ITIH4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ITIH4
Entrez Gene ID	3700
Full Name	inter-alpha-trypsin inhibitor heavy chain family member 4
Synonyms	GP120,H4P,IHRP,ITI-HC4,ITIHL1,PK-120,PK120
General protein information	Preferred Names inter-alpha-trypsin inhibitor heavy chain family member 4 Names inter-alpha-trypsin inhibitor heavy chain H4 ITI heavy chain H4 inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) inter-alpha-inhibitor heavy chain 4 inter-alpha-trypsin inhibitor family heavy chain-related protein inter-alpha-trypsin inhibitor, heavy chain-like, 1 plasma kallikrein-sensitive glycoprotein 120
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3p21.1
Summary	The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
Disorder MIM:	600564
Disorder Html:	{Hypercholesterolemia, susceptibility to}, 143890 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001166449.1	NP_001159921.1	inter-alpha-trypsin inhibitor heavy chain H4 isoform 2 precursor
NM_002218.4	NP_002209.2	inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor
NM_002218.5	NP_002209.2	inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor

Pathways from BioSystems

Homologies

	ITIH4	XP_002802831.1
Canis lupus familiaris (dog)	ITIH4	XP_848765.3
Rattus norvegicus (Norway rat)	Itih4	NP_062242.2
Pan troglodytes (chimpanzee)	ITIH4	XP_001172688.1
Bos taurus (cattle)	ITIH4	NP_001015590.2
Homo sapiens (human)	ITIH4	NP_001159921.1
Mus musculus (house mouse)	Itih4	NP_061216.2
Danio rerio (zebrafish)	zgc:112265	NP_001020335.1
Xenopus tropicalis (tropical clawed frog)	LOC100487172	XP_002941978.2

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO
Journal of proteome research16(8)3083-3091(2017 Aug)

ITIH4: Effective Serum Marker, Early Warning and Diagnosis, Hepatocellular Carcinoma.
Li X, Li B, Li B, Guo T, Sun Z, Li X, Chen L, Chen W, Chen P, Mao Y, Zeng Y
Pathology oncology research : POR(2017 Aug)

Schizophrenia risk variants in ITIH4 and CALN1 regulate gene expression in the dorsolateral prefrontal cortex.
Ohi K, Shimada T, Nitta Y, Kihara H, Okubo H, Uehara T, Kawasaki Y
Psychiatric genetics26(3)142-3(2016 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this report has further supported for associations of genetic variants in the ITIH4 and CALN1 genes with schizophrenia and provided the first evidence that the variants regulate ITIH4 AND CALN1 expression in the dorsolateral prefrontal cortex
Title: Schizophrenia risk variants in ITIH4 and CALN1 regulate gene expression in the dorsolateral prefrontal cortex.

confirmed the association of schizophrenia with ITIH3/4 in a Han Chinese population
Title: Loci with genome-wide associations with schizophrenia in the Han Chinese population.

ITIH4 peptide isoform as a preterm birth biomarker and its associated SNP implications
Title: Serological targeted analysis of an ITIH4 peptide isoform: a preterm birth biomarker and its associated SNP implications.

Serum ITIH4 may be a PM10-specific biomarker in COPD and may be related to inflammation.
Title: Inter-alpha-trypsin inhibitor heavy chain 4: a novel biomarker for environmental exposure to particulate air pollution in patients with chronic obstructive pulmonary disease.

Isoform-specific ITIH4 glycosylation and utilization of O-glycosylation sites on ITIH4 differs between cell lines and serum.
Title: Site-specific glycan microheterogeneity of inter-alpha-trypsin inhibitor heavy chain H4.

