INSL4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	INSL4
Entrez Gene ID	3641
Full Name	insulin like 4
Synonyms	EPIL,PLACENTIN
General protein information	Preferred Names insulin like 4 Names early placenta insulin-like peptide early placenta insulin-like peptide (EPIL) insulin-like 4 (placenta) insulin-like peptide 4
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p24.1
Summary	INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast. [provided by RefSeq, Jul 2008].
Disorder MIM:	600910

mRNA and Protein(s)

mRNA	Protein	Name
NM_002195.1	NP_002186.1	early placenta insulin-like peptide precursor
NM_002195.2	NP_002186.1	early placenta insulin-like peptide precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	INSL4	NP_001171285.1
Homo sapiens (human)	INSL4	NP_002186.1
	INSL4	XP_001082488.1

Gene Ontology
Bibliography

Related articles in PubMed

Relaxin, its receptor (RXFP1), and insulin-like peptide 4 expression through gestation and in placenta accreta.
Goh W, Yamamoto SY, Thompson KS, Bryant-Greenwood GD
Reproductive sciences (Thousand Oaks, Calif.)20(8)968-80(2013 Aug)

A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
Asano K, Matsushita T, Umeno J, Hosono N, Takahashi A, Kawaguchi T, Matsumoto T, Matsui T, Kakuta Y, Kinouchi Y, Shimosegawa T, Hosokawa M, Arimura Y, Shinomura Y, Kiyohara Y, Tsunoda T, Kamatani N, Iida M, Nakamura Y, Kubo M
Nature genetics41(12)1325-9(2009 Dec)

Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth.
Millar L, Streiner N, Webster L, Yamamoto S, Okabe R, Kawamata T, Shimoda J, B?llesbach E, Schwabe C, Bryant-Greenwood G
Biology of reproduction73(4)695-702(2005 Oct)

[Expression of early placenta insulin-like growth factor (EPIL) in breast cancer cells provides an autocrine loop with enhancement of predominantly HER-2-related invasivity].
B?rger H, Kemming D, Helms M, Feldmann U, Matuschek A, B?cker W, Brandt B
Verhandlungen der Deutschen Gesellschaft fur Pathologie89201-6(2005)

Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Zhang Z, Henzel WJ
Protein science : a publication of the Protein Society13(10)2819-24(2004 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Report decreased INSL4 gene expression in both the invasive and the noninvasive areas of villous trophoblast in patients with placenta accreta.
Title: Relaxin, its receptor (RXFP1), and insulin-like peptide 4 expression through gestation and in placenta accreta.

Expression of the INSL4 gene was doubled in the placenta of the growth-restricted twin compared to the normally grown sibling, suggesting that it may be linked to a higher level of apoptosis and loss of cell viability
Title: Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth.

A tight interaction between HER-2 gene and EPIL in invasive breast cancer cells is probable.
Title: [Expression of early placenta insulin-like growth factor (EPIL) in breast cancer cells provides an autocrine loop with enhancement of predominantly HER-2-related invasivity].

We identified an INSL4 alternatively spliced mRNA species that encodes putative novel INSL4-like peptides.
Title: Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element.

The following INSL4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the INSL4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29107	NM_002195.2 Latest version!	Homo sapiens insulin like 4 (INSL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29107	NM_002195.1	Homo sapiens insulin like 4 (INSL4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

INSL4 ( NM_002195.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_002186.1 Homo sapiens insulin like 4 (INSL4), mRNA.

Price & Availability↑

CloneID	OHu29107
Clone ID Related Accession (Same CDS sequence)	NM_002195.1 , NM_002195.2
Accession Version	NM_002195.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-22
Organism	Homo sapiens(human)
Product	early placenta insulin-like peptide precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L34838.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L34838.1, BC026254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END##

ATGGCCAGCC TGTTCCGGTC CTATCTGCCA GCAATCTGGC TGCTGCTGAG CCAACTCCTT 
AGAGAAAGCC TAGCAGCAGA GCTGAGGGGA TGTGGTCCCC GATTTGGAAA ACACTTGCTG 
TCATATTGCC CCATGCCTGA GAAGACATTC ACCACCACCC CAGGAGGGTG GCTGCTGGAA 
TCTGGACGTC CCAAAGAAAT GGTGTCAACC TCCAACAACA AAGATGGACA AGCCTTAGGT 
ACGACATCAG AATTCATTCC TAATTTGTCA CCAGAGCTGA AGAAACCACT GTCTGAAGGG 
CAGCCATCAT TGAAGAAAAT AATACTTTCC CGCAAAAAGA GAAGTGGACG TCACAGATTT 
GATCCATTCT GTTGTGAAGT AATTTGTGAC GATGGAACTT CAGTTAAATT ATGTACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002186.1
CDS	106..525
Translation	MASLFRSYLPAIWLLLSQLLRESLAAELRGCGPRFGKHLLSYCPMPEKTFTTTPGGWLLESGRPKEMVSTSNNKDGQALGTTSEFIPNLSPELKKPLSEGQPSLKKIILSRKKRSGRHRFDPFCCEVICDDGTSVKLCT

Target ORF information:

RefSeq Version	NM_002195.1
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like 4 (INSL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002195.1

ORF Insert Sequence:

