IL10RB cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	IL10RB
Entrez Gene ID	3588
Full Name	interleukin 10 receptor subunit beta
Synonyms	CDW210B,CRF2-4,CRFB4,D21S58,D21S66,IL-10R2
General protein information	Preferred Names interleukin 10 receptor subunit beta Names interleukin-10 receptor subunit beta IL-10 receptor subunit beta IL-10R subunit 2 IL-10R subunit beta IL-10RB cytokine receptor class-II CRF2-4 cytokine receptor class-II member 4 cytokine receptor family 2 member 4 cytokine receptor family II, member 4 interleukin 10 receptor, beta interleukin-10 receptor subunit 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 21 Map Location: 21q22.11
Summary	The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008].
Disorder MIM:	123889
Disorder Html:	{Hepatitis B virus, susceptibility to}, 610424 (3); Inflammatory bowel disease 25, early onset, autosomal recessive, 612567 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000628.4	NP_000619.3	interleukin-10 receptor subunit beta precursor
NM_000628.5	NP_000619.3	interleukin-10 receptor subunit beta precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Il10rb	NP_032375.2
Rattus norvegicus (Norway rat)	Il10rb	NP_001100581.1
Xenopus tropicalis (tropical clawed frog)	il10rb	NP_001165294.1
Homo sapiens (human)	IL10RB	NP_000619.3
Bos taurus (cattle)	IL10RB	NP_001070443.1
Gallus gallus (chicken)	IL10RB	NP_990188.1
Danio rerio (zebrafish)	crfb4	NP_001077337.1
Pan troglodytes (chimpanzee)	IL10RB	XP_531433.2
Canis lupus familiaris (dog)	LOC100856489	XP_003640120.1
	IL10RB	XP_001094340.2
Canis lupus familiaris (dog)	IL10RB	XP_535581.2

Gene Ontology
Bibliography

Related articles in PubMed

Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features.
Fitzpatrick AM, Stephenson ST, Brown MR, Nguyen K, Douglas S, Brown LA
The journal of allergy and clinical immunology. In practice5(2)410-419.e4(2017 Mar - Apr)

Association Between Interleukin-10 Receptors and the CD45-Immunophenotype of Central Nervous System Tumors: A Preliminary Study.
Zadka L, Kram P, Koscinski J, Jankowski R, Kaczmarek M, Piatek K, Kulus M, Gomu?kiewicz A, Piotrowska A, Dziegiel P
Anticancer research37(10)5777-5783(2017 10)

Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early Onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey.
Huang Z, Peng K, Li X, Zhao R, You J, Cheng X, Wang Z, Wang Y, Wu B, Wang H, Zeng H, Yu Z, Zheng C, Wang Y, Huang Y
Inflammatory bowel diseases23(4)578-590(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

systemic mRNA expression of IL10RB strongly differentiated children who failed to achieve asthma control with triamcinolone administration
Title: Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features.

IL-10 and IL-10R gene polymorphisms may not contribute to the susceptibility to MM but may be associated with the severity and prognosis of MM. In particular, IL-10RB K47E polymorphism may contribute to the poor prognosis of MM patients treated with thalidomide and/or bortezomib.
Title: Polymorphism of IL-10 receptor ? affects the prognosis of multiple myeloma patients treated with thalidomide and/or bortezomib.

Expression of IL10R subunits within the leukocyte population (CD45(+) cells) was significantly higher in primary brain tumors than in metastases.
Title: Association Between Interleukin-10 Receptors and the CD45-Immunophenotype of Central Nervous System Tumors: A Preliminary Study.

IL10R2 Overexpression promotes IL22/STAT3 signaling in colorectal carcinogenesis.
Title: IL10R2 Overexpression Promotes IL22/STAT3 Signaling in Colorectal Carcinogenesis.

High IL10RB expression is associated with diffuse large B-cell lymphoma.
Title: IL10 receptor is a novel therapeutic target in DLBCLs.

The following IL10RB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL10RB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu56008	NM_000628.5 Latest version!	Homo sapiens interleukin 10 receptor subunit beta (IL10RB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu56008	NM_000628.4	Homo sapiens interleukin 10 receptor subunit beta (IL10RB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IL10RB ( NM_000628.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000619.3 Homo sapiens interleukin 10 receptor subunit beta (IL10RB), mRNA.