The following ITIH4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ITIH4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19427	NM_002218.5 Latest version!	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu15407	NM_001166449.1 Latest version!	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$636.30 $909.00
View Old Accession Versions >>
OHu19427	NM_002218.4	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ITIH4 ( NM_002218.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_002209.2 Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19427
Clone ID Related Accession (Same CDS sequence)	NM_002218.4 , NM_002218.5
Accession Version	NM_002218.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2793bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-10
Organism	Homo sapiens(human)
Product	inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC412911.1, BC136392.1, BC136393.1 and AW291001.1. This sequence is a reference standard in the RefSeqGene project. On Oct 24, 2009 this sequence version replaced NM_002218.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC136393.1, D38595.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCCC CAAGGCCTGT CCGTACCTGC AGCAAAGTTC TCGTCCTGCT TTCACTGCTG 
GCCATCCACC AGACTACTAC TGCCGAAAAG AATGGCATCG ACATCTACAG CCTCACCGTG 
GACTCCAGGG TCTCATCCCG ATTTGCCCAC ACGGTCGTCA CCAGCCGAGT GGTCAATAGG 
GCCAATACTG TGCAGGAGGC CACCTTCCAG ATGGAGCTGC CCAAGAAAGC CTTCATCACC 
AACTTCTCCA TGATCATCGA TGGCATGACC TACCCAGGGA TCATCAAGGA GAAGGCTGAA 
GCCCAGGCAC AGTACAGCGC AGCAGTGGCC AAGGGAAAGA GCGCTGGCCT CGTCAAGGCC 
ACCGGGAGAA ACATGGAGCA GTTCCAGGTG TCGGTCAGTG TGGCTCCCAA TGCCAAGATC 
ACCTTTGAGC TGGTCTATGA GGAGCTGCTC AAGCGGCGTT TGGGGGTGTA CGAGCTGCTG 
CTGAAAGTGC GGCCCCAGCA GCTGGTCAAG CACCTGCAGA TGGACATTCA CATCTTCGAG 
CCCCAGGGCA TCAGCTTTCT GGAGACAGAG AGCACCTTCA TGACCAACCA GCTGGTAGAC 
GCCCTCACCA CCTGGCAGAA TAAGACCAAG GCTCACATCC GGTTCAAGCC AACACTTTCC 
CAGCAGCAAA AGTCCCCAGA GCAGCAAGAA ACAGTCCTGG ACGGCAACCT CATTATCCGC 
TATGATGTGG ACCGGGCCAT CTCCGGGGGC TCCATTCAGA TCGAGAACGG CTACTTTGTA 
CACTACTTTG CCCCCGAGGG CCTAACCACA ATGCCCAAGA ATGTGGTCTT TGTCATTGAC 
AAGAGCGGCT CCATGAGTGG CAGGAAAATC CAGCAGACCC GGGAAGCCCT AATCAAGATC 
CTGGATGACC TCAGCCCCAG AGACCAGTTC AACCTCATCG TCTTCAGTAC AGAAGCAACT 
CAGTGGAGGC CATCACTGGT GCCAGCCTCA GCCGAGAACG TGAACAAGGC CAGGAGCTTT 
GCTGCGGGCA TCCAGGCCCT GGGAGGGACC AACATCAATG ATGCAATGCT GATGGCTGTG 
CAGTTGCTGG ACAGCAGCAA CCAGGAGGAG CGGCTGCCCG AAGGGAGTGT CTCACTCATC 
ATCCTGCTCA CCGATGGCGA CCCCACTGTG GGGGAGACTA ACCCCAGGAG CATCCAGAAT 
AACGTGCGGG AAGCTGTAAG TGGCCGGTAC AGCCTCTTCT GCCTGGGCTT CGGTTTCGAC 
GTCAGCTATG CCTTCCTGGA GAAGCTGGCA CTGGACAATG GCGGCCTGGC CCGGCGCATC 
CATGAGGACT CAGACTCTGC CCTGCAGCTC CAGGACTTCT ACCAGGAAGT GGCCAACCCA 
CTGCTGACAG CAGTGACCTT CGAGTACCCA AGCAATGCCG TGGAGGAGGT CACTCAGAAC 
AACTTCCGGC TCCTCTTCAA GGGCTCAGAG ATGGTGGTGG CTGGGAAGCT CCAGGACCGG 
GGGCCTGATG TGCTCACAGC CACAGTCAGT GGGAAGCTGC CTACACAGAA CATCACTTTC 
CAAACGGAGT CCAGTGTGGC AGAGCAGGAG GCGGAGTTCC AGAGCCCCAA GTATATCTTC 
CACAACTTCA TGGAGAGGCT CTGGGCATAC CTGACTATCC AGCAGCTGCT GGAGCAAACT 
GTCTCCGCAT CCGATGCTGA TCAGCAGGCC CTCCGGAACC AAGCGCTGAA TTTATCACTT 
GCCTACAGCT TTGTCACGCC TCTCACATCT ATGGTAGTCA CCAAACCCGA TGACCAAGAG 
CAGTCTCAAG TTGCTGAGAA GCCCATGGAA GGCGAAAGTA GAAACAGGAA TGTCCACTCA 
GGTTCCACTT TCTTCAAATA TTATCTCCAG GGAGCAAAAA TACCAAAACC AGAGGCTTCC 
TTTTCTCCAA GAAGAGGATG GAATAGACAA GCTGGAGCTG CTGGCTCCCG GATGAATTTC 
AGACCTGGGG TTCTCAGCTC CAGGCAACTT GGACTCCCAG GACCTCCTGA TGTTCCTGAC 
CATGCTGCTT ACCACCCCTT CCGCCGTCTG GCCATCTTGC CTGCTTCAGC ACCACCAGCC 
ACCTCAAATC CTGATCCAGC TGTGTCTCGT GTCATGAATA TGAAAATCGA AGAAACAACC 
ATGACAACCC AAACCCCAGC CCCCATACAG GCTCCCTCTG CCATCCTGCC ACTGCCTGGG 
CAGAGTGTGG AGCGGCTCTG TGTGGACCCC AGACACCGCC AGGGGCCAGT GAACCTGCTC 
TCAGACCCTG AGCAAGGGGT TGAGGTGACT GGCCAGTATG AGAGGGAGAA GGCTGGGTTC 
TCATGGATCG AAGTGACCTT CAAGAACCCC CTGGTATGGG TTCACGCATC CCCTGAACAC 
GTGGTGGTGA CTCGGAACCG AAGAAGCTCT GCGTACAAGT GGAAGGAGAC GCTATTCTCA 
GTGATGCCCG GCCTGAAGAT GACCATGGAC AAGACGGGTC TCCTGCTGCT CAGTGACCCA 
GACAAAGTGA CCATCGGCCT GTTGTTCTGG GATGGCCGTG GGGAGGGGCT CCGGCTCCTT 
CTGCGTGACA CTGACCGCTT CTCCAGCCAC GTTGGAGGGA CCCTTGGCCA GTTTTACCAG 
GAGGTGCTCT GGGGATCTCC AGCAGCATCA GATGACGGCA GACGCACGCT GAGGGTTCAG 
GGCAATGACC ACTCTGCCAC CAGAGAGCGC AGGCTGGATT ACCAGGAGGG GCCCCCGGGA 
GTGGAGATTT CCTGCTGGTC TGTGGAGCTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002209.2
CDS	60..2852
Translation	MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETTMTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQGNDHSATRERRLDYQEGPPGVEISCWSVEL

Target ORF information:

RefSeq Version	NM_002218.4
Organism	Homo sapiens(human)
Definition	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002218.4

ORF Insert Sequence:

ATGAAGCCCC CAAGGCCTGT CCGTACCTGC AGCAAAGTTC TCGTCCTGCT TTCACTGCTG 
GCCATCCACC AGACTACTAC TGCCGAAAAG AATGGCATCG ACATCTACAG CCTCACCGTG 
GACTCCAGGG TCTCATCCCG ATTTGCCCAC ACGGTCGTCA CCAGCCGAGT GGTCAATAGG 
GCCAATACTG TGCAGGAGGC CACCTTCCAG ATGGAGCTGC CCAAGAAAGC CTTCATCACC 
AACTTCTCCA TGATCATCGA TGGCATGACC TACCCAGGGA TCATCAAGGA GAAGGCTGAA 
GCCCAGGCAC AGTACAGCGC AGCAGTGGCC AAGGGAAAGA GCGCTGGCCT CGTCAAGGCC 
ACCGGGAGAA ACATGGAGCA GTTCCAGGTG TCGGTCAGTG TGGCTCCCAA TGCCAAGATC 
ACCTTTGAGC TGGTCTATGA GGAGCTGCTC AAGCGGCGTT TGGGGGTGTA CGAGCTGCTG 
CTGAAAGTGC GGCCCCAGCA GCTGGTCAAG CACCTGCAGA TGGACATTCA CATCTTCGAG 
CCCCAGGGCA TCAGCTTTCT GGAGACAGAG AGCACCTTCA TGACCAACCA GCTGGTAGAC 
GCCCTCACCA CCTGGCAGAA TAAGACCAAG GCTCACATCC GGTTCAAGCC AACACTTTCC 
CAGCAGCAAA AGTCCCCAGA GCAGCAAGAA ACAGTCCTGG ACGGCAACCT CATTATCCGC 
TATGATGTGG ACCGGGCCAT CTCCGGGGGC TCCATTCAGA TCGAGAACGG CTACTTTGTA 
CACTACTTTG CCCCCGAGGG CCTAACCACA ATGCCCAAGA ATGTGGTCTT TGTCATTGAC 
AAGAGCGGCT CCATGAGTGG CAGGAAAATC CAGCAGACCC GGGAAGCCCT AATCAAGATC 
CTGGATGACC TCAGCCCCAG AGACCAGTTC AACCTCATCG TCTTCAGTAC AGAAGCAACT 
CAGTGGAGGC CATCACTGGT GCCAGCCTCA GCCGAGAACG TGAACAAGGC CAGGAGCTTT 
GCTGCGGGCA TCCAGGCCCT GGGAGGGACC AACATCAATG ATGCAATGCT GATGGCTGTG 
CAGTTGCTGG ACAGCAGCAA CCAGGAGGAG CGGCTGCCCG AAGGGAGTGT CTCACTCATC 
ATCCTGCTCA CCGATGGCGA CCCCACTGTG GGGGAGACTA ACCCCAGGAG CATCCAGAAT 
AACGTGCGGG AAGCTGTAAG TGGCCGGTAC AGCCTCTTCT GCCTGGGCTT CGGTTTCGAC 
GTCAGCTATG CCTTCCTGGA GAAGCTGGCA CTGGACAATG GCGGCCTGGC CCGGCGCATC 
CATGAGGACT CAGACTCTGC CCTGCAGCTC CAGGACTTCT ACCAGGAAGT GGCCAACCCA 
CTGCTGACAG CAGTGACCTT CGAGTACCCA AGCAATGCCG TGGAGGAGGT CACTCAGAAC 
AACTTCCGGC TCCTCTTCAA GGGCTCAGAG ATGGTGGTGG CTGGGAAGCT CCAGGACCGG 
GGGCCTGATG TGCTCACAGC CACAGTCAGT GGGAAGCTGC CTACACAGAA CATCACTTTC 
CAAACGGAGT CCAGTGTGGC AGAGCAGGAG GCGGAGTTCC AGAGCCCCAA GTATATCTTC 
CACAACTTCA TGGAGAGGCT CTGGGCATAC CTGACTATCC AGCAGCTGCT GGAGCAAACT 
GTCTCCGCAT CCGATGCTGA TCAGCAGGCC CTCCGGAACC AAGCGCTGAA TTTATCACTT 
GCCTACAGCT TTGTCACGCC TCTCACATCT ATGGTAGTCA CCAAACCCGA TGACCAAGAG 
CAGTCTCAAG TTGCTGAGAA GCCCATGGAA GGCGAAAGTA GAAACAGGAA TGTCCACTCA 
GGTTCCACTT TCTTCAAATA TTATCTCCAG GGAGCAAAAA TACCAAAACC AGAGGCTTCC 
TTTTCTCCAA GAAGAGGATG GAATAGACAA GCTGGAGCTG CTGGCTCCCG GATGAATTTC 
AGACCTGGGG TTCTCAGCTC CAGGCAACTT GGACTCCCAG GACCTCCTGA TGTTCCTGAC 
CATGCTGCTT ACCACCCCTT CCGCCGTCTG GCCATCTTGC CTGCTTCAGC ACCACCAGCC 
ACCTCAAATC CTGATCCAGC TGTGTCTCGT GTCATGAATA TGAAAATCGA AGAAACAACC 
ATGACAACCC AAACCCCAGC CCCCATACAG GCTCCCTCTG CCATCCTGCC ACTGCCTGGG 
CAGAGTGTGG AGCGGCTCTG TGTGGACCCC AGACACCGCC AGGGGCCAGT GAACCTGCTC 
TCAGACCCTG AGCAAGGGGT TGAGGTGACT GGCCAGTATG AGAGGGAGAA GGCTGGGTTC 
TCATGGATCG AAGTGACCTT CAAGAACCCC CTGGTATGGG TTCACGCATC CCCTGAACAC 
GTGGTGGTGA CTCGGAACCG AAGAAGCTCT GCGTACAAGT GGAAGGAGAC GCTATTCTCA 
GTGATGCCCG GCCTGAAGAT GACCATGGAC AAGACGGGTC TCCTGCTGCT CAGTGACCCA 
GACAAAGTGA CCATCGGCCT GTTGTTCTGG GATGGCCGTG GGGAGGGGCT CCGGCTCCTT 
CTGCGTGACA CTGACCGCTT CTCCAGCCAC GTTGGAGGGA CCCTTGGCCA GTTTTACCAG 
GAGGTGCTCT GGGGATCTCC AGCAGCATCA GATGACGGCA GACGCACGCT GAGGGTTCAG 
GGCAATGACC ACTCTGCCAC CAGAGAGCGC AGGCTGGATT ACCAGGAGGG GCCCCCGGGA 
GTGGAGATTT CCTGCTGGTC TGTGGAGCTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITIH4 ( NM_002218.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_002209.2 Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu19427
Clone ID Related Accession (Same CDS sequence)	NM_002218.4 , NM_002218.5