ATGGCCAGCC TGTTCCGGTC CTATCTGCCA GCAATCTGGC TGCTGCTGAG CCAACTCCTT 
AGAGAAAGCC TAGCAGCAGA GCTGAGGGGA TGTGGTCCCC GATTTGGAAA ACACTTGCTG 
TCATATTGCC CCATGCCTGA GAAGACATTC ACCACCACCC CAGGAGGGTG GCTGCTGGAA 
TCTGGACGTC CCAAAGAAAT GGTGTCAACC TCCAACAACA AAGATGGACA AGCCTTAGGT 
ACGACATCAG AATTCATTCC TAATTTGTCA CCAGAGCTGA AGAAACCACT GTCTGAAGGG 
CAGCCATCAT TGAAGAAAAT AATACTTTCC CGCAAAAAGA GAAGTGGACG TCACAGATTT 
GATCCATTCT GTTGTGAAGT AATTTGTGAC GATGGAACTT CAGTTAAATT ATGTACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

INSL4 ( NM_002195.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_002186.1 Homo sapiens insulin like 4 (INSL4), mRNA.

Price & Availability↑

CloneID	OHu29107
Clone ID Related Accession (Same CDS sequence)	NM_002195.1 , NM_002195.2
Accession Version	NM_002195.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 420bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	early placenta insulin-like peptide precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from L34838.1 and AL133547.16. On May 17, 2019 this sequence version replaced NM_002195.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AU136752.2, AK291543.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2146236 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000239316.4/ ENSP00000239316.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGCCAGCC TGTTCCGGTC CTATCTGCCA GCAATCTGGC TGCTGCTGAG CCAACTCCTT 
AGAGAAAGCC TAGCAGCAGA GCTGAGGGGA TGTGGTCCCC GATTTGGAAA ACACTTGCTG 
TCATATTGCC CCATGCCTGA GAAGACATTC ACCACCACCC CAGGAGGGTG GCTGCTGGAA 
TCTGGACGTC CCAAAGAAAT GGTGTCAACC TCCAACAACA AAGATGGACA AGCCTTAGGT 
ACGACATCAG AATTCATTCC TAATTTGTCA CCAGAGCTGA AGAAACCACT GTCTGAAGGG 
CAGCCATCAT TGAAGAAAAT AATACTTTCC CGCAAAAAGA GAAGTGGACG TCACAGATTT 
GATCCATTCT GTTGTGAAGT AATTTGTGAC GATGGAACTT CAGTTAAATT ATGTACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_002186.1
CDS	106..525
Translation	MASLFRSYLPAIWLLLSQLLRESLAAELRGCGPRFGKHLLSYCPMPEKTFTTTPGGWLLESGRPKEMVSTSNNKDGQALGTTSEFIPNLSPELKKPLSEGQPSLKKIILSRKKRSGRHRFDPFCCEVICDDGTSVKLCT

Target ORF information:

RefSeq Version	NM_002195.2
Organism	Homo sapiens(human)
Definition	Homo sapiens insulin like 4 (INSL4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002195.2

ORF Insert Sequence:

ATGGCCAGCC TGTTCCGGTC CTATCTGCCA GCAATCTGGC TGCTGCTGAG CCAACTCCTT 
AGAGAAAGCC TAGCAGCAGA GCTGAGGGGA TGTGGTCCCC GATTTGGAAA ACACTTGCTG 
TCATATTGCC CCATGCCTGA GAAGACATTC ACCACCACCC CAGGAGGGTG GCTGCTGGAA 
TCTGGACGTC CCAAAGAAAT GGTGTCAACC TCCAACAACA AAGATGGACA AGCCTTAGGT 
ACGACATCAG AATTCATTCC TAATTTGTCA CCAGAGCTGA AGAAACCACT GTCTGAAGGG 
CAGCCATCAT TGAAGAAAAT AATACTTTCC CGCAAAAAGA GAAGTGGACG TCACAGATTT 
GATCCATTCT GTTGTGAAGT AATTTGTGAC GATGGAACTT CAGTTAAATT ATGTACATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Relaxin, its receptor (RXFP1), and insulin-like peptide 4 expression through gestation and in placenta accreta.
Reproductive sciences (Thousand Oaks, Calif.)20(8)968-80(2013 Aug)
Goh W,Yamamoto SY,Thompson KS,Bryant-Greenwood GD

A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
Nature genetics41(12)1325-9(2009 Dec)
Asano K,Matsushita T,Umeno J,Hosono N,Takahashi A,Kawaguchi T,Matsumoto T,Matsui T,Kakuta Y,Kinouchi Y,Shimosegawa T,Hosokawa M,Arimura Y,Shinomura Y,Kiyohara Y,Tsunoda T,Kamatani N,Iida M,Nakamura Y,Kubo M

Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth.
Biology of reproduction73(4)695-702(2005 Oct)
Millar L,Streiner N,Webster L,Yamamoto S,Okabe R,Kawamata T,Shimoda J,B?llesbach E,Schwabe C,Bryant-Greenwood G

[Expression of early placenta insulin-like growth factor (EPIL) in breast cancer cells provides an autocrine loop with enhancement of predominantly HER-2-related invasivity].
Verhandlungen der Deutschen Gesellschaft fur Pathologie89201-6(2005)
B?rger H,Kemming D,Helms M,Feldmann U,Matuschek A,B?cker W,Brandt B

Signal peptide prediction based on analysis of experimentally verified cleavage sites.
Protein science : a publication of the Protein Society13(10)2819-24(2004 Oct)
Zhang Z,Henzel WJ

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INSL4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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