Gene Symbol | JAK2 |
Entrez Gene ID | 3717 |
Full Name | Janus kinase 2 |
Synonyms | JTK10,THCYT3 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Polycythemia vera, somatic, 263300 (3); Thrombocythemia 3, 614521 (3); Myelofibrosis, somatic, 254450 (3); Erythrocytosis, somatic, 133100 (3); Leukemia, acute myeloid, somatic, 601626 (3); {Budd-Chiari syndrome, somatic}, 600880 (3) |