Accession Version	NM_002218.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2793bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	inter-alpha-trypsin inhibitor heavy chain H4 isoform 1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC136392.1, BC136393.1, AW291001.1 and AC006254.10. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_002218.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D38595.1, BC136393.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155590 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000266041.9/ ENSP00000266041.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCCC CAAGGCCTGT CCGTACCTGC AGCAAAGTTC TCGTCCTGCT TTCACTGCTG 
GCCATCCACC AGACTACTAC TGCCGAAAAG AATGGCATCG ACATCTACAG CCTCACCGTG 
GACTCCAGGG TCTCATCCCG ATTTGCCCAC ACGGTCGTCA CCAGCCGAGT GGTCAATAGG 
GCCAATACTG TGCAGGAGGC CACCTTCCAG ATGGAGCTGC CCAAGAAAGC CTTCATCACC 
AACTTCTCCA TGATCATCGA TGGCATGACC TACCCAGGGA TCATCAAGGA GAAGGCTGAA 
GCCCAGGCAC AGTACAGCGC AGCAGTGGCC AAGGGAAAGA GCGCTGGCCT CGTCAAGGCC 
ACCGGGAGAA ACATGGAGCA GTTCCAGGTG TCGGTCAGTG TGGCTCCCAA TGCCAAGATC 
ACCTTTGAGC TGGTCTATGA GGAGCTGCTC AAGCGGCGTT TGGGGGTGTA CGAGCTGCTG 
CTGAAAGTGC GGCCCCAGCA GCTGGTCAAG CACCTGCAGA TGGACATTCA CATCTTCGAG 
CCCCAGGGCA TCAGCTTTCT GGAGACAGAG AGCACCTTCA TGACCAACCA GCTGGTAGAC 
GCCCTCACCA CCTGGCAGAA TAAGACCAAG GCTCACATCC GGTTCAAGCC AACACTTTCC 
CAGCAGCAAA AGTCCCCAGA GCAGCAAGAA ACAGTCCTGG ACGGCAACCT CATTATCCGC 
TATGATGTGG ACCGGGCCAT CTCCGGGGGC TCCATTCAGA TCGAGAACGG CTACTTTGTA 
CACTACTTTG CCCCCGAGGG CCTAACCACA ATGCCCAAGA ATGTGGTCTT TGTCATTGAC 
AAGAGCGGCT CCATGAGTGG CAGGAAAATC CAGCAGACCC GGGAAGCCCT AATCAAGATC 
CTGGATGACC TCAGCCCCAG AGACCAGTTC AACCTCATCG TCTTCAGTAC AGAAGCAACT 
CAGTGGAGGC CATCACTGGT GCCAGCCTCA GCCGAGAACG TGAACAAGGC CAGGAGCTTT 
GCTGCGGGCA TCCAGGCCCT GGGAGGGACC AACATCAATG ATGCAATGCT GATGGCTGTG 
CAGTTGCTGG ACAGCAGCAA CCAGGAGGAG CGGCTGCCCG AAGGGAGTGT CTCACTCATC 
ATCCTGCTCA CCGATGGCGA CCCCACTGTG GGGGAGACTA ACCCCAGGAG CATCCAGAAT 
AACGTGCGGG AAGCTGTAAG TGGCCGGTAC AGCCTCTTCT GCCTGGGCTT CGGTTTCGAC 
GTCAGCTATG CCTTCCTGGA GAAGCTGGCA CTGGACAATG GCGGCCTGGC CCGGCGCATC 
CATGAGGACT CAGACTCTGC CCTGCAGCTC CAGGACTTCT ACCAGGAAGT GGCCAACCCA 
CTGCTGACAG CAGTGACCTT CGAGTACCCA AGCAATGCCG TGGAGGAGGT CACTCAGAAC 
AACTTCCGGC TCCTCTTCAA GGGCTCAGAG ATGGTGGTGG CTGGGAAGCT CCAGGACCGG 
GGGCCTGATG TGCTCACAGC CACAGTCAGT GGGAAGCTGC CTACACAGAA CATCACTTTC 
CAAACGGAGT CCAGTGTGGC AGAGCAGGAG GCGGAGTTCC AGAGCCCCAA GTATATCTTC 
CACAACTTCA TGGAGAGGCT CTGGGCATAC CTGACTATCC AGCAGCTGCT GGAGCAAACT 
GTCTCCGCAT CCGATGCTGA TCAGCAGGCC CTCCGGAACC AAGCGCTGAA TTTATCACTT 
GCCTACAGCT TTGTCACGCC TCTCACATCT ATGGTAGTCA CCAAACCCGA TGACCAAGAG 
CAGTCTCAAG TTGCTGAGAA GCCCATGGAA GGCGAAAGTA GAAACAGGAA TGTCCACTCA 
GGTTCCACTT TCTTCAAATA TTATCTCCAG GGAGCAAAAA TACCAAAACC AGAGGCTTCC 
TTTTCTCCAA GAAGAGGATG GAATAGACAA GCTGGAGCTG CTGGCTCCCG GATGAATTTC 
AGACCTGGGG TTCTCAGCTC CAGGCAACTT GGACTCCCAG GACCTCCTGA TGTTCCTGAC 
CATGCTGCTT ACCACCCCTT CCGCCGTCTG GCCATCTTGC CTGCTTCAGC ACCACCAGCC 
ACCTCAAATC CTGATCCAGC TGTGTCTCGT GTCATGAATA TGAAAATCGA AGAAACAACC 
ATGACAACCC AAACCCCAGC CCCCATACAG GCTCCCTCTG CCATCCTGCC ACTGCCTGGG 
CAGAGTGTGG AGCGGCTCTG TGTGGACCCC AGACACCGCC AGGGGCCAGT GAACCTGCTC 
TCAGACCCTG AGCAAGGGGT TGAGGTGACT GGCCAGTATG AGAGGGAGAA GGCTGGGTTC 
TCATGGATCG AAGTGACCTT CAAGAACCCC CTGGTATGGG TTCACGCATC CCCTGAACAC 
GTGGTGGTGA CTCGGAACCG AAGAAGCTCT GCGTACAAGT GGAAGGAGAC GCTATTCTCA 
GTGATGCCCG GCCTGAAGAT GACCATGGAC AAGACGGGTC TCCTGCTGCT CAGTGACCCA 
GACAAAGTGA CCATCGGCCT GTTGTTCTGG GATGGCCGTG GGGAGGGGCT CCGGCTCCTT 
CTGCGTGACA CTGACCGCTT CTCCAGCCAC GTTGGAGGGA CCCTTGGCCA GTTTTACCAG 
GAGGTGCTCT GGGGATCTCC AGCAGCATCA GATGACGGCA GACGCACGCT GAGGGTTCAG 
GGCAATGACC ACTCTGCCAC CAGAGAGCGC AGGCTGGATT ACCAGGAGGG GCCCCCGGGA 
GTGGAGATTT CCTGCTGGTC TGTGGAGCTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002209.2
CDS	31..2823
Translation	MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNVHSGSTFFKYYLQGAKIPKPEASFSPRRGWNRQAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETTMTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQGNDHSATRERRLDYQEGPPGVEISCWSVEL