Price & Availability↑

CloneID	OHu56008
Clone ID Related Accession (Same CDS sequence)	NM_000628.4 , NM_000628.5
Accession Version	NM_000628.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-12
Organism	Homo sapiens(human)
Product	interleukin-10 receptor subunit beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU133530.2, BC001903.1, Z17227.1 and AI025402.1. On Jun 14, 2012 this sequence version replaced NM_000628.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.111246.1, Z17227.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGTGGA GCCTTGGGAG CTGGCTGGGT GGCTGCCTGC TGGTGTCAGC ATTGGGAATG 
GTACCACCTC CCGAAAATGT CAGAATGAAT TCTGTTAATT TCAAGAACAT TCTACAGTGG 
GAGTCACCTG CTTTTGCCAA AGGGAACCTG ACTTTCACAG CTCAGTACCT AAGTTATAGG 
ATATTCCAAG ATAAATGCAT GAATACTACC TTGACGGAAT GTGATTTCTC AAGTCTTTCC 
AAGTATGGTG ACCACACCTT GAGAGTCAGG GCTGAATTTG CAGATGAGCA TTCAGACTGG 
GTAAACATCA CCTTCTGTCC TGTGGATGAC ACCATTATTG GACCCCCTGG AATGCAAGTA 
GAAGTACTTG CTGATTCTTT ACATATGCGT TTCTTAGCCC CTAAAATTGA GAATGAATAC 
GAAACTTGGA CTATGAAGAA TGTGTATAAC TCATGGACTT ATAATGTGCA ATACTGGAAA 
AACGGTACTG ATGAAAAGTT TCAAATTACT CCCCAGTATG ACTTTGAGGT CCTCAGAAAC 
CTGGAGCCAT GGACAACTTA TTGTGTTCAA GTTCGAGGGT TTCTTCCTGA TCGGAACAAA 
GCTGGGGAAT GGAGTGAGCC TGTCTGTGAG CAAACAACCC ATGACGAAAC GGTCCCCTCC 
TGGATGGTGG CCGTCATCCT CATGGCCTCG GTCTTCATGG TCTGCCTGGC ACTCCTCGGC 
TGCTTCGCCT TGCTGTGGTG CGTTTACAAG AAGACAAAGT ACGCCTTCTC CCCTAGGAAT 
TCTCTTCCAC AGCACCTGAA AGAGTTTTTG GGCCATCCTC ATCATAACAC ACTTCTGTTT 
TTCTCCTTTC CATTGTCGGA TGAGAATGAT GTTTTTGACA AGCTAAGTGT CATTGCAGAA 
GACTCTGAGA GCGGCAAGCA GAATCCTGGT GACAGCTGCA GCCTCGGGAC CCCGCCTGGG 
CAGGGGCCCC AAAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000619.3
CDS	107..1084
Translation	MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQVEVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLRNLEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMASVFMVCLALLGCFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDENDVFDKLSVIAEDSESGKQNPGDSCSLGTPPGQGPQS

Target ORF information:

RefSeq Version	NM_000628.4
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 10 receptor subunit beta (IL10RB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000628.4

ORF Insert Sequence:

ATGGCGTGGA GCCTTGGGAG CTGGCTGGGT GGCTGCCTGC TGGTGTCAGC ATTGGGAATG 
GTACCACCTC CCGAAAATGT CAGAATGAAT TCTGTTAATT TCAAGAACAT TCTACAGTGG 
GAGTCACCTG CTTTTGCCAA AGGGAACCTG ACTTTCACAG CTCAGTACCT AAGTTATAGG 
ATATTCCAAG ATAAATGCAT GAATACTACC TTGACGGAAT GTGATTTCTC AAGTCTTTCC 
AAGTATGGTG ACCACACCTT GAGAGTCAGG GCTGAATTTG CAGATGAGCA TTCAGACTGG 
GTAAACATCA CCTTCTGTCC TGTGGATGAC ACCATTATTG GACCCCCTGG AATGCAAGTA 
GAAGTACTTG CTGATTCTTT ACATATGCGT TTCTTAGCCC CTAAAATTGA GAATGAATAC 
GAAACTTGGA CTATGAAGAA TGTGTATAAC TCATGGACTT ATAATGTGCA ATACTGGAAA 
AACGGTACTG ATGAAAAGTT TCAAATTACT CCCCAGTATG ACTTTGAGGT CCTCAGAAAC 
CTGGAGCCAT GGACAACTTA TTGTGTTCAA GTTCGAGGGT TTCTTCCTGA TCGGAACAAA 
GCTGGGGAAT GGAGTGAGCC TGTCTGTGAG CAAACAACCC ATGACGAAAC GGTCCCCTCC 
TGGATGGTGG CCGTCATCCT CATGGCCTCG GTCTTCATGG TCTGCCTGGC ACTCCTCGGC 
TGCTTCGCCT TGCTGTGGTG CGTTTACAAG AAGACAAAGT ACGCCTTCTC CCCTAGGAAT 
TCTCTTCCAC AGCACCTGAA AGAGTTTTTG GGCCATCCTC ATCATAACAC ACTTCTGTTT 
TTCTCCTTTC CATTGTCGGA TGAGAATGAT GTTTTTGACA AGCTAAGTGT CATTGCAGAA 
GACTCTGAGA GCGGCAAGCA GAATCCTGGT GACAGCTGCA GCCTCGGGAC CCCGCCTGGG 
CAGGGGCCCC AAAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

IL10RB ( NM_000628.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000619.3 Homo sapiens interleukin 10 receptor subunit beta (IL10RB), mRNA.

Price & Availability↑

CloneID	OHu56008
Clone ID Related Accession (Same CDS sequence)	NM_000628.4 , NM_000628.5
Accession Version	NM_000628.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	interleukin-10 receptor subunit beta precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU133530.2, BC001903.1, Z17227.1 and AI025402.1. On Nov 22, 2018 this sequence version replaced NM_000628.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.681251.1, SRR5189667.251949.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000290200.7/ ENSP00000290200.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGTGGA GCCTTGGGAG CTGGCTGGGT GGCTGCCTGC TGGTGTCAGC ATTGGGAATG 
GTACCACCTC CCGAAAATGT CAGAATGAAT TCTGTTAATT TCAAGAACAT TCTACAGTGG 
GAGTCACCTG CTTTTGCCAA AGGGAACCTG ACTTTCACAG CTCAGTACCT AAGTTATAGG 
ATATTCCAAG ATAAATGCAT GAATACTACC TTGACGGAAT GTGATTTCTC AAGTCTTTCC 
AAGTATGGTG ACCACACCTT GAGAGTCAGG GCTGAATTTG CAGATGAGCA TTCAGACTGG 
GTAAACATCA CCTTCTGTCC TGTGGATGAC ACCATTATTG GACCCCCTGG AATGCAAGTA 
GAAGTACTTG CTGATTCTTT ACATATGCGT TTCTTAGCCC CTAAAATTGA GAATGAATAC 
GAAACTTGGA CTATGAAGAA TGTGTATAAC TCATGGACTT ATAATGTGCA ATACTGGAAA 
AACGGTACTG ATGAAAAGTT TCAAATTACT CCCCAGTATG ACTTTGAGGT CCTCAGAAAC 
CTGGAGCCAT GGACAACTTA TTGTGTTCAA GTTCGAGGGT TTCTTCCTGA TCGGAACAAA 
GCTGGGGAAT GGAGTGAGCC TGTCTGTGAG CAAACAACCC ATGACGAAAC GGTCCCCTCC 
TGGATGGTGG CCGTCATCCT CATGGCCTCG GTCTTCATGG TCTGCCTGGC ACTCCTCGGC 
TGCTTCGCCT TGCTGTGGTG CGTTTACAAG AAGACAAAGT ACGCCTTCTC CCCTAGGAAT 
TCTCTTCCAC AGCACCTGAA AGAGTTTTTG GGCCATCCTC ATCATAACAC ACTTCTGTTT 
TTCTCCTTTC CATTGTCGGA TGAGAATGAT GTTTTTGACA AGCTAAGTGT CATTGCAGAA 
GACTCTGAGA GCGGCAAGCA GAATCCTGGT GACAGCTGCA GCCTCGGGAC CCCGCCTGGG 
CAGGGGCCCC AAAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000619.3
CDS	100..1077
Translation	MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQVEVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLRNLEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMASVFMVCLALLGCFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDENDVFDKLSVIAEDSESGKQNPGDSCSLGTPPGQGPQS

