!	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu58567	XM_017001246.1 Latest version!	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OHu26729	NM_172362.3 Latest version!	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$657.30 $939.00
View Old Accession Versions >>
OHu26729	NM_172362.2	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$657.30 $939.00
OHu26359	NM_002238.3	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNH1 ( NM_002238.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002229.1 Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26359
Clone ID Related Accession (Same CDS sequence)	NM_002238.4 , NM_002238.3
Accession Version	NM_002238.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2889bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-27
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092017.2, AJ001366.1, AF078741.1 and AC096636.1. On Jun 1, 2019 this sequence version replaced NM_002238.3. Transcript Variant: This variant (2), also known as eag, lacks an alternate in-frame segment, as compared to variant 1. It encodes isoform 2, which is shorter but has the same N- and C-termini as isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.236761.1, AJ001366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATGG CTGGGGGCAG GAGGGGACTA GTGGCCCCTC AAAACACGTT TCTGGAGAAT 
ATTGTTCGGC GGTCCAATGA TACTAATTTT GTGTTGGGGA ATGCTCAGAT AGTGGACTGG 
CCTATTGTGT ACAGCAATGA TGGATTTTGC AAGCTGTCTG GCTATCACAG GGCAGAAGTG 
ATGCAAAAAA GCAGCACCTG CAGTTTTATG TATGGGGAGC TGACTGATAA AGACACGATT 
GAAAAAGTGC GGCAAACATT TGAGAACTAT GAGATGAATT CCTTTGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTCTTT GTGAAAATTG CTCCAATTCG AAACGAACAG 
GATAAAGTGG TTTTATTTCT TTGCACTTTC AGTGACATAA CAGCTTTCAA ACAGCCAATT 
GAGGATGATT CATGTAAAGG CTGGGGGAAG TTTGCTCGGC TGACAAGAGC ACTGACAAGC 
AGCAGGGGTG TCCTGCAGCA GCTGGCTCCA AGCGTGCAAA AAGGCGAGAA TGTCCACAAG 
CACTCCCGCC TGGCAGAGGT CCTACAGCTG GGCTCAGACA TCCTTCCCCA GTACAAGCAA 
GAGGCACCAA AGACTCCCCC TCACATCATC TTACATTATT GTGTTTTTAA GACCACGTGG 
GATTGGATCA TCTTGATCTT GACCTTCTAT ACAGCCATCT TGGTCCCTTA TAATGTCTCC 
TTCAAAACCA GGCAGAATAA TGTGGCCTGG CTGGTTGTTG ATAGCATCGT GGATGTTATC 
TTTTTGGTGG ACATTGTGCT CAATTTTCAT ACCACCTTTG TTGGACCAGC AGGGGAGGTG 
ATTTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATTGACCTT 
CTGTCCTGTT TGCCATATGA TGTCATCAAC GCTTTTGAGA ACGTGGATGA GGGCATCAGC 
AGCCTGTTCA GCTCTCTAAA AGTTGTCCGG CTGCTCCGTC TTGGGCGAGT GGCCCGTAAG 
CTGGACCACT ACATTGAATA TGGAGCTGCT GTGCTGGTCC TGCTGGTGTG TGTGTTTGGG 
CTGGCTGCAC ACTGGATGGC CTGCATCTGG TACAGCATTG GGGACTATGA GATCTTTGAC 
GAGGACACCA AGACAATCCG CAACAACAGC TGGCTGTACC AACTAGCGAT GGACATTGGC 
ACCCCTTACC AGTTTAATGG GTCTGGCTCA GGGAAGTGGG AAGGTGGTCC CAGCAAGAAT 
TCTGTCTACA TCTCCTCGTT GTATTTCACA ATGACCAGCC TCACCAGTGT GGGCTTTGGG 
AACATCGCCC CATCCACAGA CATTGAGAAG ATCTTTGCAG TGGCCATCAT GATGATTGGC 
TCACTTCTCT ATGCCACCAT CTTCGGGAAT GTGACGACTA TTTTCCAACA GATGTATGCC 
AACACCAACA GATACCATGA GATGCTCAAC AGTGTTCGGG ACTTCCTGAA GCTCTACCAG 
GTGCCAAAAG GATTGAGTGA GCGAGTAATG GATTATATTG TGTCCACTTG GTCCATGTCC 
AGAGGCATTG ACACAGAGAA GGTCCTGCAG ATCTGCCCCA AGGACATGAG AGCCGACATC 
TGCGTGCACC TGAACCGCAA GGTGTTCAAG GAGCACCCGG CCTTCCGGCT GGCCAGTGAT 
GGCTGCCTCC GGGCACTGGC CATGGAGTTC CAGACGGTGC ACTGTGCCCC AGGGGACCTC 
ATCTACCATG CAGGAGAGAG CGTTGACAGC CTCTGCTTTG TGGTTTCTGG CTCCCTGGAG 
GTGATCCAAG ATGATGAGGT GGTGGCCATT CTAGGAAAAG GAGACGTGTT TGGAGATGTG 
TTCTGGAAGG AAGCCACCCT TGCCCAGTCC TGTGCCAATG TTAGGGCCTT GACCTACTGT 
GATCTGCATG TGATCAAGCG GGATGCCCTG CAGAAAGTGC TGGAATTCTA CACGGCCTTC 
TCCCATTCCT TCTCCCGGAA CCTGATTCTG ACGTACAACT TGAGGAAGAG GATTGTGTTC 
CGGAAGATCA GCGATGTGAA ACGTGAAGAG GAAGAACGCA TGAAACGAAA GAATGAGGCC 
CCCCTGATCT TGCCCCCGGA CCACCCTGTC CGGCGCCTCT TCCAGAGATT CCGACAGCAG 
AAAGAGGCCA GGCTGGCAGC TGAGAGAGGG GGCCGGGACC TGGATGACCT AGATGTGGAG 
AAGGGCAATG TCCTTACAGA GCATGCCTCC GCCAACCACA GCCTCGTGAA GGCCAGCGTG 
GTCACCGTGC GTGAGAGTCC TGCCACGCCC GTATCCTTCC AGGCAGCCTC CACCTCCGGG 
GTGCCAGACC ACGCAAAGCT ACAGGCGCCA GGGTCCGAGT GCCTGGGCCC CAAGGGGGGC 
GGGGGCGATT GTGCCAAGCG CAAAAGCTGG GCCCGCTTCA AAGATGCTTG CGGGAAGAGT 
GAGGACTGGA ACAAGGTGTC CAAGGCTGAG TCGATGGAGA CACTTCCCGA GAGGACAAAA 
GCGTCAGGCG AGGCCACACT GAAGAAGACA GACTCGTGTG ACAGTGGCAT CACCAAGAGC 
GACTTGCGCC TGGACAACGT GGGTGAGGCC AGGAGTCCCC AGGATCGGAG TCCCATCCTG 
GCAGAGGTCA AGCATTCGTT CTACCCCATC CCTGAGCAGA CGCTGCAGGC CACAGTCCTG 
GAGGTGAGGC ACGAGCTGAA GGAGGACATC AAGGCCTTAA ACGCCAAAAT GACCAATATT 
GAGAAACAGC TCTCTGAGAT ACTCAGGATA TTAACTTCCA GAAGATCCTC TCAGTCTCCT 
CAGGAGTTGT TTGAAATATC GAGGCCACAG TCCCCAGAAT CAGAGAGAGA CATTTTTGGA 
GCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002229.1
CDS	204..3092
Translation	MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS

Target ORF information:

RefSeq Version	NM_002238.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002238.4

ORF Insert Sequence:

ATGACCATGG CTGGGGGCAG GAGGGGACTA GTGGCCCCTC AAAACACGTT TCTGGAGAAT 
ATTGTTCGGC GGTCCAATGA TACTAATTTT GTGTTGGGGA ATGCTCAGAT AGTGGACTGG 
CCTATTGTGT ACAGCAATGA TGGATTTTGC AAGCTGTCTG GCTATCACAG GGCAGAAGTG 
ATGCAAAAAA GCAGCACCTG CAGTTTTATG TATGGGGAGC TGACTGATAA AGACACGATT 
GAAAAAGTGC GGCAAACATT TGAGAACTAT GAGATGAATT CCTTTGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTCTTT GTGAAAATTG CTCCAATTCG AAACGAACAG 
GATAAAGTGG TTTTATTTCT TTGCACTTTC AGTGACATAA CAGCTTTCAA ACAGCCAATT 
GAGGATGATT CATGTAAAGG CTGGGGGAAG TTTGCTCGGC TGACAAGAGC ACTGACAAGC 
AGCAGGGGTG TCCTGCAGCA GCTGGCTCCA AGCGTGCAAA AAGGCGAGAA TGTCCACAAG 
CACTCCCGCC TGGCAGAGGT CCTACAGCTG GGCTCAGACA TCCTTCCCCA GTACAAGCAA 
GAGGCACCAA AGACTCCCCC TCACATCATC TTACATTATT GTGTTTTTAA GACCACGTGG 
GATTGGATCA TCTTGATCTT GACCTTCTAT ACAGCCATCT TGGTCCCTTA TAATGTCTCC 
TTCAAAACCA GGCAGAATAA TGTGGCCTGG CTGGTTGTTG ATAGCATCGT GGATGTTATC 
TTTTTGGTGG ACATTGTGCT CAATTTTCAT ACCACCTTTG TTGGACCAGC AGGGGAGGTG 
ATTTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATTGACCTT 
CTGTCCTGTT TGCCATATGA TGTCATCAAC GCTTTTGAGA ACGTGGATGA GGGCATCAGC 
AGCCTGTTCA GCTCTCTAAA AGTTGTCCGG CTGCTCCGTC TTGGGCGAGT GGCCCGTAAG 
CTGGACCACT ACATTGAATA TGGAGCTGCT GTGCTGGTCC TGCTGGTGTG TGTGTTTGGG 
CTGGCTGCAC ACTGGATGGC CTGCATCTGG TACAGCATTG GGGACTATGA GATCTTTGAC 
GAGGACACCA AGACAATCCG CAACAACAGC TGGCTGTACC AACTAGCGAT GGACATTGGC 
ACCCCTTACC AGTTTAATGG GTCTGGCTCA GGGAAGTGGG AAGGTGGTCC CAGCAAGAAT 
TCTGTCTACA TCTCCTCGTT GTATTTCACA ATGACCAGCC TCACCAGTGT GGGCTTTGGG 
AACATCGCCC CATCCACAGA CATTGAGAAG ATCTTTGCAG TGGCCATCAT GATGATTGGC 
TCACTTCTCT ATGCCACCAT CTTCGGGAAT GTGACGACTA TTTTCCAACA GATGTATGCC 
AACACCAACA GATACCATGA GATGCTCAAC AGTGTTCGGG ACTTCCTGAA GCTCTACCAG 
GTGCCAAAAG GATTGAGTGA GCGAGTAATG GATTATATTG TGTCCACTTG GTCCATGTCC 
AGAGGCATTG ACACAGAGAA GGTCCTGCAG ATCTGCCCCA AGGACATGAG AGCCGACATC 
TGCGTGCACC TGAACCGCAA GGTGTTCAAG GAGCACCCGG CCTTCCGGCT GGCCAGTGAT 
GGCTGCCTCC GGGCACTGGC CATGGAGTTC CAGACGGTGC ACTGTGCCCC AGGGGACCTC 
ATCTACCATG CAGGAGAGAG CGTTGACAGC CTCTGCTTTG TGGTTTCTGG CTCCCTGGAG 
GTGATCCAAG ATGATGAGGT GGTGGCCATT CTAGGAAAAG GAGACGTGTT TGGAGATGTG 
TTCTGGAAGG AAGCCACCCT TGCCCAGTCC TGTGCCAATG TTAGGGCCTT GACCTACTGT 
GATCTGCATG TGATCAAGCG GGATGCCCTG CAGAAAGTGC TGGAATTCTA CACGGCCTTC 
TCCCATTCCT TCTCCCGGAA CCTGATTCTG ACGTACAACT TGAGGAAGAG GATTGTGTTC 
CGGAAGATCA GCGATGTGAA ACGTGAAGAG GAAGAACGCA TGAAACGAAA GAATGAGGCC 
CCCCTGATCT TGCCCCCGGA CCACCCTGTC CGGCGCCTCT TCCAGAGATT CCGACAGCAG 
AAAGAGGCCA GGCTGGCAGC TGAGAGAGGG GGCCGGGACC TGGATGACCT AGATGTGGAG 
AAGGGCAATG TCCTTACAGA GCATGCCTCC GCCAACCACA GCCTCGTGAA GGCCAGCGTG 
GTCACCGTGC GTGAGAGTCC TGCCACGCCC GTATCCTTCC AGGCAGCCTC CACCTCCGGG 
GTGCCAGACC ACGCAAAGCT ACAGGCGCCA GGGTCCGAGT GCCTGGGCCC CAAGGGGGGC 
GGGGGCGATT GTGCCAAGCG CAAAAGCTGG GCCCGCTTCA AAGATGCTTG CGGGAAGAGT 
GAGGACTGGA ACAAGGTGTC CAAGGCTGAG TCGATGGAGA CACTTCCCGA GAGGACAAAA 
GCGTCAGGCG AGGCCACACT GAAGAAGACA GACTCGTGTG ACAGTGGCAT CACCAAGAGC 
GACTTGCGCC TGGACAACGT GGGTGAGGCC AGGAGTCCCC AGGATCGGAG TCCCATCCTG 
GCAGAGGTCA AGCATTCGTT CTACCCCATC CCTGAGCAGA CGCTGCAGGC CACAGTCCTG 
GAGGTGAGGC ACGAGCTGAA GGAGGACATC AAGGCCTTAA ACGCCAAAAT GACCAATATT 
GAGAAACAGC TCTCTGAGAT ACTCAGGATA TTAACTTCCA GAAGATCCTC TCAGTCTCCT 
CAGGAGTTGT TTGAAATATC GAGGCCACAG TCCCCAGAAT CAGAGAGAGA CATTTTTGGA 
GCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNH1 ( NM_002238.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_002229.1 Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu26359
Clone ID Related Accession (Same CDS sequence)	NM_002238.4 , NM_002238.3
Accession Version	NM_002238.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2889bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-01-20
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ001366.1, AF078741.1 and AC096636.1. On Jul 16, 2008 this sequence version replaced NM_002238.2. Transcript Variant: This variant (2), also known as eag, lacks an alternate in-frame segment, as compared to variant 1. It encodes isoform 2, which is shorter but has the same N- and C-termini as isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ001366.1, SRR1803615.236761.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATGG CTGGGGGCAG GAGGGGACTA GTGGCCCCTC AAAACACGTT TCTGGAGAAT 
ATTGTTCGGC GGTCCAATGA TACTAATTTT GTGTTGGGGA ATGCTCAGAT AGTGGACTGG 
CCTATTGTGT ACAGCAATGA TGGATTTTGC AAGCTGTCTG GCTATCACAG GGCAGAAGTG 
ATGCAAAAAA GCAGCACCTG CAGTTTTATG TATGGGGAGC TGACTGATAA AGACACGATT 
GAAAAAGTGC GGCAAACATT TGAGAACTAT GAGATGAATT CCTTTGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTCTTT GTGAAAATTG CTCCAATTCG AAACGAACAG 
GATAAAGTGG TTTTATTTCT TTGCACTTTC AGTGACATAA CAGCTTTCAA ACAGCCAATT 
GAGGATGATT CATGTAAAGG CTGGGGGAAG TTTGCTCGGC TGACAAGAGC ACTGACAAGC 
AGCAGGGGTG TCCTGCAGCA GCTGGCTCCA AGCGTGCAAA AAGGCGAGAA TGTCCACAAG 
CACTCCCGCC TGGCAGAGGT CCTACAGCTG GGCTCAGACA TCCTTCCCCA GTACAAGCAA 
GAGGCACCAA AGACTCCCCC TCACATCATC TTACATTATT GTGTTTTTAA GACCACGTGG 
GATTGGATCA TCTTGATCTT GACCTTCTAT ACAGCCATCT TGGTCCCTTA TAATGTCTCC 
TTCAAAACCA GGCAGAATAA TGTGGCCTGG CTGGTTGTTG ATAGCATCGT GGATGTTATC 
TTTTTGGTGG ACATTGTGCT CAATTTTCAT ACCACCTTTG TTGGACCAGC AGGGGAGGTG 
ATTTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATTGACCTT 
CTGTCCTGTT TGCCATATGA TGTCATCAAC GCTTTTGAGA ACGTGGATGA GGGCATCAGC 
AGCCTGTTCA GCTCTCTAAA AGTTGTCCGG CTGCTCCGTC TTGGGCGAGT GGCCCGTAAG 
CTGGACCACT ACATTGAATA TGGAGCTGCT GTGCTGGTCC TGCTGGTGTG TGTGTTTGGG 
CTGGCTGCAC ACTGGATGGC CTGCATCTGG TACAGCATTG GGGACTATGA GATCTTTGAC 
GAGGACACCA AGACAATCCG CAACAACAGC TGGCTGTACC AACTAGCGAT GGACATTGGC 
ACCCCTTACC AGTTTAATGG GTCTGGCTCA GGGAAGTGGG AAGGTGGTCC CAGCAAGAAT 
TCTGTCTACA TCTCCTCGTT GTATTTCACA ATGACCAGCC TCACCAGTGT GGGCTTTGGG 
AACATCGCCC CATCCACAGA CATTGAGAAG ATCTTTGCAG TGGCCATCAT GATGATTGGC 
TCACTTCTCT ATGCCACCAT CTTCGGGAAT GTGACGACTA TTTTCCAACA GATGTATGCC 
AACACCAACA GATACCATGA GATGCTCAAC AGTGTTCGGG ACTTCCTGAA GCTCTACCAG 
GTGCCAAAAG GATTGAGTGA GCGAGTAATG GATTATATTG TGTCCACTTG GTCCATGTCC 
AGAGGCATTG ACACAGAGAA GGTCCTGCAG ATCTGCCCCA AGGACATGAG AGCCGACATC 
TGCGTGCACC TGAACCGCAA GGTGTTCAAG GAGCACCCGG CCTTCCGGCT GGCCAGTGAT 
GGCTGCCTCC GGGCACTGGC CATGGAGTTC CAGACGGTGC ACTGTGCCCC AGGGGACCTC 
ATCTACCATG CAGGAGAGAG CGTTGACAGC CTCTGCTTTG TGGTTTCTGG CTCCCTGGAG 
GTGATCCAAG ATGATGAGGT GGTGGCCATT CTAGGAAAAG GAGACGTGTT TGGAGATGTG 
TTCTGGAAGG AAGCCACCCT TGCCCAGTCC TGTGCCAATG TTAGGGCCTT GACCTACTGT 
GATCTGCATG TGATCAAGCG GGATGCCCTG CAGAAAGTGC TGGAATTCTA CACGGCCTTC 
TCCCATTCCT TCTCCCGGAA CCTGATTCTG ACGTACAACT TGAGGAAGAG GATTGTGTTC 
CGGAAGATCA GCGATGTGAA ACGTGAAGAG GAAGAACGCA TGAAACGAAA GAATGAGGCC 
CCCCTGATCT TGCCCCCGGA CCACCCTGTC CGGCGCCTCT TCCAGAGATT CCGACAGCAG 
AAAGAGGCCA GGCTGGCAGC TGAGAGAGGG GGCCGGGACC TGGATGACCT AGATGTGGAG 
AAGGGCAATG TCCTTACAGA GCATGCCTCC GCCAACCACA GCCTCGTGAA GGCCAGCGTG 
GTCACCGTGC GTGAGAGTCC TGCCACGCCC GTATCCTTCC AGGCAGCCTC CACCTCCGGG 
GTGCCAGACC ACGCAAAGCT ACAGGCGCCA GGGTCCGAGT GCCTGGGCCC CAAGGGGGGC 
GGGGGCGATT GTGCCAAGCG CAAAAGCTGG GCCCGCTTCA AAGATGCTTG CGGGAAGAGT 
GAGGACTGGA ACAAGGTGTC CAAGGCTGAG TCGATGGAGA CACTTCCCGA GAGGACAAAA 
GCGTCAGGCG AGGCCACACT GAAGAAGACA GACTCGTGTG ACAGTGGCAT CACCAAGAGC 
GACTTGCGCC TGGACAACGT GGGTGAGGCC AGGAGTCCCC AGGATCGGAG TCCCATCCTG 
GCAGAGGTCA AGCATTCGTT CTACCCCATC CCTGAGCAGA CGCTGCAGGC CACAGTCCTG 
GAGGTGAGGC ACGAGCTGAA GGAGGACATC AAGGCCTTAA ACGCCAAAAT GACCAATATT 
GAGAAACAGC TCTCTGAGAT ACTCAGGATA TTAACTTCCA GAAGATCCTC TCAGTCTCCT 
CAGGAGTTGT TTGAAATATC GAGGCCACAG TCCCCAGAAT CAGAGAGAGA CATTTTTGGA 
GCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002229.1
CDS	171..3059
Translation	MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS

Target ORF information:

RefSeq Version	NM_002238.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002238.3

ORF Insert Sequence:

ATGACCATGG CTGGGGGCAG GAGGGGACTA GTGGCCCCTC AAAACACGTT TCTGGAGAAT 
ATTGTTCGGC GGTCCAATGA TACTAATTTT GTGTTGGGGA ATGCTCAGAT AGTGGACTGG 
CCTATTGTGT ACAGCAATGA TGGATTTTGC AAGCTGTCTG GCTATCACAG GGCAGAAGTG 
ATGCAAAAAA GCAGCACCTG CAGTTTTATG TATGGGGAGC TGACTGATAA AGACACGATT 
GAAAAAGTGC GGCAAACATT TGAGAACTAT GAGATGAATT CCTTTGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTCTTT GTGAAAATTG CTCCAATTCG AAACGAACAG 
GATAAAGTGG TTTTATTTCT TTGCACTTTC AGTGACATAA CAGCTTTCAA ACAGCCAATT 
GAGGATGATT CATGTAAAGG CTGGGGGAAG TTTGCTCGGC TGACAAGAGC ACTGACAAGC 
AGCAGGGGTG TCCTGCAGCA GCTGGCTCCA AGCGTGCAAA AAGGCGAGAA TGTCCACAAG 
CACTCCCGCC TGGCAGAGGT CCTACAGCTG GGCTCAGACA TCCTTCCCCA GTACAAGCAA 
GAGGCACCAA AGACTCCCCC TCACATCATC TTACATTATT GTGTTTTTAA GACCACGTGG 
GATTGGATCA TCTTGATCTT GACCTTCTAT ACAGCCATCT TGGTCCCTTA TAATGTCTCC 
TTCAAAACCA GGCAGAATAA TGTGGCCTGG CTGGTTGTTG ATAGCATCGT GGATGTTATC 
TTTTTGGTGG ACATTGTGCT CAATTTTCAT ACCACCTTTG TTGGACCAGC AGGGGAGGTG 
ATTTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATTGACCTT 
CTGTCCTGTT TGCCATATGA TGTCATCAAC GCTTTTGAGA ACGTGGATGA GGGCATCAGC 
AGCCTGTTCA GCTCTCTAAA AGTTGTCCGG CTGCTCCGTC TTGGGCGAGT GGCCCGTAAG 
CTGGACCACT ACATTGAATA TGGAGCTGCT GTGCTGGTCC TGCTGGTGTG TGTGTTTGGG 
CTGGCTGCAC ACTGGATGGC CTGCATCTGG TACAGCATTG GGGACTATGA GATCTTTGAC 
GAGGACACCA AGACAATCCG CAACAACAGC TGGCTGTACC AACTAGCGAT GGACATTGGC 
ACCCCTTACC AGTTTAATGG GTCTGGCTCA GGGAAGTGGG AAGGTGGTCC CAGCAAGAAT 
TCTGTCTACA TCTCCTCGTT GTATTTCACA ATGACCAGCC TCACCAGTGT GGGCTTTGGG 
AACATCGCCC CATCCACAGA CATTGAGAAG ATCTTTGCAG TGGCCATCAT GATGATTGGC 
TCACTTCTCT ATGCCACCAT CTTCGGGAAT GTGACGACTA TTTTCCAACA GATGTATGCC 
AACACCAACA GATACCATGA GATGCTCAAC AGTGTTCGGG ACTTCCTGAA GCTCTACCAG 
GTGCCAAAAG GATTGAGTGA GCGAGTAATG GATTATATTG TGTCCACTTG GTCCATGTCC 
AGAGGCATTG ACACAGAGAA GGTCCTGCAG ATCTGCCCCA AGGACATGAG AGCCGACATC 
TGCGTGCACC TGAACCGCAA GGTGTTCAAG GAGCACCCGG CCTTCCGGCT GGCCAGTGAT 
GGCTGCCTCC GGGCACTGGC CATGGAGTTC CAGACGGTGC ACTGTGCCCC AGGGGACCTC 
ATCTACCATG CAGGAGAGAG CGTTGACAGC CTCTGCTTTG TGGTTTCTGG CTCCCTGGAG 
GTGATCCAAG ATGATGAGGT GGTGGCCATT CTAGGAAAAG GAGACGTGTT TGGAGATGTG 
TTCTGGAAGG AAGCCACCCT TGCCCAGTCC TGTGCCAATG TTAGGGCCTT GACCTACTGT 
GATCTGCATG TGATCAAGCG GGATGCCCTG CAGAAAGTGC TGGAATTCTA CACGGCCTTC 
TCCCATTCCT TCTCCCGGAA CCTGATTCTG ACGTACAACT TGAGGAAGAG GATTGTGTTC 
CGGAAGATCA GCGATGTGAA ACGTGAAGAG GAAGAACGCA TGAAACGAAA GAATGAGGCC 
CCCCTGATCT TGCCCCCGGA CCACCCTGTC CGGCGCCTCT TCCAGAGATT CCGACAGCAG 
AAAGAGGCCA GGCTGGCAGC TGAGAGAGGG GGCCGGGACC TGGATGACCT AGATGTGGAG 
AAGGGCAATG TCCTTACAGA GCATGCCTCC GCCAACCACA GCCTCGTGAA GGCCAGCGTG 
GTCACCGTGC GTGAGAGTCC TGCCACGCCC GTATCCTTCC AGGCAGCCTC CACCTCCGGG 
GTGCCAGACC ACGCAAAGCT ACAGGCGCCA GGGTCCGAGT GCCTGGGCCC CAAGGGGGGC 
GGGGGCGATT GTGCCAAGCG CAAAAGCTGG GCCCGCTTCA AAGATGCTTG CGGGAAGAGT 
GAGGACTGGA ACAAGGTGTC CAAGGCTGAG TCGATGGAGA CACTTCCCGA GAGGACAAAA 
GCGTCAGGCG AGGCCACACT GAAGAAGACA GACTCGTGTG ACAGTGGCAT CACCAAGAGC 
GACTTGCGCC TGGACAACGT GGGTGAGGCC AGGAGTCCCC AGGATCGGAG TCCCATCCTG 
GCAGAGGTCA AGCATTCGTT CTACCCCATC CCTGAGCAGA CGCTGCAGGC CACAGTCCTG 
GAGGTGAGGC ACGAGCTGAA GGAGGACATC AAGGCCTTAA ACGCCAAAAT GACCAATATT 
GAGAAACAGC TCTCTGAGAT ACTCAGGATA TTAACTTCCA GAAGATCCTC TCAGTCTCCT 
CAGGAGTTGT TTGAAATATC GAGGCCACAG TCCCCAGAAT CAGAGAGAGA CATTTTTGGA 
GCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNH1 ( XM_017001246.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016856735.1 Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant X1, mRNA.