Target ORF information:

RefSeq Version	NM_002218.5
Organism	Homo sapiens(human)
Definition	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002218.5

ORF Insert Sequence:

ATGAAGCCCC CAAGGCCTGT CCGTACCTGC AGCAAAGTTC TCGTCCTGCT TTCACTGCTG 
GCCATCCACC AGACTACTAC TGCCGAAAAG AATGGCATCG ACATCTACAG CCTCACCGTG 
GACTCCAGGG TCTCATCCCG ATTTGCCCAC ACGGTCGTCA CCAGCCGAGT GGTCAATAGG 
GCCAATACTG TGCAGGAGGC CACCTTCCAG ATGGAGCTGC CCAAGAAAGC CTTCATCACC 
AACTTCTCCA TGATCATCGA TGGCATGACC TACCCAGGGA TCATCAAGGA GAAGGCTGAA 
GCCCAGGCAC AGTACAGCGC AGCAGTGGCC AAGGGAAAGA GCGCTGGCCT CGTCAAGGCC 
ACCGGGAGAA ACATGGAGCA GTTCCAGGTG TCGGTCAGTG TGGCTCCCAA TGCCAAGATC 
ACCTTTGAGC TGGTCTATGA GGAGCTGCTC AAGCGGCGTT TGGGGGTGTA CGAGCTGCTG 
CTGAAAGTGC GGCCCCAGCA GCTGGTCAAG CACCTGCAGA TGGACATTCA CATCTTCGAG 
CCCCAGGGCA TCAGCTTTCT GGAGACAGAG AGCACCTTCA TGACCAACCA GCTGGTAGAC 
GCCCTCACCA CCTGGCAGAA TAAGACCAAG GCTCACATCC GGTTCAAGCC AACACTTTCC 
CAGCAGCAAA AGTCCCCAGA GCAGCAAGAA ACAGTCCTGG ACGGCAACCT CATTATCCGC 
TATGATGTGG ACCGGGCCAT CTCCGGGGGC TCCATTCAGA TCGAGAACGG CTACTTTGTA 
CACTACTTTG CCCCCGAGGG CCTAACCACA ATGCCCAAGA ATGTGGTCTT TGTCATTGAC 
AAGAGCGGCT CCATGAGTGG CAGGAAAATC CAGCAGACCC GGGAAGCCCT AATCAAGATC 
CTGGATGACC TCAGCCCCAG AGACCAGTTC AACCTCATCG TCTTCAGTAC AGAAGCAACT 
CAGTGGAGGC CATCACTGGT GCCAGCCTCA GCCGAGAACG TGAACAAGGC CAGGAGCTTT 
GCTGCGGGCA TCCAGGCCCT GGGAGGGACC AACATCAATG ATGCAATGCT GATGGCTGTG 
CAGTTGCTGG ACAGCAGCAA CCAGGAGGAG CGGCTGCCCG AAGGGAGTGT CTCACTCATC 
ATCCTGCTCA CCGATGGCGA CCCCACTGTG GGGGAGACTA ACCCCAGGAG CATCCAGAAT 
AACGTGCGGG AAGCTGTAAG TGGCCGGTAC AGCCTCTTCT GCCTGGGCTT CGGTTTCGAC 
GTCAGCTATG CCTTCCTGGA GAAGCTGGCA CTGGACAATG GCGGCCTGGC CCGGCGCATC 
CATGAGGACT CAGACTCTGC CCTGCAGCTC CAGGACTTCT ACCAGGAAGT GGCCAACCCA 
CTGCTGACAG CAGTGACCTT CGAGTACCCA AGCAATGCCG TGGAGGAGGT CACTCAGAAC 
AACTTCCGGC TCCTCTTCAA GGGCTCAGAG ATGGTGGTGG CTGGGAAGCT CCAGGACCGG 
GGGCCTGATG TGCTCACAGC CACAGTCAGT GGGAAGCTGC CTACACAGAA CATCACTTTC 
CAAACGGAGT CCAGTGTGGC AGAGCAGGAG GCGGAGTTCC AGAGCCCCAA GTATATCTTC 
CACAACTTCA TGGAGAGGCT CTGGGCATAC CTGACTATCC AGCAGCTGCT GGAGCAAACT 
GTCTCCGCAT CCGATGCTGA TCAGCAGGCC CTCCGGAACC AAGCGCTGAA TTTATCACTT 
GCCTACAGCT TTGTCACGCC TCTCACATCT ATGGTAGTCA CCAAACCCGA TGACCAAGAG 
CAGTCTCAAG TTGCTGAGAA GCCCATGGAA GGCGAAAGTA GAAACAGGAA TGTCCACTCA 
GGTTCCACTT TCTTCAAATA TTATCTCCAG GGAGCAAAAA TACCAAAACC AGAGGCTTCC 
TTTTCTCCAA GAAGAGGATG GAATAGACAA GCTGGAGCTG CTGGCTCCCG GATGAATTTC 
AGACCTGGGG TTCTCAGCTC CAGGCAACTT GGACTCCCAG GACCTCCTGA TGTTCCTGAC 
CATGCTGCTT ACCACCCCTT CCGCCGTCTG GCCATCTTGC CTGCTTCAGC ACCACCAGCC 
ACCTCAAATC CTGATCCAGC TGTGTCTCGT GTCATGAATA TGAAAATCGA AGAAACAACC 
ATGACAACCC AAACCCCAGC CCCCATACAG GCTCCCTCTG CCATCCTGCC ACTGCCTGGG 
CAGAGTGTGG AGCGGCTCTG TGTGGACCCC AGACACCGCC AGGGGCCAGT GAACCTGCTC 
TCAGACCCTG AGCAAGGGGT TGAGGTGACT GGCCAGTATG AGAGGGAGAA GGCTGGGTTC 
TCATGGATCG AAGTGACCTT CAAGAACCCC CTGGTATGGG TTCACGCATC CCCTGAACAC 
GTGGTGGTGA CTCGGAACCG AAGAAGCTCT GCGTACAAGT GGAAGGAGAC GCTATTCTCA 
GTGATGCCCG GCCTGAAGAT GACCATGGAC AAGACGGGTC TCCTGCTGCT CAGTGACCCA 
GACAAAGTGA CCATCGGCCT GTTGTTCTGG GATGGCCGTG GGGAGGGGCT CCGGCTCCTT 
CTGCGTGACA CTGACCGCTT CTCCAGCCAC GTTGGAGGGA CCCTTGGCCA GTTTTACCAG 
GAGGTGCTCT GGGGATCTCC AGCAGCATCA GATGACGGCA GACGCACGCT GAGGGTTCAG 
GGCAATGACC ACTCTGCCAC CAGAGAGCGC AGGCTGGATT ACCAGGAGGG GCCCCCGGGA 
GTGGAGATTT CCTGCTGGTC TGTGGAGCTG TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ITIH4 ( NM_001166449.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001159921.1 Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 2, mRNA.