Target ORF information:

RefSeq Version	NM_000628.5
Organism	Homo sapiens(human)
Definition	Homo sapiens interleukin 10 receptor subunit beta (IL10RB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000628.5

ORF Insert Sequence:

ATGGCGTGGA GCCTTGGGAG CTGGCTGGGT GGCTGCCTGC TGGTGTCAGC ATTGGGAATG 
GTACCACCTC CCGAAAATGT CAGAATGAAT TCTGTTAATT TCAAGAACAT TCTACAGTGG 
GAGTCACCTG CTTTTGCCAA AGGGAACCTG ACTTTCACAG CTCAGTACCT AAGTTATAGG 
ATATTCCAAG ATAAATGCAT GAATACTACC TTGACGGAAT GTGATTTCTC AAGTCTTTCC 
AAGTATGGTG ACCACACCTT GAGAGTCAGG GCTGAATTTG CAGATGAGCA TTCAGACTGG 
GTAAACATCA CCTTCTGTCC TGTGGATGAC ACCATTATTG GACCCCCTGG AATGCAAGTA 
GAAGTACTTG CTGATTCTTT ACATATGCGT TTCTTAGCCC CTAAAATTGA GAATGAATAC 
GAAACTTGGA CTATGAAGAA TGTGTATAAC TCATGGACTT ATAATGTGCA ATACTGGAAA 
AACGGTACTG ATGAAAAGTT TCAAATTACT CCCCAGTATG ACTTTGAGGT CCTCAGAAAC 
CTGGAGCCAT GGACAACTTA TTGTGTTCAA GTTCGAGGGT TTCTTCCTGA TCGGAACAAA 
GCTGGGGAAT GGAGTGAGCC TGTCTGTGAG CAAACAACCC ATGACGAAAC GGTCCCCTCC 
TGGATGGTGG CCGTCATCCT CATGGCCTCG GTCTTCATGG TCTGCCTGGC ACTCCTCGGC 
TGCTTCGCCT TGCTGTGGTG CGTTTACAAG AAGACAAAGT ACGCCTTCTC CCCTAGGAAT 
TCTCTTCCAC AGCACCTGAA AGAGTTTTTG GGCCATCCTC ATCATAACAC ACTTCTGTTT 
TTCTCCTTTC CATTGTCGGA TGAGAATGAT GTTTTTGACA AGCTAAGTGT CATTGCAGAA 
GACTCTGAGA GCGGCAAGCA GAATCCTGGT GACAGCTGCA GCCTCGGGAC CCCGCCTGGG 
CAGGGGCCCC AAAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systemic Corticosteroid Responses in Children with Severe Asthma: Phenotypic and Endotypic Features.
The journal of allergy and clinical immunology. In practice5(2)410-419.e4(2017 Mar - Apr)
Fitzpatrick AM,Stephenson ST,Brown MR,Nguyen K,Douglas S,Brown LA

Association Between Interleukin-10 Receptors and the CD45-Immunophenotype of Central Nervous System Tumors: A Preliminary Study.
Anticancer research37(10)5777-5783(2017 10)
Zadka L,Kram P,Koscinski J,Jankowski R,Kaczmarek M,Piatek K,Kulus M,Gomu?kiewicz A,Piotrowska A,Dziegiel P

Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early Onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey.
Inflammatory bowel diseases23(4)578-590(2017 Apr)
Huang Z,Peng K,Li X,Zhao R,You J,Cheng X,Wang Z,Wang Y,Wu B,Wang H,Zeng H,Yu Z,Zheng C,Wang Y,Huang Y

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IL10RB cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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