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CloneID	OHu58567
Clone ID Related Accession (Same CDS sequence)	XM_017001246.1
Accession Version	XM_017001246.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCCTGCA TCTGGTACAG CATTGGGGAC TATGAGATCT TTGACGAGGA CACCAAGACA 
ATCCGCAACA ACAGCTGGCT GTACCAACTA GCGATGGACA TTGGCACCCC TTACCAGTTT 
AATGGGTCTG GCTCAGGGAA GTGGGAAGGT GGTCCCAGCA AGAATTCTGT CTACATCTCC 
TCGTTGTATT TCACAATGAC CAGCCTCACC AGTGTGGGCT TTGGGAACAT CGCCCCATCC 
ACAGACATTG AGAAGATCTT TGCAGTGGCC ATCATGATGA TTGGCTCACT TCTCTATGCC 
ACCATCTTCG GGAATGTGAC GACTATTTTC CAACAGATGT ATGCCAACAC CAACAGATAC 
CATGAGATGC TCAACAGTGT TCGGGACTTC CTGAAGCTCT ACCAGGTGCC AAAAGGATTG 
AGTGAGCGAG TAATGGATTA TATTGTGTCC ACTTGGTCCA TGTCCAGAGG CATTGACACA 
GAGAAGGTCC TGCAGATCTG CCCCAAGGAC ATGAGAGCCG ACATCTGCGT GCACCTGAAC 
CGCAAGGTGT TCAAGGAGCA CCCGGCCTTC CGGCTGGCCA GTGATGGCTG CCTCCGGGCA 
CTGGCCATGG AGTTCCAGAC GGTGCACTGT GCCCCAGGGG ACCTCATCTA CCATGCAGGA 
GAGAGCGTTG ACAGCCTCTG CTTTGTGGTT TCTGGCTCCC TGGAGGTGAT CCAAGATGAT 
GAGGTGGTGG CCATTCTAGG AAAAGGAGAC GTGTTTGGAG ATGTGTTCTG GAAGGAAGCC 
ACCCTTGCCC AGTCCTGTGC CAATGTTAGG GCCTTGACCT ACTGTGATCT GCATGTGATC 
AAGCGGGATG CCCTGCAGAA AGTGCTGGAA TTCTACACGG CCTTCTCCCA TTCCTTCTCC 
CGGAACCTGA TTCTGACGTA CAACTTGAGG AAGAGGATTG TGTTCCGGAA GATCAGCGAT 
GTGAAACGTG AAGAGGAAGA ACGCATGAAA CGAAAGAATG AGGCCCCCCT GATCTTGCCC 
CCGGACCACC CTGTCCGGCG CCTCTTCCAG AGATTCCGAC AGCAGAAAGA GGCCAGGCTG 
GCAGCTGAGA GAGGGGGCCG GGACCTGGAT GACCTAGATG TGGAGAAGGG CAATGTCCTT 
ACAGAGCATG CCTCCGCCAA CCACAGCCTC GTGAAGGCCA GCGTGGTCAC CGTGCGTGAG 
AGTCCTGCCA CGCCCGTATC CTTCCAGGCA GCCTCCACCT CCGGGGTGCC AGACCACGCA 
AAGCTACAGG CGCCAGGGTC CGAGTGCCTG GGCCCCAAGG GGGGCGGGGG CGATTGTGCC 
AAGCGCAAAA GCTGGGCCCG CTTCAAAGAT GCTTGCGGGA AGAGTGAGGA CTGGAACAAG 
GTGTCCAAGG CTGAGTCGAT GGAGACACTT CCCGAGAGGA CAAAAGCGTC AGGCGAGGCC 
ACACTGAAGA AGACAGACTC GTGTGACAGT GGCATCACCA AGAGCGACTT GCGCCTGGAC 
AACGTGGGTG AGGCCAGGAG TCCCCAGGAT CGGAGTCCCA TCCTGGCAGA GGTCAAGCAT 
TCGTTCTACC CCATCCCTGA GCAGACGCTG CAGGCCACAG TCCTGGAGGT GAGGCACGAG 
CTGAAGGAGG ACATCAAGGC CTTAAACGCC AAAATGACCA ATATTGAGAA ACAGCTCTCT 
GAGATACTCA GGATATTAAC TTCCAGAAGA TCCTCTCAGT CTCCTCAGGA GTTGTTTGAA 
ATATCGAGGC CACAGTCCCC AGAATCAGAG AGAGACATTT TTGGAGCCAG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016856735.1
CDS	485..2278
Translation	MACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS

Target ORF information:

RefSeq Version	XM_017001246.1
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017001246.1

ORF Insert Sequence:

ATGGCCTGCA TCTGGTACAG CATTGGGGAC TATGAGATCT TTGACGAGGA CACCAAGACA 
ATCCGCAACA ACAGCTGGCT GTACCAACTA GCGATGGACA TTGGCACCCC TTACCAGTTT 
AATGGGTCTG GCTCAGGGAA GTGGGAAGGT GGTCCCAGCA AGAATTCTGT CTACATCTCC 
TCGTTGTATT TCACAATGAC CAGCCTCACC AGTGTGGGCT TTGGGAACAT CGCCCCATCC 
ACAGACATTG AGAAGATCTT TGCAGTGGCC ATCATGATGA TTGGCTCACT TCTCTATGCC 
ACCATCTTCG GGAATGTGAC GACTATTTTC CAACAGATGT ATGCCAACAC CAACAGATAC 
CATGAGATGC TCAACAGTGT TCGGGACTTC CTGAAGCTCT ACCAGGTGCC AAAAGGATTG 
AGTGAGCGAG TAATGGATTA TATTGTGTCC ACTTGGTCCA TGTCCAGAGG CATTGACACA 
GAGAAGGTCC TGCAGATCTG CCCCAAGGAC ATGAGAGCCG ACATCTGCGT GCACCTGAAC 
CGCAAGGTGT TCAAGGAGCA CCCGGCCTTC CGGCTGGCCA GTGATGGCTG CCTCCGGGCA 
CTGGCCATGG AGTTCCAGAC GGTGCACTGT GCCCCAGGGG ACCTCATCTA CCATGCAGGA 
GAGAGCGTTG ACAGCCTCTG CTTTGTGGTT TCTGGCTCCC TGGAGGTGAT CCAAGATGAT 
GAGGTGGTGG CCATTCTAGG AAAAGGAGAC GTGTTTGGAG ATGTGTTCTG GAAGGAAGCC 
ACCCTTGCCC AGTCCTGTGC CAATGTTAGG GCCTTGACCT ACTGTGATCT GCATGTGATC 
AAGCGGGATG CCCTGCAGAA AGTGCTGGAA TTCTACACGG CCTTCTCCCA TTCCTTCTCC 
CGGAACCTGA TTCTGACGTA CAACTTGAGG AAGAGGATTG TGTTCCGGAA GATCAGCGAT 
GTGAAACGTG AAGAGGAAGA ACGCATGAAA CGAAAGAATG AGGCCCCCCT GATCTTGCCC 
CCGGACCACC CTGTCCGGCG CCTCTTCCAG AGATTCCGAC AGCAGAAAGA GGCCAGGCTG 
GCAGCTGAGA GAGGGGGCCG GGACCTGGAT GACCTAGATG TGGAGAAGGG CAATGTCCTT 
ACAGAGCATG CCTCCGCCAA CCACAGCCTC GTGAAGGCCA GCGTGGTCAC CGTGCGTGAG 
AGTCCTGCCA CGCCCGTATC CTTCCAGGCA GCCTCCACCT CCGGGGTGCC AGACCACGCA 
AAGCTACAGG CGCCAGGGTC CGAGTGCCTG GGCCCCAAGG GGGGCGGGGG CGATTGTGCC 
AAGCGCAAAA GCTGGGCCCG CTTCAAAGAT GCTTGCGGGA AGAGTGAGGA CTGGAACAAG 
GTGTCCAAGG CTGAGTCGAT GGAGACACTT CCCGAGAGGA CAAAAGCGTC AGGCGAGGCC 
ACACTGAAGA AGACAGACTC GTGTGACAGT GGCATCACCA AGAGCGACTT GCGCCTGGAC 
AACGTGGGTG AGGCCAGGAG TCCCCAGGAT CGGAGTCCCA TCCTGGCAGA GGTCAAGCAT 
TCGTTCTACC CCATCCCTGA GCAGACGCTG CAGGCCACAG TCCTGGAGGT GAGGCACGAG 
CTGAAGGAGG ACATCAAGGC CTTAAACGCC AAAATGACCA ATATTGAGAA ACAGCTCTCT 
GAGATACTCA GGATATTAAC TTCCAGAAGA TCCTCTCAGT CTCCTCAGGA GTTGTTTGAA 
ATATCGAGGC CACAGTCCCC AGAATCAGAG AGAGACATTT TTGGAGCCAG CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNH1 ( NM_172362.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_758872.1 Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA.

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CloneID	OHu26729
Clone ID Related Accession (Same CDS sequence)	NM_172362.3 , NM_172362.2
Accession Version	NM_172362.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2970bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-27
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092017.2, AJ001366.1, AF078742.1 and AC096636.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_172362.2. Transcript Variant: This variant (1), also known as eagB, encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF078742.1, SRR1803612.181704.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000271751.10/ ENSP00000271751.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCATGG CTGGGGGCAG GAGGGGACTA GTGGCCCCTC AAAACACGTT TCTGGAGAAT 
ATTGTTCGGC GGTCCAATGA TACTAATTTT GTGTTGGGGA ATGCTCAGAT AGTGGACTGG 
CCTATTGTGT ACAGCAATGA TGGATTTTGC AAGCTGTCTG GCTATCACAG GGCAGAAGTG 
ATGCAAAAAA GCAGCACCTG CAGTTTTATG TATGGGGAGC TGACTGATAA AGACACGATT 
GAAAAAGTGC GGCAAACATT TGAGAACTAT GAGATGAATT CCTTTGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTCTTT GTGAAAATTG CTCCAATTCG AAACGAACAG 
GATAAAGTGG TTTTATTTCT TTGCACTTTC AGTGACATAA CAGCTTTCAA ACAGCCAATT 
GAGGATGATT CATGTAAAGG CTGGGGGAAG TTTGCTCGGC TGACAAGAGC ACTGACAAGC 
AGCAGGGGTG TCCTGCAGCA GCTGGCTCCA AGCGTGCAAA AAGGCGAGAA TGTCCACAAG 
CACTCCCGCC TGGCAGAGGT CCTACAGCTG GGCTCAGACA TCCTTCCCCA GTACAAGCAA 
GAGGCACCAA AGACTCCCCC TCACATCATC TTACATTATT GTGTTTTTAA GACCACGTGG 
GATTGGATCA TCTTGATCTT GACCTTCTAT ACAGCCATCT TGGTCCCTTA TAATGTCTCC 
TTCAAAACCA GGCAGAATAA TGTGGCCTGG CTGGTTGTTG ATAGCATCGT GGATGTTATC 
TTTTTGGTGG ACATTGTGCT CAATTTTCAT ACCACCTTTG TTGGACCAGC AGGGGAGGTG 
ATTTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATTGACCTT 
CTGTCCTGTT TGCCATATGA TGTCATCAAC GCTTTTGAGA ACGTGGATGA GGTTAGTGCC 
TTTATGGGTG ATCCAGGGAA GATTGGTTTT GCTGATCAGA TTCCACCACC ACTGGAGGGG 
AGAGAGAGTC AGGGCATCAG CAGCCTGTTC AGCTCTCTAA AAGTTGTCCG GCTGCTCCGT 
CTTGGGCGAG TGGCCCGTAA GCTGGACCAC TACATTGAAT ATGGAGCTGC TGTGCTGGTC 
CTGCTGGTGT GTGTGTTTGG GCTGGCTGCA CACTGGATGG CCTGCATCTG GTACAGCATT 
GGGGACTATG AGATCTTTGA CGAGGACACC AAGACAATCC GCAACAACAG CTGGCTGTAC 
CAACTAGCGA TGGACATTGG CACCCCTTAC CAGTTTAATG GGTCTGGCTC AGGGAAGTGG 
GAAGGTGGTC CCAGCAAGAA TTCTGTCTAC ATCTCCTCGT TGTATTTCAC AATGACCAGC 
CTCACCAGTG TGGGCTTTGG GAACATCGCC CCATCCACAG ACATTGAGAA GATCTTTGCA 
GTGGCCATCA TGATGATTGG CTCACTTCTC TATGCCACCA TCTTCGGGAA TGTGACGACT 
ATTTTCCAAC AGATGTATGC CAACACCAAC AGATACCATG AGATGCTCAA CAGTGTTCGG 
GACTTCCTGA AGCTCTACCA GGTGCCAAAA GGATTGAGTG AGCGAGTAAT GGATTATATT 
GTGTCCACTT GGTCCATGTC CAGAGGCATT GACACAGAGA AGGTCCTGCA GATCTGCCCC 
AAGGACATGA GAGCCGACAT CTGCGTGCAC CTGAACCGCA AGGTGTTCAA GGAGCACCCG 
GCCTTCCGGC TGGCCAGTGA TGGCTGCCTC CGGGCACTGG CCATGGAGTT CCAGACGGTG 
CACTGTGCCC CAGGGGACCT CATCTACCAT GCAGGAGAGA GCGTTGACAG CCTCTGCTTT 
GTGGTTTCTG GCTCCCTGGA GGTGATCCAA GATGATGAGG TGGTGGCCAT TCTAGGAAAA 
GGAGACGTGT TTGGAGATGT GTTCTGGAAG GAAGCCACCC TTGCCCAGTC CTGTGCCAAT 
GTTAGGGCCT TGACCTACTG TGATCTGCAT GTGATCAAGC GGGATGCCCT GCAGAAAGTG 
CTGGAATTCT ACACGGCCTT CTCCCATTCC TTCTCCCGGA ACCTGATTCT GACGTACAAC 
TTGAGGAAGA GGATTGTGTT CCGGAAGATC AGCGATGTGA AACGTGAAGA GGAAGAACGC 
ATGAAACGAA AGAATGAGGC CCCCCTGATC TTGCCCCCGG ACCACCCTGT CCGGCGCCTC 
TTCCAGAGAT TCCGACAGCA GAAAGAGGCC AGGCTGGCAG CTGAGAGAGG GGGCCGGGAC 
CTGGATGACC TAGATGTGGA GAAGGGCAAT GTCCTTACAG AGCATGCCTC CGCCAACCAC 
AGCCTCGTGA AGGCCAGCGT GGTCACCGTG CGTGAGAGTC CTGCCACGCC CGTATCCTTC 
CAGGCAGCCT CCACCTCCGG GGTGCCAGAC CACGCAAAGC TACAGGCGCC AGGGTCCGAG 
TGCCTGGGCC CCAAGGGGGG CGGGGGCGAT TGTGCCAAGC GCAAAAGCTG GGCCCGCTTC 
AAAGATGCTT GCGGGAAGAG TGAGGACTGG AACAAGGTGT CCAAGGCTGA GTCGATGGAG 
ACACTTCCCG AGAGGACAAA AGCGTCAGGC GAGGCCACAC TGAAGAAGAC AGACTCGTGT 
GACAGTGGCA TCACCAAGAG CGACTTGCGC CTGGACAACG TGGGTGAGGC CAGGAGTCCC 
CAGGATCGGA GTCCCATCCT GGCAGAGGTC AAGCATTCGT TCTACCCCAT CCCTGAGCAG 
ACGCTGCAGG CCACAGTCCT GGAGGTGAGG CACGAGCTGA AGGAGGACAT CAAGGCCTTA 
AACGCCAAAA TGACCAATAT TGAGAAACAG CTCTCTGAGA TACTCAGGAT ATTAACTTCC 
AGAAGATCCT CTCAGTCTCC TCAGGAGTTG TTTGAAATAT CGAGGCCACA GTCCCCAGAA 
TCAGAGAGAG ACATTTTTGG AGCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758872.1
CDS	204..3173
Translation	MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS

Target ORF information:

RefSeq Version	NM_172362.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172362.3

ORF Insert Sequence:

ATGACCATGG CTGGGGGCAG GAGGGGACTA GTGGCCCCTC AAAACACGTT TCTGGAGAAT 
ATTGTTCGGC GGTCCAATGA TACTAATTTT GTGTTGGGGA ATGCTCAGAT AGTGGACTGG 
CCTATTGTGT ACAGCAATGA TGGATTTTGC AAGCTGTCTG GCTATCACAG GGCAGAAGTG 
ATGCAAAAAA GCAGCACCTG CAGTTTTATG TATGGGGAGC TGACTGATAA AGACACGATT 
GAAAAAGTGC GGCAAACATT TGAGAACTAT GAGATGAATT CCTTTGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTCTTT GTGAAAATTG CTCCAATTCG AAACGAACAG 
GATAAAGTGG TTTTATTTCT TTGCACTTTC AGTGACATAA CAGCTTTCAA ACAGCCAATT 
GAGGATGATT CATGTAAAGG CTGGGGGAAG TTTGCTCGGC TGACAAGAGC ACTGACAAGC 
AGCAGGGGTG TCCTGCAGCA GCTGGCTCCA AGCGTGCAAA AAGGCGAGAA TGTCCACAAG 
CACTCCCGCC TGGCAGAGGT CCTACAGCTG GGCTCAGACA TCCTTCCCCA GTACAAGCAA 
GAGGCACCAA AGACTCCCCC TCACATCATC TTACATTATT GTGTTTTTAA GACCACGTGG 
GATTGGATCA TCTTGATCTT GACCTTCTAT ACAGCCATCT TGGTCCCTTA TAATGTCTCC 
TTCAAAACCA GGCAGAATAA TGTGGCCTGG CTGGTTGTTG ATAGCATCGT GGATGTTATC 
TTTTTGGTGG ACATTGTGCT CAATTTTCAT ACCACCTTTG TTGGACCAGC AGGGGAGGTG 
ATTTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATTGACCTT 
CTGTCCTGTT TGCCATATGA TGTCATCAAC GCTTTTGAGA ACGTGGATGA GGTTAGTGCC 
TTTATGGGTG ATCCAGGGAA GATTGGTTTT GCTGATCAGA TTCCACCACC ACTGGAGGGG 
AGAGAGAGTC AGGGCATCAG CAGCCTGTTC AGCTCTCTAA AAGTTGTCCG GCTGCTCCGT 
CTTGGGCGAG TGGCCCGTAA GCTGGACCAC TACATTGAAT ATGGAGCTGC TGTGCTGGTC 
CTGCTGGTGT GTGTGTTTGG GCTGGCTGCA CACTGGATGG CCTGCATCTG GTACAGCATT 
GGGGACTATG AGATCTTTGA CGAGGACACC AAGACAATCC GCAACAACAG CTGGCTGTAC 
CAACTAGCGA TGGACATTGG CACCCCTTAC CAGTTTAATG GGTCTGGCTC AGGGAAGTGG 
GAAGGTGGTC CCAGCAAGAA TTCTGTCTAC ATCTCCTCGT TGTATTTCAC AATGACCAGC 
CTCACCAGTG TGGGCTTTGG GAACATCGCC CCATCCACAG ACATTGAGAA GATCTTTGCA 
GTGGCCATCA TGATGATTGG CTCACTTCTC TATGCCACCA TCTTCGGGAA TGTGACGACT 
ATTTTCCAAC AGATGTATGC CAACACCAAC AGATACCATG AGATGCTCAA CAGTGTTCGG 
GACTTCCTGA AGCTCTACCA GGTGCCAAAA GGATTGAGTG AGCGAGTAAT GGATTATATT 
GTGTCCACTT GGTCCATGTC CAGAGGCATT GACACAGAGA AGGTCCTGCA GATCTGCCCC 
AAGGACATGA GAGCCGACAT CTGCGTGCAC CTGAACCGCA AGGTGTTCAA GGAGCACCCG 
GCCTTCCGGC TGGCCAGTGA TGGCTGCCTC CGGGCACTGG CCATGGAGTT CCAGACGGTG 
CACTGTGCCC CAGGGGACCT CATCTACCAT GCAGGAGAGA GCGTTGACAG CCTCTGCTTT 
GTGGTTTCTG GCTCCCTGGA GGTGATCCAA GATGATGAGG TGGTGGCCAT TCTAGGAAAA 
GGAGACGTGT TTGGAGATGT GTTCTGGAAG GAAGCCACCC TTGCCCAGTC CTGTGCCAAT 
GTTAGGGCCT TGACCTACTG TGATCTGCAT GTGATCAAGC GGGATGCCCT GCAGAAAGTG 
CTGGAATTCT ACACGGCCTT CTCCCATTCC TTCTCCCGGA ACCTGATTCT GACGTACAAC 
TTGAGGAAGA GGATTGTGTT CCGGAAGATC AGCGATGTGA AACGTGAAGA GGAAGAACGC 
ATGAAACGAA AGAATGAGGC CCCCCTGATC TTGCCCCCGG ACCACCCTGT CCGGCGCCTC 
TTCCAGAGAT TCCGACAGCA GAAAGAGGCC AGGCTGGCAG CTGAGAGAGG GGGCCGGGAC 
CTGGATGACC TAGATGTGGA GAAGGGCAAT GTCCTTACAG AGCATGCCTC CGCCAACCAC 
AGCCTCGTGA AGGCCAGCGT GGTCACCGTG CGTGAGAGTC CTGCCACGCC CGTATCCTTC 
CAGGCAGCCT CCACCTCCGG GGTGCCAGAC CACGCAAAGC TACAGGCGCC AGGGTCCGAG 
TGCCTGGGCC CCAAGGGGGG CGGGGGCGAT TGTGCCAAGC GCAAAAGCTG GGCCCGCTTC 
AAAGATGCTT GCGGGAAGAG TGAGGACTGG AACAAGGTGT CCAAGGCTGA GTCGATGGAG 
ACACTTCCCG AGAGGACAAA AGCGTCAGGC GAGGCCACAC TGAAGAAGAC AGACTCGTGT 
GACAGTGGCA TCACCAAGAG CGACTTGCGC CTGGACAACG TGGGTGAGGC CAGGAGTCCC 
CAGGATCGGA GTCCCATCCT GGCAGAGGTC AAGCATTCGT TCTACCCCAT CCCTGAGCAG 
ACGCTGCAGG CCACAGTCCT GGAGGTGAGG CACGAGCTGA AGGAGGACAT CAAGGCCTTA 
AACGCCAAAA TGACCAATAT TGAGAAACAG CTCTCTGAGA TACTCAGGAT ATTAACTTCC 
AGAAGATCCT CTCAGTCTCC TCAGGAGTTG TTTGAAATAT CGAGGCCACA GTCCCCAGAA 
TCAGAGAGAG ACATTTTTGG AGCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNH1 ( NM_172362.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_758872.1 Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA.