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CloneID	OHu15407
Clone ID Related Accession (Same CDS sequence)	NM_001166449.1
Accession Version	NM_001166449.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2703bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-18
Organism	Homo sapiens(human)
Product	inter-alpha-trypsin inhibitor heavy chain H4 isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC412911.1, AK298412.1, AC006254.10, BC136392.1 and AW291001.1. Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK298412.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155590, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCCC CAAGGCCTGT CCGTACCTGC AGCAAAGTTC TCGTCCTGCT TTCACTGCTG 
GCCATCCACC AGACTACTAC TGCCGAAAAG AATGGCATCG ACATCTACAG CCTCACCGTG 
GACTCCAGGG TCTCATCCCG ATTTGCCCAC ACGGTCGTCA CCAGCCGAGT GGTCAATAGG 
GCCAATACTG TGCAGGAGGC CACCTTCCAG ATGGAGCTGC CCAAGAAAGC CTTCATCACC 
AACTTCTCCA TGATCATCGA TGGCATGACC TACCCAGGGA TCATCAAGGA GAAGGCTGAA 
GCCCAGGCAC AGTACAGCGC AGCAGTGGCC AAGGGAAAGA GCGCTGGCCT CGTCAAGGCC 
ACCGGGAGAA ACATGGAGCA GTTCCAGGTG TCGGTCAGTG TGGCTCCCAA TGCCAAGATC 
ACCTTTGAGC TGGTCTATGA GGAGCTGCTC AAGCGGCGTT TGGGGGTGTA CGAGCTGCTG 
CTGAAAGTGC GGCCCCAGCA GCTGGTCAAG CACCTGCAGA TGGACATTCA CATCTTCGAG 
CCCCAGGGCA TCAGCTTTCT GGAGACAGAG AGCACCTTCA TGACCAACCA GCTGGTAGAC 
GCCCTCACCA CCTGGCAGAA TAAGACCAAG GCTCACATCC GGTTCAAGCC AACACTTTCC 
CAGCAGCAAA AGTCCCCAGA GCAGCAAGAA ACAGTCCTGG ACGGCAACCT CATTATCCGC 
TATGATGTGG ACCGGGCCAT CTCCGGGGGC TCCATTCAGA TCGAGAACGG CTACTTTGTA 
CACTACTTTG CCCCCGAGGG CCTAACCACA ATGCCCAAGA ATGTGGTCTT TGTCATTGAC 
AAGAGCGGCT CCATGAGTGG CAGGAAAATC CAGCAGACCC GGGAAGCCCT AATCAAGATC 
CTGGATGACC TCAGCCCCAG AGACCAGTTC AACCTCATCG TCTTCAGTAC AGAAGCAACT 
CAGTGGAGGC CATCACTGGT GCCAGCCTCA GCCGAGAACG TGAACAAGGC CAGGAGCTTT 
GCTGCGGGCA TCCAGGCCCT GGGAGGGACC AACATCAATG ATGCAATGCT GATGGCTGTG 
CAGTTGCTGG ACAGCAGCAA CCAGGAGGAG CGGCTGCCCG AAGGGAGTGT CTCACTCATC 
ATCCTGCTCA CCGATGGCGA CCCCACTGTG GGGGAGACTA ACCCCAGGAG CATCCAGAAT 
AACGTGCGGG AAGCTGTAAG TGGCCGGTAC AGCCTCTTCT GCCTGGGCTT CGGTTTCGAC 
GTCAGCTATG CCTTCCTGGA GAAGCTGGCA CTGGACAATG GCGGCCTGGC CCGGCGCATC 
CATGAGGACT CAGACTCTGC CCTGCAGCTC CAGGACTTCT ACCAGGAAGT GGCCAACCCA 
CTGCTGACAG CAGTGACCTT CGAGTACCCA AGCAATGCCG TGGAGGAGGT CACTCAGAAC 
AACTTCCGGC TCCTCTTCAA GGGCTCAGAG ATGGTGGTGG CTGGGAAGCT CCAGGACCGG 