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CloneID	OHu26729
Clone ID Related Accession (Same CDS sequence)	NM_172362.3 , NM_172362.2
Accession Version	NM_172362.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2970bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily H member 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ001366.1, AF078742.1 and AC096636.1. This sequence is a reference standard in the RefSeqGene project. On Jul 16, 2008 this sequence version replaced NM_172362.1. Transcript Variant: This variant (1), also known as eagB, encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF078742.1, SRR1803613.58675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2157437 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATGG CTGGGGGCAG GAGGGGACTA GTGGCCCCTC AAAACACGTT TCTGGAGAAT 
ATTGTTCGGC GGTCCAATGA TACTAATTTT GTGTTGGGGA ATGCTCAGAT AGTGGACTGG 
CCTATTGTGT ACAGCAATGA TGGATTTTGC AAGCTGTCTG GCTATCACAG GGCAGAAGTG 
ATGCAAAAAA GCAGCACCTG CAGTTTTATG TATGGGGAGC TGACTGATAA AGACACGATT 
GAAAAAGTGC GGCAAACATT TGAGAACTAT GAGATGAATT CCTTTGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTCTTT GTGAAAATTG CTCCAATTCG AAACGAACAG 
GATAAAGTGG TTTTATTTCT TTGCACTTTC AGTGACATAA CAGCTTTCAA ACAGCCAATT 
GAGGATGATT CATGTAAAGG CTGGGGGAAG TTTGCTCGGC TGACAAGAGC ACTGACAAGC 
AGCAGGGGTG TCCTGCAGCA GCTGGCTCCA AGCGTGCAAA AAGGCGAGAA TGTCCACAAG 
CACTCCCGCC TGGCAGAGGT CCTACAGCTG GGCTCAGACA TCCTTCCCCA GTACAAGCAA 
GAGGCACCAA AGACTCCCCC TCACATCATC TTACATTATT GTGTTTTTAA GACCACGTGG 
GATTGGATCA TCTTGATCTT GACCTTCTAT ACAGCCATCT TGGTCCCTTA TAATGTCTCC 
TTCAAAACCA GGCAGAATAA TGTGGCCTGG CTGGTTGTTG ATAGCATCGT GGATGTTATC 
TTTTTGGTGG ACATTGTGCT CAATTTTCAT ACCACCTTTG TTGGACCAGC AGGGGAGGTG 
ATTTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATTGACCTT 
CTGTCCTGTT TGCCATATGA TGTCATCAAC GCTTTTGAGA ACGTGGATGA GGTTAGTGCC 
TTTATGGGTG ATCCAGGGAA GATTGGTTTT GCTGATCAGA TTCCACCACC ACTGGAGGGG 
AGAGAGAGTC AGGGCATCAG CAGCCTGTTC AGCTCTCTAA AAGTTGTCCG GCTGCTCCGT 
CTTGGGCGAG TGGCCCGTAA GCTGGACCAC TACATTGAAT ATGGAGCTGC TGTGCTGGTC 
CTGCTGGTGT GTGTGTTTGG GCTGGCTGCA CACTGGATGG CCTGCATCTG GTACAGCATT 
GGGGACTATG AGATCTTTGA CGAGGACACC AAGACAATCC GCAACAACAG CTGGCTGTAC 
CAACTAGCGA TGGACATTGG CACCCCTTAC CAGTTTAATG GGTCTGGCTC AGGGAAGTGG 
GAAGGTGGTC CCAGCAAGAA TTCTGTCTAC ATCTCCTCGT TGTATTTCAC AATGACCAGC 
CTCACCAGTG TGGGCTTTGG GAACATCGCC CCATCCACAG ACATTGAGAA GATCTTTGCA 
GTGGCCATCA TGATGATTGG CTCACTTCTC TATGCCACCA TCTTCGGGAA TGTGACGACT 
ATTTTCCAAC AGATGTATGC CAACACCAAC AGATACCATG AGATGCTCAA CAGTGTTCGG 
GACTTCCTGA AGCTCTACCA GGTGCCAAAA GGATTGAGTG AGCGAGTAAT GGATTATATT 
GTGTCCACTT GGTCCATGTC CAGAGGCATT GACACAGAGA AGGTCCTGCA GATCTGCCCC 
AAGGACATGA GAGCCGACAT CTGCGTGCAC CTGAACCGCA AGGTGTTCAA GGAGCACCCG 
GCCTTCCGGC TGGCCAGTGA TGGCTGCCTC CGGGCACTGG CCATGGAGTT CCAGACGGTG 
CACTGTGCCC CAGGGGACCT CATCTACCAT GCAGGAGAGA GCGTTGACAG CCTCTGCTTT 
GTGGTTTCTG GCTCCCTGGA GGTGATCCAA GATGATGAGG TGGTGGCCAT TCTAGGAAAA 
GGAGACGTGT TTGGAGATGT GTTCTGGAAG GAAGCCACCC TTGCCCAGTC CTGTGCCAAT 
GTTAGGGCCT TGACCTACTG TGATCTGCAT GTGATCAAGC GGGATGCCCT GCAGAAAGTG 
CTGGAATTCT ACACGGCCTT CTCCCATTCC TTCTCCCGGA ACCTGATTCT GACGTACAAC 
TTGAGGAAGA GGATTGTGTT CCGGAAGATC AGCGATGTGA AACGTGAAGA GGAAGAACGC 
ATGAAACGAA AGAATGAGGC CCCCCTGATC TTGCCCCCGG ACCACCCTGT CCGGCGCCTC 
TTCCAGAGAT TCCGACAGCA GAAAGAGGCC AGGCTGGCAG CTGAGAGAGG GGGCCGGGAC 
CTGGATGACC TAGATGTGGA GAAGGGCAAT GTCCTTACAG AGCATGCCTC CGCCAACCAC 
AGCCTCGTGA AGGCCAGCGT GGTCACCGTG CGTGAGAGTC CTGCCACGCC CGTATCCTTC 
CAGGCAGCCT CCACCTCCGG GGTGCCAGAC CACGCAAAGC TACAGGCGCC AGGGTCCGAG 
TGCCTGGGCC CCAAGGGGGG CGGGGGCGAT TGTGCCAAGC GCAAAAGCTG GGCCCGCTTC 
AAAGATGCTT GCGGGAAGAG TGAGGACTGG AACAAGGTGT CCAAGGCTGA GTCGATGGAG 
ACACTTCCCG AGAGGACAAA AGCGTCAGGC GAGGCCACAC TGAAGAAGAC AGACTCGTGT 
GACAGTGGCA TCACCAAGAG CGACTTGCGC CTGGACAACG TGGGTGAGGC CAGGAGTCCC 
CAGGATCGGA GTCCCATCCT GGCAGAGGTC AAGCATTCGT TCTACCCCAT CCCTGAGCAG 
ACGCTGCAGG CCACAGTCCT GGAGGTGAGG CACGAGCTGA AGGAGGACAT CAAGGCCTTA 
AACGCCAAAA TGACCAATAT TGAGAAACAG CTCTCTGAGA TACTCAGGAT ATTAACTTCC 
AGAAGATCCT CTCAGTCTCC TCAGGAGTTG TTTGAAATAT CGAGGCCACA GTCCCCAGAA 
TCAGAGAGAG ACATTTTTGG AGCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_758872.1
CDS	171..3140
Translation	MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFGAS

Target ORF information:

RefSeq Version	NM_172362.2
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel subfamily H member 1 (KCNH1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_172362.2

ORF Insert Sequence:

ATGACCATGG CTGGGGGCAG GAGGGGACTA GTGGCCCCTC AAAACACGTT TCTGGAGAAT 
ATTGTTCGGC GGTCCAATGA TACTAATTTT GTGTTGGGGA ATGCTCAGAT AGTGGACTGG 
CCTATTGTGT ACAGCAATGA TGGATTTTGC AAGCTGTCTG GCTATCACAG GGCAGAAGTG 
ATGCAAAAAA GCAGCACCTG CAGTTTTATG TATGGGGAGC TGACTGATAA AGACACGATT 
GAAAAAGTGC GGCAAACATT TGAGAACTAT GAGATGAATT CCTTTGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTCTTT GTGAAAATTG CTCCAATTCG AAACGAACAG 
GATAAAGTGG TTTTATTTCT TTGCACTTTC AGTGACATAA CAGCTTTCAA ACAGCCAATT 
GAGGATGATT CATGTAAAGG CTGGGGGAAG TTTGCTCGGC TGACAAGAGC ACTGACAAGC 
AGCAGGGGTG TCCTGCAGCA GCTGGCTCCA AGCGTGCAAA AAGGCGAGAA TGTCCACAAG 
CACTCCCGCC TGGCAGAGGT CCTACAGCTG GGCTCAGACA TCCTTCCCCA GTACAAGCAA 
GAGGCACCAA AGACTCCCCC TCACATCATC TTACATTATT GTGTTTTTAA GACCACGTGG 
GATTGGATCA TCTTGATCTT GACCTTCTAT ACAGCCATCT TGGTCCCTTA TAATGTCTCC 
TTCAAAACCA GGCAGAATAA TGTGGCCTGG CTGGTTGTTG ATAGCATCGT GGATGTTATC 
TTTTTGGTGG ACATTGTGCT CAATTTTCAT ACCACCTTTG TTGGACCAGC AGGGGAGGTG 
ATTTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATTGACCTT 
CTGTCCTGTT TGCCATATGA TGTCATCAAC GCTTTTGAGA ACGTGGATGA GGTTAGTGCC 
TTTATGGGTG ATCCAGGGAA GATTGGTTTT GCTGATCAGA TTCCACCACC ACTGGAGGGG 
AGAGAGAGTC AGGGCATCAG CAGCCTGTTC AGCTCTCTAA AAGTTGTCCG GCTGCTCCGT 
CTTGGGCGAG TGGCCCGTAA GCTGGACCAC TACATTGAAT ATGGAGCTGC TGTGCTGGTC 
CTGCTGGTGT GTGTGTTTGG GCTGGCTGCA CACTGGATGG CCTGCATCTG GTACAGCATT 
GGGGACTATG AGATCTTTGA CGAGGACACC AAGACAATCC GCAACAACAG CTGGCTGTAC 
CAACTAGCGA TGGACATTGG CACCCCTTAC CAGTTTAATG GGTCTGGCTC AGGGAAGTGG 
GAAGGTGGTC CCAGCAAGAA TTCTGTCTAC ATCTCCTCGT TGTATTTCAC AATGACCAGC 
CTCACCAGTG TGGGCTTTGG GAACATCGCC CCATCCACAG ACATTGAGAA GATCTTTGCA 
GTGGCCATCA TGATGATTGG CTCACTTCTC TATGCCACCA TCTTCGGGAA TGTGACGACT 
ATTTTCCAAC AGATGTATGC CAACACCAAC AGATACCATG AGATGCTCAA CAGTGTTCGG 
GACTTCCTGA AGCTCTACCA GGTGCCAAAA GGATTGAGTG AGCGAGTAAT GGATTATATT 
GTGTCCACTT GGTCCATGTC CAGAGGCATT GACACAGAGA AGGTCCTGCA GATCTGCCCC 
AAGGACATGA GAGCCGACAT CTGCGTGCAC CTGAACCGCA AGGTGTTCAA GGAGCACCCG 
GCCTTCCGGC TGGCCAGTGA TGGCTGCCTC CGGGCACTGG CCATGGAGTT CCAGACGGTG 
CACTGTGCCC CAGGGGACCT CATCTACCAT GCAGGAGAGA GCGTTGACAG CCTCTGCTTT 
GTGGTTTCTG GCTCCCTGGA GGTGATCCAA GATGATGAGG TGGTGGCCAT TCTAGGAAAA 
GGAGACGTGT TTGGAGATGT GTTCTGGAAG GAAGCCACCC TTGCCCAGTC CTGTGCCAAT 
GTTAGGGCCT TGACCTACTG TGATCTGCAT GTGATCAAGC GGGATGCCCT GCAGAAAGTG 
CTGGAATTCT ACACGGCCTT CTCCCATTCC TTCTCCCGGA ACCTGATTCT GACGTACAAC 
TTGAGGAAGA GGATTGTGTT CCGGAAGATC AGCGATGTGA AACGTGAAGA GGAAGAACGC 
ATGAAACGAA AGAATGAGGC CCCCCTGATC TTGCCCCCGG ACCACCCTGT CCGGCGCCTC 
TTCCAGAGAT TCCGACAGCA GAAAGAGGCC AGGCTGGCAG CTGAGAGAGG GGGCCGGGAC 
CTGGATGACC TAGATGTGGA GAAGGGCAAT GTCCTTACAG AGCATGCCTC CGCCAACCAC 
AGCCTCGTGA AGGCCAGCGT GGTCACCGTG CGTGAGAGTC CTGCCACGCC CGTATCCTTC 
CAGGCAGCCT CCACCTCCGG GGTGCCAGAC CACGCAAAGC TACAGGCGCC AGGGTCCGAG 
TGCCTGGGCC CCAAGGGGGG CGGGGGCGAT TGTGCCAAGC GCAAAAGCTG GGCCCGCTTC 
AAAGATGCTT GCGGGAAGAG TGAGGACTGG AACAAGGTGT CCAAGGCTGA GTCGATGGAG 
ACACTTCCCG AGAGGACAAA AGCGTCAGGC GAGGCCACAC TGAAGAAGAC AGACTCGTGT 
GACAGTGGCA TCACCAAGAG CGACTTGCGC CTGGACAACG TGGGTGAGGC CAGGAGTCCC 
CAGGATCGGA GTCCCATCCT GGCAGAGGTC AAGCATTCGT TCTACCCCAT CCCTGAGCAG 
ACGCTGCAGG CCACAGTCCT GGAGGTGAGG CACGAGCTGA AGGAGGACAT CAAGGCCTTA 
AACGCCAAAA TGACCAATAT TGAGAAACAG CTCTCTGAGA TACTCAGGAT ATTAACTTCC 
AGAAGATCCT CTCAGTCTCC TCAGGAGTTG TTTGAAATAT CGAGGCCACA GTCCCCAGAA 
TCAGAGAGAG ACATTTTTGG AGCCAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Kv10.1 potassium channel: from the brain to the tumors.
Biochemistry and cell biology = Biochimie et biologie cellulaire95(5)531-536(2017 Oct)
C?zares-Ordo?ez V,Pardo LA

The electric fence to cell-cycle progression: Do local changes in membrane potential facilitate disassembly of the primary cilium?: Timely and localized expression of a potassium channel may set the conditions that allow retraction of the primary cilium.
BioEssays : news and reviews in molecular, cellular and developmental biology39(6)(2017 Jun)
Urrego D,S?nchez A,Tomczak AP,Pardo LA

The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression.
Science signaling10(473)(2017 Apr)
Becchetti A,Crescioli S,Zanieri F,Petroni G,Mercatelli R,Coppola S,Gasparoli L,D'Amico M,Pillozzi S,Crociani O,Stefanini M,Fiore A,Carraresi L,Morello V,Manoli S,Brizzi MF,Ricci D,Rinaldi M,Masi A,Schmidt T,Quercioli F,Defilippi P,Arcangeli A

The involvement of Eag1 potassium channels and miR-34a in rotenone-induced death of dopaminergic SH-SY5Y cells.
Molecular medicine reports15(4)1479-1488(2017 Apr)
Horst CH,Titze-de-Almeida R,Titze-de-Almeida SS

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KCNH1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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