GGGCCTGATG TGCTCACAGC CACAGTCAGT GGGAAGCTGC CTACACAGAA CATCACTTTC 
CAAACGGAGT CCAGTGTGGC AGAGCAGGAG GCGGAGTTCC AGAGCCCCAA GTATATCTTC 
CACAACTTCA TGGAGAGGCT CTGGGCATAC CTGACTATCC AGCAGCTGCT GGAGCAAACT 
GTCTCCGCAT CCGATGCTGA TCAGCAGGCC CTCCGGAACC AAGCGCTGAA TTTATCACTT 
GCCTACAGCT TTGTCACGCC TCTCACATCT ATGGTAGTCA CCAAACCCGA TGACCAAGAG 
CAGTCTCAAG TTGCTGAGAA GCCCATGGAA GGCGAAAGTA GAAACAGGAA TGTCCACTCA 
GCTGGAGCTG CTGGCTCCCG GATGAATTTC AGACCTGGGG TTCTCAGCTC CAGGCAACTT 
GGACTCCCAG GACCTCCTGA TGTTCCTGAC CATGCTGCTT ACCACCCCTT CCGCCGTCTG 
GCCATCTTGC CTGCTTCAGC ACCACCAGCC ACCTCAAATC CTGATCCAGC TGTGTCTCGT 
GTCATGAATA TGAAAATCGA AGAAACAACC ATGACAACCC AAACCCCAGC CCCCATACAG 
GCTCCCTCTG CCATCCTGCC ACTGCCTGGG CAGAGTGTGG AGCGGCTCTG TGTGGACCCC 
AGACACCGCC AGGGGCCAGT GAACCTGCTC TCAGACCCTG AGCAAGGGGT TGAGGTGACT 
GGCCAGTATG AGAGGGAGAA GGCTGGGTTC TCATGGATCG AAGTGACCTT CAAGAACCCC 
CTGGTATGGG TTCACGCATC CCCTGAACAC GTGGTGGTGA CTCGGAACCG AAGAAGCTCT 
GCGTACAAGT GGAAGGAGAC GCTATTCTCA GTGATGCCCG GCCTGAAGAT GACCATGGAC 
AAGACGGGTC TCCTGCTGCT CAGTGACCCA GACAAAGTGA CCATCGGCCT GTTGTTCTGG 
GATGGCCGTG GGGAGGGGCT CCGGCTCCTT CTGCGTGACA CTGACCGCTT CTCCAGCCAC 
GTTGGAGGGA CCCTTGGCCA GTTTTACCAG GAGGTGCTCT GGGGATCTCC AGCAGCATCA 
GATGACGGCA GACGCACGCT GAGGGTTCAG GGCAATGACC ACTCTGCCAC CAGAGAGCGC 
AGGCTGGATT ACCAGGAGGG GCCCCCGGGA GTGGAGATTT CCTGCTGGTC TGTGGAGCTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001159921.1
CDS	60..2762
Translation	MKPPRPVRTCSKVLVLLSLLAIHQTTTAEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIIDGMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSVSVAPNAKITFELVYEELLKRRLGVYELLLKVRPQQLVKHLQMDIHIFEPQGISFLETESTFMTNQLVDALTTWQNKTKAHIRFKPTLSQQQKSPEQQETVLDGNLIIRYDVDRAISGGSIQIENGYFVHYFAPEGLTTMPKNVVFVIDKSGSMSGRKIQQTREALIKILDDLSPRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDSSNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAFLEKLALDNGGLARRIHEDSDSALQLQDFYQEVANPLLTAVTFEYPSNAVEEVTQNNFRLLFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYIFHNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQEQSQVAEKPMEGESRNRNVHSAGAAGSRMNFRPGVLSSRQLGLPGPPDVPDHAAYHPFRRLAILPASAPPATSNPDPAVSRVMNMKIEETTMTTQTPAPIQAPSAILPLPGQSVERLCVDPRHRQGPVNLLSDPEQGVEVTGQYEREKAGFSWIEVTFKNPLVWVHASPEHVVVTRNRRSSAYKWKETLFSVMPGLKMTMDKTGLLLLSDPDKVTIGLLFWDGRGEGLRLLLRDTDRFSSHVGGTLGQFYQEVLWGSPAASDDGRRTLRVQGNDHSATRERRLDYQEGPPGVEISCWSVEL

Target ORF information:

RefSeq Version	NM_001166449.1
Organism	Homo sapiens(human)
Definition	Homo sapiens inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001166449.1

ORF Insert Sequence:

ATGAAGCCCC CAAGGCCTGT CCGTACCTGC AGCAAAGTTC TCGTCCTGCT TTCACTGCTG 
GCCATCCACC AGACTACTAC TGCCGAAAAG AATGGCATCG ACATCTACAG CCTCACCGTG 
GACTCCAGGG TCTCATCCCG ATTTGCCCAC ACGGTCGTCA CCAGCCGAGT GGTCAATAGG 
GCCAATACTG TGCAGGAGGC CACCTTCCAG ATGGAGCTGC CCAAGAAAGC CTTCATCACC 
AACTTCTCCA TGATCATCGA TGGCATGACC TACCCAGGGA TCATCAAGGA GAAGGCTGAA 
GCCCAGGCAC AGTACAGCGC AGCAGTGGCC AAGGGAAAGA GCGCTGGCCT CGTCAAGGCC 
ACCGGGAGAA ACATGGAGCA GTTCCAGGTG TCGGTCAGTG TGGCTCCCAA TGCCAAGATC 
ACCTTTGAGC TGGTCTATGA GGAGCTGCTC AAGCGGCGTT TGGGGGTGTA CGAGCTGCTG 
CTGAAAGTGC GGCCCCAGCA GCTGGTCAAG CACCTGCAGA TGGACATTCA CATCTTCGAG 
CCCCAGGGCA TCAGCTTTCT GGAGACAGAG AGCACCTTCA TGACCAACCA GCTGGTAGAC 
GCCCTCACCA CCTGGCAGAA TAAGACCAAG GCTCACATCC GGTTCAAGCC AACACTTTCC 
CAGCAGCAAA AGTCCCCAGA GCAGCAAGAA ACAGTCCTGG ACGGCAACCT CATTATCCGC 
TATGATGTGG ACCGGGCCAT CTCCGGGGGC TCCATTCAGA TCGAGAACGG CTACTTTGTA 
CACTACTTTG CCCCCGAGGG CCTAACCACA ATGCCCAAGA ATGTGGTCTT TGTCATTGAC 
AAGAGCGGCT CCATGAGTGG CAGGAAAATC CAGCAGACCC GGGAAGCCCT AATCAAGATC 
CTGGATGACC TCAGCCCCAG AGACCAGTTC AACCTCATCG TCTTCAGTAC AGAAGCAACT 
CAGTGGAGGC CATCACTGGT GCCAGCCTCA GCCGAGAACG TGAACAAGGC CAGGAGCTTT 
GCTGCGGGCA TCCAGGCCCT GGGAGGGACC AACATCAATG ATGCAATGCT GATGGCTGTG 
CAGTTGCTGG ACAGCAGCAA CCAGGAGGAG CGGCTGCCCG AAGGGAGTGT CTCACTCATC 
ATCCTGCTCA CCGATGGCGA CCCCACTGTG GGGGAGACTA ACCCCAGGAG CATCCAGAAT 
AACGTGCGGG AAGCTGTAAG TGGCCGGTAC AGCCTCTTCT GCCTGGGCTT CGGTTTCGAC 
GTCAGCTATG CCTTCCTGGA GAAGCTGGCA CTGGACAATG GCGGCCTGGC CCGGCGCATC 
CATGAGGACT CAGACTCTGC CCTGCAGCTC CAGGACTTCT ACCAGGAAGT GGCCAACCCA 
CTGCTGACAG CAGTGACCTT CGAGTACCCA AGCAATGCCG TGGAGGAGGT CACTCAGAAC 
AACTTCCGGC TCCTCTTCAA GGGCTCAGAG ATGGTGGTGG CTGGGAAGCT CCAGGACCGG 
GGGCCTGATG TGCTCACAGC CACAGTCAGT GGGAAGCTGC CTACACAGAA CATCACTTTC 
CAAACGGAGT CCAGTGTGGC AGAGCAGGAG GCGGAGTTCC AGAGCCCCAA GTATATCTTC 
CACAACTTCA TGGAGAGGCT CTGGGCATAC CTGACTATCC AGCAGCTGCT GGAGCAAACT 
GTCTCCGCAT CCGATGCTGA TCAGCAGGCC CTCCGGAACC AAGCGCTGAA TTTATCACTT 
GCCTACAGCT TTGTCACGCC TCTCACATCT ATGGTAGTCA CCAAACCCGA TGACCAAGAG 
CAGTCTCAAG TTGCTGAGAA GCCCATGGAA GGCGAAAGTA GAAACAGGAA TGTCCACTCA 
GCTGGAGCTG CTGGCTCCCG GATGAATTTC AGACCTGGGG TTCTCAGCTC CAGGCAACTT 
GGACTCCCAG GACCTCCTGA TGTTCCTGAC CATGCTGCTT ACCACCCCTT CCGCCGTCTG 
GCCATCTTGC CTGCTTCAGC ACCACCAGCC ACCTCAAATC CTGATCCAGC TGTGTCTCGT 
GTCATGAATA TGAAAATCGA AGAAACAACC ATGACAACCC AAACCCCAGC CCCCATACAG 
GCTCCCTCTG CCATCCTGCC ACTGCCTGGG CAGAGTGTGG AGCGGCTCTG TGTGGACCCC 
AGACACCGCC AGGGGCCAGT GAACCTGCTC TCAGACCCTG AGCAAGGGGT TGAGGTGACT 
GGCCAGTATG AGAGGGAGAA GGCTGGGTTC TCATGGATCG AAGTGACCTT CAAGAACCCC 
CTGGTATGGG TTCACGCATC CCCTGAACAC GTGGTGGTGA CTCGGAACCG AAGAAGCTCT 
GCGTACAAGT GGAAGGAGAC GCTATTCTCA GTGATGCCCG GCCTGAAGAT GACCATGGAC 
AAGACGGGTC TCCTGCTGCT CAGTGACCCA GACAAAGTGA CCATCGGCCT GTTGTTCTGG 
GATGGCCGTG GGGAGGGGCT CCGGCTCCTT CTGCGTGACA CTGACCGCTT CTCCAGCCAC 
GTTGGAGGGA CCCTTGGCCA GTTTTACCAG GAGGTGCTCT GGGGATCTCC AGCAGCATCA 
GATGACGGCA GACGCACGCT GAGGGTTCAG GGCAATGACC ACTCTGCCAC CAGAGAGCGC 
AGGCTGGATT ACCAGGAGGG GCCCCCGGGA GTGGAGATTT CCTGCTGGTC TGTGGAGCTG 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Journal of proteome research16(8)3083-3091(2017 Aug)
Naba A,Pearce OMT,Del Rosario A,Ma D,Ding H,Rajeeve V,Cutillas PR,Balkwill FR,Hynes RO

ITIH4: Effective Serum Marker, Early Warning and Diagnosis, Hepatocellular Carcinoma.
Pathology oncology research : POR(2017 Aug)
Li X,Li B,Li B,Guo T,Sun Z,Li X,Chen L,Chen W,Chen P,Mao Y,Zeng Y

Schizophrenia risk variants in ITIH4 and CALN1 regulate gene expression in the dorsolateral prefrontal cortex.
Psychiatric genetics26(3)142-3(2016 Jun)
Ohi K,Shimada T,Nitta Y,Kihara H,Okubo H,Uehara T,Kawasaki Y

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ITIH4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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